rta-408 has been researched along with Cerebral-Hemorrhage* in 1 studies
1 other study(ies) available for rta-408 and Cerebral-Hemorrhage
| Article | Year |
|---|---|
The Novel Nrf2 Activator Omaveloxolone Regulates Microglia Phenotype and Ameliorates Secondary Brain Injury after Intracerebral Hemorrhage in Mice.
The polarization of microglia is recognized as a crucial factor in reducing neuroinflammation and promoting hematoma clearance after intracerebral hemorrhage (ICH). Previous studies have revealed that redox components participate in the regulation of microglial polarization. Recently, the novel Nrf2 activator omaveloxolone (Omav) has been validated to improve neurological function in patients with neurodegenerative disorders by regulating antioxidant responses. In this study, we examined the efficacy of Omav in ICH. Omav significantly promoted Nrf2 nuclear accumulation and the expression of HO-1 and NQO1 in BV2 cells. In addition, both Topics: Animals; Brain Injuries; Cerebral Hemorrhage; Humans; Mice; Microglia; NF-E2-Related Factor 2; Phenotype; Triterpenes | 2022 |