rs-39604 and Diarrhea

rs-39604 has been researched along with Diarrhea* in 1 studies

Other Studies

1 other study(ies) available for rs-39604 and Diarrhea

ArticleYear
New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.
    European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3

    The synthesis of new 5-HT(3) receptor antagonists is an interesting field of research because of their wide therapeutic use. The aim of this work is to functionally characterise a new series of benzimidazole derivatives previously described. These compounds bind to 5-HT(3) receptors and have been evaluated using in vitro (rat tunica muscularis mucosae) and in vivo tests (Bezold-Jarisch reflex in rat and gastrointestinal motility and spontaneous motility in mice). Ondansetron and 1-[4-amino-5-chloro-2-(3,5-dimethoxyphenil)methyloxy]-3-[1-[2-methylsulfonylamino]piperidin-4-yl]propan-1-one hydrochloride (RS 39604) were used as well known 5-HT(3) and 5-HT(4) receptor antagonists. These benzimidazole derivatives have proved to be 5-HT(3) receptor antagonists. Interestingly, they are as active as ondansetron when they are intraperitoneally (i.p.) or orally (p.o.) administered and, in mice, they seem to induce fewer behavioural changes at similar effective doses than does ondansetron. The present results confirm the usefulness of the previously proposed pharmacophore and justify the interest in these new benzimidazole derivatives.

    Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Aza Compounds; Behavior, Animal; Benzimidazoles; Carbachol; Diarrhea; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Motility; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ondansetron; Piperidines; Propane; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Reflex; Serotonin; Serotonin Antagonists

2003