ruboxistaurin has been researched along with Diabetes Mellitus, Type 1 in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, SK; Li, MQ; Yuan, YF | 1 |
| Alicic, RZ; Tuttle, KR | 1 |
| Aiello, LP; Danis, RP; Davis, MD; Girach, A; Jimenez, MC; Milton, RC; Sheetz, MJ; Vignati, L; Zhi, X | 1 |
| Cherney, DZ; Diamandis, EP; Konvalinka, A; Lai, V; Lorraine, J; Miller, JA; Reich, H; Scholey, JW; Soosaipillai, A; Zinman, B | 1 |
| Majji, AB; Sahu, AK | 1 |
| Bradley, TJ; Cherney, DZ; Lai, V; Reich, HN; Scholey, JW; Slorach, C; Zinman, B | 1 |
| Lagrèze, WA | 1 |
| Aiello, LP; Klemp, K; Larsen, M; Lund-Andersen, H; Sander, B; Strøm, C | 1 |
| Aiello, LP; Arora, V; Bursell, SE; Clermont, A; Davis, MD; Sheetz, MJ | 1 |
| Barlow, PM; Bastyr, EJ; Casellini, CM; Casey, M; Pittenger, G; Rice, AL; Simmons, K; Vinik, AI; Wolka, AM | 1 |
2 review(s) available for ruboxistaurin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Novel therapies for diabetic kidney disease.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Antioxidants; Bosentan; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endothelins; Enzyme Inhibitors; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Indoles; Janus Kinases; Maleimides; Polyamines; Protein Kinase C; Pyridones; Pyridoxamine; Sevelamer; Sulfonamides | 2014 |
[New prospects in the treatment of diabetic retinopathy. Current situation and pharmacological developments].
Topics: Adult; Aged; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme Inhibitors; Female; Humans; Indoles; Integrins; Laser Coagulation; Male; Maleimides; Mass Screening; Matrix Metalloproteinase Inhibitors; Middle Aged; Pregnancy; Pregnancy in Diabetics; Protein Kinase C; Risk Factors; Vascular Endothelial Growth Factor A | 2003 |
6 trial(s) available for ruboxistaurin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Indoles; Macular Edema; Male; Maleimides; Middle Aged; Protein Kinase C; Severity of Illness Index; Time Factors; Vision Disorders; Vision Tests; Visual Acuity | 2009 |
Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Glucose; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Female; Glucose Clamp Technique; Hemodynamics; Humans; Hyperglycemia; Indoles; Infusions, Intravenous; Male; Maleimides; Pilot Projects; Protein Kinase C; Protein Kinase C beta; Renin-Angiotensin System | 2012 |
Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Double-Blind Method; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Indoles; Macular Edema; Male; Maleimides; Middle Aged; Protein Kinase C; Retina; Retinal Vessels | 2005 |
Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Blood Flow Velocity; Blood-Retinal Barrier; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Double-Blind Method; Enzyme Inhibitors; Female; Hemodynamics; Humans; Indoles; Male; Maleimides; Middle Aged; Protein Kinase C; Protein Kinase C beta; Retinal Vessels | 2006 |
Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Indoles; Laser Coagulation; Macular Edema; Male; Maleimides; Middle Aged; Prospective Studies; Protein Kinase C; Protein Kinase C beta; Treatment Outcome; Visual Acuity | 2007 |
A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy.
Topics: Aged; Blood Flow Velocity; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Humans; Indoles; Male; Maleimides; Microcirculation; Middle Aged; Placebos; Protein Kinase C; Protein Kinase C beta; Racial Groups; Regional Blood Flow; Skin | 2007 |
3 other study(ies) available for ruboxistaurin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Specific PKC βII inhibitor: one stone two birds in the treatment of diabetic foot ulcers.
Topics: Animals; Blood Glucose; Capillaries; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Foot; Indoles; Male; Maleimides; Mice, Inbred ICR; Molecular Targeted Therapy; Neovascularization, Physiologic; Neutrophils; Protein Kinase C beta; Protein Kinase Inhibitors; Wound Healing | 2018 |
Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study.
Topics: Albuminuria; Blood Pressure; Chemokine CCL2; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Filtration Rate; Hemodynamics; Humans; Indoles; Kidney; Maleimides; Protein Kinase C; Protein Kinase C beta | 2009 |
Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema.
Topics: Administration, Oral; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme Inhibitors; Humans; Indoles; Macular Edema; Maleimides; Protein Kinase C; Severity of Illness Index; Vision Disorders; Vision Tests; Visual Acuity | 2010 |