ru-66647 and Pseudomonas-Infections

The 14-membered macrolides, such as clarithromycin (CAM) and erythromycin (EM), are effective against diffuse panbronchiolitis. However, there have been no studies on the effects of telithromycin (TEL) on chronic respiratory infection in vivo. In this study, we determined the effect of TEL on an experimental murine model of chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation. TEL significantly reduced the number of viable bacteria but had no effect on the proliferation of lymphocytes. In contrast, CAM decreased the number of lymphocytes but had no effect on the number of viable bacteria in the lung. These results suggest that TEL and CAM have different effects on chronic respiratory infection caused by P. aeruginosa.

Topics: Animals; Anti-Bacterial Agents; Biofilms; Chronic Disease; Clarithromycin; Disease Models, Animal; Ketolides; Lung; Lymphocytes; Male; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Tract Infections