ru-66647 has been researched along with Genital-Diseases--Female* in 2 studies
2 other study(ies) available for ru-66647 and Genital-Diseases--Female
| Article | Year |
|---|---|
In vitro and in vivo antibacterial activities of telithromycin.
Telithromycin is one of the ketolides, characterised by a 3-keto group instead of L-cladinose and a C(11)-C(12) carbamate link by an alkyl chain to a pyridinum and imidazolium ring side chain. We evaluated in vitro and in vivo antibacterial activities of telithromycin against gynaecological pathogens.. In the vitro study, the antibacterial activity of telithromycin against 180 isolates (isolated in the year 2000) of Streptococcus agalactiae (n = 33), Enterococcus faecalis (n = 22), Neisseria gonorrhoeae (n = 30), Peptostreptococcus anaerobius (n = 20), Finegoldia magna (n = 20), Bacteroides fragilis (n = 25) and Prevotella bivia (n = 30) was compared with that of erythromycin A, clarithromycin, azithromycin, ampicillin and levofloxacin. In the in vivo study, the efficacy of telithromycin was evaluated using experimental intra-abdominal abscesses in mice caused by B. fragilis (minimum inhibitory concentration of telithromycin 0.5 mg/l).. In the in vitro study, telithromycin inhibited more than 50% of clinical isolates of S. agalactiae, E. faecalis, N. gonorrhoeae, P. anaerobius, F. magna, B. fragilis and P. bivia at concentrations of 0.016, 0.063, 0.063, 0.032, 0.032, 0.5 and 0.25 mg/l, respectively. Telithromycin inhibited more than 90% of these clinical isolates at concentrations of 0.016, 4, 0.125, 0.063, 0.063, 4 and 1 mg/l, respectively. In the in vivo study, telithromycin inhibited abscess formation and significantly decreased viable cell counts in abscesses in comparison with the untreated group.. These in vitro and in vivo antibacterial activities suggest that telithromycin could be a potential candidate for the treatment of bacterial infections complicated by chlamydial infection. Topics: Abdominal Abscess; Animals; Anti-Bacterial Agents; Bacterial Infections; Bacteroidaceae; Bacteroides fragilis; Enterococcus faecalis; Female; Genital Diseases, Female; Gram-Negative Aerobic Rods and Cocci; Gram-Positive Cocci; Ketolides; Macrolides; Mice; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Peptostreptococcus; Prevotella; Streptococcus agalactiae | 2003 |
In vitro antibacterial activities of telithromycin, a new ketolide, against bacteria causing infections in obstetric and gynaecological patients.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Delivery, Obstetric; Female; Genital Diseases, Female; Humans; Ketolides; Macrolides; Microbial Sensitivity Tests; Pregnancy; Pregnancy Complications, Infectious | 2000 |