ru-66647 and Nephritis--Interstitial

Telithromycin, a ketolide antibiotic used for the treatment of community-acquired respiratory infections, is widely prescribed in primary care practice. Treatment-related adverse events are mainly of gastrointestinal origin and generally mild in intensity. The authors report the first case of telithromycin-induced severe acute interstitial nephritis. Practitioners should be aware of the possibility that telithromycin therapy could result in this form of drug-induced acute renal failure.

Topics: Acute Disease; Adolescent; Humans; Ketolides; Kidney; Male; Methylprednisolone; Nephritis, Interstitial; Respiratory Tract Infections