roussin-s-black-salt and Melanoma

roussin-s-black-salt has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for roussin-s-black-salt and Melanoma

Article	Year
NO-dependent phototoxicity of Roussin's black salt against cancer cells. Nitric oxide : biology and chemistry, 2004, Volume: 10, Issue:1 A metal-nitrosyl complex, Roussin's black salt (RBS), releases nitric oxide after illumination. Approximately 3.7 NO molecules were released from one RBS molecule. Both short- and long-term effects of photogenerated NO on the two neoplastic cell lines: human (SK-MEL188) and mouse (S91) have been investigated. Exogenous NO from RBS was toxic to cells in a dose-dependent manner. Apoptotic damage predominates in the response to the injury, as shown by TUNEL assay. NO and its short-lived metabolites, but not other RBS photoproducts, are responsible for cellular death. RBS in dark was toxic to cells at concentrations above 1 microM. This relatively high cytotoxicity of RBS in the dark prevents its application as a systemic anticancer agent in vivo, unless it is applied locally. Topics: Animals; Apoptosis; Cell Line, Tumor; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Humans; Iron Compounds; Melanoma; Mice; Neoplasms; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds	2004

Article

Year

NO-dependent phototoxicity of Roussin's black salt against cancer cells.

Nitric oxide : biology and chemistry, 2004, Volume: 10, Issue:1

A metal-nitrosyl complex, Roussin's black salt (RBS), releases nitric oxide after illumination. Approximately 3.7 NO molecules were released from one RBS molecule. Both short- and long-term effects of photogenerated NO on the two neoplastic cell lines: human (SK-MEL188) and mouse (S91) have been investigated. Exogenous NO from RBS was toxic to cells in a dose-dependent manner. Apoptotic damage predominates in the response to the injury, as shown by TUNEL assay. NO and its short-lived metabolites, but not other RBS photoproducts, are responsible for cellular death. RBS in dark was toxic to cells at concentrations above 1 microM. This relatively high cytotoxicity of RBS in the dark prevents its application as a systemic anticancer agent in vivo, unless it is applied locally.

Topics: Animals; Apoptosis; Cell Line, Tumor; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Humans; Iron Compounds; Melanoma; Mice; Neoplasms; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds

2004