roxindole and Parkinson-Disease

roxindole has been researched along with Parkinson-Disease* in 1 studies

Trials

1 trial(s) available for roxindole and Parkinson-Disease

Article	Year
Treatment of Parkinson's disease with the partial dopamine agonist EMD 49980. Movement disorders : official journal of the Movement Disorder Society, 1993, Volume: 8, Issue:2 The motor effects of the partial dopamine agonist EMD 49980 were evaluated in parkinsonian patients under controlled conditions. EMD 49980 monotherapy resulted in a mild improvement in parkinsonian symptoms, but when co-administered with levodopa, had no significant effect on dyskinesias or on the antiparkinsonian effect of the dopamine precursor. These results suggest that EMD 49980 exerts a net weak dopamine agonist effect but fails to ameliorate levodopa-induced dyskinesias. Topics: Adult; Brain; Dopamine Agents; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Indoles; Levodopa; Male; Middle Aged; Neurologic Examination; Oxindoles; Parkinson Disease; Pyridines; Receptors, Dopamine	1993

Article

Year

Treatment of Parkinson's disease with the partial dopamine agonist EMD 49980.

Movement disorders : official journal of the Movement Disorder Society, 1993, Volume: 8, Issue:2

The motor effects of the partial dopamine agonist EMD 49980 were evaluated in parkinsonian patients under controlled conditions. EMD 49980 monotherapy resulted in a mild improvement in parkinsonian symptoms, but when co-administered with levodopa, had no significant effect on dyskinesias or on the antiparkinsonian effect of the dopamine precursor. These results suggest that EMD 49980 exerts a net weak dopamine agonist effect but fails to ameliorate levodopa-induced dyskinesias.

Topics: Adult; Brain; Dopamine Agents; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Indoles; Levodopa; Male; Middle Aged; Neurologic Examination; Oxindoles; Parkinson Disease; Pyridines; Receptors, Dopamine

1993