ruboxistaurin has been researched along with Alloxan Diabetes in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (18.18) | 18.2507 |
| 2000's | 16 (48.48) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, M; Ran, C; Wang, H; Xu, Y; Zhang, J; Zhao, F | 1 |
| Cheng, L; Fu, H; Lee, S; Li, G; Liu, T; Tse, G; Wang, H; Wang, X; Xu, A; Xu, Y | 1 |
| Das, SK; Li, MQ; Yuan, YF | 1 |
| Ge, ZD; Irwin, MG; Jin, J; Lei, S; Li, H; Liao, S; Liu, Y; Qiao, S; Wong, GT; Xia, Z | 1 |
| Ahmed, RM; Al-Amin, MA; Al-Onazi, AS; Al-Rasheed, NM; Attia, HA; Poizat, C | 1 |
| Gao, B; Gilbert, RE; Ingram, AJ; Kelly, DJ; Krepinsky, JC; Peng, F; Wu, D; Zhang, B | 1 |
| Kumar, U; Lin, G; MacLeod, KM; McNeill, JH; Nagareddy, PR; Rajput, PS; Soliman, H | 1 |
| Advani, A; Connelly, KA; Cox, AJ; Gilbert, RE; Kelly, DJ; Krum, H; Prior, DL; Thai, K; Zhang, Y | 1 |
| Cao, F; Guo, W; Hwang, A; Si, R; Sun, D; Wang, H; Wei, L; Yin, Z; Yuan, Y; Zhang, R; Zhang, Y | 1 |
| Cao, F; Di, C; Hwang, A; Lee, A; Li, F; Sun, D; Wang, H; Wei, L; Yin, Z; Yuan, Y; Zhang, R | 1 |
| Anderson, S; Beard, DR; Komers, R; Oyama, TT | 1 |
| Cahill, C; Geraldes, P; King, GL; Kitada, M; Li, C; Li, Q; Matsumoto, M; Mima, A; Ohshiro, Y; Rask-Madsen, C; White, GS | 1 |
| Gao, X; Irwin, MG; Lei, S; Liu, Y; Mao, X; Vanhoutte, PM; Wang, T; Wong, GT; Xia, Z | 1 |
| Chai, Q; d'Uscio, LV; He, T; Katusic, ZS; Lee, HC; Lu, T; Yu, L | 1 |
| Cameron, NE; Cotter, MA; Jack, AM | 1 |
| Gilbert, RE; Gow, RM; Hepper, C; Jaworski, K; Kelly, DJ; Kemp, BE; Wilkinson-Berka, JL; Zhang, Y | 1 |
| Abiko, A; Abiko, T; Adamis, AP; Bursell, SE; Clermont, AC; Horio, N; King, GL; Shoelson, B; Takahashi, J | 1 |
| Bornfeldt, KE; Isshiki, K; King, GL; Ma, RC; Park, JY; Rauniyar, RK; Sotiropoulos, KB; Yokota, T | 1 |
| Kashiwagi, A; Kim, H; Koya, D; Maeda, K; Sasaki, T; Yasuda, H | 1 |
| Cameron, NE; Cotter, MA; Nangle, MR | 1 |
| Anderson, PW; Tuttle, KR | 1 |
| Chanty, A; Gilbert, RE; Gow, RM; Kelly, DJ; Zhang, Y | 1 |
| Kashiwagi, A; Koya, D; Maeda, K; Matsuura, H; Omatsu-Kanbe, M; Sanada, M; Tahara, M; Yasuda, H | 1 |
| Lamping, KG; Lee, HC; Wang, XL; Zhou, W | 1 |
| Hayase, F; Kashiwagi, A; Kitada-Hamada, K; Maeda, K; Matsuura, H; Omatsu-Kanbe, M; Sanada, M; Yasuda, H | 1 |
| Ballas, LM; Bursell, SE; Clermont, A; Feener, EP; Heath, WF; Ishii, H; Jirousek, MR; Kern, TS; King, GL; Koya, D; Stramm, LE; Takagi, C; Xia, P | 1 |
| Ishii, H; Jirousek, MR; King, GL; Koya, D; Kuboki, K; Lin, YW | 1 |
| Bursell, SE; Clermont, AC; Ishii, H; King, GL; Mori, F; Takagi, C; Takagi, H | 1 |
| Engerman, RL; Farid, N; Jirousek, MR; Kern, TS; Kowluru, RA; Stramm, L | 1 |
| Kasuga, M; Kojima, H; Kusunoki, H; Liu, BF; Miyata, S; Suzuki, K; Uriuhara, A | 1 |
| Chaya, S; Hamada, Y; Hotta, N; Ienaga, K; Kamiya, H; Kasuya, Y; Kato, K; Koh, N; Miwa, K; Mizubayashi, R; Nakamura, J; Nakashima, E; Nakayama, M; Naruse, K; Sakakibara, F; Yasuda, Y | 1 |
| Haneda, M; Isshiki, K; Kashiwagi, A; Kikkawa, R; King, GL; Koya, D; Maeda, S; Nakagawa, H; Sato, H; Sugimoto, T; Ways, DK; Yasuda, H | 1 |
| Honda, Y; Kiryu, J; Miyamoto, K; Nishiwaki, H; Nonaka, A; Ogura, Y; Tsujikawa, A; Yamashiro, K | 1 |
1 review(s) available for ruboxistaurin and Alloxan Diabetes
| Article | Year |
|---|---|
A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition.
