rs100642 and Disease-Models--Animal

rs100642 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for rs100642 and Disease-Models--Animal

Article	Year
Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642). Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:2 Breast cancer (BCa) was induced in vivo in female rats with 7,12-dimethylbenz(a)anthracene (DMBA). Two main questions were addressed. Firstly, would the carcinogenesis be accompanied by oxidative stress as signalled by superoxide dismutase, glutathione peroxidase, malondialdehyde and total nitrate? Secondly, would treating the rats additionally with a blocker of voltage-gated sodium channel (VGSC) activity, shown previously to promote BCa progression, affect the oxidative responses? The DMBA-induced increases in the antioxidant systems were completely blocked by the VGSC inhibitor RS100642, which also significantly prolonged the lifespan. We conclude that VGSC inhibition in vivo can significantly protect against oxidative stress and improve survival from tumour burden. Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Female; Glutathione Peroxidase; Malondialdehyde; Mammary Neoplasms, Experimental; Mexiletine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Channel Blockers; Superoxide Dismutase	2012

Article

Year

Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642).

Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:2

Breast cancer (BCa) was induced in vivo in female rats with 7,12-dimethylbenz(a)anthracene (DMBA). Two main questions were addressed. Firstly, would the carcinogenesis be accompanied by oxidative stress as signalled by superoxide dismutase, glutathione peroxidase, malondialdehyde and total nitrate? Secondly, would treating the rats additionally with a blocker of voltage-gated sodium channel (VGSC) activity, shown previously to promote BCa progression, affect the oxidative responses? The DMBA-induced increases in the antioxidant systems were completely blocked by the VGSC inhibitor RS100642, which also significantly prolonged the lifespan. We conclude that VGSC inhibition in vivo can significantly protect against oxidative stress and improve survival from tumour burden.

Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Female; Glutathione Peroxidase; Malondialdehyde; Mammary Neoplasms, Experimental; Mexiletine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Channel Blockers; Superoxide Dismutase

2012