Compounds > rotenone
Page last updated: 2024-08-17

rotenone and Parkinson Disease

rotenone has been researched along with Parkinson Disease in 476 studies

Research

Studies (476)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (1.68)18.2507
2000's83 (17.44)29.6817
2010's184 (38.66)24.3611
2020's201 (42.23)2.80

Authors

AuthorsStudies
Feng, Y; Han, J; Iqbal, J; Mellick, GD; Nguyen, DT; Pierens, GK; Wood, SA1
Alturfan, AA; Cansız, D; Emekli-Alturfan, E; Sürmen, MG; Sürmen, S; Ünal, İ; Üstündağ, ÜV1
Battaglini, M; Ciofani, G; Desii, A; Genchi, G; Lavarello, C; Marino, A; Petretto, A1
Balmus, IM; Ciobica, A; Dobrin, R; Doroftei, B; Ilie, OD; Jijie, R; Nicoara, M; Nita, IB; Paduraru, E; Robea, MA1
Bao, XQ; Li, G; Ma, J; Ning, J; Shang, M; Zhang, D; Zhao, Z1
Kaur, J; Khairnar, A; Khunt, D; Rakshe, S; Sharma, M; Sharma, N1
Goldstein, DS; Halperin, R; Landau, R; Leibowitz, A; Sharabi, Y; Sullivan, P; Zibly, Z1
Ahn, EH; Chen, G; Kang, SS; Liu, X; Xia, Y; Ye, K; Zhang, Z1
Ding, W; Li, R; Si, Y; Wang, K; Wen, S; Yan, Z; Yang, F; Yao, L1
Chen, M; Dong, J; Li, Q; Luo, H; Peng, C; Peng, Y; Shi, F; Xu, X1
Abdel Gawad, S; Fikry, H; Saleh, LA1
Alturfan, AA; Beler, M; Cansız, D; Emekli-Alturfan, E; Kara Subaşat, H; Karagöz, A; Mega Tiber, P; Ünal, İ; Üstündağ, FD; Üstündağ, ÜV1
Castorina, A; Thomas Broome, S1
Brotchie, JM; Chiu, WH; Decher, N; Dolga, AM; Geibl, FF; Griesbach, M; Henrich, MT; Kiper, AK; Komadowski, MA; Koprich, JB; Lee, B; Matschke, LA; Oertel, WH; Rinné, S; Stöhr, A1
Alturfan, AA; Büyükkayhan, D; Cansız, D; Emekli-Alturfan, E; Sürmen, MG; Sürmen, S; Ünal, İ; Üstündağ, ÜV1
Badalyan, SH; Darbinyan, LV; Hambardzumyan, LE; Manukyan, LP; Sarkisian, VH; Simonyan, KV1
Chen, Z; Gu, H; Hu, Y; Huang, Y; Li, H; Shen, L; Shen, Y; Sun, B; Xu, X; Yang, J; Zhang, J1
Choi, WS; Chung, I; Chung, JH; Hah, SM; Kang, J; Kim, H; Kim, HS; Lee, J; Park, HA; Shin, MJ1
Hou, L; Huang, R; Ruan, Z; Sun, W; Wang, Q; Zhang, D; Zhao, J1
Atlas, D; Wiesen, T1
Behera, SK; Karthikkeyan, G; Modi, PK; Pervaje, R; Prasad, TSK; Upadhyay, SS1
Akhtar, MS; Mahdi, AA; Pandey, S; Rumman, M; Singh, B; Ubaid, S1
Ayoub, BM; Hendy, MS; Michel, HE; Mowaka, S; Tadros, MM1
Cho, HH; Hwang, J; Jang, S; Jeong, HS; Kim, BC; Kim, E; Ramalingam, M1
Dey, AK; Kumar, R; Kumari, R; Maiti, TK; Saha, S1
Adebayo, OG; Adebayo, OR; Aduema, W; Ajayi, AM; Akpakpan, E; Ben-Azu, B; Emmanuel, MU; Onuoha, OG; Orji, BO1
Anantharam, V; Charli, A; Jin, H; Kanthasamy, A; Kanthasamy, AG; Malovic, E; Palanisamy, BN; Samidurai, M; Sarkar, S; Zenitsky, G1
Geng, D; Li, Q; Li, Y; Liu, Q; Liu, Z; Wang, H; Wang, L; Xie, W; Zhang, R1
Adebayo, OG; Aduema, W; Akpotu, AE; Asiwe, JN; Ben-Azu, B; Brown, PI; Buduburisi, BR; Igbokwe, V; Kolawole, TA; Onwuka, FC; Onyeleonu, I; Umoren, EB; Wopara, I1
Choi, HJ; Huh, YE; Kwon, Y; Moon, SH1
Jakubowski, H; Jodynis-Liebert, J; Kujawska, M; Kurpik, M; Szulc, M; Witucki, Ł; Łukasz Mikołajczak, P1
Iqbal, F; Kanwal, S; Musaddiq, S; Perveen, S; Sadiq, R1
Adeyemi, OO; Awogbindin, IO; Ishola, IO; Olubodun-Obadun, TG; Oluwafemi, OA; Onuelu, JE1
Abdelraouf, SM; Al-Kady, RH; Motawi, TK; Senousy, MA2
Chiou, A; Dermon, CR; Fanarioti, E; Karathanos, VT; Karvelas, M; Tsarouchi, M; Vasilakopoulou, PB1
Dong, N; Yang, Z1
Bian, LH; Guo, JY; Li, JY; Li, QY; Shi, JL; Wan, GH; Wang, XM; Wang, YQ; Wang, ZY; Wei, XJ; Yang, X; Yao, ZW1
Gao, Y; Hong, JS; Hou, L; Li, D; Li, N; Li, S; Liu, J; Tian, L; Tu, D; Wang, Q; Zhang, X; Zhao, J1
Agrawal, BK; Chakrabarti, S; Chakrabarti, SS; Chandan, G; Ganguly, U; Pal, S; Saini, RV; Singh, S; Thakur, R1
Biswas, P; Hasan, W; Jain, J; Jat, D; Yadav, RS1
Bian, L; Guo, J; Li, J; Li, Q; Shi, J; Wan, G; Wang, X; Wang, Y; Wei, X; Yang, X; Yao, Z1
Adachi, K; Katagiri, A; Kato, T; Nozaki, K; Sato, H; Satoh, K; Toyoda, H; Yin, DX1
Li, R; Shi, W; Yan, Z; Yao, L1
da Silva, RS; de Melo, MG; de Paiva, IHR; do Nascimento, MIX; Duarte-Silva, EP; Mendonça, IP; Peixoto, CA1
Ablat, N; Ablimit, M; Han, H; Liu, R; Pu, X; Sun, Y; Xu, F; Zhao, X1
Ahmed, HI; Albohy, A; Azab, SS; Kamal, RE; Menze, E1
Cho, J; Elkamhawy, A; Gouda, NA; Lee, CH; Lee, D; Lee, K; Lu, Q; Nada, H; Quan, G1
Behera, SK; Chatterjee, S; Kale, R; Khairnar, A; Mukarram, M; Parihar, N; Sayyed, AA; Sharma, M; Sharma, N; Soni, R1
El-Deeb, NK; El-Tanbouly, DM; El-Yamany, MF; Khattab, MA; Mohamed, AF1
de Andrade, GM; de Assis, ALC; de Barros Viana, GS; de Siqueira, EA; Lima, DB; Magalhães, EP; Marinho, MM; Martins, AMC; Sampaio, TL1
Bakhtiari, N; Farbood, Y; Ghafouri, S; Hajipour, S; Khoshnam, SE; Mansouri, E; Sarkaki, A; Vastegani, SM1
Abe, T; Higashitani, A; Muto, K; Nagasawa, S; Suzuki, C; Ueda, M; Wu, X1
Cao, X; Du, W; Gan, J; Han, B; Han, X; He, J; Li, G; Wang, T; Wang, Z; Zhao, Y; Zheng, W1
Barbiero, JK; Bassani, T; Boschen, S; Da Cunha, C; Ramos, DC; Vital, MABF1
Si, Y; Sun, L; Yan, Z; Yang, F; Yao, L; Yu, J1
Bang, Y; Choi, HJ; Jung, K; Kim, M; Kwon, Y; Moon, SH1
Annunziato, L; Della Notte, S; Scorziello, A; Secondo, A; Sisalli, MJ; Ventra, C1
Anantharam, V; Bargues-Carot, A; Huang, M; Jin, H; Kanthasamy, A; Kanthasamy, AG; Riaz, Z; Wickham, H; Zenitsky, G1
Hettiarachchi, P; Jarosova, R; Johnson, MA; Niyangoda, SS1
Chatterjee, S; Gadepalli, A; Kate, A; Khairnar, A; Parekh, P; Sayyed, AA; Sharma, M; Sharma, N1
Azar, YO; Badawi, GA; Ibrahim, SM; Zaki, HF1
Gurke, R; Manderscheid, C; Niederberger, E; Schreiber, Y; Tegeder, I; Wilken-Schmitz, A1
Dolrahman, N; Mukkhaphrom, W; Sutirek, J; Thong-Asa, W1
Al-Abbasi, FA; Albaqami, FF; Alharthy, KM; Altharawi, A; Althurwi, HN; Alzarea, SI; Kazmi, I; Nadeem, MS1
Adeyeye, TA; Babatunde, BR; Johnson, VF; Shallie, PD1
Jiang, Z; Li, H; Li, Y; Ma, J; Qian, Z; Zhou, S; Zhou, X1
Munissi, JJE; Nyandoro, SS; Shadrack, DM; Stephano, F; Tibashailwa, N1
Banik, NL; Drasites, KP; Haque, A; Matzelle, D; Myatich, A; Shams, R; Shields, DC; Zaman, V1
Gazzin, S; Jayanti, S; Moretti, R; Tiribelli, C1
Liu, ZB; Ma, X; Qiao, HF; Wang, Q; Wang, Y; Yuan, W1
Certik, M; Gajdos, P; Hajduchova, D; Halasova, E; Holic, R; Pecova, R; Pokusa, M1
Khatri, DK; Kumar, R; Preeti, K; Shirgadwar, SM; Singh, SB1
Atta, R; El-Baz, AA; Imbaby, S; Khalil, S; Mahmoud, OM; Mohammad, HMF1
Akhtari, K; Feligioni, M; Gerhardt, E; Hassanzadeh, K; Morrone, C; Outeiro, TF; Zaccagnini, L1
da Silva Martins, C; de Barros Viana, GS; de Castro Brito, GA; de Menezes, RRPPB; de Siqueira, EA; Lima, DB; Magalhães, EP; Martins, AMC; Neves, KRT; Sampaio, TL1
Chai, C; Lim, GGY; Lim, KL; Nair, A; Tang, W; Thundyil, J; Tng, TJW; Yao, TP; Yeow, SQZ1
Abd El Fattah, MA; Mohamed, YT; Rabie, MA; Salama, A1
Chovsepian, A; Dening, Y; Dieterich, M; Dirscherl, P; Falkai, P; Giese, A; Giesert, F; Herms, J; Khairnar, A; Levin, J; Pan-Montojo, F; Ruf, V; Schmidt, F; Stievenard, A; Straßl, T; Weisenhorn, DV; Wurst, W1
Boldt, ABW; Dos Santos, PI; Kretzschmar, GC; Lima, MMS; Macedo, DA; Ribeiro Pinto, LF; Rodrigues, LS; Soares-Lima, SC; Targa, ADS1
Alturfan, AA; Beler, M; Cansız, D; Emekli-Alturfan, E; Güzel, E; Sezer, Z; Sürmen, MG; Sürmen, S; Ünal, İ; Üstündağ, ÜV1
Khairnar, A; Sharma, M; Sharma, N1
Ibarra-Gutiérrez, MT; Orozco-Ibarra, M; Serrano-García, N1
Dermon, CR; Fanarioti, E; Karathanos, VT; Tsarouchi, M1
Bavarsad, K; Farbood, Y; Mard, SA; Sarkaki, A; Sheikhpour, E1
ElGamal, RZ; Menze, ET; Tadros, MG1
Allodi, S; Correa, CL; de Andrade Gomes, CAB; de Barros, CM; Medeiros, TB; Mello, AA; Nogueira, NDS1
Dai, JW; Hu, XM; Qiu, Z; Song, LZ; Xu, B; Xu, CC; Xu, N; Yang, H; Yu, Z1
Adem, A; Azimullah, S; Beiram, R; Jalal, FY; Jayaraj, RL; Meeran, MFN; Ojha, S1
Essam, RM; Kandil, EA1
Atarod, D; Ghasemi, A; Gholami, M; Goliaei, B; Habibi-Kelishomi, Z; Mamashli, F; Meratan, AA; Mohammad-Zaheri, M; Moosavi-Movahedi, F; Obeidi, N; Pirhaghi, M; Saboury, AA; Salmani, B; Shahsavani, MB1
Cai, Z; Chen, J; Fu, C; Li, M; Liu, X; Lu, R; Ming, Q; Peng, Y; Xie, A; Xie, Z; Zhang, H; Zheng, D; Zhong, J1
Birla, H; Dilnashin, H; Keshri, PK; Rathore, AS; Singh, R; Singh, S; Singh, SP; Singh, SS; Zahra, W1
Catalkaya, E; Colcimen, N; Goceroglu, R; Ozdemir, HS; Sagmanligil, V; Yasar, S; Yunusoglu, O1
Abdel-Sattar, E; Abdulmalek, SA; Ali, DE; Allam, EA; Bassam, SM; Elatrebi, S; Ghareeb, DA; Habiba, ES; Omar, EM1
Guo, J; Li, M; Li, W; Ling, L; Liu, Z; Pan, X; Wang, H; Zhang, K; Zhang, M1
Chaves, NSG; Dahleh, MMM; de Almeida, FP; de Carvalho, AS; Fernandes, EJ; Gonçalves, OH; Guerra, GP; Janner, DE; Leimann, FV; Musachio, EAS; Poetini, MR; Prigol, M; Ramborger, BP; Reginaldo, JC; Roehrs, R1
He, JY; Li, DD; Long, H; Qin, TY; Wen, Q; Zhang, F; Zhang, SB1
Chandramohan, V; Chithra, Y; Dey, G; Ghose, V; Gowthami, N; Srinivas Bharath, MM; Vasudev, V1
Adeyemi, OO; Awogbindin, IO; Ishola, IO; Olajiga, AE; Olubodun-Obadun, TG1
Azimullah, S; Beiram, R; Eddin, LB; Jha, NK; Nagoor Meeran, MF; Ojha, S1
Aleksandrova, Y; Ardashov, O; Chaprov, K; Neganova, M; Podturkina, A; Salakhutdinov, N; Volcho, K; Yandulova, E1
Azevedo, EM; Chuproski, AP; Ilkiw, J; Lima, MMS; Miloch, J1
Chen, RS; Chen, YC; Cheng, YC; Chiu, CC; Chiu, TJ; Hsu, CC; Hwang, TL; Liu, HF; Liu, YC; Lu, JC; Wang, HL; Wang, YT; Wei, KC; Weng, YH; Yeh, TH1
Abdel Rasheed, NO; Abdelaziz, AM; El-Sayed, RM; Zaki, HF1
Chang, MY; Cheng, SH; Lee, YZ; Lin, YF; Tsai, YC; Wu, CC1
Chen, W; Chu, C; Guo, H; Li, Y; Tian, F; Yu, L; Zhai, Q1
Hou, L; Li, S; Liu, J; Wang, Q; Wang, R; Wu, M; Zhang, Y; Zhao, J1
Ahmed, S; El-Sayed, MM; Kandeil, MA; Khalaf, MM1
Desouky, MA; Elsherbiny, DA; George, MY; Michel, HE1
Cheng, YZ; Gu, L; Hou, TZ; Yang, HM; Zhang, H; Zhang, JN1
Arajyan, G; Hovsepyan, V; Musheghyan, G; Poghosyan, M; Sarkissian, J1
El-Latif, AMA; Fattah, MAAE; Kenawy, SA; Rabie, MA; Sayed, RH1
Aboellail, TA; Chatterjee, D; Kirkley, KS; Rocha, SM; Smeyne, RJ; Tjalkens, RB1
Bakhtiari, N; Farbood, Y; Ghafouri, S; Khoshnam, SE; Mansouri, E; Moradi Vastegani, S; Sarkaki, A1
El-Deeb, AM; El-Tanbouly, DM; El-Yamany, MF; Mohamed, AF1
Albalawi, MA; Alzlaiq, WA; Atif, HM; Bilasy, SE; Eladl, MA; Elaidy, SM; ElSayed, MH; Farag, NE; Helal, MA; Helaly, AMN; Hisham, FA; Ibrahiem, AT; Khella, HWZ; Osman, NMS; Zaitone, SA1
Anguchamy, V; Muthuvel, A1
Arunachalam, S; Ayoob, K; Azimullah, S; Beiram, R; Meeran, MFN; Ojha, S1
El-Khatib, AS; F Mohamed, A; Khattab, MM; Mansour, HM1
Guo, J; Li, M; Li, Y; Ling, L; Liu, F; Luo, S; Ma, B; Wang, H1
Bilal, B; Erbas, O; Erdogan, MA; Kirazlar, M; Yigitturk, G1
Cao, X; Du, W; Gan, J; Han, B; Han, X; He, J; Li, G; Wang, T; Wang, Z; Xu, B; Zheng, W1
Cai, X; Cao, P; Chen, B; He, Z; Qin, Y; Shen, J; Wang, Y; Xu, Y; Yang, Y; Ye, J; Zhou, Q1
Adeyeye, TA; Babatunde, BR; Ehireme, SE; Shallie, PD1
Darbinyan, L; Hambardzumyan, L; Manukyan, L; Simonyan, K1
Entezari, M; Hashemi, M; Hojati, V; Khosravi, F; Mirzaei, S1
Fay-Karmon, T; Gutman-Sharabi, N; Halperin, R; Khashab, R; Landau, R; Leibowitz, A; Shabtai, Z; Sharabi, Y1
Birla, H; Dilnashin, H; Keshri, PK; Keswani, C; Rathore, AS; Singh, R; Singh, SP; Singh, SS; Zahra, W1
Akçay, Y; Gözde Aslan, Ç; Kaplan Algin, A; Mehtap Çinar, G; Şaban Akkurt, S; Tomruk, C; Ulukaya, S; Uyanikgil, Y1
Alp, HH; Huyut, Z; Kocak, Y; Onay, E; Oto, G; Turkan, F1
Albalakhi, A; Bakshi, R; Lin, S; Madore, V; Schwarzschild, MA; Stimpson, T; Xia, N; Xu, Y1
Chakkittukandiyil, A; Kothandan, R; Rymbai, E; Selvaraj, D; Selvaraj, J; Sugumar, D1
Cadet, P; Neuwirth, LS; Zhu, W1
El-Khatib, AS; Khattab, MM; Mansour, HM; Mohamed, AF1
Cardoso, FDS; de Andrade, GM; de Barros Viana, GS; de Castro Brito, GA; Dos Santos, JCC; Lima, MPP; Nascimento, TS; Oliveira, AV; Oliveira, LF; Rebouças, CDSM1
Aghsami, M; Ashabi, G; Fartoosi, A; Kheradmand, A; Montazeri, H; Salari, Z; Shariatpanahi, M1
Abdelrahman, SS; El-Ansary, MR; El-Yamany, MF; Hassan, NF; Khidr, HY; Rabie, MA1
Jimenez-Del-Rio, M; Quintero-Espinosa, DA; Velez-Pardo, C1
Garikapati, KK; Krishnamurthy, PT; Kumari, M; Sola, P1
Bakhtiari, N; Farbood, Y; Ghafouri, S; Khoshnam, SE; Moradi Vastegani, S; Sarkaki, A1
Ding, Y; Huang, W; Kong, D; Li, L; Lim, K; Lu, X; Ma, B; Wang, Q; Wu, Q; Xin, C; Xu, J; Yang, ND; Zhang, C; Zhang, H; Zhou, T1
Abd El Fattah, MA; Ahmed, LA; El-Sayeh, BM; Kandil, EA; Sayed, RH2
Chen, LH; Chen, WH; Le, ZS; Qian, H; Yu, B; Yu, F1
Ahn, EH; Alam, AM; Cao, X; Chandrasekharan, B; Chen, G; Kang, SS; Liu, X; Neish, AS; Ye, K; Zhang, Z1
Chen, J; Ding, F; Ge, D; Guo, H; Guo, X; Lu, J; Lu, X; Shi, Y; Zhang, Q; Zhang, Y1
Altinoz, MA; Alturfan, AA; Ateş, PS; Çalışkan-Ak, E; Elmaci, I; Emekli-Alturfan, E; Ünal, İ; Üstündağ, ÜV1
Hassanzadeh, K; Peluso, I; Rahimmi, A; Rajabi, A1
Chang, HF; Chiu, TL; Huang, HY; Wang, MJ; Wu, HR1
Mursaleen, L; Somavarapu, S; Zariwala, MG1
El-Shamarka, MEA; Kozman, MR; Messiha, BAS1
Bai, H; Ding, Y; Huang, W; Ji, L; Kong, D; Li, L; Li, X; Lu, S; Rong, Z; Xin, C; Yang, X; Yao, C; Zhang, C1
Hanpude, P; Jangir, D; Kumar, R; Kumar, S; Kumari, R; Maiti, TK; Singh, AK1
Fu, F; Han, B; He, J; Li, C; Meng, X; Wang, T; Wang, Z; Zhang, L1
Abdel-Moneim, AM; Abdou, HM; Alfwuaires, M; Essawy, AE; Mohammed, NA; Tass, MA1
Ahlawat, J; Deemer, E; Narayan, M; Neupane, R; Sreenivasan, ST1
Al-Emam, A; Al-Shraim, M; Kranner, B; Moldzio, R; Radad, K; Rausch, WD; Wang, F1
Asanuma, M; Furukawa, C; Imafuku, F; Isooka, N; Kikuoka, R; Miyazaki, I; Sun, J1
Dai, Y; Hou, S; Jiang, N; Lin, Q; Lin, Y1
Geng, Y; Liu, Y; Xu, W; Zhang, L; Zhang, N1
Avci, B; Bilge, SS; Bozkurt, A; Günaydin, C; Önger, ME1
Gold, R; Haghikia, A; Metzdorf, J; Ostendorf, F; Tönges, L1
Brunetti, G; Calabrese, EJ; Calabrese, V; Crea, R; Di Rosa, G; Saul, N; Schmitz-Linneweber, C; Scuto, M; Trovato Salinaro, A1
Imai, Y1
Chang, Y; Chen, S; He, D; Li, Y; Wang, G; Wu, H; Xiao, Z; Xie, M; Xu, C; Zhou, G1
Feng, Y; Ma, J; Yuan, L1
Awasthi, A; Corrie, L; Kapoor, B; Kaur, J; Khurana, N; Khurana, S; Khursheed, R; Kumar, R; Sharma, N; Singh, SK; Verma, S; Vyas, M1
Birla, H; Dilnashin, H; Keswani, C; Rai, SN; Rathore, AS; Singh, R; Singh, RK; Singh, SP; Singh, SS; Zahra, W1
Wang, HL; Xiao, G; Xue, J1
Freeman, JL; Wasel, O1
Andersen, ML; de Freitas Cavalcante, S; Dos Santos Lima, GZ; Fontenele-Araújo, J; Lima, MMS; Rodrigues, LS; Targa, ADS; Torterolo, P1
Jia, G; Liu, Y; Sun, C; Wang, X; Wang, Y1
Alecu, JE; Klein, P; Krach, F; Mautner, L; Prots, I; Roybon, L; Schneider, Y; Simmnacher, K; Winner, B; Xiang, W1
Andersen, DC; Corthals, A; Gazerani, P; Huijbers, IJ; Jønsson, K; Kroese, LJ; Lichota, J; Mørk, K; Mørkholt, AS; Nieland, JDV; Oklinski, MKE; Pritchard, CEJ; Skjønnemand, MN; Trabjerg, MS1
Archana, R; Pazhanivel, N; Senthilkumar, S; Shakila, R; Subhashini, S; Thanalakshmi, J1
Adem, A; Azimullah, S; Beiram, R; Jalal, FY; Jayaraj, RL; Mf, NM; Ojha, SK1
Chaturvedi, RK; Dubey, A; Kumar, D; Priya, S; Raj, R; Sharma, SK; Srivastava, T1
Choudhury, SR; Karmakar, S; Srivastava, AK1
Chen, G; He, Q; Li, PA; Zhang, M1
Afiyatullov, SS; Chingizova, EA; Girich, EV; Menchinskaya, ES; Ngoc, NTD; Pislyagin, EA; Pivkin, MV; Popov, RS; Smetanina, OF; Trinh, PTH; Yurchenko, AN; Yurchenko, EA1
Eroğlu, HA; Makav, M1
Bhattarai, Y; Farrugia, G; Grover, M; Kandimalla, KK; Kashyap, PC; Margolis, KG; McLean, PJ; Moor, W; Pu, M; Ross, OA; Si, J; Till, L1
Adolfs, Y; Buijsman, RC; de Man, J; de Wit, J; Gerard Sterrenburg, J; Grobben, Y; Hartog, M; Kraneveld, AD; Muller, M; Pasterkamp, RJ; Perez-Pardo, P; Tutone, M; Uitdehaag, JCM; van Cauter, F; van Doornmalen, AM; Vu-Pham, D; Willemsen-Seegers, N; Zaman, GJR1
Berry, TM; Moustafa, AA1
Arab, HH; Safar, MM; Shahin, NN1
Kumar, P; Kumar, S1
Guo, XH; Han, YY; Li, HF; Ruan, WL; Shen, SH; Xu, Y; Xu, YL; Zhang, H; Zhao, MN1
Cheng, B; Dou, S; Shao, Z; Wang, C; Wang, H; Xu, X; Zhu, J1
Karthikkeyan, G; Modi, PK; Pervaje, R; Pervaje, SK; Prasad, TSK1
Berger, JP; Constable, R; Di Natale, M; Diwakarla, S; Finkelstein, DI; Furness, JB; Kauhausen, J; Lee, S; McQuade, RM; Parish, CL; Ringuet, MT; Singleton, LM; Wu, H1
Khurana, N; Muthuraman, A; Sharma, N; Utreja, P1
Förster, N; Gold, R; Hasse, B; Kiwatrowski, N; Metzdorf, J; Mosig, A; Ostendorf, F; Pallapies, F; Schikora, J; Selbach, L; Tönges, L1
Aibaidula, Y; Aimaiti, M; Aisa, Y; Chen, Q; Feng, X; Lei, X; Mi, N; Wumaier, A; Xirepu, X; Zhang, Y1
Hickey, MA; Innos, J1
Ahmed, YR; Aziz, WM; Hamed, MAA; Khalil, WKB; Naser, AFA1
Maegawa, H; Niwa, H1
Du, G; Kong, D; Liang, Y; Song, J; Wei, G; Zhao, X; Zhou, Q1
Chen, S; Gao, Y; Liu, Y; Tan, J; Wang, Y; Wu, H; Xiao, Z; Yan, H; Yi, S1
Xue, Y; Yan, F; Yu, S; Zheng, X1
Altinoz, MA; Alturfan, AA; Cansız, D; Elmacı, İ; Emekli-Alturfan, E; Ünal, İ; Üstündağ, ÜV1
Gozes, I; Ivashko-Pachima, Y; Seroogy, KB; Sharabi, Y1
Ho, DH; Nam, D; Park, SW; Seo, MK; Seol, W; Son, I1
Chen, C; Liang, Y; Lu, Y; Tang, L; Wang, W; Zhang, Z; Zhao, Y; Zhu, G1
Chai, Z; Fan, H; Jin, X; Li, Y; Ma, C; Song, L; Sun, M; Wang, Q; Xiao, W; Yu, J; Zhang, B1
Jedsadavitayakol, S; Jutarattananon, S; Thong-Asa, W1
Kanninen, KM; White, AR1
Cole, NJ; Hesselson, D; Nguyen, DT; Olzomer, EM; Phillips, BR; Poon, GP; Puvanendran, A; Zhang, Y1
Anusha, C; Joseph, LD; Sumathi, T1
Fleming, SM1
Chidambaram, R; Dhanalakshmi, C; Essa, MM; Gobi, VV; Justin Thenmozhi, A; Kalandar, A; Manivasagam, T; Rajasankar, S; Ramkumar, M1
Haddad, D; Nakamura, K1
Du, G; Du, L; Yang, Y; Zhang, W; Zhang, X1
Cao, X; Kuang, L; Lu, Z1
Duan, CL; Hao, XM; Li, LD; Li, YJ1
Concannon, RM; Dowd, E; McCabe, K; McKernan, DP1
Du, G; Du, L; Yang, Y; Zhang, W; Zhang, X; Zhou, Q1
Berwin, BL; Havrda, MC; Martinez, EM; Patankar, YR; von Herrmann, KM; Wang, L; Weier, JM; Young, AL1
Abdel-Tawab, AM; Bahaa, N; Khalifa, AE; Salama, RM; Schaalan, MF; Tadros, MG1
Azmy, MS; El-Naga, RN; Menze, ET; Tadros, MG1
Chen, Y; Huang, K; Jing, X; Lei, M; Liang, Y; Lin, D; Liu, J; Peng, S; Tao, E; Wu, X; Xiao, S; Yang, L; Zeng, Z; Zheng, D; Zhou, T1
Bruchhaus, I; El-Kholy, S; Fink, C; Hoffmann, J; Nolte, S; Roeder, T; Stephano, F; von Frieling, J1
Bahgat, AK; Hedya, SA; Safar, MM2
Deshmukh, R; Kumar, P; Sharma, S1
Andrade-da-Costa, BLDS; Augusto, RL; Braz, GRF; de Souza, FTC; de Souza, IA; Lafayette, SSL; Lagranha, CJ; Medeiros-Linard, CFB; Perreira, RCR; Sereniki, A; Smailli, SS; Trevisan, MTS; Wanderley, AG1
Bicca, MA; Hara, DB; Morais, LH; Poli, A; Takahashi, RN1
Bao, XX; Ding, H; Li, WW; Ma, HH; Zhu, M1
Liang, S; Ping, Z; Tao, W; Wenfeng, C; Xiaomu, W; Xufang, X1
Abin-Carriquiry, JA; Costa, G; Dajas, F; Ferreira, M; Mouhape, C; Prunell, G1
Arnold, B; Berman, SB; Calderon, MJ; Greenamyre, JT; Howlett, EH; Sanders, LH; St Croix, CM; Van Laar, VS1
Andrabi, SS; Parveen, S; Parvez, S; Rasheed, MZ; Salman, M; Shaquiquzzaman, M; Tabassum, H1
Chen, C; Chen, J; Chen, Y; Fu, Y; Ge, R; Hou, Y; Ji, D; Wang, H; Zhang, N; Zheng, Q1
Inmozhi Sivakamasundari, R; Rekha, KR1
Aurich, MF; Lima, MMS; Noseda, ACD; Rodrigues, LS; Targa, ADS1
da Silva Ribeiro, CY; de Aguiar Montenegro, N; de Andrade, RR; Del Bel Guimarães, E; Domingues, ACM; Ferreira, GG; Horst, CH; Schlemmer, F; Titze-de-Almeida, R; Titze-de-Almeida, SS1
Andoh-Noda, T; Banno, S; Chai, M; Hattori, N; Imaizumi, Y; Ito, M; Kohyama, J; Okano, H; Saya, H; Sone, T; Sugawara, M; Tabata, Y; Tsukahara, K; Yamazaki, K1
Ayton, D; Ayton, S; Barker, AL; Bush, AI; Warren, N1
Hartley, RC; Murphy, MP; Oliveira, JMA; Pinho, BR; Reis, SD1
Fang, Q; Homberg, JR; Li, W; Liao, P; Liu, C; Luan, Y; Meng, X; Shan, L; Shen, J; Swaab, DF; Wang, J; Zhou, P1
Prabu, K; Rajasankar, S; Ramkumar, M; Swaminathan Johnson, WM; Venkatesh Gobi, V2
Rajendran, M; Ramachandran, R1
Dodiya, HB; Engen, PA; Forsyth, CB; Green, SJ; Keshavarzian, A; Kordower, JH; Naqib, A; Pahan, K; Patel, J; Roy, A; Shaikh, M; Shannon, KM; Voigt, RM1
Bobrovskaya, L; Johnson, ME; Zhou, XF1
Amoroso, S; Bastioli, G; Calabresi, P; Castaldo, P; Magi, S; Piccirillo, S; Tozzi, A1
Chowdhury, NR; Dorieux, FWC; Fagotti, J; Ilkiw, JL; Lima, MMS; Louzada, FM; Middleton, B; Noseda, ACD; Pennings, JLA; Rodrigues, LS; Scarante, FF; Skene, DJ; Swann, JR; Targa, ADS; van der Veen, DR1
Bandez, MJ; Boveris, A; López-Cepero, JM; Navarro, A; Valdez, LB; Zaobornyj, T1
Abd El-Lateef, AS; Alzahrani, S; Elkazaz, AY; Elshaer, RE; Ezzat, W; Mohammad, HMF; Toraih, E; Zaitone, SA1
Castro, S; De Miranda, BR; Fazzari, M; Greenamyre, JT; Rocha, EM1
Greenamyre, JT; McCoy, JL; Tapias, V1
Ansari, SA; Azimullah, S; Javed, H; Meeran, MFN; Ojha, S1
Humpel, C; Ucar, B1
Callizot, N; Combes, M; Henriques, A; Poindron, P1
Bhurtel, S; Choi, DY; Choi, H; Hong, JT; Katila, N; Maharjan, S; Neupane, S; Srivastav, S1
De Miranda, BR; Greenamyre, JT1
Goldman, SM; Tanner, CM1
Adem, A; Azimullah, S; Beiram, R; Jalal, FY; Jayaraj, RL; Meeran, MFN; Ojha, SK1
Chen, J; Hu, H; Li, LX; Liu, CF; Lv, DJ; Wang, F; Wei, SZ; Xie, AM1
Bu, J; He, Y; Liu, J; Qiao, X1
Benedí, J; Delgado, M; Fernández-Ruiz, J; García-Arencibia, M; García-García, L; Gómez del Rio, MA; Iglesias, I; Pozo, MA; Sánchez-Reus, MI1
Berg, D; Brockmann, K; Burbulla, LF; Dhingra, A; Gasser, T; Glatza, M; Hargus, G; Heck, SA; Höing, S; Klewin, M; Klingauf, J; Kluba, T; Krüger, R; Kuhlmann, T; Maisel, M; Müller, H; Müller, S; Psathaki, OE; Reinhardt, P; Schmid, B; Schöler, HR; Schöndorf, DC; Sterneckert, J; Thiel, CS; Tsytsyura, Y; Wagner, L; Wu, G1
Jang, IS; Oh, WK; Park, J; Ryu, HW1
Andrieu, T; Baron, T; Bétemps, D; Chorfa, A; Hogeveen, K; Lazizzera, C; Morignat, E1
Lenaers, G; Reynier, P; Thany, SH1
Bähr, M; Bertsch, U; Bötzel, K; Deeg, AA; Eiden, M; Frank, T; Geissen, M; Giese, A; Griesinger, C; Groschup, M; Hirschberger, T; Krauth, JJ; Kretzschmar, H; Leidel, F; Leonov, A; Levin, J; Mitteregger-Kretzschmar, G; Pan-Montojo, F; Pilger, J; Prix, C; Ryazanov, S; Samwer, M; Schmidt, F; Shi, S; Tavan, P; Teichmann, U; Uhr, M; Urlaub, H; Wagner, J; Weishaupt, JH; Zinth, W; Zweckstetter, M1
Ge, JB; Gu, JH; Liang, ZQ; Qin, ZH; Wang, Z; Wu, F1
Fu, Q; Liu, X; Wang, Y; Wu, Z1
Alvarez-Fischer, D; Fuchs, J; Grünewald, A; Guerreiro, S; Hartmann, A; Hirsch, EC; Lombès, A; Lu, L; Michel, PP; Noelker, C; Oertel, WH; Vulinović, F1
Berndt, N; Bulik, S; Holzhütter, HG1
Bennett, JP; Keeney, PM; Thomas, RR1
Kamel, F1
Chen, D; Gao, F; Hu, Q; Wang, G1
Gajbhiye, A; Khurana, N1
Ding, QF; Liu, CB; Lu, FB; Pan, HB; Wang, R1
Braidy, N; Essa, MM; Guillemin, GJ; Karthikeyan, S; Manivasagam, T; Prasad, NR; Selvaraju, S; Tamilselvam, K; Thenmozhi, AJ1
Choi, BS; Kim, H; Kim, S; Kim, SJ; Lee, HJ; Park, SE; Sapkota, K1
Chae, S; Im, AR; Kim, YH; Kim, YS; Lee, HW; Lee, MY; Uddin, MR1
Du, GH; Fang, JS; Gao, L; Liu, AL; Yuan, TY; Zhao, G1
Cannon, JR; Greenamyre, JT; Tapias, V1
Armstrong, SM; Moore, C; Willis, GL1
Ferruzzi, MG; Grace, MH; Lila, MA; Rochet, JC; Roy, SL; Simon, JE; Strathearn, KE; Tambe, MA; Wu, QL; Yousef, GG1
Aglan, H; Ahmed, H; Atta, H; Ghazy, M; Salem, A1
Carriere, CH; Kang, NH; Niles, LP2
Chen, L; Chen, S; Guo, M; Huang, S; Liu, C; Liu, L; Ren, Q; Xu, C; Xu, Y; Ye, Y; Zhang, H; Zhou, Q1
Gokul, K1
Chen, NH; Gao, Y; Gao, YN; Guo, XF; Huang, JY; Ma, KL; Yan, JQ; Yuan, YH; Zhang, WQ1
Nehru, B; Thakur, P2
Ambrosi, G; Armentero, MT; Blandini, F; Bombardieri, CR; Ghezzi, C; Mastroberardino, PG; Milanese, C; Pacchetti, C; Payan-Gomez, C; Sepe, S; Zangaglia, R1
Chang, CJ; Chu, CT; Dickinson, BC; Greenamyre, JT; Hu, X; Mastroberardino, PG; McCoy, J; Sanders, LH; Van Houten, B1
Jang, W; Jo, KD; Kim, HJ; Lee, MK; Li, H; Song, SH; Yang, HO1
Lee, D; Podolsky, E; Qi, C; Varga, SJ1
Ahmad, ST; Liao, J; Morin, LW1
Bétourné, A; Ferré, CA; Foret, C; Gonzalez-Dunia, D; Hunot, S; Monnet, Y; Peyrin, JM; Szelechowski, M; Thouard, A1
Abdallah, DM; Al-Shorbagy, MY; Arab, HH; Nassar, NN1
Bae, N; Cha, JW; Chung, S; Gu, MY; Kim, HJ; Oh, H; Oh, MS; Yang, HO1
Bhudhikanok, GS; Blair, A; Chade, A; Comyns, K; Furlong, M; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Richards, M; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM1
Abdelkader, NF; Safar, MM; Salem, HA1
Bobrovskaya, L; Johnson, ME1
Gu, Z; Liu, S; Lv, X; Sun, H; Xie, Y; Yin, L; Yin, S; Zhang, J1
Denny Joseph, KM1
Lavalley, N; McFerrin, M; Slone, SR; Wang, B; Yacoubian, TA1
Jiang, H; Shen, X; Tan, Z; Xu, H1
Gao, Q; Ou, Z; Tong, Q; Wu, L; Zhang, Y; Zhu, D1
Bourque, MJ; Giguère, N; Lévesque, M; Pacelli, C; Slack, RS; Trudeau, LÉ1
Cheng, X; Li, S; Liu, B; Lv, C; Ma, Y; Mao, W; Sun, J; Zhang, J1
Moldzio, R; Radad, K; Rausch, WD1
Antonioli, L; Ballabeni, V; Barocelli, E; Bernardini, N; Blandizzi, C; Colucci, R; Fornai, M; Pellegrini, C1
Bobrovskaya, L; Johnson, ME; Lim, Y; Senthilkumaran, M; Zhou, XF1
Chen, LL; Durairajan, SS; Han, QB; Huang, YY; Li, M; Liu, LF; Lu, JH; Song, JX; Zeng, Y1
Cui, Q; Li, X; Zhu, H1
Akcan, U; Bilgiç, B; Gürvit, H; Hanağası, H; Haytural, H; İdrisoğlu, HA; Küçükali, Cİ; Özbek, Z; Özdemir, Ö; Tüzün, E; Yalçınkaya, N1
Jiang, T; Ou, Z; Tong, Q; Wu, L; Zhang, Y; Zhu, D1
Bajaj, L; Chaudhury, A; Di Ronza, A; Lotfi, P; Neilson, J; Pal, R; Palmieri, M; Rodney, GG; Sardiello, M; Sharma, J1
Berman, SB; Hastings, TG; Van Laar, VS1
Chen, M; Du, T; Duan, C; Gao, G; Liu, J; Wang, Y; Yang, H1
Elbatsh, MM; Gaballah, HH; Tahoon, NM; Zakaria, SS1
Chen, S; Cheng, Q; Ding, F; Ke, K; Qin, J; Yu, S; Zhang, J; Zhang, Q1
Cook, AL; Dong, LF; Mackay-Sim, A; Matigian, N; Mellick, GD; Murtaza, M; Neuzil, J; Ravishankar, S; Shan, J; Silburn, P; Todorovic, M; Wood, SA1
Fathalla, AM; Moustafa, AA; Soliman, AM1
Cao, M; Chen, Y; Huang, H; Ni, Y; Zhang, Y; Zhou, H1
Arévalo, E; Arnhold, M; Chopin, M; Dening, Y; Funk, RH; Gille, G; Pan-Montojo, F; Reichmann, H; Schwarz, M1
Bazzan, AJ; Bowen, B; Cai, J; Iacovitti, L; Intenzo, CM; Kremens, D; Liang, TW; Monti, DA; Newberg, AB; Wei, X; Wintering, NA; Zabrecky, G; Zhong, L1
Concannon, RM; Dowd, E; Finn, DP; Okine, BN1
Cannon, J; Wise, JP1
Abdel-Tawab, AM; Esmat, A; Khalifa, AE; Michel, HE; Tadros, MG1
Cai, X; Cao, P; Chen, B; Chen, J; Cheng, X; Hu, Z; Lu, W; Shen, J; Sun, X; Wang, X; Wu, L; Yan, H; Yang, J; Yang, Y; Ye, J; Zhou, Q1
He, X; Ren, J; Wang, Y; Yuan, J; Zhao, Y1
Chidambaram, R; Dhanalakshmi, C; Essa, MM; Justin Thenmozhi, A; Manivasagam, T; Rajasankar, S; Ramkumar, M; Venkatesh Gobi, V1
Li, M; Liu, Q; Wood, K; Yang, L; Yang, X; Zhao, P; Zhu, X1
Almeida, MF; D'Unhao, AM; Ferrari, MF; Silva, CM1
Martella, G; Pisani, A; Schirinzi, T1
Deepthy, J; Ezhil, P; Kalaiselvi, P; Kishore Kumar, SN; Saraswathi, U; Thangarajeswari, M; Yogesh Kanna, S1
Ascenzi, P; Beltrami, AP; Bertuzzi, M; Cesselli, D; Codrich, M; Espinoza, S; Francescatto, M; Giacca, M; Gustincich, S; Leanza, G; Persichetti, F; Russo, R; Zentilin, L; Zucchelli, S1
Jungling, A; Kiss, T; Maasz, G; Petrovics, D; Pirger, Z; Reglodi, D; Rivnyak, A; Tamas, A; Zrinyi, Z1
Booth, H; Bowden, R; Cowley, SA; Heger, A; Hu, M; Lang, C; Robertson, P; Sandor, C; Vowles, J; Wade-Martins, R; Webber, C; Witty, L1
Ho, PW; Ho, SL; Kung, MH; Lam, CS; Leung, GC; Li, L; Liu, HF; Pang, SY; Ramsden, DB1
Jang, W; Kang, SY; Kim, HJ; Kim, HT; Lee, SB; Yang, HO1
Pan, PK; Qiao, LY; Wen, XN1
Abd El Fattah, MA; Badawi, GA; El Sayed, MI; Zaki, HF1
Broersen, LM; Dodiya, HB; Douna, H; Garssen, J; Keshavarzian, A; Kraneveld, AD; Lopes da Silva, S; Perez-Pardo, P; van Wijk, N1
Feng, Z; Hao, J; Jia, H; Li, X; Liu, J; Liu, Z; Shen, W; Zhang, H1
Choi, WS; Kruse, SE; Palmiter, RD; Xia, Z1
Eells, JT; Liang, HL; Whelan, HT; Wong-Riley, MT; Ying, R1
Banik, NL; Butler, JT; Ray, SK; Samantaray, S1
Dhillon, AS; Levin, JL; Lowry, LK; Nalbone, JT; Plotkin, GM; Shepherd, S; Tarbutton, GL1
Feng, J; Jiang, H; Nakaso, K; Ren, Y; Yang, F1
Moldzio, R; Piskernik, C; Radad, K; Rausch, WD1
Hasegawa, T; Kikuchi, A; Kobayashi, M; Sugeno, N; Takeda, A1
Hayashi, T; Kawasaki, A; Kotake, Y; Nakachi, K; Ohta, S; Sugihara, K; Trosko, JE1
Anderson, M; Betarbet, R; Cheng, D; Chu, CT; Gearing, M; Greenamyre, JT; Gutekunst, CA; Hoffman, EK; Horowitz, MP; Mastroberardino, PG; Na, HM; Peng, J; Taylor, G; Trojanowski, JQ1
Nehru, B; Verma, R1
Bradner, J; Caudle, WM; Kitsou, E; Li, J; Zhang, J1
Falk, T; Sherman, SJ; Zhang, S1
Chen, S; Fan, X; Gu, Q; Le, W; Li, L; Li, X; Ming, M; Yang, D1
Cannon, JR; Drolet, RE; Greenamyre, JT; Montero, L1
Barber, JR; Chen, J; Liu, G; Ng, SC; Reddy, PS; Yoon, IS; Zhang, B; Zhang, M; Zhou, Y1
Liu, L; Wang, X; Wang, Y1
Hillard, CJ; Kalivendi, SV; Kalyanaraman, B; Yedlapudi, D1
Cao, X; Chen, C; Huang, J; Jia, M; Liang, Z; Lin, Z; Liu, X; Sun, S; Wang, F; Wang, T; Xiong, J; Xiong, N; Zhang, Z1
Jackson, T; Jengelley, TA; Jnobaptiste, R; McNaught, KS1
Kawamata, J; Takahashi, R; Takeuchi, H1
Cannon, JR; Drolet, R; Greenamyre, JT; Mastroberardino, PG1
Anichtchik, O; Dening, Y; Funk, RH; Gille, G; Jackson, S; Jung, R; Knels, L; Pan-Montojo, F; Pursche, S; Reichmann, H; Spillantini, MG1
Bayersdorfer, F; Botella, JA; Schneuwly, S; Voigt, A1
Hu, Y; Tong, Y1
Ao, N; Jia, H; Li, X; Liu, J; Luo, C; Shen, W; Wang, X; Yan, B; Zhang, H1
Arnold, B; Berman, SB; Cassady, SJ; VanLaar, VS1
Cannon, JR; Greenamyre, JT1
Beilina, A; Blackinton, J; Cedazo-Minguez, A; Cookson, MR; Maric, D; McCoy, MK; Miller, D; Sandebring, A; Thomas, KJ; van der Brug, M1
Caldwell, GA; Caldwell, KA; Hamamichi, S; Harrington, AJ; Schieltz, JM; Slone, SR; Standaert, DG; Yacoubian, TA1
Bhudhikanok, GS; Blair, A; Cambi, F; Chade, AR; Comyns, K; Fernandez, HH; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Priestley, B; Richards, MB; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM1
Lu, GQ; Wang, XJ; Wang, Y; Yan, ZQ; Zhang, JD; Zhang, S; Zhao, YX; Zhou, HY1
Choi, WS; Palmiter, RD; Xia, Z1
Colosio, C; Moretto, A1
Akashi, S; Arai, T; Kimura, T; Kobayashi, S; Kuramochi, K; Sugawara, F; Takeuchi, T; Watanabe, N1
Choong, CJ; Say, YH1
Lesort, M; Slone, SR; Yacoubian, TA1
Caccamo, D; Calabrò, E; Condello, S; Currò, M; Ferlazzo, N; Ientile, R; Magazù, S; Satriano, J1
Abdin, AA; Sarhan, NI1
Kim, MK; Kim, S; Kim, SJ; Park, SE; Sapkota, K1
Abo-Elmatty, DM; Shaalan, AA; Zaitone, SA1
Ariga, H; Funayama, R; Honda, T; Inden, M; Ito, N; Kitamura, Y; Nishimura, K; Niwa, R; Taira, T; Takahashi, K; Takata, K; Taniguchi, T1
Cao, X; Chen, C; Hou, L; Huang, J; Jia, M; Liang, Z; Lin, Z; Sun, S; Wang, T; Xiong, J; Xiong, N; Yang, H; Zhang, Z1
Tieu, K1
Chesselet, MF; McDowell, K1
Hwang, O; Kim, EM; Lee, JA; Rhim, H; Shin, EJ1
Butler, EK; Falkenburger, B; Gerhardt, E; Karsten, P; Lutz, AK; Reinartz, A; Schulz, JB; Toegel, JP; Voigt, A; Winklhofer, KF1
Chen, C; Ghoorah, D; Huang, J; Jia, M; Kong, X; Lin, Z; Long, X; Wang, T; Xiong, J; Xiong, N1
ElDakroory, SAE; Elghaffar, HA; ElHak, SG; Elhusseiny, M; ElTantawy, D; Ghanem, AA; Salama, M1
Chen, YP; Feng, XY; Li, WW; Zhang, QQ; Zhu, M1
Duan, C; Gao, H; Lu, L; Qi, Z; Yang, H; Yang, W; Zhao, C1
Kabiraj, P; Miranda, M; Narayan, M; Pal, R; Varela-Ramirez, A1
Barcia, E; Fernández, M; Fernández-Carballido, A; Garcia, L; Negro, S; Slowing, K1
Erbaş, O; Oltulu, F; Taşkiran, D1
Arias-Carrión, O; El-Gamal, M; Ellaithy, A; Helmy, B; Mohamed, M; Salama, M; Sheashaa, H; Sobh, M; Tantawy, D1
Krieglstein, K; Spittau, B; Tolosa, A; Zhou, X1
Dowd, E; Kirik, D; Mulcahy, P; O'Brien, T; O'Doherty, A; Paucard, A1
Jantas, D; Konieczny, J; Kuśmierczyk, J; Lasoń, W; Lenda, T; Lorenc-Koci, E; Roman, A1
Sanders, LH; Timothy Greenamyre, J1
El-Gamal, A; El-Gamal, M; Ellaithy, A; Helmy, B; Mohamed, M; Reda, A; Salama, M; Sheashaa, H; Sobh, M; Tantawy, D1
Baptista, M; Betarbet, R; Cookson, MR; Greenamyre, JT; Lund, S; Panov, AV; Sherer, TB; Stout, AK1
Tai, KK; Truong, DD1
Bonetta, L1
Angelastro, JM; Greene, LA; Harding, HP; Ron, D; Ryu, EJ; Vitolo, OV1
Trojanowski, JQ1
Halliday, GM; Orr, CF; Rowe, DB1
Gao, HM; Hong, JS; Liu, B; Zhang, W2
Betarbet, R; Greenamyre, JT; Kim, JH; Sherer, TB1
Broussolle, E; Thobois, S1
Bové, J; Perier, C; Przedborski, S; Vila, M1
Imam, SZ1
Gao, HM; Hong, JS; Liu, B1
Di Monte, DA1
Breidert, T; Cohen-Salmon, C; Feger, J; Hirsch, EC; Höglinger, G; Launay, JM; Parain, K; Prigent, A; Rousselet, E; Ruberg, M1
Feng, J; Jiang, H; Ren, Y; Zhao, J1
Gaston, B; Gu, Z; Lipton, SA; Ma, Y; Masliah, E; Nakamura, T; Palmer, LA; Rockenstein, EM; Shi, ZQ; Uehara, T; Yao, D; Zhang, Z1
Uversky, VN1
DiMatteo, K1
Caboni, P; Casida, JE; Greenamyre, JT; Na, HM; Sherer, TB; Taylor, G; Zhang, N1
Alam, M; Schmidt, WJ1
Friedrich, MJ2
Wang, XJ; Xu, JX1
Pasha, MK; Rajput, AH; Sharma, RK1
Kress, GJ; Reynolds, IJ1
Chen, SD; Fan, GH; Qi, C; Wang, G; Zhou, HY1
Feng, J; Jiang, H; Jiang, Q; Liu, W; Ren, Y1
Gu, W; Huang, J; Li, Y; Liu, H; Xu, Z; Yan, Z; Yang, Y; Zhu, X1
Armstrong-Gold, CE; Bonini, NM; Heutink, P; Meulener, M; Pallanck, LJ; Rizzu, P; Wes, PD; Whitworth, AJ1
Alfonso, A; Burnam, L; Hoener, M; Liu, L; Perier, C; Przedborski, S; Rodrigues, CM; Saha, S; Sluder, A; Steer, C; Ved, R; Westlund, B; Wolozin, B1
Dikalov, S; Greenamyre, JT; Panov, A; Shalbuyeva, N; Sherer, T; Taylor, G1
Chew, KC; Dawson, TM; Dawson, VL; Ho, MW; Ko, HS; Lim, KL; Lim, TM; Pletnikova, O; Soong, TW; Tay, SP; Thomas, B; Troncoso, J; Tsang, F; Wang, C1
Cho, Y; Choi, HJ; Hwang, O; Kim, SW; Lee, SY; No, H1
Flotte, TR; Matsuno-Yagi, A; Nakamaru-Ogiso, E; Seo, BB; Yagi, T1
Hulette, C; Jin, J; Pan, C; Wadhwa, R; Wang, Y; Zhang, J; Zhang, T1
Casarejos, MJ; García de Yébenes, J; Mena, MA; Menéndez, J; Rodríguez-Navarro, JA; Solano, RM1
Mirzaei, H; Regnier, F; Rochet, JC; Schieler, JL1
Lev, N; Melamed, E; Offen, D1
Bernardi, G; Calabresi, P; Costa, C; Martella, G; Mercuri, NB; Pisani, A; Shen, J; Tscherter, A1
Kordower, JH; O'Malley, J; Soderstrom, K; Steece-Collier, K1
Davis, J; Jin, J; Li, GJ; Pan, C; Wang, Y; Zhang, J; Zhu, D1
German, DC; Liang, CL; Luby-Phelps, K; Wang, TT1
Hirata, Y; Kiuchi, K; Meguro, T1
Feng, J1
Elliott, CJ; Hernádi, L; Hiripi, L; Szabó, H; Vehovszky, A1
Chan, CS; Guzman, JN; Ilijic, E; Mercer, JN; Meredith, GE; Rick, C; Surmeier, DJ; Tkatch, T1
Staines, DR1
Feng, J; Ren, Y1
Chung, WG; Maier, CS; Miranda, CL1
Gille, G; Radad, K; Rausch, WD1
Barreto, G; Bertolino, LA; Capani, F; Giraldez, LD; Madureira de Oliveria, D; Saraceno, E; Valverde G De Andrade, D1
Ferree, A; Guillily, M; Riley, M; Saha, S; Wolozin, B1
Hulleman, JD; Li, L; Liu, F; Nguyen, JL; Rochet, JC1
James-Kracke, M; Miller, RL; Sun, AY; Sun, GY1
Bonham, CC; Davisson, VJ; Hindupur, J; Liu, F; Nguyen, JL; Rochet, JC; Ruf, KJ; Schieler, JL; Wood, KV; Zhu, J1
Cooper, JM; Hartley, A; Heron, C; Schapira, AH; Stone, JM1
Griffiths, HR; Lunec, J; Willets, JM; Williams, AC1
Cooper, JM; Schapira, AH; Seaton, TA2
Itakura, T; Nakai, K; Nakao, N1
Blandini, F; Greenamyre, JT; Nappi, G1
Eisenhofer, G; Harvey-White, J; Kirk, K; Kopin, IJ; Lamensdorf, I; Nechustan, A1
Giasson, BI; Lee, VM1
Betarbet, R; Garcia-Osuna, M; Greenamyre, JT; MacKenzie, G; Panov, AV; Sherer, TB1
Adam-Vizi, V; Chinopoulos, C1
Bennett, JP; Borland, K; Parks, JK; Sherer, TB; Trimmer, PA; Tuttle, JB1
Helmuth, L1
Brown, AM; Burke, WJ; Conway, AD; Jain, JC; Kristal, BS; Li, SW; Ulluci, PA1
Fink, AL; Li, J; Uversky, VN1
Cadet, JL; Cutler, RG; Duan, W; Kruman, II; Ladenheim, B; Mattson, MP1
Aschner, M; Seegal, RF1
Wesemann, W1

Reviews

27 review(s) available for rotenone and Parkinson Disease

ArticleYear
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
    International journal of molecular sciences, 2022, Sep-16, Volume: 23, Issue:18

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; DDT; Dieldrin; Herbicides; Humans; Manganese; Mitochondria; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pesticides; Risk Factors; Rotenone; Trichloroethanes; Vanadium

2022
Rotenone-Induced Model of Parkinson's Disease: Beyond Mitochondrial Complex I Inhibition.
    Molecular neurobiology, 2023, Volume: 60, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Electron Transport Complex I; Oxidopamine; Parkinson Disease; Rats; Rotenone

2023
Use of invertebrates to model chemically induced parkinsonism-symptoms.
    Biochemical Society transactions, 2023, 02-27, Volume: 51, Issue:1

    Topics: Animals; Disease Models, Animal; Humans; Invertebrates; Parkinson Disease; Parkinsonian Disorders; Rotenone

2023
Rotenone: from modelling to implication in Parkinson's disease.
    Folia neuropathologica, 2019, Volume: 57, Issue:4

    Topics: Animals; Cell Death; Disease Models, Animal; Humans; Inflammation; Parkinson Disease; Reactive Oxygen Species; Rotenone

2019
Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration.
    International journal of molecular sciences, 2020, Aug-20, Volume: 21, Issue:17

    Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Knockdown Techniques; Neurotoxicity Syndromes; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Rotenone; Zebrafish; Zebrafish Proteins

2020
Using Rotenone to Model Parkinson's Disease in Mice: A Review of the Role of Pharmacokinetics.
    Chemical research in toxicology, 2021, 05-17, Volume: 34, Issue:5

    Topics: Animals; Disease Models, Animal; Electron Transport Complex I; Mice; Parkinson Disease; Rotenone

2021
Mechanisms of Gene-Environment Interactions in Parkinson's Disease.
    Current environmental health reports, 2017, Volume: 4, Issue:2

    Topics: Environmental Exposure; Gene-Environment Interaction; Genetic Predisposition to Disease; Herbicides; Humans; Insecticides; Mutation; Paraquat; Parkinson Disease; Risk Factors; Rotenone

2017
Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease.
    Neurobiology of disease, 2020, Volume: 135

    Topics: Animals; Brain; Disease Models, Animal; Gastrointestinal Diseases; Gastrointestinal Microbiome; Humans; Parkinson Disease; Rotenone

2020
An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions.
    Neurotoxicology, 2015, Volume: 46

    Topics: Animals; Disease Models, Animal; Gene-Environment Interaction; Humans; Insecticides; Parkinson Disease; Rotenone

2015
Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence.
    Parkinsonism & related disorders, 2015, Volume: 21, Issue:12

    Topics: alpha-Synuclein; Animals; Cholecystokinin; Efferent Pathways; Enteric Nervous System; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Humans; Mice; Mice, Transgenic; Models, Neurological; Neuromuscular Junction; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Protein Aggregates; Rats; Rotenone; Translational Research, Biomedical; Vagus Nerve

2015
[Pathogenesis of sporadic Parkinson's disease: contribution of genetic and environmental risk factors].
    Rinsho shinkeigaku = Clinical neurology, 2009, Volume: 49, Issue:11

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Glucosylceramidase; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mitochondria; Mutation; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Risk Factors; Rotenone

2009
Lessons from the rotenone model of Parkinson's disease.
    Trends in pharmacological sciences, 2010, Volume: 31, Issue:4

    Topics: Animals; Disease Models, Animal; Environmental Exposure; Humans; Parkinson Disease; Parkinson Disease, Secondary; Rotenone

2010
A trojan horse for Parkinson's disease.
    Science signaling, 2010, Apr-06, Volume: 3, Issue:116

    Topics: Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mutation, Missense; Neurons; Parkinson Disease; Protein Serine-Threonine Kinases; Rotenone

2010
Neurotoxic in vivo models of Parkinson's disease recent advances.
    Progress in brain research, 2010, Volume: 184

    Topics: Animals; Disease Models, Animal; Dopamine; Humans; MPTP Poisoning; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Sympatholytics; Uncoupling Agents

2010
Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease.
    Neurotoxicology, 2011, Volume: 32, Issue:4

    Topics: Animals; Brain; Dieldrin; Dose-Response Relationship, Drug; Humans; Maneb; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides; Pyrethrins; Risk Assessment; Risk Factors; Rotenone; Time Factors; Toxicity Tests

2011
A guide to neurotoxic animal models of Parkinson's disease.
    Cold Spring Harbor perspectives in medicine, 2011, Volume: 1, Issue:1

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Haplorhini; Lewy Bodies; Mice; MPTP Poisoning; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Substantia Nigra

2011
Animal models of the non-motor features of Parkinson's disease.
    Neurobiology of disease, 2012, Volume: 46, Issue:3

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Humans; Hydroxydopamines; MPTP Poisoning; Neurotoxins; Parkinson Disease; Parkinson Disease, Secondary; Risk Factors; Rotenone; Uncoupling Agents

2012
Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models.
    Critical reviews in toxicology, 2012, Volume: 42, Issue:7

    Topics: alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Humans; Lewy Bodies; Mitochondria; Oxidative Stress; Parkinson Disease; Proteolysis; Rotenone; Substantia Nigra

2012
Oxidative damage to macromolecules in human Parkinson disease and the rotenone model.
    Free radical biology & medicine, 2013, Volume: 62

    Topics: Animals; Disease Models, Animal; DNA Damage; Dopaminergic Neurons; Humans; Lipid Metabolism; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Proteins; Rotenone

2013
An inflammatory review of Parkinson's disease.
    Progress in neurobiology, 2002, Volume: 68, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Gangliosides; Humans; Immunologic Surveillance; Lipopolysaccharides; Microglia; Monitoring, Immunologic; Neurons; Oxidopamine; Parkinson Disease; Rotenone; Signal Transduction

2002
[Genetics and environmental factors of Parkinson disease].
    Revue neurologique, 2002, Volume: 158 Spec no 1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Dopamine Agents; Environmental Exposure; Humans; Insecticides; Ligases; Nerve Tissue Proteins; Parkinson Disease; Risk Factors; Rotenone; Synucleins; Ubiquitin-Protein Ligases

2002
The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
    The Lancet. Neurology, 2003, Volume: 2, Issue:9

    Topics: alpha-Synuclein; Animals; Corpus Striatum; Environmental Exposure; Herbicides; Humans; Insecticides; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Neurotoxins; Oncogene Proteins; Paraquat; Parkinson Disease; Protein Deglycase DJ-1; Risk Factors; Rotenone; Synucleins; Twin Studies as Topic

2003
Animal models of Parkinson's disease in rodents induced by toxins: an update.
    Journal of neural transmission. Supplementum, 2003, Issue:65

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic Agents; Animals; Basal Ganglia; Brain Stem; Disease Models, Animal; Dopamine; Dopamine Agents; Nerve Degeneration; Neurons; Oxidopamine; Parkinson Disease; Rodentia; Rotenone; Uncoupling Agents

2003
Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration.
    Cell and tissue research, 2004, Volume: 318, Issue:1

    Topics: Animals; Disease Models, Animal; Fungicides, Industrial; Herbicides; Maneb; Nerve Degeneration; Neurotoxins; Paraquat; Parkinson Disease; Rotenone; Uncoupling Agents

2004
Neural repair strategies for Parkinson's disease: insights from primate models.
    Cell transplantation, 2006, Volume: 15, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Transplantation; Deep Brain Stimulation; Disease Models, Animal; Fungicides, Industrial; Glial Cell Line-Derived Neurotrophic Factor; Herbicides; Humans; Maneb; Nerve Degeneration; Oxidopamine; Paraquat; Parkinson Disease; Pesticides; Primates; Rotenone

2006
Microtubule: a common target for parkin and Parkinson's disease toxins.
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2006, Volume: 12, Issue:6

    Topics: Animals; Humans; Microtubules; Models, Biological; Neurons; Parkinson Disease; Protein Binding; Rotenone; Tubulin; Ubiquitin-Protein Ligases

2006
Oxidative and inflammatory pathways in Parkinson's disease.
    Neurochemical research, 2009, Volume: 34, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Herbicides; Humans; Inflammation; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neurotoxins; Nitric Oxide Synthase; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Kinase C; Rotenone

2009

Trials

1 trial(s) available for rotenone and Parkinson Disease

ArticleYear
N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Acetylcysteine; Aged; Antioxidants; Caudate Nucleus; Cell Differentiation; Cell Survival; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Female; Human Embryonic Stem Cells; Humans; Male; Mesencephalon; Middle Aged; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Pilot Projects; Putamen; Rotenone; Single Photon Emission Computed Tomography Computed Tomography; Tissue Culture Techniques

2016

Other Studies

448 other study(ies) available for rotenone and Parkinson Disease

ArticleYear
Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line.
    Bioorganic & medicinal chemistry, 2020, 11-01, Volume: 28, Issue:21

    Topics: Alkaloids; Cell Line; Circular Dichroism; Density Functional Theory; Humans; Lysosomes; Magnetic Resonance Spectroscopy; Microscopy, Fluorescence; Mitochondria; Molecular Conformation; Papaveraceae; Parkinson Disease; Plant Extracts; Plants, Medicinal

2020
Quantitative phosphoproteomics to resolve the cellular responses to octanoic acid in rotenone exposed zebrafish.
    Journal of food biochemistry, 2021, Volume: 45, Issue:10

    Topics: Animals; Caprylates; Parkinson Disease; Rotenone; Zebrafish

2021
Liposomes loaded with polyphenol-rich grape pomace extracts protect from neurodegeneration in a rotenone-based
    Biomaterials science, 2021, Dec-07, Volume: 9, Issue:24

    Topics: Antioxidants; Humans; Liposomes; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Plant Extracts; Polyphenols; Rotenone; Vitis

2021
The Possible Role of
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Animals; Bifidobacterium longum; Disease Models, Animal; Humans; Lacticaseibacillus rhamnosus; Locomotion; Oxidative Stress; Parkinson Disease; Rotenone; Zebrafish

2021
Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis.
    Microbiome, 2021, 11-17, Volume: 9, Issue:1

    Topics: Animals; Brain-Gut Axis; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Parkinson Disease; Rotenone; Signal Transduction; Toll-Like Receptor 4

2021
Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons.
    Neurotoxicity research, 2022, Volume: 40, Issue:1

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Parkinson Disease; Rotenone; Substantia Nigra

2022
The rat rotenone model reproduces the abnormal pattern of central catecholamine metabolism found in Parkinson's disease.
    Disease models & mechanisms, 2022, 01-01, Volume: 15, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamines; Dopamine; Parkinson Disease; Rats; Rotenone

2022
UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022, Volume: 9, Issue:7

    Topics: Animals; Dopamine; Mice; Mice, Transgenic; Parkinson Disease; Proteolysis; Rotenone

2022
Longitudinal metabolomics profiling of serum amino acids in rotenone-induced Parkinson's mouse model.
    Amino acids, 2022, Volume: 54, Issue:1

    Topics: Amino Acids, Branched-Chain; Animals; Longitudinal Studies; Metabolomics; Mice; Mice, Inbred C57BL; Parkinson Disease; Rotenone

2022
The Protective Effects of Mogroside V Against Neuronal Damages by Attenuating Mitochondrial Dysfunction via Upregulating Sirtuin3.
    Molecular neurobiology, 2022, Volume: 59, Issue:4

    Topics: Antioxidants; Dopaminergic Neurons; Humans; Mitochondria; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Sirtuin 3; Triterpenes

2022
Neuroprotective effects of curcumin on the cerebellum in a rotenone-induced Parkinson's Disease Model.
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:5

    Topics: Animals; Cerebellum; Curcumin; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rotenone

2022
3-Pyridinylboronic Acid Ameliorates Rotenone-Induced Oxidative Stress Through Nrf2 Target Genes in Zebrafish Embryos.
    Neurochemical research, 2022, Volume: 47, Issue:6

    Topics: Animals; Antioxidants; Boron; Boronic Acids; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Parkinson Disease; Pyridines; Rotenone; Zebrafish

2022
The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease.
    International journal of molecular sciences, 2022, Feb-06, Volume: 23, Issue:3

    Topics: Animals; Buspirone; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Injections, Intraperitoneal; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Rotenone; Vasoactive Intestinal Peptide

2022
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.
    Scientific reports, 2022, 02-24, Volume: 12, Issue:1

    Topics: alpha-Synuclein; Animals; Cells, Cultured; Disease Models, Animal; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Neurons; Norepinephrine; Parkinson Disease; Pars Compacta; Prodromal Symptoms; Rotenone; Small-Conductance Calcium-Activated Potassium Channels

2022
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:5

    Topics: Animals; Caprylates; Chromatography, Liquid; Cytoskeletal Proteins; Cytoskeleton; Oxidation-Reduction; Parkinson Disease; Proteomics; Rotenone; Tandem Mass Spectrometry; Zebrafish

2022
Protective effect of curcumin against rotenone-induced substantia nigra pars compacta neuronal dysfunction.
    Metabolic brain disease, 2022, Volume: 37, Issue:4

    Topics: Animals; Curcumin; Dopaminergic Neurons; Male; Parkinson Disease; Pars Compacta; Rats; Rotenone; Substantia Nigra

2022
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.
    Molecular medicine (Cambridge, Mass.), 2022, 03-07, Volume: 28, Issue:1

    Topics: Adenosine Triphosphate; alpha-Synuclein; Animals; Dependovirus; Disease Models, Animal; Electron Transport Complex I; Genetic Therapy; Mammals; Mice; Neurodegenerative Diseases; Parkinson Disease; Reactive Oxygen Species; Rotenone; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

2022
Neuroprotective effects of ATPase inhibitory factor 1 preventing mitochondrial dysfunction in Parkinson's disease.
    Scientific reports, 2022, 03-09, Volume: 12, Issue:1

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Mice; Mitochondria; Neuroprotective Agents; Parkinson Disease; Rotenone

2022
Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson's Disease Mouse Model.
    International journal of molecular sciences, 2022, Mar-03, Volume: 23, Issue:5

    Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Microglia; Parkinson Disease; Permeability; Rotenone

2022
Novel anti-apoptotic L-DOPA precursors SuperDopa and SuperDopamide as potential neuroprotective agents for halting/delaying progression of Parkinson's disease.
    Cell death & disease, 2022, 03-11, Volume: 13, Issue:3

    Topics: Animals; Antioxidants; Dopaminergic Neurons; HEK293 Cells; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2022
Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson's disease by restoring the mTORC1-AMPK1 axis in autophagic regulation.
    Phytotherapy research : PTR, 2022, Volume: 36, Issue:5

    Topics: Autophagy; Glycyrrhiza; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Rotenone

2022
SIRT1 Mediates Neuroprotective and Neurorescue Effects of Camel α-Lactalbumin and Oleic Acid Complex on Rotenone-Induced Parkinson's Disease.
    ACS chemical neuroscience, 2022, 04-20, Volume: 13, Issue:8

    Topics: Animals; Camelus; Lactalbumin; Neuroprotection; Neuroprotective Agents; Oleic Acid; Oxidative Stress; Parkinson Disease; Rotenone; Sirtuin 1

2022
Omarigliptin attenuates rotenone-induced Parkinson's disease in rats: Possible role of oxidative stress, endoplasmic reticulum stress and immune modulation.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 164

    Topics: Animals; Dopaminergic Neurons; Endoplasmic Reticulum Stress; Heterocyclic Compounds, 2-Ring; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Pyrans; Rats; Rotenone

2022
Autophagy Signaling by Neural-Induced Human Adipose Tissue-Derived Stem Cell-Conditioned Medium during Rotenone-Induced Toxicity in SH-SY5Y Cells.
    International journal of molecular sciences, 2022, Apr-10, Volume: 23, Issue:8

    Topics: Adipose Tissue; AMP-Activated Protein Kinases; Autophagy; Beclin-1; Culture Media, Conditioned; Glycogen Synthase Kinase 3 beta; Humans; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Neural Stem Cells; Parkinson Disease; Proto-Oncogene Proteins c-akt; Rotenone; TOR Serine-Threonine Kinases

2022
S-Nitrosylation of OTUB1 Alters Its Stability and Ubc13 Binding.
    ACS chemical neuroscience, 2022, 05-18, Volume: 13, Issue:10

    Topics: Amyloid; Animals; Cysteine; Cysteine Endopeptidases; Mice; Nitric Oxide; Parkinson Disease; Protein Processing, Post-Translational; Rotenone; Ubiquitin-Conjugating Enzymes

2022
The Anti-Parkinson Potential of Gingko biloba-Supplement Mitigates Cortico-Cerebellar Degeneration and Neuropathobiological Alterations via Inflammatory and Apoptotic Mediators in Mice.
    Neurochemical research, 2022, Volume: 47, Issue:8

    Topics: Animals; Apoptosis; Disease Models, Animal; Dopamine; Ginkgo biloba; Mice; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinson Disease; Plant Preparations; Rotenone

2022
Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Park
    The international journal of biochemistry & cell biology, 2022, Volume: 147

    Topics: Animals; Brain-Gut Axis; Inflammation; Mitochondria; Neuroglia; Parkinson Disease; Pesticides; Rats; Rotenone

2022
circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease.
    Cell death & disease, 2022, 05-19, Volume: 13, Issue:5

    Topics: alpha-Synuclein; Animals; Cell Proliferation; Dopaminergic Neurons; Mammals; Mice; MicroRNAs; Parkinson Disease; RNA, Circular; Rotenone

2022
Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone-induced mice model of Parkinson's disease: Role of executioner caspase-3/Nrf2/ARE signaling.
    Journal of food biochemistry, 2022, Volume: 46, Issue:9

    Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Dopamine; Ginkgo biloba; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Rotenone

2022
Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson's disease.
    Archives of pharmacal research, 2022, Volume: 45, Issue:6

    Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Olfaction Disorders; Parkinson Disease; Prodromal Symptoms; Rotenone; Trehalose; Tyrosine 3-Monooxygenase

2022
Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease.
    Nutrients, 2022, May-11, Volume: 14, Issue:10

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Fruit and Vegetable Juices; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Vaccinium macrocarpon

2022
Neuroprotective effects of 2-(2-thienyl) benzothiazoline on gross motor skill deficits in rotenone induced rat model of Parkinson's disease.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:2

    Topics: Aged; Animals; Benzothiazoles; Humans; Motor Skills; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2022
Morin ameliorates rotenone-induced Parkinson disease in mice through antioxidation and anti-neuroinflammation: gut-brain axis involvement.
    Brain research, 2022, 08-15, Volume: 1789

    Topics: Acetylcholinesterase; Animals; Antioxidants; Brain-Gut Axis; Disease Models, Animal; Flavonoids; Glutathione; Male; Mice; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone

2022
Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p.
    Chemico-biological interactions, 2022, Aug-01, Volume: 362

    Topics: alpha-Synuclein; Animals; Apoptosis; Autophagy; Beclin-1; Benzhydryl Compounds; Catalase; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Glucosides; Heat-Shock Proteins; MicroRNAs; Parkinson Disease; Rats; Rotenone; Transcription Factor CHOP

2022
Brain polar phenol content, behavioural and neurochemical effects of Corinthian currant in a rotenone rat model of Parkinson's disease.
    Nutritional neuroscience, 2023, Volume: 26, Issue:7

    Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dopaminergic Neurons; Neuroprotective Agents; Parkinson Disease; Phenol; Rats; Ribes; Rotenone; Substantia Nigra

2023
Glycitein exerts neuroprotective effects in Rotenone-triggered oxidative stress and apoptotic cell death in the cellular model of Parkinson's disease.
    Acta biochimica Polonica, 2022, Jun-12, Volume: 69, Issue:2

    Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Isoflavones; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone

2022
Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 153

    Topics: Animals; Parkinson Disease; Parkinson Disease, Secondary; Polycyclic Sesquiterpenes; Rats; Rotenone

2022
A novel synthetic peptide SVHRSP attenuates dopaminergic neurodegeneration by inhibiting NADPH oxidase-mediated neuroinflammation in experimental models of Parkinson's disease.
    Free radical biology & medicine, 2022, 08-01, Volume: 188

    Topics: Animals; Dopamine; Dopaminergic Neurons; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Models, Theoretical; NADPH Oxidases; Neuroinflammatory Diseases; Parkinson Disease; Peptides; Rotenone

2022
Protective effects of cyclosporine A on neurodegeneration and motor impairment in rotenone-induced experimental models of Parkinson's disease.
    European journal of pharmacology, 2022, Aug-15, Volume: 929

    Topics: Animals; Cyclosporine; Humans; Models, Theoretical; Motor Disorders; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Rotenone

2022
Neuroprotective effect of quercetin against rotenone-induced neuroinflammation and alterations in mice behavior.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dopamine; Mice; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; Pesticides; Quercetin; Rotenone

2022
Nootkatone alleviates rotenone-induced Parkinson's disease symptoms through activation of the PI3K/Akt signaling pathway.
    Phytotherapy research : PTR, 2022, Volume: 36, Issue:11

    Topics: Animals; Dopaminergic Neurons; Molecular Docking Simulation; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rotenone; Signal Transduction

2022
Taste Impairments in a Parkinson's Disease Model Featuring Intranasal Rotenone Administration in Mice.
    Journal of Parkinson's disease, 2022, Volume: 12, Issue:6

    Topics: Administration, Intranasal; Animals; Disease Models, Animal; Mice; Olfaction Disorders; Parkinson Disease; Rotenone; Taste; Tyrosine 3-Monooxygenase

2022
Role of the gut-microbiota-metabolite axis in the rotenone model of early-stage Parkinson's Disease.
    Metabolic brain disease, 2022, Volume: 37, Issue:7

    Topics: Alanine; Animals; Asparagine; Gastrointestinal Microbiome; Glutamine; Hydroxyproline; Methionine; Mice; Parkinson Disease; Rotenone; Serine; Threonine

2022
Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus.
    Inflammopharmacology, 2022, Volume: 30, Issue:5

    Topics: Animals; Antidepressive Agents; Autophagy; Disease Models, Animal; Hippocampus; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Parkinson Disease; Quality of Life; Rotenone; Substantia Nigra; Sucrose; Transcription Factors

2022
Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model.
    Neuropharmacology, 2022, 10-01, Volume: 217

    Topics: Animals; Carthamus tinctorius; Flavonoids; Molecular Docking Simulation; Parkinson Disease; Plant Extracts; Rats; Rotenone

2022
Neuroprotective repositioning and anti-tau effect of carvedilol on rotenone induced neurotoxicity in rats: Insights from an insilico& in vivo anti-Parkinson's disease study.
    European journal of pharmacology, 2022, Oct-15, Volume: 932

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carvedilol; Glial Fibrillary Acidic Protein; Glycogen Synthase; Glycogen Synthase Kinase 3 beta; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Rats; Receptors, N-Methyl-D-Aspartate; Rotenone; Tyrosine 3-Monooxygenase

2022
Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling.
    European journal of medicinal chemistry, 2022, Nov-15, Volume: 242

    Topics: Animals; Antioxidants; Cytochrome P-450 CYP2B1; Heme Oxygenase-1; Neuroprotective Agents; Neurotoxins; NF-E2-Related Factor 2; Oxidative Stress; Oxidopamine; Parkinson Disease; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Rotenone

2022
Chlorogenic Acid: a Polyphenol from Coffee Rendered Neuroprotection Against Rotenone-Induced Parkinson's Disease by GLP-1 Secretion.
    Molecular neurobiology, 2022, Volume: 59, Issue:11

    Topics: alpha-Synuclein; Amino Acids; Animals; Chlorogenic Acid; Coffee; Dopaminergic Neurons; Glucagon-Like Peptide 1; Glycogen Synthase Kinase 3 beta; Mice; Molecular Docking Simulation; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Polyphenols; Proto-Oncogene Proteins c-akt; RNA, Messenger; Rotenone; Secretagogues

2022
Crosstalk between PI3K/AKT/KLF4 signaling and microglia M1/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson's disease.
    International immunopharmacology, 2022, Volume: 112

    Topics: Animals; Arginase; Drug Repositioning; Microglia; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rotenone; Tyrosine 3-Monooxygenase; Wortmannin

2022
1α,25-Dihydroxyvitamin D3 (VD3) Shows a Neuroprotective Action Against Rotenone Toxicity on PC12 Cells: An In Vitro Model of Parkinson's Disease.
    Neurochemical research, 2023, Volume: 48, Issue:1

    Topics: Animals; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Reactive Oxygen Species; Rotenone; Superoxides

2023
Neuroprotective effect of anethole against rotenone induced non-motor deficits and oxidative stress in rat model of Parkinson's disease.
    Behavioural brain research, 2023, 02-02, Volume: 437

    Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Superoxide Dismutase

2023
Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson's Disease Model of
    International journal of molecular sciences, 2022, Aug-24, Volume: 23, Issue:17

    Topics: Adenosine Triphosphate; Animals; Caenorhabditis elegans; Humans; Indoleacetic Acids; Mammals; Muscular Dystrophy, Duchenne; Parkinson Disease; Phenylbutyrates; Rotenone

2022
Rosmarinic Acid Attenuates Rotenone-Induced Neurotoxicity in SH-SY5Y Parkinson's Disease Cell Model through Abl Inhibition.
    Nutrients, 2022, Aug-26, Volume: 14, Issue:17

    Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Cell Survival; Cinnamates; Depsides; Humans; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Reactive Oxygen Species; Rosmarinic Acid; Rotenone

2022
Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease.
    Behavioural pharmacology, 2022, 12-01, Volume: 33, Issue:8

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Fenofibrate; Male; Neurodegenerative Diseases; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Peroxisome Proliferator-Activated Receptors; Rats; Rotenone; Substantia Nigra

2022
Role of gut microbiota-derived branched-chain amino acids in the pathogenesis of Parkinson's disease: An animal study.
    Brain, behavior, and immunity, 2022, Volume: 106

    Topics: Amino Acids, Branched-Chain; Animals; Gastrointestinal Microbiome; Inflammation; Interleukin-6; Lipopolysaccharides; Mice; Parkinson Disease; RNA, Ribosomal, 16S; Rotenone; Tumor Necrosis Factor-alpha

2022
Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson's disease mice model.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:4

    Topics: Animals; Autophagy; Humans; Mice; Neuroblastoma; Parkinson Disease; Rotenone; Ubiquitins; Ursolic Acid

2023
L-Ornithine L-Aspartate Restores Mitochondrial Function and Modulates Intracellular Calcium Homeostasis in Parkinson's Disease Models.
    Cells, 2022, 09-17, Volume: 11, Issue:18

    Topics: Aspartic Acid; Calcium; Dipeptides; Dopaminergic Neurons; Fluorescent Dyes; Homeostasis; Humans; Mitochondria; Neuroblastoma; Ornithine; Oxidopamine; Parkinson Disease; Reactive Oxygen Species; Rotenone

2022
Dopamine Release Impairments Accompany Locomotor and Cognitive Deficiencies in Rotenone-Treated Parkinson's Disease Model Zebrafish.
    Chemical research in toxicology, 2022, 11-21, Volume: 35, Issue:11

    Topics: Animals; Cognition; Disease Models, Animal; Dopamine; Parkinson Disease; Rotenone; Zebrafish

2022
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin's neuroprotection in a rotenone-induced mouse model of Parkinson's disease.
    Metabolic brain disease, 2022, Volume: 37, Issue:8

    Topics: alpha-Synuclein; AMP-Activated Protein Kinases; Animals; Autophagy; Mice; Neuroprotection; Parkinson Disease; Rats; Rotenone

2022
Agmatine-mediated inhibition of NMDA receptor expression and amelioration of dyskinesia via activation of Nrf2 and suppression of HMGB1/RAGE/TLR4/MYD88/NF-κB signaling cascade in rotenone lesioned rats.
    Life sciences, 2022, Dec-15, Volume: 311, Issue:Pt A

    Topics: Agmatine; Animals; Antioxidants; Dyskinesias; HMGB1 Protein; Levodopa; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; NF-kappa B; Oxidopamine; Parkinson Disease; Rats; Receptors, N-Methyl-D-Aspartate; Rotenone; Signal Transduction; Toll-Like Receptor 4

2022
Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice.
    International journal of molecular sciences, 2022, Oct-21, Volume: 23, Issue:20

    Topics: alpha-Synuclein; Animals; Body Weight; Chromatography, Liquid; Disease Models, Animal; Mice; Mice, Inbred C57BL; Parkinson Disease; Parkinsonian Disorders; Rotenone; Substantia Nigra; Tandem Mass Spectrometry

2022
Benefits of p-coumaric acid in mice with rotenone-induced neurodegeneration.
    Metabolic brain disease, 2023, Volume: 38, Issue:1

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Male; Malondialdehyde; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone; Tumor Necrosis Factor-alpha

2023
Europinidin Inhibits Rotenone-Activated Parkinson's Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways.
    Molecules (Basel, Switzerland), 2022, Oct-23, Volume: 27, Issue:21

    Topics: Animals; Cytokines; Disease Models, Animal; Dopamine; Lipid Peroxidation; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rodentia; Rotenone

2022
Rotenone induced olfactory deficit in Parkinson's disease rat model: The protective role of adenosine A
    Journal of chemical neuroanatomy, 2023, Volume: 127

    Topics: Animals; Brain; Caffeine; Disease Models, Animal; Male; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Rotenone

2023
The Mechanism of SNHG8/Microrna-421-3p/Sorting Nexin 8 Axis on Dopaminergic Neurons in Substantia Nigra in a Mouse Model of Parkinson's Disease.
    Neurochemical research, 2023, Volume: 48, Issue:3

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; MicroRNAs; Neurodegenerative Diseases; Parkinson Disease; Rotenone; Sorting Nexins; Substantia Nigra

2023
Neuroprotective potential of cinnamoyl derivatives against Parkinson's disease indicators in Drosophila melanogaster and in silico models.
    Neurotoxicology, 2023, Volume: 94

    Topics: Animals; Computer Simulation; Disease Models, Animal; Drosophila melanogaster; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone

2023
Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Calpain; Dopaminergic Neurons; Humans; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra

2022
Bilirubin Prevents the TH
    International journal of molecular sciences, 2022, Nov-17, Volume: 23, Issue:22

    Topics: Bilirubin; Dopamine; Dopaminergic Neurons; Humans; Nerve Degeneration; Parkinson Disease; Rotenone; Tumor Necrosis Factor-alpha

2022
[Effects of early electroacupuncture on the expression of Iba-1 and TNF-α in Parkinson's disease mice].
    Zhen ci yan jiu = Acupuncture research, 2022, Nov-25, Volume: 47, Issue:11

    Topics: Animals; Electroacupuncture; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Rotenone; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase

2022
Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length.
    General physiology and biophysics, 2022, Volume: 41, Issue:6

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Fatty Acids; Jejunum; Mice; Parkinson Disease; Rotenone

2022
Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk.
    Journal of Alzheimer's disease : JAD, 2023, Volume: 94, Issue:s1

    Topics: Animals; Antioxidants; Autophagy; Humans; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Inbred C57BL; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Phloretin; Prospective Studies; Rotenone; TOR Serine-Threonine Kinases

2023
Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism.
    Journal of chemical neuroanatomy, 2023, Volume: 127

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dopamine; Male; Microglia; Neuroprotective Agents; Parkinson Disease; Parkinsonian Disorders; Rats; Rotenone

2023
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.
    Mechanisms of ageing and development, 2023, Volume: 209

    Topics: alpha-Synuclein; Humans; Parkinson Disease; Protein Isoforms; Rotenone; Sumoylation

2023
Vitamin D3 actions on astrocyte cells: A target for therapeutic strategy in Parkinson's disease?
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Astrocytes; Cholecalciferol; Dopaminergic Neurons; Humans; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone

2023
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease.
    Human molecular genetics, 2023, 04-20, Volume: 32, Issue:9

    Topics: Animals; Homeostasis; Humans; Lipid Metabolism; Lipoprotein Lipase; Mice; Mice, Knockout; Neurons; Parkinson Disease; Rotenone; Signal Transduction; Sterol Regulatory Element Binding Protein 2; Ubiquitin-Protein Ligases

2023
Neuroprotective effect of secukinumab against rotenone induced Parkinson's disease in rat model: Involvement of IL-17, HMGB-1/TLR4 axis and BDNF/TrKB cascade.
    International immunopharmacology, 2023, Volume: 114

    Topics: Animals; Brain-Derived Neurotrophic Factor; HMGB Proteins; Interleukin-17; Neuroprotective Agents; Parkinson Disease; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, trkB; Rotenone; Toll-Like Receptor 4

2023
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
    Scientific reports, 2022, 12-19, Volume: 12, Issue:1

    Topics: alpha-Synuclein; Animals; Dopaminergic Neurons; Mice; Paraquat; Parkinson Disease; Rotenone

2022
Repaglinide Elicits a Neuroprotective Effect in Rotenone-Induced Parkinson's Disease in Rats: Emphasis on Targeting the DREAM-ER Stress BiP/ATF6/CHOP Trajectory and Activation of Mitophagy.
    ACS chemical neuroscience, 2023, 01-04, Volume: 14, Issue:1

    Topics: Activating Transcription Factor 6; Animals; Apoptosis; Calcium; Endoplasmic Reticulum Stress; Kv Channel-Interacting Proteins; Male; Mitophagy; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Transcription Factor CHOP

2023
Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory and
    Genes, 2022, 12-17, Volume: 13, Issue:12

    Topics: Animals; Disease Models, Animal; Folic Acid; Parkinson Disease; Rats; Rotenone; Vitamin B 12

2022
Identification of molecular network of gut-brain axis associated with neuroprotective effects of PPARδ-ligand erucic acid in rotenone-induced Parkinson's disease model in zebrafish.
    The European journal of neuroscience, 2023, Volume: 57, Issue:4

    Topics: Acetylcholinesterase; Animals; Brain-Gut Axis; Chromatography, Liquid; Disease Models, Animal; Erucic Acids; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Ligands; Neuroprotective Agents; Parkinson Disease; PPAR delta; Rotenone; Tandem Mass Spectrometry; Zebrafish; Zebrafish Proteins

2023
Intranasal Rotenone Induces Alpha-Synuclein Accumulation, Neuroinflammation and Dopaminergic Neurodegeneration in Middle-Aged Mice.
    Neurochemical research, 2023, Volume: 48, Issue:5

    Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; Mice; Neuroinflammatory Diseases; Parkinson Disease; Rotenone

2023
Protective Effects of Currants (
    International journal of molecular sciences, 2022, Dec-27, Volume: 24, Issue:1

    Topics: Animals; Antioxidants; Anxiety; Comorbidity; Disease Models, Animal; Dopaminergic Neurons; Neuroprotective Agents; Parkinson Disease; Rats; Ribes; Rotenone; Serotonin; Vitis

2022
The effects of gallic acid and vagotomy on motor function, intestinal transit, brain electrophysiology and oxidative stress alterations in a rat model of Parkinson's disease induced by rotenone.
    Life sciences, 2023, Feb-15, Volume: 315

    Topics: Animals; Brain; Disease Models, Animal; Electrophysiology; Gallic Acid; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Vagotomy

2023
Linagliptin counteracts rotenone's toxicity in non-diabetic rat model of Parkinson's disease: Insights into the neuroprotective roles of DJ-1, SIRT-1/Nrf-2 and implications of HIF1-α.
    European journal of pharmacology, 2023, Feb-15, Volume: 941

    Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Hypoglycemic Agents; Linagliptin; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Protein Deglycase DJ-1; Rats; Rotenone; Sirtuin 1

2023
The effect of electroacupuncture at ST25 on Parkinson's disease constipation through regulation of autophagy in the enteric nervous system.
    Anatomical record (Hoboken, N.J. : 2007), 2023, Volume: 306, Issue:12

    Topics: Animals; Constipation; Electroacupuncture; Enteric Nervous System; Parkinson Disease; Rats; Rotenone; Ubiquitin-Protein Ligases

2023
Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy.
    Molecules (Basel, Switzerland), 2023, Jan-10, Volume: 28, Issue:2

    Topics: alpha-Synuclein; Antioxidants; Apoptosis; Autophagy; Cytokines; Dopaminergic Neurons; Humans; Inflammation; Oxidative Stress; Parkinson Disease; Rotenone

2023
p-CREB and p-DARPP-32 orchestrating the modulatory role of cAMP/PKA signaling pathway enhanced by Roflumilast in rotenone-induced Parkinson's disease in rats.
    Chemico-biological interactions, 2023, Feb-25, Volume: 372

    Topics: Animals; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Parkinson Disease; Phosphoproteins; Rats; Rotenone; Signal Transduction

2023
Neuroprotective Effect of Propolis Polyphenol-Based Nanosheets in Cellular and Animal Models of Rotenone-Induced Parkinson's Disease.
    ACS chemical neuroscience, 2023, 03-01, Volume: 14, Issue:5

    Topics: Animals; Antioxidants; Disease Models, Animal; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Polyphenols; Propolis; Rotenone

2023
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
    Ecotoxicology and environmental safety, 2023, Mar-01, Volume: 252

    Topics: Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Humans; Inflammation; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Poly (ADP-Ribose) Polymerase-1; Rotenone

2023
Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway.
    Scientific reports, 2023, 02-11, Volume: 13, Issue:1

    Topics: alpha-Synuclein; Animals; Brain-Derived Neurotrophic Factor; Dopaminergic Neurons; Glycogen Synthase Kinase 3 beta; Mice; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Proto-Oncogene Proteins c-akt; Rotenone

2023
Investigation of the pharmacological, behavioral, and biochemical effects of boron in parkinson-indicated rats.
    Cellular and molecular biology (Noisy-le-Grand, France), 2022, Aug-31, Volume: 68, Issue:8

    Topics: Animals; Antioxidants; Boron; Disease Models, Animal; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Rotenone

2022
HR LC-MS/MS metabolomic profiling of Yucca aloifolia fruit and the potential neuroprotective effect on rotenone-induced Parkinson's disease in rats.
    PloS one, 2023, Volume: 18, Issue:2

    Topics: Animals; Anthocyanins; Chromatography, Liquid; Fruit; Male; Neuroprotective Agents; Parkinson Disease; Plant Extracts; Rats; Rotenone; Tandem Mass Spectrometry; Yucca

2023
Impact of age on the rotenone-induced sporadic Parkinson's disease model using Drosophila melanogaster.
    Neuroscience letters, 2023, 05-14, Volume: 805

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Drosophila melanogaster; Male; Parkinson Disease; Rotenone

2023
β-carotene-loaded nanoparticles protect against neuromotor damage, oxidative stress, and dopamine deficits in a model of Parkinson's disease in Drosophila melanogaster.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2023, Volume: 268

    Topics: Acetylcholinesterase; Animals; Antioxidants; beta Carotene; Disease Models, Animal; Dopamine; Drosophila melanogaster; Nanoparticles; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2023
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.
    CNS neuroscience & therapeutics, 2023, Volume: 29, Issue:8

    Topics: Animals; Dopamine; Dopaminergic Neurons; Lipopolysaccharides; Neuroinflammatory Diseases; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Rats; Rotenone

2023
Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease.
    Neurochemical research, 2023, Volume: 48, Issue:8

    Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Dopaminergic Neurons; Electron Transport Complex I; Humans; Paraquat; Parkinson Disease; Proteomics; Rotenone

2023
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats.
    Neurotoxicology, 2023, Volume: 96

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Male; Neurodegenerative Diseases; Neuroinflammatory Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone

2023
Limonene, a Monoterpene, Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Modulating Neuroinflammation, Hippo Signaling and Apoptosis in Rats.
    International journal of molecular sciences, 2023, Mar-09, Volume: 24, Issue:6

    Topics: Animals; Apoptosis; Dopaminergic Neurons; Glutathione; Hippo Signaling Pathway; Limonene; Monoterpenes; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2023
Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson's Disease Model by Alleviating Mitochondrial Dysfunction.
    International journal of molecular sciences, 2023, Mar-19, Volume: 24, Issue:6

    Topics: Animals; Cell Line, Tumor; Humans; Mitochondria; Monoterpenes; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phenotype; Reactive Oxygen Species; Rotenone

2023
Metabolic dysfunctions in the intranigral rotenone model of Parkinson's disease.
    Experimental brain research, 2023, Volume: 241, Issue:5

    Topics: Animals; Cholesterol; Disease Models, Animal; Dopaminergic Neurons; Male; Neurodegenerative Diseases; Parkinson Disease; Rats; Rats, Wistar; Rotenone

2023
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
    Biochemical pharmacology, 2023, Volume: 212

    Topics: Animals; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Humans; Inflammasomes; Interleukin-6; Mice; Microglia; Neuroblastoma; Neuroinflammatory Diseases; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Receptors, Formyl Peptide; Rotenone; Tumor Necrosis Factor-alpha; Zebrafish

2023
Cilostazol novel neuroprotective mechanism against rotenone-induced Parkinson's disease in rats: Correlation between Nrf2 and HMGB1/TLR4/PI3K/Akt/mTOR signaling.
    International immunopharmacology, 2023, Volume: 117

    Topics: Animals; Cilostazol; HMGB1 Protein; Mammals; Neuroprotection; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinson Disease; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rotenone; Toll-Like Receptor 4; TOR Serine-Threonine Kinases

2023
Neuroprotective Effects of
    International journal of molecular sciences, 2023, Apr-05, Volume: 24, Issue:7

    Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Lactobacillus plantarum; Mice; Mice, Inbred C57BL; MicroRNAs; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Rotenone

2023
    Nutrients, 2023, Apr-01, Volume: 15, Issue:7

    Topics: Amino Acids, Branched-Chain; Animals; Dopamine; Gastrointestinal Microbiome; Lactobacillus plantarum; Mice; Parkinson Disease; RNA, Ribosomal, 16S; Rotenone

2023
NLRP3 mediates the neuroprotective effects of SVHRSP derived from scorpion venom in rotenone-induced experimental Parkinson's disease model.
    Journal of ethnopharmacology, 2023, Aug-10, Volume: 312

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Inflammasomes; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Rotenone; Scorpion Venoms

2023
A novel protective modality against rotenone-induced Parkinson's disease: A pre-clinical study with dulaglutide.
    International immunopharmacology, 2023, Volume: 119

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Mice; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2023
Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and endoplasmic reticulum stress.
    Chemico-biological interactions, 2023, Jul-01, Volume: 379

    Topics: alpha-Synuclein; Animals; Endoplasmic Reticulum Stress; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Rats; Rotenone; Ubiquitin

2023
The Parkinson's disease-associated protein α-synuclein inhibits hepatoma by exosome delivery.
    Molecular carcinogenesis, 2023, Volume: 62, Issue:8

    Topics: alpha-Synuclein; Animals; Carcinoma, Hepatocellular; Exosomes; Humans; Liver Neoplasms; Parkinson Disease; Rats; Rotenone

2023
SYNAPTIC PROCESSES IN THE ANTINOCICEPTIVE SOMATOSENSORY CORTEX SI OF THE BRAIN ACTIVATED BY THE VENTRAL POSTERIOR-LATERAL THALAMIC NUCLEUS IN A ROTENONE MODEL OF PARKINSON'S DISEASE.
    Georgian medical news, 2023, Issue:336

    Topics: Analgesics; Animals; Parkinson Disease; Rats; Rotenone; Somatosensory Cortex; Ventral Thalamic Nuclei

2023
Inosine attenuates rotenone-induced Parkinson's disease in rats by alleviating the imbalance between autophagy and apoptosis.
    Drug development research, 2023, Volume: 84, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Apoptosis; Autophagy; Mammals; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2023
Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease.
    Glia, 2023, Volume: 71, Issue:9

    Topics: alpha-Synuclein; Animals; Autophagy; Dopaminergic Neurons; Female; Male; Mice; Microglia; Neurodegenerative Diseases; Neuroinflammatory Diseases; NF-kappa B; Parkinson Disease; Rotenone

2023
Anti-inflammatory, anti-apoptotic, and neuroprotective potentials of anethole in Parkinson's disease-like motor and non-motor symptoms induced by rotenone in rats.
    Metabolic brain disease, 2023, Volume: 38, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2023
Novel trajectories of the NK1R antagonist aprepitant in rotenone-induced Parkinsonism-like symptoms in rats: Involvement of ERK5/KLF4/p62/Nrf2 signaling axis.
    Chemico-biological interactions, 2023, Aug-01, Volume: 380

    Topics: Animals; Antioxidants; Aprepitant; Kruppel-Like Factor 4; Mitogen-Activated Protein Kinase 7; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Rats; Receptors, Neurokinin-1; Rotenone; Signal Transduction

2023
Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF-κB pathway: Molecular docking and biological investigations.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 164

    Topics: Animals; Betacyanins; Down-Regulation; Male; Malondialdehyde; Mice; Molecular Docking Simulation; Myeloid Differentiation Factor 88; NF-kappa B; Parkinson Disease; Parkinsonian Disorders; Rotenone; Toll-Like Receptor 4

2023
Enhancing the neuroprotective effect of squid outer skin astaxanthin against rotenone-induced neurotoxicity in in-vitro model for Parkinson's disease.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 178

    Topics: Animals; Antioxidants; Decapodiformes; Humans; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Rotenone

2023
Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats.
    International journal of molecular sciences, 2023, Jun-08, Volume: 24, Issue:12

    Topics: Animals; Antioxidants; Apoptosis; Cytokines; Dopaminergic Neurons; Glutamic Acid; Humans; Inflammation; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rotenone

2023
Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease.
    European journal of pharmacology, 2023, Sep-05, Volume: 954

    Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Dopaminergic Neurons; Drug Repositioning; Lapatinib; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rotenone

2023
Dyclonine relieves the Parkinson's disease progression in rotenone-induced Drosophila model.
    Behavioural brain research, 2023, 08-24, Volume: 452

    Topics: Animals; Disease Progression; Dopaminergic Neurons; Drosophila; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Rotenone

2023
Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease.
    Journal of chemical neuroanatomy, 2023, Volume: 132

    Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Lacosamide; Male; Malondialdehyde; Mice; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tumor Necrosis Factor-alpha

2023
LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson's Disease Cell Model.
    International journal of molecular sciences, 2023, Jul-05, Volume: 24, Issue:13

    Topics: Adenosine Triphosphate; Apoptosis; Astrocytes; Dopaminergic Neurons; Down-Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glycogen Synthase Kinase 3 beta; Humans; Neuroblastoma; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinson Disease; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rotenone

2023
Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt A

    Topics: Animals; Chromatography, Liquid; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Rotenone; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases

2024
Caffeine alleviates anxiety-like behavior and brainstem lesions in a rotenone-induced rat model of Parkinson's disease.
    Journal of chemical neuroanatomy, 2023, Volume: 132

    Topics: Animals; Anxiety; Caffeine; Disease Models, Animal; Dopamine; Male; Mesencephalon; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Rotenone

2023
EFFECTS OF DIMETHYL SULFOXIDE ON HIPPOCAMPAL ACTIVITY IN A ROTENONE-INDUCED RAT MODEL OF PARKINSON'S DISEASE.
    Georgian medical news, 2023, Issue:339

    Topics: Dimethyl Sulfoxide; Hippocampus; Humans; Neurodegenerative Diseases; Parkinson Disease; Rotenone

2023
Curcumin neuroprotective effects in Parkinson disease during pregnancy.
    Brain research bulletin, 2023, Volume: 201

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Curcumin; Female; Mice; MicroRNAs; Necrosis; Neuroprotective Agents; Parkinson Disease; Pregnancy; Proto-Oncogene Proteins c-bcl-2; RNA, Circular; Rotenone

2023
Dihydroxyphenylacetaldehyde Lowering Treatment Improves Locomotor and Neurochemical Abnormalities in the Rat Rotenone Model: Relevance to the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson's Disease.
    International journal of molecular sciences, 2023, Aug-07, Volume: 24, Issue:15

    Topics: Acetylcysteine; Aldehyde Dehydrogenase; Animals; Dopamine; Monoamine Oxidase Inhibitors; Parkinson Disease; Rats; Rotenone; Selegiline

2023
Neuroprotective Effects of
    ACS chemical neuroscience, 2023, 09-06, Volume: 14, Issue:17

    Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Mice; Mitochondria; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone; Tinospora

2023
Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease.
    Neuroscience letters, 2023, 09-25, Volume: 814

    Topics: alpha-Synuclein; Animals; Dimethyl Sulfoxide; Disease Models, Animal; Humans; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra

2023
Effects of fluoride on oxidative DNA damage, nitric oxide level, lipid peroxidation and cholinesterase enzyme activity in a rotenone-induced experimental Parkinson's model.
    Neurological research, 2023, Volume: 45, Issue:11

    Topics: Animals; Antioxidants; Cholinesterases; Fluorides; Glutathione; Lipid Peroxidation; Nitric Oxide; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Rotenone

2023
Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson's disease.
    Scientific reports, 2023, 09-20, Volume: 13, Issue:1

    Topics: Animals; Mice; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Parkinson Disease; Rotenone

2023
The identification of cianidanol as a selective estrogen receptor beta agonist and evaluation of its neuroprotective effects on Parkinson's disease models.
    Life sciences, 2023, Nov-15, Volume: 333

    Topics: Animals; Catechin; Disease Models, Animal; Estrogen Receptor beta; Estrogens; Humans; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2023
Regulation of the Endogenous Opiate Signaling Pathway against Oxidative Stress and Inflammation: A Considerable Approach for Exploring Preclinical Treatment of Parkinson's Disease.
    Pharmacology, 2023, Volume: 108, Issue:6

    Topics: Animals; Dopaminergic Neurons; Humans; Inflammation; Morphine; Naloxone; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxidative Stress; Oxidopamine; Parkinson Disease; Rotenone; Signal Transduction

2023
Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 181

    Topics: Animals; Caspase 8; Dopamine; Ferroptosis; HSP90 Heat-Shock Proteins; Molecular Chaperones; Parkinson Disease; Parkinsonian Disorders; Rats; Rotenone

2023
The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease.
    Neurobiology of aging, 2023, Volume: 132

    Topics: Animals; Brain; Brain-Gut Axis; Inflammation; Parkinson Disease; Rats; Rotenone

2023
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson's disease model.
    BMC pharmacology & toxicology, 2023, 11-07, Volume: 24, Issue:1

    Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Catalase; Disease Models, Animal; Inflammation; Interleukin-6; Male; Neuroprotective Agents; Parkinson Disease; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Rotenone; Sericins; Signal Transduction; Tumor Necrosis Factor-alpha

2023
Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis.
    International immunopharmacology, 2023, Volume: 125, Issue:Pt B

    Topics: alpha-Synuclein; Animals; Brain-Derived Neurotrophic Factor; Formoterol Fumarate; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rotenone; Ubiquitin-Protein Ligases

2023
High Yield of Functional Dopamine-like Neurons Obtained in NeuroForsk 2.0 Medium to Study Acute and Chronic Rotenone Effects on Oxidative Stress, Autophagy, and Apoptosis.
    International journal of molecular sciences, 2023, Oct-30, Volume: 24, Issue:21

    Topics: Apoptosis; Autophagy; Caspase 3; Chronic Disease; Dopamine; Dopaminergic Neurons; Humans; Hydrogen Peroxide; Oxidative Stress; Parkinson Disease; Rotenone

2023
Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson's disease.
    Scientific reports, 2023, 11-15, Volume: 13, Issue:1

    Topics: alpha-Synuclein; Animals; Drug Carriers; Gene Expression; Humans; Lipids; Mice; Nanoparticles; Neuroblastoma; Oxidative Stress; Parkinson Disease; Particle Size; Polysorbates; Rats; Rotenone

2023
Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats.
    PloS one, 2023, Volume: 18, Issue:11

    Topics: alpha-Synuclein; Animals; Antioxidants; Blood-Brain Barrier; Disease Models, Animal; Monoamine Oxidase; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Superoxide Dismutase; Weight Loss

2023
α-Arbutin Protects Against Parkinson's Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo.
    Neuromolecular medicine, 2020, Volume: 22, Issue:1

    Topics: Adenosine Triphosphate; Adenylate Kinase; Animals; Antioxidants; Apoptosis; Arbutin; Autophagy; Cell Line, Tumor; Drosophila melanogaster; Drosophila Proteins; Drug Evaluation, Preclinical; Ericaceae; Female; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Rotenone; Ubiquitin-Protein Ligases

2020
Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.
    Clinical and experimental pharmacology & physiology, 2019, Volume: 46, Issue:12

    Topics: Albendazole; Animals; Behavior, Animal; Cell Death; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Molecular Targeted Therapy; Neuroprotection; Neuroprotective Agents; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Rotenone

2019
Identification of Biomolecular Information in Rotenone-Induced Cellular Model of Parkinson's Disease by Public Microarray Data Analysis.
    Journal of computational biology : a journal of computational molecular cell biology, 2020, Volume: 27, Issue:6

    Topics: Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Microarray Analysis; MicroRNAs; Parkinson Disease; Protein Interaction Maps; Rotenone; Transcription Factors

2020
Initiation of Parkinson's disease from gut to brain by δ-secretase.
    Cell research, 2020, Volume: 30, Issue:1

    Topics: alpha-Synuclein; Animals; Brain; Brain Stem; Cell Line; Cells, Cultured; Colon; Cysteine Endopeptidases; Gastrointestinal Tract; Humans; Mice; Neurofibrillary Tangles; Parkinson Disease; Phosphorylation; Rats; Rotenone; Synucleinopathies; tau Proteins; Vagus Nerve

2020
Involvement of Akt/mTOR in the Neurotoxicity of Rotenone-Induced Parkinson's Disease Models.
    International journal of environmental research and public health, 2019, 10-10, Volume: 16, Issue:20

    Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred ICR; Parkinson Disease; Proto-Oncogene Proteins c-akt; Rotenone; TOR Serine-Threonine Kinases

2019
Neuroprotective effects of mitoquinone and oleandrin on Parkinson's disease model in zebrafish.
    The International journal of neuroscience, 2020, Volume: 130, Issue:6

    Topics: Animals; Cardenolides; Disease Models, Animal; Female; Fish Proteins; Gene Expression; Locomotion; Male; Mitochondria; Neuroprotective Agents; Organophosphorus Compounds; Parkinson Disease; Parkinsonian Disorders; Rotenone; Synucleins; Ubiquinone; Zebrafish

2020
miR-185 and SEPT5 Genes May Contribute to Parkinson's Disease Pathophysiology.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Aged; Animals; Cell Cycle Proteins; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Gene Expression; Humans; Male; MicroRNAs; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Septins; Substantia Nigra; Transfection

2019
Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis.
    Cells, 2019, 12-19, Volume: 9, Issue:1

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA Damage; Dopaminergic Neurons; Drug Synergism; Gene Knockdown Techniques; Humans; Male; Parkinson Disease; Peroxiredoxins; Primary Cell Culture; Rats; Rotenone; Signal Transduction; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2019
Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity.
    Journal of Parkinson's disease, 2020, Volume: 10, Issue:1

    Topics: Antioxidants; Cell Line, Tumor; Curcumin; Deferoxamine; Humans; Iron Chelating Agents; Lipid Peroxidation; Nanotechnology; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease; Rotenone

2020
The protective effect of inosine against rotenone-induced Parkinson's disease in mice; role of oxido-nitrosative stress, ERK phosphorylation, and A2AR expression.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:6

    Topics: Animals; Corpus Striatum; Extracellular Signal-Regulated MAP Kinases; Inosine; Male; Mice; Neuroprotective Agents; Nitrosative Stress; Parkinson Disease; Phosphorylation; Receptor, Adenosine A2A; Rotenone; Substantia Nigra

2020
Polydatin protects SH-SY5Y in models of Parkinson's disease by promoting Atg5-mediated but parkin-independent autophagy.
    Neurochemistry international, 2020, Volume: 134

    Topics: Autophagy; Autophagy-Related Protein 5; Cell Death; Dopaminergic Neurons; Humans; Membrane Potential, Mitochondrial; Neuroprotective Agents; Parkinson Disease; Reactive Oxygen Species; Rotenone; Ubiquitin-Protein Ligases

2020
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
    The Journal of biological chemistry, 2020, 03-13, Volume: 295, Issue:11

    Topics: Actin Cytoskeleton; alpha-Synuclein; Amyloid; Animals; Apoptosis; Cell Death; Cell Line, Tumor; Computer Simulation; Cytoskeleton; Deubiquitinating Enzymes; Disease Models, Animal; Endocytosis; Male; Mice, Inbred C57BL; Mitochondria; Models, Biological; Nanostructures; Neurons; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Phosphoserine; Protein Aggregates; Protein Multimerization; Reactive Oxygen Species; Rotenone

2020
Neuroprotective effects of Danshensu on rotenone-induced Parkinson's disease models in vitro and in vivo.
    BMC complementary medicine and therapies, 2020, Jan-23, Volume: 20, Issue:1

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Disease Models, Animal; Flow Cytometry; Humans; Lactates; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Rotarod Performance Test; Rotenone

2020
Oral Supplements of
    Current pharmaceutical biotechnology, 2020, Volume: 21, Issue:12

    Topics: Administration, Oral; Animals; Antioxidants; Brain; Cytokines; Dietary Supplements; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Ginkgo biloba; Glutathione; Lipid Peroxidation; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease; Plant Extracts; Random Allocation; Rats; Rotenone; Superoxide Dismutase

2020
Chitosan-Ellagic Acid Nanohybrid for Mitigating Rotenone-induced Oxidative Stress.
    ACS applied materials & interfaces, 2020, Apr-22, Volume: 12, Issue:16

    Topics: Antioxidants; Apoptosis; Cell Line; Chitosan; Ellagic Acid; Humans; Nanoparticles; Oxidative Stress; Parkinson Disease; Rotenone

2020
Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson's Disease.
    International journal of molecular sciences, 2020, May-04, Volume: 21, Issue:9

    Topics: alpha-Synuclein; Animals; Behavior, Animal; Biomarkers; Cholinergic Neurons; Disease Models, Animal; Dopaminergic Neurons; Electron Transport Complex I; Environmental Exposure; Fluorescent Antibody Technique; Insecticides; Male; Mice; Mitochondria; Motor Disorders; Myenteric Plexus; Nervous System Diseases; Parkinson Disease; Rotenone; Substantia Nigra

2020
Monascin exhibits neuroprotective effects in rotenone model of Parkinson's disease via antioxidation and anti-neuroinflammation.
    Neuroreport, 2020, 06-07, Volume: 31, Issue:9

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Encephalitis; Heterocyclic Compounds, 3-Ring; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Rats, Sprague-Dawley; Rotenone

2020
Long noncoding RNA GAS5 promotes microglial inflammatory response in Parkinson's disease by regulating NLRP3 pathway through sponging miR-223-3p.
    International immunopharmacology, 2020, Volume: 85

    Topics: Animals; Behavior, Animal; Binding Sites; Cell Line; Computational Biology; Disease Models, Animal; Down-Regulation; Gene Knockdown Techniques; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; MicroRNAs; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; RNA, Long Noncoding; Rotenone; Substantia Nigra; Tumor Necrosis Factor-alpha; Up-Regulation

2020
Neuroprotective action of agmatine in rotenone-induced model of Parkinson's disease: Role of BDNF/cREB and ERK pathway.
    Behavioural brain research, 2020, 08-17, Volume: 392

    Topics: Agmatine; Animals; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Cell Survival; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; MAP Kinase Signaling System; Neuronal Plasticity; Neurons; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Signal Transduction

2020
Propionic Acid and Fasudil as Treatment Against Rotenone Toxicity in an In Vitro Model of Parkinson's Disease.
    Molecules (Basel, Switzerland), 2020, May-28, Volume: 25, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Dopaminergic Neurons; Female; Immunohistochemistry; Neuroprotective Agents; Parkinson Disease; Pregnancy; Propionates; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Rotenone; Tyrosine 3-Monooxygenase

2020
Healthspan Enhancement by Olive Polyphenols in
    International journal of molecular sciences, 2020, May-29, Volume: 21, Issue:11

    Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Biomarkers; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Diet, Mediterranean; Disease Models, Animal; Dopaminergic Neurons; Humans; Longevity; Microscopy, Fluorescence; Olea; Olive Oil; Parkinson Disease; Polyphenols; Rotenone

2020
Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders".
    International journal of molecular sciences, 2020, Jun-15, Volume: 21, Issue:12

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Early Diagnosis; Humans; Lewy Body Disease; Oxidopamine; Parkinson Disease; Rotenone

2020
Bisdemethoxycurcumin exerts a cell-protective effect via JAK2/STAT3 signaling in a rotenone-induced Parkinson's disease model in vitro.
    Folia histochemica et cytobiologica, 2020, Volume: 58, Issue:2

    Topics: Antioxidants; Cell Line, Tumor; Cell Survival; Diarylheptanoids; Humans; Janus Kinase 2; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone; Signal Transduction; STAT3 Transcription Factor

2020
β-Methylphenylalanine exerts neuroprotective effects in a Parkinson's disease model by protecting against tyrosine hydroxylase depletion.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:17

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aminobutyrates; Animals; Cell Survival; Dopamine; Humans; Membrane Potential, Mitochondrial; Molecular Docking Simulation; Neuroprotective Agents; Parkinson Disease; Rats; Reactive Oxygen Species; RNA, Messenger; Rotenone; Tyrosine 3-Monooxygenase

2020
Enhanced oral bioavailability and neuroprotective effect of fisetin through its SNEDDS against rotenone-induced Parkinson's disease rat model.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 144

    Topics: Administration, Oral; Animals; Biological Availability; Disease Models, Animal; Female; Flavonols; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone

2020
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model.
    CNS & neurological disorders drug targets, 2020, Volume: 19, Issue:7

    Topics: alpha-Synuclein; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Rotenone; Triterpenes; Ursolic Acid

2020
Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.
    Biochemical and biophysical research communications, 2020, 10-20, Volume: 531, Issue:3

    Topics: Animals; Brain Injuries; Disease Progression; Drosophila melanogaster; Drosophila Proteins; Head; Homeostasis; Iron; Neurons; Neurotoxins; Oxidative Stress; Parkinson Disease; Phenotype; RNA Interference; Rotenone; Transferrins

2020
Disruption of neocortical synchronisation during slow-wave sleep in the rotenone model of Parkinson's disease.
    Journal of sleep research, 2021, Volume: 30, Issue:3

    Topics: Animals; Electroencephalography; Humans; Insecticides; Male; Neocortex; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Sleep, Slow-Wave

2021
Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model.
    Neuroscience letters, 2020, 11-01, Volume: 738

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopaminergic Neurons; Male; Microglia; Parkinson Disease; Proteasome Endopeptidase Complex; Rats, Wistar; Rotenone; Substantia Nigra; Up-Regulation

2020
Unique signatures of stress-induced senescent human astrocytes.
    Experimental neurology, 2020, Volume: 334

    Topics: Astrocytes; Cell Survival; Cells, Cultured; Cellular Senescence; Female; Humans; Hydrogen Peroxide; Induced Pluripotent Stem Cells; Middle Aged; Oxidative Stress; Parkinson Disease; Rotenone; TOR Serine-Threonine Kinases; Transcriptome

2020
Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models.
    Scientific reports, 2020, 09-24, Volume: 10, Issue:1

    Topics: Animals; Brain; Carnitine O-Palmitoyltransferase; Encephalomyelitis, Autoimmune, Experimental; Female; Gastrointestinal Microbiome; Male; Metabolic Networks and Pathways; Mice; Mutation; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Superoxide Dismutase-1

2020
Role of caloric vestibular stimulation in improvement of motor symptoms and inhibition of neuronal degeneration in rotenone model of Parkinson's disease - An experimental study.
    Physiology international, 2020, Oct-17, Volume: 107, Issue:3

    Topics: Animals; Disease Models, Animal; Male; Parkinson Disease; Rats; Rats, Wistar; Reproducibility of Results; Rotenone; Substantia Nigra

2020
Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways.
    International journal of molecular sciences, 2020, Oct-16, Volume: 21, Issue:20

    Topics: alpha-Synuclein; Animals; Antioxidants; Antiparkinson Agents; Apoptosis; Astrocytes; Autophagy; Corpus Striatum; Dopaminergic Neurons; Male; Oxidative Stress; Parkinson Disease; Pentanoic Acids; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Rotenone; TOR Serine-Threonine Kinases; Uncoupling Agents

2020
Fast kinetics of environmentally induced α-synuclein aggregation mediated by structural alteration in NAC region and result in structure dependent cytotoxicity.
    Scientific reports, 2020, 10-27, Volume: 10, Issue:1

    Topics: alpha-Synuclein; Biopolymers; Circular Dichroism; Environmental Pollutants; Humans; Kinetics; Microscopy, Electron, Transmission; Molecular Dynamics Simulation; Parkinson Disease; Protein Aggregation, Pathological; Protein Structure, Secondary; Risk Factors; Rotenone

2020
Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models.
    Neuropharmacology, 2021, 08-15, Volume: 194

    Topics: alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Female; Humans; Melatonin; Mice; Mice, Inbred BALB C; Models, Animal; Neuroprotection; Parkinson Disease; Phosphorylation; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Proteasome Endopeptidase Complex; Rats; Rotenone; Ubiquitination

2021
Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson's Disease.
    Neuro-degenerative diseases, 2020, Volume: 20, Issue:2-3

    Topics: Animals; Caspase 1; Cell Death; Cell Survival; Cyclosporine; Humans; Inflammasomes; Interleukin-1beta; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Pyroptosis; Reactive Oxygen Species; Rotenone; Signal Transduction

2020
Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of
    Marine drugs, 2020, Nov-30, Volume: 18, Issue:12

    Topics: Animals; Antiparkinson Agents; Aspergillus; Cell Line, Tumor; Cell Survival; Mice; Molecular Structure; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Penicillium; Reactive Oxygen Species; Rotenone; Secondary Metabolism; Structure-Activity Relationship; Vietnam

2020
Recuperative effect of estrogen on rotenone-induced experimental model of Parkinson's disease in rats.
    Environmental science and pollution research international, 2021, Volume: 28, Issue:17

    Topics: Animals; Disease Models, Animal; Estrogens; Female; Humans; Parkinson Disease; Rats; Rats, Wistar; Rotenone

2021
Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease.
    Gut microbes, 2021, 01-01, Volume: 13, Issue:1

    Topics: Animals; Brain-Gut Axis; Disease Models, Animal; Dysbiosis; Dystonic Disorders; Female; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Tract; Germ-Free Life; Male; Mice; Parkinson Disease; Rotenone; Tight Junctions; Tyrosine 3-Monooxygenase

2021
Pharmacological validation of TDO as a target for Parkinson's disease.
    The FEBS journal, 2021, Volume: 288, Issue:14

    Topics: Animals; Brain; Cognition; Disease Models, Animal; Enzyme Inhibitors; Insecticides; Male; Mice; Mice, Inbred C57BL; Motor Activity; Parkinson Disease; Rotenone; Small Molecule Libraries; Tryptophan Oxygenase

2021
A novel treatment strategy to prevent Parkinson's disease: focus on iron regulatory protein 1 (IRP1).
    The International journal of neuroscience, 2023, Volume: 133, Issue:1

    Topics: Aconitate Hydratase; Animals; Iron; Iron Regulatory Protein 1; Parkinson Disease; Rats; Rotenone; Sulfur

2023
Targeting ROS-Dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson's Disease Rat Model.
    ACS chemical neuroscience, 2021, 02-17, Volume: 12, Issue:4

    Topics: Animals; Benzhydryl Compounds; Glucosides; Glycogen Synthase Kinase 3 beta; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Rotenone

2021
The Beneficial Effect of Rice Bran Extract Against Rotenone-Induced Experimental Parkinson's Disease in Rats.
    Current molecular pharmacology, 2021, Volume: 14, Issue:3

    Topics: Animals; Disease Models, Animal; Oryza; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Rats; Rotenone

2021
[Improvement effect of proanthocyanidins on cell viability of rotenone-induced Parkinson's disease model].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2020, Volume: 36, Issue:5

    Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Neuroprotective Agents; Parkinson Disease; Proanthocyanidins; Reactive Oxygen Species; Rotenone

2020
Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway.
    Neuropeptides, 2021, Volume: 87

    Topics: alpha-Synuclein; AMP-Activated Protein Kinases; Apoptosis; Cell Line, Tumor; Drug Evaluation, Preclinical; Gene Expression Regulation; Ghrelin; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; Nerve Tissue Proteins; Neuroblastoma; Oxidative Stress; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Kinases; Protein Transport; Reactive Oxygen Species; Rotenone; Signal Transduction; Sirtuin 1; Ubiquitin-Protein Ligases

2021
Prevention of MEK-ERK-1/2 hyper-activation underlines the neuroprotective effect of Glycyrrhiza glabra L. (Yashtimadhu) against rotenone-induced cellular and molecular aberrations.
    Journal of ethnopharmacology, 2021, Jun-28, Volume: 274

    Topics: Apoptosis; Caspases; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Enzyme Activation; Glycyrrhiza; Humans; MAP Kinase Signaling System; Mitochondrial Proteins; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Neuroprotective Agents; Parkinson Disease; Plant Extracts; Reactive Oxygen Species; Rotenone

2021
The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.
    Scientific reports, 2021, 04-12, Volume: 11, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acute Disease; Animals; Cell Count; Chronic Disease; Colon; Disease Models, Animal; Feces; Ganglia; Gastrointestinal Tract; Intestinal Pseudo-Obstruction; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nitric Oxide Synthase Type I; Oxidopamine; Parkinson Disease; Phenotype; Rotenone

2021
Pharmacological evaluation of vanillic acid in rotenone-induced Parkinson's disease rat model.
    European journal of pharmacology, 2021, Jul-15, Volume: 903

    Topics: Animals; Antioxidants; Antiparkinson Agents; Behavior, Animal; Body Weight; Carbidopa; Catalase; Catalepsy; Disease Models, Animal; Dopamine; Drug Combinations; Female; Glutathione; Levodopa; Locomotion; Male; Mesencephalon; Muscular Diseases; Oxidative Stress; Parkinson Disease; Postural Balance; Rats, Sprague-Dawley; Rotenone; Superoxides; Thiobarbituric Acid Reactive Substances; Vanillic Acid

2021
A Propagated Skeleton Approach to High Throughput Screening of Neurite Outgrowth for In Vitro Parkinson's Disease Modelling.
    Cells, 2021, 04-17, Volume: 10, Issue:4

    Topics: Automation; Cell Line, Tumor; Dopaminergic Neurons; High-Throughput Screening Assays; Humans; Mesencephalon; Models, Biological; Neuronal Outgrowth; Parkinson Disease; Rotenone

2021
Acteoside exerts neuroprotection effects in the model of Parkinson's disease via inducing autophagy: Network pharmacology and experimental study.
    European journal of pharmacology, 2021, Jul-15, Volume: 903

    Topics: Adenylate Kinase; alpha-Synuclein; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Computational Biology; Drosophila melanogaster; Glucosides; HEK293 Cells; Humans; Longevity; Membrane Potential, Mitochondrial; Models, Biological; Motor Activity; Neurons; Neuroprotective Agents; Parkinson Disease; Phenols; Rats; Reactive Oxygen Species; Rotenone

2021
Parkinsonism-like Disease Induced by Rotenone in Rats: Treatment Role of Curcumin, Dopamine Agonist and Adenosine A
    Current aging science, 2022, 02-03, Volume: 15, Issue:1

    Topics: Adenosine; Aged; Animals; Curcumin; Disease Models, Animal; Dopamine Agonists; Humans; Inflammation Mediators; Mice; Neuroprotective Agents; Parkinson Disease; Parkinsonian Disorders; Rats; Receptor, Adenosine A2A; Rotenone

2022
Generation of Mitochondrial Toxin Rodent Models of Parkinson's Disease Using 6-OHDA , MPTP , and Rotenone.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2322

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurotoxins; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Rodentia; Rotenone

2021
Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 140

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Flavanones; Flavonoids; Homeostasis; Inflammation; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neuroprotective Agents; Neurotransmitter Agents; Parkinson Disease; Protein-Tyrosine Kinases; Rotenone; Signal Transduction

2021
Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway.
    Brain and behavior, 2021, Volume: 11, Issue:8

    Topics: Animals; Diet; Disease Models, Animal; Hydrocarbons, Aromatic; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone; Tryptophan

2021
FBXO22, ubiquitination degradation of PHLPP1, ameliorates rotenone induced neurotoxicity by activating AKT pathway.
    Toxicology letters, 2021, Oct-10, Volume: 350

    Topics: Animals; Apoptosis; Cells, Cultured; Down-Regulation; F-Box Proteins; Gene Expression Regulation; Humans; Male; Models, Animal; Neuroblastoma; Neurotoxins; Nuclear Proteins; Parkinson Disease; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rotenone; Signal Transduction; Ubiquitination

2021
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish.
    Molecular biology reports, 2021, Volume: 48, Issue:6

    Topics: Animals; Brain; Brain-Gut Axis; Caprylates; Disease Models, Animal; Gastrointestinal Tract; Glutathione; Inflammation; Lipid Peroxidation; Oxidative Stress; Parkinson Disease; Rotenone; Superoxide Dismutase; Zebrafish; Zebrafish Proteins

2021
Parkinson Disease-Modification Encompassing Rotenone and 6-Hydroxydopamine Neurotoxicity by the Microtubule-Protecting Drug Candidate SKIP.
    Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:8

    Topics: Animals; Antiparkinson Agents; Cell Line, Tumor; Dopaminergic Neurons; Humans; Male; Microtubules; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra

2021
LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Aging; Cellular Senescence; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lysosomes; Neurons; Oxidative Stress; Parkinson Disease; Rotenone

2021
UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson's disease mice after oral administration of Wen-Shen-Yang-Gan decoction.
    Aging, 2021, 08-02, Volume: 13, Issue:15

    Topics: Administration, Oral; Animals; Antiparkinson Agents; Cheminformatics; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopaminergic Neurons; Male; Metabolomics; Mice; Mice, Inbred C57BL; Multivariate Analysis; Neuroprotective Agents; Parkinson Disease; Plant Extracts; Rotenone; Substantia Nigra; Tandem Mass Spectrometry

2021
Hyperoside Reduces Rotenone-induced Neuronal Injury by Suppressing Autophagy.
    Neurochemical research, 2021, Volume: 46, Issue:12

    Topics: Animals; Apoptosis; Autophagy; Insecticides; Male; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neuroprotective Agents; Parkinson Disease; Quercetin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone

2021
Benefits of betanin in rotenone-induced Parkinson mice.
    Metabolic brain disease, 2021, Volume: 36, Issue:8

    Topics: Animals; Betacyanins; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2021
Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenon
    Journal of neurochemistry, 2017, Volume: 141, Issue:1

    Topics: Humans; Interferon Type I; Neurons; Neurotoxicity Syndromes; Parkinson Disease; Rotenone

2017
Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.
    Cell chemical biology, 2017, Apr-20, Volume: 24, Issue:4

    Topics: Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Behavior, Animal; Cell Line, Tumor; Disease Models, Animal; Electron Transport Complex I; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Parkinson Disease; Protein Kinases; Protein Serine-Threonine Kinases; RNA Interference; Rotenone; Sequestosome-1 Protein; Trifluoperazine; Zebrafish; Zebrafish Proteins

2017
Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.
    Chemico-biological interactions, 2017, May-01, Volume: 269

    Topics: Animals; Apigenin; Apoptosis; Behavior, Animal; Calcium-Transporting ATPases; Catalase; Corpus Striatum; Disease Models, Animal; Immunohistochemistry; Inflammation; Male; Nerve Growth Factors; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase

2017
Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells.
    BMC complementary and alternative medicine, 2017, Apr-18, Volume: 17, Issue:1

    Topics: Cell Death; Cell Line, Tumor; Cell Survival; Curcuma; Curcumin; Cytochromes c; Diarylheptanoids; Dopaminergic Neurons; Humans; Insecticides; Membrane Potential, Mitochondrial; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Rotenone

2017
PINK1-Based Screen Shines Light on Autophagy Enhancers for Parkinson's Disease.
    Cell chemical biology, 2017, 04-20, Volume: 24, Issue:4

    Topics: Animals; Autophagy; Parkinson Disease; Protein Kinases; Protein Serine-Threonine Kinases; Rotenone; Zebrafish

2017
Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats.
    Molecular neurobiology, 2018, Volume: 55, Issue:5

    Topics: alpha-Synuclein; Animals; Dabigatran; Dopamine; Dopaminergic Neurons; Inflammation; Male; Neostriatum; Neuroprotective Agents; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Rats, Wistar; Rotenone; Substantia Nigra; Thrombin

2018
Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats.
    International immunopharmacology, 2017, Volume: 50

    Topics: Animals; Brain Injuries; Cell Line; Cytokines; Disease Models, Animal; Flavanones; Humans; Inflammation Mediators; Male; Mice; Microglia; Motor Activity; Neurogenic Inflammation; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Scutellaria baicalensis; Toll-Like Receptor 4

2017
Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy.
    Biological & pharmaceutical bulletin, 2017, Sep-01, Volume: 40, Issue:9

    Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopamine; Flavanones; Homeostasis; Humans; Insecticides; Male; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Rotenone; Scutellaria baicalensis

2017
Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson's disease in differentiated SH-SY5Y cells.
    Journal of Asian natural products research, 2017, Volume: 19, Issue:8

    Topics: alpha-Synuclein; Apoptosis; Autophagy; Cell Survival; Dose-Response Relationship, Drug; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Neuroprotective Agents; Parkinson Disease; Reactive Oxygen Species; Rotenone; Xanthones

2017
Time-course of striatal Toll-like receptor expression in neurotoxic, environmental and inflammatory rat models of Parkinson's disease.
    Journal of neuroimmunology, 2017, 09-15, Volume: 310

    Topics: Animals; Corpus Striatum; Cytokines; Disease Models, Animal; Gene Expression Regulation; Oxidopamine; Parkinson Disease; Poly I-C; Rats; Rats, Sprague-Dawley; Rotenone; Time Factors; Toll-Like Receptors

2017
Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis.
    Scientific reports, 2017, 08-30, Volume: 7, Issue:1

    Topics: Animals; Disease Models, Animal; Flavanones; Mitochondria; Neuroprotective Agents; Organelle Biogenesis; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Therapeutic Uses

2017
Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 09-01, Volume: 159, Issue:1

    Topics: Animals; Behavior, Animal; Cells, Cultured; Female; Inflammation; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Parkinson Disease; Rotenone; Stomach; Substantia Nigra; Toxicity Tests, Chronic

2017
Potential neuroprotective effect of androst-5-ene-3β, 17β-diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model.
    Journal of cellular physiology, 2018, Volume: 233, Issue:8

    Topics: alpha-Synuclein; Androstenediol; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Estrogen Receptor beta; Inflammation Mediators; Male; Motor Activity; Neurons; Neuroprotective Agents; NF-kappa B; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2018
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.
    Molecular neurobiology, 2018, Volume: 55, Issue:8

    Topics: alpha-Synuclein; Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Body Weight; Corpus Striatum; Filgrastim; Humans; Inflammation; Male; Mesencephalon; Microglia; Motor Activity; Nerve Growth Factors; Neuroprotective Agents; Parkinson Disease; Rats, Wistar; Rotenone; Tyrosine 3-Monooxygenase

2018
Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease.
    Gene, 2018, Mar-20, Volume: 647

    Topics: Apoptosis; Cell Cycle; Cell Line; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Humans; Mitochondria; Parkinson Disease; Rotenone; Signal Transduction

2018
Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson's disease model.
    Scientific reports, 2018, 02-05, Volume: 8, Issue:1

    Topics: Animals; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Gene Expression Profiling; Parkinson Disease; Pesticides; Rotenone; Wnt Signaling Pathway

2018
Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model.
    Molecular neurobiology, 2018, Volume: 55, Issue:9

    Topics: Animals; Apoptosis; Autophagy; Behavior, Animal; Biomarkers; Cilostazol; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Inflammation Mediators; Male; Motor Activity; Neostriatum; Neuroprotective Agents; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Rats, Wistar; Rotarod Performance Test; Rotenone; Sirtuin 1; Tyrosine 3-Monooxygenase

2018
Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats.
    Neurochemistry international, 2018, Volume: 116

    Topics: Animals; Antioxidants; Dopamine; Dopaminergic Neurons; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats, Wistar; Rotenone; Spermidine

2018
Anacardic Acids from Cashew Nuts Prevent Behavioral Changes and Oxidative Stress Induced by Rotenone in a Rat Model of Parkinson's Disease.
    Neurotoxicity research, 2018, Volume: 34, Issue:2

    Topics: Anacardic Acids; Animals; Antioxidants; Brain; Disease Models, Animal; Electron Transport Chain Complex Proteins; Exploratory Behavior; Insecticides; Lipid Peroxidation; Locomotion; Male; Maze Learning; Mental Disorders; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Rotarod Performance Test; Rotenone; Superoxide Dismutase

2018
Early signs of colonic inflammation, intestinal dysfunction, and olfactory impairments in the rotenone-induced mouse model of Parkinson's disease.
    Behavioural pharmacology, 2018, Volume: 29, Issue:2 and 3-Sp

    Topics: Animals; Brain; Colon; Disease Models, Animal; Gastrointestinal Tract; Inflammation; Mice; Neurons; Olfactory Bulb; Parkinson Disease; Peroxidase; Rotenone

2018
Preliminary optimization of a Chinese herbal medicine formula based on the neuroprotective effects in a rat model of rotenone-induced Parkinson's disease.
    Journal of integrative medicine, 2018, Volume: 16, Issue:4

    Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Neuroprotective Agents; Parkinson Disease; Plants, Medicinal; Rats; Rats, Wistar; Rotenone

2018
GAPDH rs1136666 SNP indicates a high risk of Parkinson's disease.
    Neuroscience letters, 2018, 10-15, Volume: 685

    Topics: Antioxidants; Apoptosis; Case-Control Studies; Cell Survival; Female; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Male; Oxidative Stress; Parkinson Disease; Risk; Rotenone; Sex Factors

2018
Nicotine-Induced Neuroprotection in Rotenone In Vivo and In Vitro Models of Parkinson's Disease: Evidences for the Involvement of the Labile Iron Pool Level as the Underlying Mechanism.
    Neurotoxicity research, 2019, Volume: 35, Issue:1

    Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Embryo, Mammalian; Exploratory Behavior; Fluoresceins; Forelimb; Insecticides; Iron; Male; Medial Forebrain Bundle; Mesencephalon; Motor Activity; Nicotine; Nicotinic Agonists; Parkinson Disease; Pars Compacta; Rats; Rats, Sprague-Dawley; Rotenone; Tubulin; Tyrosine 3-Monooxygenase

2019
Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 08-22, Volume: 38, Issue:34

    Topics: Animals; Axons; Cerebral Cortex; DNA Replication; DNA, Mitochondrial; Electron Transport Complex I; Electron Transport Complex IV; Endoplasmic Reticulum; Female; Humans; Male; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proton-Translocating ATPases; Neurites; Neurons; Organelle Biogenesis; Oxidative Stress; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Rotenone; Uncoupling Agents

2018
Melatonin Improves Behavioral and Biochemical Outcomes in a Rotenone-Induced Rat Model of Parkinson's Disease.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2018, Volume: 37, Issue:2

    Topics: Animals; Disease Models, Animal; Male; Melatonin; Muscle Strength; Neurotoxins; Neurotransmitter Agents; Parkinson Disease; Postural Balance; Psychomotor Disorders; Rats; Rats, Wistar; Rotenone; Tyrosine 3-Monooxygenase

2018
Dysregulation of bcl-2 enhanced rotenone-induced α-synuclein aggregation associated with autophagic pathways.
    Neuroreport, 2018, 09-26, Volume: 29, Issue:14

    Topics: alpha-Synuclein; Animals; Autophagy; Dopaminergic Neurons; Humans; Male; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; RNA, Small Interfering; Rotenone; Substantia Nigra

2018
Geraniol Protects Against the Protein and Oxidative Stress Induced by Rotenone in an In Vitro Model of Parkinson's Disease.
    Neurochemical research, 2018, Volume: 43, Issue:10

    Topics: Acyclic Monoterpenes; Antioxidants; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Dopaminergic Neurons; Endoplasmic Reticulum Stress; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Parkinson Disease; Rotenone; Terpenes

2018
Olfaction in female Wistar rats is influenced by dopaminergic periglomerular neurons after nigral and bulbar lesions.
    Behavioural pharmacology, 2019, Volume: 30, Issue:4

    Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; Olfactory Bulb; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Signal Transduction; Sleep Deprivation; Sleep, REM; Smell; Substantia Nigra

2019
Signature of Aberrantly Expressed microRNAs in the Striatum of Rotenone-Induced Parkinsonian Rats.
    Neurochemical research, 2018, Volume: 43, Issue:11

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Male; MicroRNAs; Neostriatum; Neuroprotective Agents; Parkinson Disease; Parkinsonian Disorders; Rats, Wistar; Rotenone; Substantia Nigra

2018
T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease.
    Stem cell reports, 2018, 11-13, Volume: 11, Issue:5

    Topics: Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line; Dopaminergic Neurons; Homeostasis; Humans; Induced Pluripotent Stem Cells; Mitochondria; Models, Biological; Neuronal Outgrowth; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Protein Kinases; Rotenone; Ubiquitin-Protein Ligases

2018
Parkinson's disease prevalence and the association with rurality and agricultural determinants.
    Parkinsonism & related disorders, 2019, Volume: 61

    Topics: Adult; Agriculture; Fabaceae; Female; Humans; Insecticides; Male; Middle Aged; Parkinson Disease; Parkinson Disease, Secondary; Prevalence; Rotenone; Rural Population; Victoria

2019
Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.
    Free radical biology & medicine, 2019, Volume: 130

    Topics: Animals; Antioxidants; Brain; Humans; Huntingtin Protein; Huntington Disease; Mitochondria; Oxidation-Reduction; Oxidative Stress; Paraquat; Parkinson Disease; Phenotype; Protein Aggregation, Pathological; Reactive Oxygen Species; Rotenone; Superoxides; Tyrosine 3-Monooxygenase; Zebrafish

2019
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
    Brain, behavior, and immunity, 2019, Volume: 76

    Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopaminergic Neurons; Histamine; Indoles; Inflammation; Male; Microglia; Nerve Degeneration; Parkinson Disease; Parkinsonian Disorders; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H4; Rotenone

2019
Demethoxycurcumin ameliorates rotenone-induced toxicity in rats.
    Frontiers in bioscience (Elite edition), 2019, 01-01, Volume: 11, Issue:1

    Topics: Animals; Apoptosis; Behavior, Animal; Cognitive Dysfunction; Curcumin; Diarylheptanoids; Disease Models, Animal; Male; Neuroprotective Agents; Parkinson Disease; Random Allocation; Rats, Wistar; Rotenone

2019
Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson's disease.
    Frontiers in bioscience (Elite edition), 2019, 01-01, Volume: 11, Issue:1

    Topics: Agaricus; Animals; Complex Mixtures; Disease Models, Animal; Male; Mice; Neuroprotective Agents; Parkinson Disease; Rotenone

2019
Fisetin protects against rotenone-induced neurotoxicity through signaling pathway.
    Frontiers in bioscience (Elite edition), 2019, 01-01, Volume: 11, Issue:1

    Topics: Antioxidants; Apoptosis; Blotting, Western; Cell Line, Tumor; Down-Regulation; Flavonoids; Flavonols; Humans; Lipid Peroxidation; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone; Signal Transduction

2019
The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: Relevance to early Parkinson's disease.
    Journal of chemical neuroanatomy, 2019, Volume: 97

    Topics: Adaptor Proteins, Vesicular Transport; Adrenal Glands; Animals; Brain-Derived Neurotrophic Factor; Colon; Olfactory Bulb; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase; Uncoupling Agents

2019
Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.
    Cell death & disease, 2019, 01-28, Volume: 10, Issue:2

    Topics: alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Humans; Mitochondria; Neurons; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Sodium-Calcium Exchanger

2019
Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers.
    Scientific reports, 2019, 02-13, Volume: 9, Issue:1

    Topics: Amino Acids, Branched-Chain; Animals; Area Under Curve; Biomarkers; Chromatography, High Pressure Liquid; Chronic Disease; Discriminant Analysis; Disease Models, Animal; Least-Squares Analysis; Male; Mass Spectrometry; Metabolome; Parkinson Disease; Rats; Rats, Wistar; ROC Curve; Rotenone; Sleep Wake Disorders

2019
Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition.
    Behavioural brain research, 2019, 06-03, Volume: 365

    Topics: Animals; Antiparkinson Agents; Apoptosis; Autophagy; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hydroxychloroquine; Male; Microtubule-Associated Proteins; Motor Activity; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Tyrosine 3-Monooxygenase

2019
Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease.
    Free radical biology & medicine, 2019, 05-01, Volume: 135

    Topics: Animals; Brain; Corpus Striatum; Disease Models, Animal; Electron Transport Complex I; Frontal Lobe; Gray Matter; Humans; Hydrogen Peroxide; Hypokinesia; Lipid Peroxidation; Locomotion; Mitochondria; Oxidative Stress; Oxygen; Parkinson Disease; Rats; Rotenone

2019
Standarized Tribulus terrestris extract protects against rotenone-induced oxidative damage and nigral dopamine neuronal loss in mice.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2018, Volume: 69, Issue:6

    Topics: Animals; Antioxidants; Disease Models, Animal; DNA Damage; Dopamine; Mice; Microglia; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Plant Extracts; Rotenone; Substantia Nigra; Tribulus; Up-Regulation

2018
Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 07-01, Volume: 170, Issue:1

    Topics: alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Female; Humans; Lysosomes; Male; Microglia; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Sex Factors; Substantia Nigra; Transferrin; Tyrosine 3-Monooxygenase

2019
Phenothiazine normalizes the NADH/NAD
    Redox biology, 2019, Volume: 24

    Topics: Animals; Biomarkers; Cell Culture Techniques; Corpus Striatum; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Mitochondria; Models, Biological; NAD; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Phenothiazines; Rats; Rotenone; Substantia Nigra

2019
Neuroprotective Effects of Thymol, a Dietary Monoterpene Against Dopaminergic Neurodegeneration in Rotenone-Induced Rat Model of Parkinson's Disease.
    International journal of molecular sciences, 2019, Mar-27, Volume: 20, Issue:7

    Topics: Animals; Catalase; Cyclooxygenase 2; Cytokines; Diet; Disease Models, Animal; Dopaminergic Neurons; Glutathione; Inflammation Mediators; Lipid Peroxidation; Male; Malondialdehyde; Neostriatum; Nerve Degeneration; Neuroglia; Neuroprotective Agents; Nitric Oxide Synthase Type II; Parkinson Disease; Rats, Wistar; Rotenone; Substantia Nigra; Superoxide Dismutase; Thymol; Tyrosine 3-Monooxygenase

2019
Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson's disease models.
    Brain research bulletin, 2019, Volume: 149

    Topics: Animals; Axotomy; Collagen; Dopamine; Dopaminergic Neurons; Glial Cell Line-Derived Neurotrophic Factor; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Neuroglia; Neuroprotection; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rotenone; Substantia Nigra; Tissue Scaffolds

2019
Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins.
    PloS one, 2019, Volume: 14, Issue:4

    Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Apoptosis; Cells, Cultured; Dopaminergic Neurons; Embryo, Mammalian; Energy Metabolism; Female; Humans; Mesencephalon; Mitochondria; Necroptosis; Necrosis; Neurotoxins; Oxidative Stress; Oxidopamine; Parkinson Disease; Primary Cell Culture; Protein Aggregation, Pathological; Rats; Rotenone

2019
Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity.
    The Journal of nutritional biochemistry, 2019, Volume: 69

    Topics: Acetylation; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Butyrates; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Glial Cell Line-Derived Neurotrophic Factor; Histones; Male; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning; Neuroglia; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Probiotics; Rotenone

2019
Response to Rotenone and Parkinson's Disease; Reduced Sensitivity in Females.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 06-01, Volume: 170, Issue:2

    Topics: Female; Humans; Incidence; Insecticides; Male; Parkinson Disease; Rotenone; Substantia Nigra

2019
Rotenone and Parkinson's Disease: Reduced Sensitivity in Females.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 06-01, Volume: 170, Issue:2

    Topics: Female; Humans; Incidence; Insecticides; Male; Parkinson Disease; Rotenone; Substantia Nigra

2019
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.
    Molecules (Basel, Switzerland), 2019, Jun-10, Volume: 24, Issue:11

    Topics: alpha-Synuclein; Animals; Antioxidants; Brain; Catalase; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Glutathione; Inflammation; Inflammation Mediators; Lipid Peroxidation; Lycopodium; Male; Malondialdehyde; Matrix Metalloproteinases; Microglia; Nerve Degeneration; Neuroprotection; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Parkinson Disease; Plant Extracts; Rats, Wistar; Rotenone; Superoxide Dismutase

2019
Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson's disease.
    Behavioural brain research, 2019, 10-17, Volume: 372

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cognition; Disease Models, Animal; Dopamine; Emotions; Male; Memory; Motor Activity; Parkinson Disease; Rotenone; Sleep Deprivation; Zebrafish

2019
Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons.
    Life sciences, 2019, Aug-15, Volume: 231

    Topics: alpha-Synuclein; Animals; Choline O-Acetyltransferase; Colon; Constipation; Disease Models, Animal; Electric Stimulation; Enteric Nervous System; Gastrointestinal Motility; Intestine, Small; Male; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2019
Neuroprotective Properties of Standardized Extracts of Hypericum perforatum on Rotenone Model of Parkinson's Disease.
    CNS & neurological disorders drug targets, 2013, Volume: 12, Issue:5

    Topics: Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Brain; Catalepsy; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Fluorodeoxyglucose F18; Hypericum; Insecticides; Liposomes; Male; Maze Learning; Neurons; Neuroprotective Agents; Parkinson Disease; Phytotherapy; Positron-Emission Tomography; Quercetin; Rats; Rats, Wistar; Rotenone; Swimming

2013
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.
    Cell stem cell, 2013, Mar-07, Volume: 12, Issue:3

    Topics: Benzamides; Cell Differentiation; Cells, Cultured; Diphenylamine; Dopamine; Extracellular Signal-Regulated MAP Kinases; Humans; Induced Pluripotent Stem Cells; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mutation; Neurons; Oxidopamine; Parkinson Disease; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Rotenone

2013
Amurensin G induces autophagy and attenuates cellular toxicities in a rotenone model of Parkinson's disease.
    Biochemical and biophysical research communications, 2013, Mar-29, Volume: 433, Issue:1

    Topics: Apoptosis Regulatory Proteins; Autophagy; Base Sequence; Beclin-1; Dibenzocycloheptenes; G2 Phase Cell Cycle Checkpoints; HEK293 Cells; Humans; Medicine, Korean Traditional; Membrane Proteins; Models, Biological; Neurotoxins; Parkinson Disease; Phytotherapy; Plants, Medicinal; Resorcinols; RNA, Small Interfering; Rotenone; Vitis

2013
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 133, Issue:2

    Topics: alpha-Synuclein; Cell Death; Cell Line, Tumor; Cell Survival; Glycine; Glyphosate; Humans; Insecticides; Maneb; Melanoma; Neuroblastoma; Paraquat; Parkinson Disease; Rotenone; Transduction, Genetic

2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
    Medecine sciences : M/S, 2013, Volume: 29, Issue:3

    Topics: alpha-Synuclein; Alzheimer Disease; Animals; Genetic Predisposition to Disease; Humans; Insecticides; Mitochondria; Neurodegenerative Diseases; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rotenone

2013
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
    Acta neuropathologica, 2013, Volume: 125, Issue:6

    Topics: alpha-Synuclein; Animals; Brain; Cell Culture Techniques; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Parkinson Disease; Prion Diseases; Prions; Pyrazoles; Pyrimidines; Rotenone

2013
p38(MAPK)/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson's disease.
    Neurochemistry international, 2013, Volume: 63, Issue:3

    Topics: Animals; bcl-2-Associated X Protein; Disease Models, Animal; Male; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; PC12 Cells; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Tumor Suppressor Protein p53; Tyrosine 3-Monooxygenase

2013
Gastrodin ameliorates Parkinson's disease by downregulating connexin 43.
    Molecular medicine reports, 2013, Volume: 8, Issue:2

    Topics: Animals; Astrocytes; Benzyl Alcohols; Cell Communication; Connexin 43; Disease Models, Animal; Down-Regulation; Gap Junctions; Gene Expression Regulation; Glucosides; Parkinson Disease; Phosphorylation; Rats; Rotenone

2013
Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism.
    Journal of neurochemistry, 2013, Volume: 127, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopaminergic Neurons; Drug Synergism; Electron Transport Complex I; Energy Metabolism; Mice; Neurotoxins; Parkinson Disease; Probenecid; Rotenone; Uricosuric Agents

2013
Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: a model-based analysis.
    The FEBS journal, 2013, Volume: 280, Issue:20

    Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Electron Transport Complex I; Energy Metabolism; Ketoglutarate Dehydrogenase Complex; Mitochondria; Neurons; Parkinson Disease; Rats; Reactive Oxygen Species; Rotenone

2013
Impaired complex-I mitochondrial biogenesis in Parkinson disease frontal cortex.
    Journal of Parkinson's disease, 2012, Volume: 2, Issue:1

    Topics: Acyl-CoA Dehydrogenases; Adolescent; Cell Line; DNA-Binding Proteins; Dopaminergic Neurons; Electron Transport Complex I; Female; Frontal Lobe; Gene Expression Regulation; Humans; Male; Microarray Analysis; MicroRNAs; Mitochondrial Proteins; Mitochondrial Turnover; Neural Stem Cells; Nuclear Respiratory Factor 1; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rotenone; Transcription Factors; Tumor Necrosis Factor-alpha

2012
Epidemiology. Paths from pesticides to Parkinson's.
    Science (New York, N.Y.), 2013, Aug-16, Volume: 341, Issue:6147

    Topics: Amyotrophic Lateral Sclerosis; Animals; Dementia; Environmental Exposure; Humans; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Risk Factors; Rotenone

2013
Rotenone directly induces BV2 cell activation via the p38 MAPK pathway.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Animals; Cell Line; Cell Nucleus; Environmental Pollutants; Humans; I-kappa B Kinase; Inflammasomes; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Transcription Factor RelA

2013
Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease.
    Neurotoxicology, 2013, Volume: 39

    Topics: Animals; Brain; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Insecticides; Male; Malvaceae; Neurotransmitter Agents; Oxidative Stress; Parkinson Disease; Phytotherapy; Plant Extracts; Postural Balance; Rats; Rats, Sprague-Dawley; Rotenone; Sensation Disorders; Thiobarbituric Acid Reactive Substances

2013
[Effect of lycopene on oxidative stress and behavioral deficits in rotenone induced model of Parkinson's disease].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2013, Volume: 29, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Carotenoids; Disease Models, Animal; Dopamine; Lycopene; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Parkinson Disease; Rotenone; Superoxide Dismutase

2013
Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease.
    Oxidative medicine and cellular longevity, 2013, Volume: 2013

    Topics: Adenosine Triphosphate; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Hesperidin; Humans; Membrane Potential, Mitochondrial; Models, Biological; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone

2013
Celastrol from 'Thunder God Vine' protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of Parkinson's disease.
    Neurochemical research, 2014, Volume: 39, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Membrane Potential, Mitochondrial; Neuroprotective Agents; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Pentacyclic Triterpenes; Rotenone; Triterpenes

2014
Neuroprotective effects of Lycium chinense Miller against rotenone-induced neurotoxicity in PC12 cells.
    The American journal of Chinese medicine, 2013, Volume: 41, Issue:6

    Topics: Adenosine Triphosphate; Animals; bcl-2-Associated X Protein; Calcium; Caspases; Cell Survival; Cells, Cultured; Lycium; Membrane Potential, Mitochondrial; Mitochondria; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Rats; Rotenone; Superoxides

2013
Discovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-Parkinson agents.
    The FEBS journal, 2014, Volume: 281, Issue:4

    Topics: Animals; Benzoquinones; Cell Line, Tumor; Cell Survival; Humans; Lactams, Macrocyclic; Male; Mitochondria; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone

2014
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
    Neurobiology of aging, 2014, Volume: 35, Issue:5

    Topics: Animals; Caspase 3; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Lythraceae; Male; Mitochondrial Diseases; Nitric Oxide Synthase Type II; Oxidative Stress; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Tyrosine

2014
Parkinson's disease, lights and melanocytes: looking beyond the retina.
    Scientific reports, 2014, Jan-29, Volume: 4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Female; Light; Male; Melanocytes; Motor Activity; Oxidopamine; Paraquat; Parkinson Disease; Rats; Rats, Sprague-Dawley; Retina; Rotenone

2014
Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease.
    Brain research, 2014, Mar-25, Volume: 1555

    Topics: Animals; Anthocyanins; Cells, Cultured; Dopaminergic Neurons; Mice; Microglia; Mitochondria; Neuroprotective Agents; Parkinson Disease; Phytotherapy; Plant Extracts; Proanthocyanidins; Rotenone; Tyrosine 3-Monooxygenase

2014
Do adipose tissue-derived mesenchymal stem cells ameliorate Parkinson's disease in rat model?
    Human & experimental toxicology, 2014, Volume: 33, Issue:12

    Topics: Adipose Tissue; Amino Acids; Animals; Antigens, CD; Brain; Brain-Derived Neurotrophic Factor; Carbidopa; Cell Differentiation; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Drug Combinations; Female; Gene Expression; Genes, sry; Levodopa; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Ovariectomy; Parkinson Disease; Rats, Sprague-Dawley; Rotenone; Transforming Growth Factor beta; Tyrosine 3-Monooxygenase

2014
Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease.
    Neuroscience, 2014, May-16, Volume: 267

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Dopaminergic Neurons; Functional Laterality; Insecticides; Male; Neuroprotective Agents; Parkinson Disease; Postural Balance; Rats; Rats, Sprague-Dawley; Rotenone; Sensation Disorders; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Valproic Acid

2014
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease.
    Cellular signalling, 2014, Volume: 26, Issue:8

    Topics: 1-Methyl-4-phenylpyridinium; AMP-Activated Protein Kinases; Animals; Apoptosis; Carrier Proteins; Caspase 3; Cell Survival; Cells, Cultured; Intracellular Signaling Peptides and Proteins; Models, Biological; Neurons; Oxidopamine; Parkinson Disease; PC12 Cells; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Rotenone; Signal Transduction; TOR Serine-Threonine Kinases

2014
Oral supplements of aqueous extract of tomato seeds alleviate motor abnormality, oxidative impairments and neurotoxicity induced by rotenone in mice: relevance to Parkinson's disease.
    Neurochemical research, 2014, Volume: 39, Issue:7

    Topics: Administration, Oral; Animals; Antioxidants; Male; Mice; Motor Skills Disorders; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease; Plant Extracts; Rotenone; Seeds; Solanum lycopersicum; Water

2014
Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway.
    Molecular neurobiology, 2014, Volume: 50, Issue:2

    Topics: alpha-Synuclein; Animals; Autophagy; Humans; Lewy Bodies; Mitogen-Activated Protein Kinase 8; Mutation; Parkinson Disease; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Rotenone; Signal Transduction; TOR Serine-Threonine Kinases

2014
Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson's disease pathology.
    Neurochemistry international, 2014, Volume: 75

    Topics: alpha-Synuclein; Animals; Body Weight; Glutathione; HSP70 Heat-Shock Proteins; Male; Nerve Tissue Proteins; Oxidation-Reduction; Parkinson Disease; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Rotenone; Sodium Salicylate; Ubiquitin

2014
Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease.
    Biochimica et biophysica acta, 2014, Volume: 1842, Issue:9

    Topics: Adenosine Triphosphate; Apoptosis; Autophagy; Case-Control Studies; Energy Metabolism; Female; Fibroblasts; Homeostasis; Humans; Male; Middle Aged; Mitochondria; Oxygen Consumption; Parkinson Disease; Proteasome Endopeptidase Complex; Rotenone; Superoxides; Ubiquitin; Uncoupling Agents

2014
Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone in the rotenone model of Parkinson's disease.
    Molecular neurobiology, 2015, Volume: 51, Issue:1

    Topics: Animals; Antioxidants; Astrocytes; Carbenoxolone; Citrulline; Cytokines; Disease Models, Animal; Electron Transport; Enzyme Activation; Glial Fibrillary Acidic Protein; Glutathione; Inflammation; Inflammation Mediators; Male; Mesencephalon; Mitochondria; Nervous System; Nitric Oxide; Nitric Oxide Synthase Type II; Parkinson Disease; Rats, Sprague-Dawley; Rotenone

2015
Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease.
    Neurobiology of disease, 2014, Volume: 70

    Topics: Aged; Aged, 80 and over; Animals; Biomarkers; Cells, Cultured; Cerebral Cortex; DNA Damage; DNA, Mitochondrial; Dopaminergic Neurons; Electron Transport Complex I; Humans; Hydrogen Peroxide; Male; Middle Aged; Parkinson Disease; Parkinsonian Disorders; Rats, Inbred Lew; Rotenone; Substantia Nigra

2014
1,25-Dyhydroxyvitamin D₃ attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy.
    Biochemical and biophysical research communications, 2014, Aug-15, Volume: 451, Issue:1

    Topics: AMP-Activated Protein Kinases; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Beclin-1; Calcitriol; Caspase 3; Cell Line; Dose-Response Relationship, Drug; Humans; Membrane Proteins; Microtubule-Associated Proteins; Neurotoxicity Syndromes; Parkinson Disease; Protective Agents; Reactive Oxygen Species; Rotenone

2014
A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease.
    Brain research, 2014, Oct-02, Volume: 1583

    Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Dopaminergic Neurons; Drosophila melanogaster; Gene-Environment Interaction; Humans; Image Processing, Computer-Assisted; Larva; Motor Activity; Mutation; Olfactory Perception; Parkinson Disease; Rotenone; Software; Video Recording

2014
Methods to characterize spontaneous and startle-induced locomotion in a rotenone-induced Parkinson's disease model of Drosophila.
    Journal of visualized experiments : JoVE, 2014, Aug-17, Issue:90

    Topics: Animals; Disease Models, Animal; Drosophila; Locomotion; Male; Parkinson Disease; Reflex, Startle; Rotenone

2014
A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson's disease.
    Nature communications, 2014, Oct-21, Volume: 5

    Topics: Animals; Axons; Disease Models, Animal; Female; HEK293 Cells; Humans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microfluidics; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptides; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Viral Nonstructural Proteins

2014
Saxagliptin: a novel antiparkinsonian approach.
    Neuropharmacology, 2015, Volume: 89

    Topics: Adamantane; Animals; Antiparkinson Agents; Body Weight; Brain; Cathepsin C; Cyclic AMP; Dipeptides; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Gene Expression Regulation; Insecticides; Lipid Peroxidation; Male; Nerve Tissue Proteins; NF-E2-Related Factor 2; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Tyrosine 3-Monooxygenase

2015
Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson's disease.
    Journal of ethnopharmacology, 2015, Jan-15, Volume: 159

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Autophagy; Medicine, Korean Traditional; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Plant Extracts; Rats; Rotenone

2015
Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease.
    Environment international, 2015, Volume: 75

    Topics: Adult; Aged; Aged, 80 and over; Agriculture; Case-Control Studies; Female; Gloves, Protective; Habits; Humans; Iowa; Male; Middle Aged; North Carolina; Occupational Exposure; Occupational Health; Paraquat; Parkinson Disease; Permethrin; Pesticides; Risk; Rotenone; Surveys and Questionnaires; Trifluralin; Workplace

2015
Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson's Disease: Modulation of Mitochondrial Perturbations.
    Molecular neurobiology, 2016, Volume: 53, Issue:2

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Behavior, Animal; Caspases; Disease Models, Animal; Dopamine; Gene Expression Regulation; Male; Mitochondria; Neostriatum; Neurons; Parkinson Disease; Rats, Wistar; RNA, Messenger; Rotenone; Ursodeoxycholic Acid

2016
The S-nitrosylation status of PCNA localized in cytosol impacts the apoptotic pathway in a Parkinson's disease paradigm.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Apoptosis; Caspase 9; Cell Line, Tumor; Cytosol; Enzyme Activation; Humans; Models, Molecular; Nitric Oxide; Oxidative Stress; Parkinson Disease; Proliferating Cell Nuclear Antigen; Protein Binding; Protein Conformation; Protein Transport; Proteome; Proteomics; Rotenone; Signal Transduction

2015
Combined oral supplementation of fish oil and quercetin enhances neuroprotection in a chronic rotenone rat model: relevance to Parkinson's disease.
    Neurochemical research, 2015, Volume: 40, Issue:5

    Topics: Administration, Oral; Animals; Disease Models, Animal; Drug Therapy, Combination; Fish Oils; Hand Strength; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Quercetin; Rats; Rats, Wistar; Rotenone

2015
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.
    Neurobiology of disease, 2015, Volume: 79

    Topics: 1-Methyl-4-phenylpyridinium; 14-3-3 Proteins; alpha-Synuclein; Animals; bcl-2-Associated X Protein; Casein Kinases; Cell Line, Tumor; Green Fluorescent Proteins; HEK293 Cells; Hippocampus; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice, Inbred C57BL; Mice, Transgenic; Parkinson Disease; Parkinsonian Disorders; Phosphorylation; Protein Serine-Threonine Kinases; Rotenone; Temporal Lobe

2015
Nesfatin-1 antagonized rotenone-induced neurotoxicity in MES23.5 dopaminergic cells.
    Peptides, 2015, Volume: 69

    Topics: Animals; Apoptosis; Calcium-Binding Proteins; DNA-Binding Proteins; Dopamine; Dopaminergic Neurons; Humans; Hybrid Cells; Membrane Potential, Mitochondrial; Mice; Mitochondria; Nerve Tissue Proteins; Neuroprotective Agents; Nucleobindins; Parkinson Disease; Rats; Reactive Oxygen Species; Rotenone; Subarachnoid Hemorrhage

2015
PPARβ/δ Agonist Provides Neuroprotection by Suppression of IRE1α-Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson's Disease.
    Molecular neurobiology, 2016, Volume: 53, Issue:6

    Topics: Animals; Apoptosis; Caspase 12; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Endoplasmic Reticulum Stress; Endoribonucleases; Fluorescent Antibody Technique; Male; Motor Activity; Multienzyme Complexes; Neostriatum; Neuroprotection; Parkinson Disease; PPAR delta; PPAR-beta; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Rotenone; Signal Transduction; Thiazoles

2016
Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons.
    Current biology : CB, 2015, Sep-21, Volume: 25, Issue:18

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Axons; Dopaminergic Neurons; Energy Metabolism; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Neuronal Plasticity; Neurotoxins; Oxidative Phosphorylation; Parkinson Disease; Pars Compacta; Rotenone; Ventral Tegmental Area

2015
Autophagy-related protein expression in the substantia nigra and eldepryl intervention in rat models of Parkinson's disease.
    Brain research, 2015, Nov-02, Volume: 1625

    Topics: Animals; Apoptosis Regulatory Proteins; Beclin-1; Disease Models, Animal; Insecticides; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Selegiline; Substantia Nigra; Time Factors

2015
Rapamycin protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture.
    Folia neuropathologica, 2015, Volume: 53, Issue:3

    Topics: Animals; Apoptosis; Cells, Cultured; Dopaminergic Neurons; Immunosuppressive Agents; Mesencephalon; Mice; Neuroprotective Agents; Parkinson Disease; Rotenone; Sirolimus; Uncoupling Agents

2015
Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease.
    Journal of chemical neuroanatomy, 2015, Volume: 70

    Topics: Adrenal Glands; Animals; Brain; Brain-Derived Neurotrophic Factor; Colon; Dopamine beta-Hydroxylase; Duodenum; Male; Organ Specificity; Parkinson Disease; Phenylethanolamine N-Methyltransferase; Phosphorylation; Protein Precursors; Rats, Sprague-Dawley; Rotenone; Tyrosine 3-Monooxygenase

2015
Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease.
    Scientific reports, 2015, Nov-18, Volume: 5

    Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Apoptosis; Cell Count; Cell Line, Tumor; Chromatography, Liquid; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drosophila; Drug Antagonism; Drugs, Chinese Herbal; Humans; Male; Mass Spectrometry; Medicine, Chinese Traditional; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone

2015
Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway.
    Molecular medicine reports, 2016, Volume: 13, Issue:2

    Topics: Animals; Antioxidants; Chromones; Curcumin; Dopaminergic Neurons; Glutathione; HEK293 Cells; Humans; Male; Malondialdehyde; Morpholines; Neuroprotection; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Proto-Oncogene Proteins c-akt; Rats, Inbred Lew; Reactive Oxygen Species; RNA, Small Interfering; Rotenone

2016
Expression changes of genes associated with apoptosis and survival processes in Parkinson's disease.
    Neuroscience letters, 2016, Feb-26, Volume: 615

    Topics: Aged; Animals; Apoptosis; Apoptosis Inducing Factor; Biomarkers; Brain; Case-Control Studies; Caspase 3; Caspase 9; Female; Humans; Leukocytes, Mononuclear; Male; Mice, Inbred C57BL; Middle Aged; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Rotenone; Signal Transduction

2016
Inhibition of endoplasmic reticulum stress-activated IRE1α-TRAF2-caspase-12 apoptotic pathway is involved in the neuroprotective effects of telmisartan in the rotenone rat model of Parkinson's disease.
    European journal of pharmacology, 2016, Apr-05, Volume: 776

    Topics: Animals; Apoptosis; Benzimidazoles; Benzoates; Caspase 12; Catalepsy; Disease Models, Animal; Dopamine; Endoplasmic Reticulum Stress; Endoribonucleases; Enzyme Activation; Male; Multienzyme Complexes; Neostriatum; Neuroprotective Agents; Parkinson Disease; Pars Compacta; PPAR delta; PPAR-beta; Protein Serine-Threonine Kinases; Rats; Rotenone; Signal Transduction; Telmisartan; TNF Receptor-Associated Factor 2

2016
NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease.
    Scientific reports, 2016, Mar-10, Volume: 6

    Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Mechanistic Target of Rapamycin Complex 1; Membrane Glycoproteins; Multiprotein Complexes; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Parkinson Disease; Rotenone; TOR Serine-Threonine Kinases

2016
Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone.
    Neurobiology of disease, 2016, Volume: 91

    Topics: Animals; Cell Death; Dopamine; Dopaminergic Neurons; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Muscle Proteins; Parkinson Disease; PC12 Cells; Rats; Rotenone

2016
The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity.
    The international journal of biochemistry & cell biology, 2016, Volume: 75

    Topics: alpha-Synuclein; Animals; Calmodulin; Cerebral Cortex; Down-Regulation; Humans; Mesencephalon; Neurons; Parkinson Disease; Phosphorylation; Protein Aggregates; Protein Phosphatase 2; Rats; Rotenone; src-Family Kinases; Tyrosine

2016
Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease.
    Chemico-biological interactions, 2016, May-05, Volume: 251

    Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Chemically-Induced Disorders; Disease Models, Animal; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Inflammation; Male; Membrane Proteins; Parkinson Disease; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Resveratrol; Rotenone; Stilbenes; Transcription Factor CHOP

2016
Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease.
    Neuropharmacology, 2016, Volume: 108

    Topics: Animals; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Mesencephalon; Neurons; Neuroprotective Agents; Parkinson Disease; PQQ Cofactor; Rats; Rats, Sprague-Dawley; Rotenone; Treatment Outcome

2016
Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson's Disease.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Apoptosis; Cell Survival; Cells, Cultured; Electron Transport Complex I; HSP27 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Mitochondria; Olfactory Mucosa; Oxidative Stress; Parkinson Disease; Rotenone

2016
Dose-dependent neuroprotective effect of caffeine on a rotenone-induced rat model of parkinsonism: A histological study.
    Neuroscience letters, 2016, 06-03, Volume: 623

    Topics: Animals; Brain; Caffeine; Dose-Response Relationship, Drug; Male; Neurons; Neuroprotective Agents; Parkinson Disease; Pars Compacta; Random Allocation; Rats; Rotenone

2016
Investigation of Long Non-coding RNA Expression Profiles in the Substantia Nigra of Parkinson's Disease.
    Cellular and molecular neurobiology, 2017, Volume: 37, Issue:2

    Topics: Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Profiling; Humans; Parkinson Disease; RNA, Long Noncoding; Rotenone; Substantia Nigra

2017
Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson's disease.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2016, Volume: 26, Issue:3

    Topics: alpha-Synuclein; Animals; Flow Cytometry; Humans; Intestines; Mice; Mice, Inbred C57BL; Parkinson Disease; Rotenone; Sympathetic Nervous System

2016
Upregulation of the cannabinoid CB2 receptor in environmental and viral inflammation-driven rat models of Parkinson's disease.
    Experimental neurology, 2016, Volume: 283, Issue:Pt A

    Topics: Analysis of Variance; Animals; CD11b Antigen; Chromatography, High Pressure Liquid; Disease Models, Animal; Environment; Functional Laterality; Insecticides; Male; Motor Activity; Parkinson Disease; Poly I-C; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; RNA, Messenger; Rotenone; Tandem Mass Spectrometry; Time Factors; Up-Regulation

2016
From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 153, Issue:2

    Topics: alpha-Synuclein; Animals; Autophagy; Cell Cycle Proteins; Corpus Striatum; Disease Models, Animal; Membrane Transport Proteins; Mesencephalon; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Transcription Factor TFIIIA

2016
Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions.
    Molecular neurobiology, 2017, Volume: 54, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain; Cyclooxygenase 2; Disease Models, Animal; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Pyrazines; Rats, Sprague-Dawley; Rotenone; Vasodilator Agents

2017
Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways.
    Scientific reports, 2016, 08-24, Volume: 6

    Topics: Animals; Autophagy; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Glutathione; Humans; Isothiocyanates; Male; Mice, Inbred BALB C; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Parkinson Disease; Rotenone; Sulfoxides; TOR Serine-Threonine Kinases

2016
Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: alpha-Synuclein; Animals; Caspase 3; Disease Models, Animal; Glucosides; Humans; Microtubule-Associated Proteins; Molecular Dynamics Simulation; Parkinson Disease; Phenols; Protein Binding; Rats; Rats, Sprague-Dawley; Rotenone

2016
Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells.
    Nutritional neuroscience, 2018, Volume: 21, Issue:2

    Topics: Agaricales; Agaricus; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2018
Neuroprotective effects of fingolimod in mouse models of Parkinson's disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:1

    Topics: Animals; Cell Line, Tumor; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Male; Mice; Neuroblastoma; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Receptors, Lysosphingolipid; Rotenone; Sphingosine-1-Phosphate Receptors

2017
Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology.
    Arquivos de neuro-psiquiatria, 2016, Volume: 74, Issue:9

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Central Nervous System; Disease Models, Animal; Hippocampus; Immunohistochemistry; Locus Coeruleus; Male; Oxidative Stress; Parkinson Disease; Protein Aggregation, Pathological; Protein Carbonylation; Rats, