ruboxistaurin has been researched along with Asymmetric Diabetic Proximal Motor Neuropathy in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 14 (82.35) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, PW; Bastyr, EJ; McGill, JB; Poi, KK; Shahri, N; Tuttle, KR | 1 |
| Haller, H; Meier, M; Menne, J | 1 |
| Boyd, A; Casselini, C; Vinik, A; Vinik, E | 1 |
| Cameron, NE; Cotter, MA; Jack, AM | 1 |
| Corder, R | 1 |
| Inoguchi, T; Umeda, F | 1 |
| Kashiwagi, A; Kim, H; Koya, D; Maeda, K; Sasaki, T; Yasuda, H | 1 |
| Evans, L | 1 |
| Nakamura, J | 1 |
| Bastyr, EJ; Bril, V; Litchy, WJ; Price, KL; Vinik, AI | 1 |
| Musch, A | 1 |
| Bearelly, S; Cooney, MJ; Dar, M; Goebel, JA; Joy, SV; Scates, AC; Taulien, CA | 1 |
| Joy, SV; Taulien, CA | 1 |
| Hayase, F; Kashiwagi, A; Kitada-Hamada, K; Maeda, K; Matsuura, H; Omatsu-Kanbe, M; Sanada, M; Yasuda, H | 1 |
| Barlow, PM; Bastyr, EJ; Casellini, CM; Casey, M; Pittenger, G; Rice, AL; Simmons, K; Vinik, AI; Wolka, AM | 1 |
| Chaya, S; Hamada, Y; Hotta, N; Ienaga, K; Kamiya, H; Kasuya, Y; Kato, K; Koh, N; Miwa, K; Mizubayashi, R; Nakamura, J; Nakashima, E; Nakayama, M; Naruse, K; Sakakibara, F; Yasuda, Y | 1 |
6 review(s) available for ruboxistaurin and Asymmetric Diabetic Proximal Motor Neuropathy
| Article | Year |
|---|---|
Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice.
Topics: Animals; Diabetic Nephropathies; Diabetic Neuropathies; Enzyme Activation; Enzyme Inhibitors; Humans; Hyperglycemia; Indoles; Isoenzymes; Kidney; Maleimides; Mice; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Models, Animal; Protein Kinase C; Protein Kinase C beta; Risk Factors | 2009 |
[Role of PKC in the pathogenesis of diabetic vascular complications].
Topics: Animals; Clinical Trials as Topic; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Protein Kinase C; Protein Kinase C beta; Risk Factors | 2002 |
[Development of therapeutic agents for diabetic neuropathies].
Topics: Aldehyde Reductase; Antioxidants; C-Peptide; Diabetic Neuropathies; Drug Design; Enzyme Inhibitors; Genetic Therapy; Glycation End Products, Advanced; Hedgehog Proteins; Humans; Indoles; Maleimides; Nerve Growth Factor; Oxidative Stress; Polymers; Protein Kinase C; Rhodanine; Thiadiazoles; Thiamine; Thiazoles; Thiazolidines; Trans-Activators; Vascular Endothelial Growth Factor A | 2005 |
[Protein kinase C beta-Inhibitor ruboxistaurin].
Topics: Adrenergic beta-Antagonists; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Indoles; Maleimides; Protein Kinase C | 2005 |
Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications.
Topics: Animals; Clinical Trials as Topic; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Indoles; Maleimides; MEDLINE; Protein Kinase C; Protein Kinase C beta; Treatment Outcome | 2005 |
Ruboxistaurin.
Topics: Animals; Clinical Trials as Topic; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Humans; Indoles; Maleimides; Protein Kinase C | 2006 |
4 trial(s) available for ruboxistaurin and Asymmetric Diabetic Proximal Motor Neuropathy
| Article | Year |
|---|---|
Effect of ruboxistaurin on albuminuria and estimated GFR in people with diabetic peripheral neuropathy: results from a randomized trial.
Topics: Adult; Albuminuria; Creatinine; Diabetic Neuropathies; Double-Blind Method; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Indoles; Male; Maleimides; Middle Aged; Peripheral Nervous System Diseases; Protein Kinase C beta; Treatment Outcome | 2015 |
Quality of life and objective measures of diabetic neuropathy in a prospective placebo-controlled trial of ruboxistaurin and topiramate.
Topics: Adult; Aged; Anticonvulsants; Diabetes Complications; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Fructose; Humans; Indoles; Male; Maleimides; Middle Aged; Placebos; Protein Kinase Inhibitors; Quality of Life; Research Design; Surveys and Questionnaires; Topiramate | 2011 |
Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy.
Topics: Action Potentials; Adult; Diabetic Neuropathies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Indoles; Logistic Models; Male; Maleimides; Middle Aged; Neural Conduction; Predictive Value of Tests; Sensory Thresholds; Severity of Illness Index; Sural Nerve; Vibration | 2005 |
A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy.
Topics: Aged; Blood Flow Velocity; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Enzyme Inhibitors; Female; Humans; Indoles; Male; Maleimides; Microcirculation; Middle Aged; Placebos; Protein Kinase C; Protein Kinase C beta; Racial Groups; Regional Blood Flow; Skin | 2007 |
7 other study(ies) available for ruboxistaurin and Asymmetric Diabetic Proximal Motor Neuropathy
| Article | Year |
|---|---|
Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Neural Conduction; Nociceptors; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sciatic Neuropathy; Splanchnic Circulation; Vasodilation | 2002 |
New hope for the treatment of diabetic complications.
Topics: Animals; Diabetic Angiopathies; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Protein Kinase C; Protein Kinase C beta; Rats | 2002 |
Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.
Topics: Animals; Arginine; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Ganglia, Spinal; Immunohistochemistry; Indoles; Male; Maleimides; NAV1.9 Voltage-Gated Sodium Channel; Neuropeptides; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nociceptors; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin | 2003 |
American Diabetes Association--63rd Scientific Sessions. Clinical data. 13-17 June 2003, New Orleans, LA, USA.
Topics: Administration, Oral; Amyloid; Diabetes Mellitus; Diabetic Neuropathies; Drug Combinations; Drug Delivery Systems; Fructose; Humans; Hypoglycemic Agents; Indoles; Insulin; Insulin Lispro; Islet Amyloid Polypeptide; Maleimides; Neuroprotective Agents; Topiramate | 2003 |
Molecule of the month. Ruboxistaurin mesilate hydrate.
Topics: Clinical Trials, Phase II as Topic; Diabetes Complications; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Humans; Indoles; Maleimides | 2003 |
Inhibitory action of protein kinase Cbeta inhibitor on tetrodotoxin-resistant Na+ current in small dorsal root ganglion neurons in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Indoles; Male; Maleimides; Membrane Potentials; Neural Conduction; Neurons, Afferent; Patch-Clamp Techniques; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2007 |
A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, Combination; Enzyme Inhibitors; Fructose; Indoles; Isoenzymes; Male; Maleimides; Motor Neurons; Neural Conduction; Protein Kinase C; Protein Kinase C beta; Pyrimidinones; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Thiazoles | 1999 |