rs-93427-007 and Hypertension

The antihypertensive activity of RS-93427, a synthetic prostanoid, was evaluated in conscious restrained spontaneously hypertensive rats. RS-93427 possesses potent antihypertensive activity when administered orally, intraduodenally, intravenously, or subcutaneously but not topically. The blood pressure reducing activity of RS-93427 in normotensive rats was comparable to that in hypertensive animals. No signs of tolerance to the antihypertensive effects were observed following fourteen days of oral administration of RS-93427. The synthetic prostanoid minimally enhanced the orthostatic hypotensive responsiveness to vertical, head up, repositioning of the restrained rats. The relative usefulness of the platelet antiaggregatory and antihypertensive properties of RS-93427 will have to be determined by clinical studies.

Topics: Administration, Cutaneous; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Duodenum; Epoprostenol; Hypertension; Injections, Intravenous; Injections, Subcutaneous; Male; Prostaglandins, Synthetic; Rats; Rats, Inbred SHR