ruboxistaurin has been researched along with Diabetic Angiopathies in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 14 (87.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, U; Lin, G; MacLeod, KM; McNeill, JH; Nagareddy, PR; Rajput, PS; Soliman, H | 1 |
| Cameron, NE; Cotter, MA; Jack, AM | 1 |
| Corder, R | 1 |
| Gilbert, RE; Gow, RM; Hepper, C; Jaworski, K; Kelly, DJ; Kemp, BE; Wilkinson-Berka, JL; Zhang, Y | 1 |
| Anderson, PW; Tuttle, KR | 1 |
| Whiteside, CI | 1 |
| Kashiwagi, A; Koya, D | 1 |
| Bearelly, S; Cooney, MJ; Dar, M; Goebel, JA; Joy, SV; Scates, AC; Taulien, CA | 1 |
| He, Z; King, GL | 1 |
| Avignon, A; Sultan, A | 1 |
| Andrassy, M; Fujita, T; Harja, E; Schmidt, AM; Yan, SF | 1 |
| Donnelly, R; Idris, I | 1 |
| Clarke, M; Dodson, PM | 1 |
| Ballas, LM; Bursell, SE; Clermont, A; Feener, EP; Heath, WF; Ishii, H; Jirousek, MR; Kern, TS; King, GL; Koya, D; Stramm, LE; Takagi, C; Xia, P | 1 |
| Dutour, A | 1 |
| Katai, N; King, GL; Way, KJ | 1 |
9 review(s) available for ruboxistaurin and Diabetic Angiopathies
| Article | Year |
|---|---|
A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition.
Topics: Animals; Animals, Genetically Modified; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Indoles; Kidney Failure, Chronic; Male; Maleimides; Mice; Mice, Mutant Strains; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Leptin; Renin | 2003 |
Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species.
Topics: Animals; Blood Vessels; Cells, Cultured; Diabetic Angiopathies; DNA; Gene Expression; Humans; Indoles; Intracellular Space; Maleimides; Protein Kinase C; Protein Kinase C beta; Reactive Oxygen Species; Treatment Outcome | 2005 |
[Progress on the drug therapy for diabetic microangiopathies: PKCbeta inhibitor].
Topics: Animals; Clinical Trials as Topic; Diabetic Angiopathies; Disease Models, Animal; Humans; Indoles; Maleimides; Protein Kinase C; Protein Kinase C beta; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2005 |
Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications.
Topics: Animals; Clinical Trials as Topic; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Indoles; Maleimides; MEDLINE; Protein Kinase C; Protein Kinase C beta; Treatment Outcome | 2005 |
PKC-B inhibition: a new therapeutic approach for diabetic complications?
Topics: Diabetes Complications; Diabetic Angiopathies; Enzyme Activation; Enzyme Inhibitors; Hypoglycemic Agents; Indoles; Maleimides; Protein Kinase C; Protein Kinase C beta | 2006 |
Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis.
Topics: Animals; Coronary Artery Disease; Coronary Restenosis; Diabetic Angiopathies; Diabetic Nephropathies; Disease Models, Animal; Early Growth Response Protein 1; Endothelium, Vascular; Humans; Indoles; Maleimides; Mice; Mitogen-Activated Protein Kinase Kinases; Myocardial Ischemia; Oxidative Stress; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Signal Transduction; Tunica Intima; Up-Regulation | 2006 |
Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy.
Topics: Animals; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyperglycemia; Hypoglycemic Agents; Indoles; Maleimides; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Randomized Controlled Trials as Topic; Treatment Outcome; Vascular Endothelial Growth Factor A | 2006 |
PKC inhibition and diabetic microvascular complications.
Topics: Animals; Clinical Trials as Topic; Diabetic Angiopathies; Diabetic Retinopathy; Diglycerides; Enzyme Activation; Humans; Indoles; Maleimides; Microcirculation; Protein Kinase C; Vascular Endothelial Growth Factor A; Vision, Low | 2007 |
Protein kinase C and the development of diabetic vascular complications.
Topics: Animals; Cardiomyopathies; Diabetic Angiopathies; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Protein Kinase C; Protein Kinase C beta; Signal Transduction | 2001 |
7 other study(ies) available for ruboxistaurin and Diabetic Angiopathies
| Article | Year |
|---|---|
Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Cardiovascular Diseases; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Induction; Enzyme Inhibitors; Glucose; Indoles; Lysine; Male; Maleimides; Mannitol; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nitric Oxide Synthase Type II; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Wistar | 2009 |
Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Neural Conduction; Nociceptors; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sciatic Neuropathy; Splanchnic Circulation; Vasodilation | 2002 |
New hope for the treatment of diabetic complications.
Topics: Animals; Diabetic Angiopathies; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Protein Kinase C; Protein Kinase C beta; Rats | 2002 |
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
Topics: Albuminuria; Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Disease Progression; Enzyme Inhibitors; Female; Hypertension; Immunohistochemistry; Indoles; Kidney; Kidney Glomerulus; Maleimides; Organ Size; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Mutant Strains; Reference Values | 2003 |
Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients?
Topics: Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indoles; Maleimides; Protein Kinase C; Protein Kinase C beta; Treatment Outcome | 2005 |
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Topics: Administration, Oral; Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glomerular Filtration Rate; Humans; Indoles; Isoenzymes; Kidney Glomerulus; Male; Maleimides; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Plasma Flow; Retina; Retinal Vessels; Substrate Specificity | 1996 |
Mechanisms of glucose toxicity. New hope for prevention of diabetic complications?
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Enzyme Inhibitors; Glucose; Hyperglycemia; Indoles; Maleimides; Rats | 1997 |