Topics: Animals; Animals, Genetically Modified; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Indoles; Kidney Failure, Chronic; Male; Maleimides; Mice; Mice, Mutant Strains; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Leptin; Renin | 2003 |
32 other study(ies) available for ruboxistaurin and Alloxan Diabetes
| Article | Year |
|---|---|
Ginsenoside Rg1 attenuates diabetic vascular endothelial dysfunction by inhibiting the calpain-1/ROS/PKC-β axis.
Topics: Animals; Calpain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelial Cells; Endothelium, Vascular; Humans; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Vascular Diseases | 2023 |
PKCβ/NF-κB pathway in diabetic atrial remodeling.
Topics: Animals; Atrial Remodeling; Cell Line; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Indoles; Male; Maleimides; Mice; Myocytes, Cardiac; NF-kappa B; Protein Kinase C beta; Rats; Rats, Wistar | 2020 |
Specific PKC βII inhibitor: one stone two birds in the treatment of diabetic foot ulcers.
Topics: Animals; Blood Glucose; Capillaries; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Foot; Indoles; Male; Maleimides; Mice, Inbred ICR; Molecular Targeted Therapy; Neovascularization, Physiologic; Neutrophils; Protein Kinase C beta; Protein Kinase Inhibitors; Wound Healing | 2018 |
Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling.
Topics: Animals; Apoptosis; Caveolin 3; Cell Line; Diabetes Mellitus, Experimental; Dinoprost; Enzyme Activation; Indoles; Isoprostanes; Male; Maleimides; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphorylation; Phthalimides; Protein Kinase C beta; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Time Factors; Transfection; Ventricular Function, Left | 2015 |
Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; GRB2 Adaptor Protein; Indoles; Kidney Function Tests; Male; Maleimides; Protein Kinase C beta; Rats, Wistar; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2016 |
PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Activation; ErbB Receptors; Female; Glucose; Indoles; Kidney; Maleimides; Mesangial Cells; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation; Transforming Growth Factor beta1; Up-Regulation | 2009 |
Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Cardiovascular Diseases; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Induction; Enzyme Inhibitors; Glucose; Indoles; Lysine; Male; Maleimides; Mannitol; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nitric Oxide Synthase Type II; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Wistar | 2009 |
Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy.
Topics: Animals; Calcium-Binding Proteins; Cardiac Catheterization; Cardiomyopathies; Collagen; Diabetes Mellitus, Experimental; Diastole; Enzyme Inhibitors; Extracellular Matrix; Gene Expression; Heart; Homozygote; Hypertrophy; Indoles; Maleimides; Myocardium; Myocytes, Cardiac; Oxidative Stress; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Transgenic; Renin; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Smad2 Protein | 2009 |
A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats.
Topics: Actins; Animals; Apoptosis; Diabetes Mellitus, Experimental; Down-Regulation; Electric Impedance; Endothelial Cells; Glucose; Indoles; Lim Kinases; Male; Maleimides; Microvessels; Myocardium; Protective Agents; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2010 |
A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats.
Topics: Animals; Antigens, CD; beta Catenin; Cadherins; Capillary Permeability; Cells, Cultured; Coronary Vessels; Diabetes Mellitus, Experimental; Electric Impedance; Endothelial Cells; Glucose; Heart; Heart Diseases; Indoles; Intercellular Junctions; Lanthanum; Male; Maleimides; Myocardium; Perfusion; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Small Interfering | 2010 |
Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats.
Topics: Animals; Blood Pressure; Blotting, Western; Diabetes Mellitus, Experimental; Hemodynamics; Indoles; Kidney; Losartan; Maleimides; Rats; rho-Associated Kinases; Streptozocin | 2011 |
Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Indoles; Insulin Receptor Substrate Proteins; Insulin Resistance; Kidney Glomerulus; Male; Maleimides; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Proteasome Inhibitors; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor, Insulin; RNA, Messenger; Signal Transduction; Ubiquitination | 2011 |
PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Dinoprost; Drug Evaluation, Preclinical; Enzyme Activation; Free Radical Scavengers; Hypertrophy, Left Ventricular; Indoles; Isoprostanes; Male; Maleimides; Myocytes, Cardiac; NADPH Oxidases; Oxidative Stress; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Superoxides; Ultrasonography | 2012 |
Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.
Topics: Animals; Arteries; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; F-Box Proteins; Forkhead Box Protein O3; Forkhead Transcription Factors; Glucose; Indoles; Large-Conductance Calcium-Activated Potassium Channel beta Subunits; Maleimides; Mice; Microscopy, Video; Muscle Proteins; Muscle, Smooth, Vascular; NADPH Oxidases; Patch-Clamp Techniques; Protein Kinase C; Protein Kinase C beta; Proteolysis; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; SKP Cullin F-Box Protein Ligases; Thiazoles; Vasodilation | 2012 |
Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Neural Conduction; Nociceptors; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sciatic Neuropathy; Splanchnic Circulation; Vasodilation | 2002 |
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
Topics: Albuminuria; Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Disease Progression; Enzyme Inhibitors; Female; Hypertension; Immunohistochemistry; Indoles; Kidney; Kidney Glomerulus; Maleimides; Organ Size; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Mutant Strains; Reference Values | 2003 |
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Topics: alpha-Tocopherol; Animals; Antioxidants; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Enzyme Inhibitors; Hemodynamics; Hydrogen Peroxide; Indoles; Insulin Resistance; Leukostasis; Male; Maleimides; Microcirculation; Microspheres; Oxidants; Oxidative Stress; Protein Kinase C; Protein Kinase C beta; Protein Kinases; Rats; Rats, Long-Evans; Rats, Zucker; Retina; Retinal Vessels; Thioctic Acid | 2003 |
Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.
Topics: Animals; Becaplermin; Capillaries; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Growth Factors; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Indoles; Insulin; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Maleimides; Mitogen-Activated Protein Kinase Kinases; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C beta; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Retina; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.
Topics: Animals; Arginine; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Ganglia, Spinal; Immunohistochemistry; Indoles; Male; Maleimides; NAV1.9 Voltage-Gated Sodium Channel; Neuropeptides; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nociceptors; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin | 2003 |
Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice.
Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Maleimides; Mice; Mice, Inbred C57BL; Muscle Relaxation; Penis; Protein Kinase C; Protein Kinase C beta | 2003 |
Protein kinase Cbeta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Female; Indoles; Kidney; Macrophage Activation; Maleimides; Nephritis, Interstitial; Osteopontin; Protein Kinase C; Protein Kinase C beta; Rats; Sialoglycoproteins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Effect of protein kinase Cbeta inhibitor on Ca2+ homeostasis in diabetic sensory neurons.
Topics: Animals; Calcium; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ganglia, Spinal; Homeostasis; Indoles; Male; Maleimides; Membrane Potentials; Mitochondria; Neurons, Afferent; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley | 2006 |
Inhibition of protein kinase Cbeta protects against diabetes-induced impairment in arachidonic acid dilation of small coronary arteries.
Topics: Animals; Arachidonic Acid; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Male; Maleimides; Oxidative Stress; Oxygenases; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase; Vasodilation | 2006 |
Inhibitory action of protein kinase Cbeta inhibitor on tetrodotoxin-resistant Na+ current in small dorsal root ganglion neurons in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Indoles; Male; Maleimides; Membrane Potentials; Neural Conduction; Neurons, Afferent; Patch-Clamp Techniques; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2007 |
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Topics: Administration, Oral; Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glomerular Filtration Rate; Humans; Indoles; Isoenzymes; Kidney Glomerulus; Male; Maleimides; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Plasma Flow; Retina; Retinal Vessels; Substrate Specificity | 1996 |
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
Topics: Administration, Oral; Animals; Arachidonic Acid; Cells, Cultured; Collagen; Diabetes Mellitus, Experimental; Diglycerides; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibronectins; Glomerular Mesangium; Glucose; Hyperglycemia; Indoles; Kidney Glomerulus; Male; Maleimides; Prostaglandins; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Transcription, Genetic; Transforming Growth Factor beta | 1997 |
Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.
Topics: Animals; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Fluorescein Angiography; Hyperglycemia; Indoles; Isoenzymes; Male; Maleimides; Piperidines; Protein Kinase C; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels | 1997 |
Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases.
Topics: Animals; Cerebral Cortex; Cohort Studies; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Galactosemias; Indoles; Maleimides; Protein Kinase C; Random Allocation; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase | 1998 |
Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products.
Topics: Adenosine Triphosphate; Animals; Cattle; Cell Separation; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Flow Cytometry; Glycation End Products, Advanced; Indoles; Macrophages, Peritoneal; Maleimides; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Norleucine; Phagocytosis; Protein Kinase C; Pyrroles | 1999 |
A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, Combination; Enzyme Inhibitors; Fructose; Indoles; Isoenzymes; Male; Maleimides; Motor Neurons; Neural Conduction; Protein Kinase C; Protein Kinase C beta; Pyrimidinones; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Thiazoles | 1999 |
Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes.
Topics: Albuminuria; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Gene Expression Regulation; Glomerular Mesangium; Indoles; Isoenzymes; Kidney Glomerulus; Male; Maleimides; Mice; Mice, Mutant Strains; Protein Kinase C; Protein Kinase C beta; Rats; Transforming Growth Factor beta | 2000 |
PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats.
Topics: Acridine Orange; Administration, Oral; Animals; Cell Adhesion; Cell Movement; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inhibitors; Fluorescent Dyes; Fluorophotometry; Indoles; Leukocytes; Male; Maleimides; Microcirculation; Protein Kinase C; Rats; Rats, Long-Evans; Retinal Vessels | 2000 |