ru-66647 and Acne-Vulgaris

ru-66647 has been researched along with Acne-Vulgaris* in 2 studies

Other Studies

2 other study(ies) available for ru-66647 and Acne-Vulgaris

Article	Year
Detection of a new erm(X)-mediated antibiotic resistance in Egyptian cutaneous propionibacteria. Anaerobe, 2010, Volume: 16, Issue:4 A total of 107 antibiotic-resistant propionibacteria were isolated from the face of 102 Egyptian acne patients, dermatology staff and controls. Erythromycin-clindamycin-resistant propionibacteria were chosen to detect erm(X) gene and it was detected in 29 of 107 (27%) strains. However, just 7 strains had IS1249I, 3 of them had also Tn5432. The erm(X) gene which is not carried on Tn5432 confers inducible resistance to telithromycin by erythromycin or clindamycin. The DNA sequences of the PCR amplification products of this new erm(X)-mediated antibiotic resistance showed >99% identity to the erm(X) gene isolated from a Corynebacterium jeikeium. Southern blotting analysis of the erm(X)-specific probe shows that there were two copies of this resistance gene integrated within the chromosomal DNA. This is the first report of erm(X) being carried by Propionibacterium acnes outside Europe. Whilst the gene is associated with Tn5432 in some strains, the data suggests other genetic element carrying erm(X). The high carriage of erm(X) may affect the efficacy of clindamycin and macrolides for acne treatment in Egypt. Topics: Acne Vulgaris; Anti-Bacterial Agents; Blotting, Southern; Clindamycin; DNA Transposable Elements; DNA, Bacterial; Drug Resistance, Bacterial; Egypt; Erythromycin; Gene Dosage; Humans; Ketolides; Macrolides; Polymerase Chain Reaction; Propionibacteriaceae; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Skin Diseases, Bacterial; Transcriptional Activation	2010
Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities. The Journal of antimicrobial chemotherapy, 2002, Volume: 49, Issue:1 Forty-five cutaneous propionibacterial isolates from six European cities were found to be highly resistant to all macrolide-lincosamide-streptogramin B antibiotics, including the ketolide telithromycin. This contrasts with previously documented phenotypes associated with 23S rRNA mutations. Sequencing of the resistance determinant showed it to be erm(X) of corynebacterial origin located on the composite transposon Tn5432. Topics: Acne Vulgaris; Anti-Bacterial Agents; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Europe; Humans; Ketolides; Lincosamides; Macrolides; Propionibacteriaceae; Streptogramin B	2002

Article

Year

Detection of a new erm(X)-mediated antibiotic resistance in Egyptian cutaneous propionibacteria.

Anaerobe, 2010, Volume: 16, Issue:4

A total of 107 antibiotic-resistant propionibacteria were isolated from the face of 102 Egyptian acne patients, dermatology staff and controls. Erythromycin-clindamycin-resistant propionibacteria were chosen to detect erm(X) gene and it was detected in 29 of 107 (27%) strains. However, just 7 strains had IS1249I, 3 of them had also Tn5432. The erm(X) gene which is not carried on Tn5432 confers inducible resistance to telithromycin by erythromycin or clindamycin. The DNA sequences of the PCR amplification products of this new erm(X)-mediated antibiotic resistance showed >99% identity to the erm(X) gene isolated from a Corynebacterium jeikeium. Southern blotting analysis of the erm(X)-specific probe shows that there were two copies of this resistance gene integrated within the chromosomal DNA. This is the first report of erm(X) being carried by Propionibacterium acnes outside Europe. Whilst the gene is associated with Tn5432 in some strains, the data suggests other genetic element carrying erm(X). The high carriage of erm(X) may affect the efficacy of clindamycin and macrolides for acne treatment in Egypt.

Topics: Acne Vulgaris; Anti-Bacterial Agents; Blotting, Southern; Clindamycin; DNA Transposable Elements; DNA, Bacterial; Drug Resistance, Bacterial; Egypt; Erythromycin; Gene Dosage; Humans; Ketolides; Macrolides; Polymerase Chain Reaction; Propionibacteriaceae; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Skin Diseases, Bacterial; Transcriptional Activation

2010

Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities.

The Journal of antimicrobial chemotherapy, 2002, Volume: 49, Issue:1

Forty-five cutaneous propionibacterial isolates from six European cities were found to be highly resistant to all macrolide-lincosamide-streptogramin B antibiotics, including the ketolide telithromycin. This contrasts with previously documented phenotypes associated with 23S rRNA mutations. Sequencing of the resistance determinant showed it to be erm(X) of corynebacterial origin located on the composite transposon Tn5432.

Topics: Acne Vulgaris; Anti-Bacterial Agents; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Europe; Humans; Ketolides; Lincosamides; Macrolides; Propionibacteriaceae; Streptogramin B

2002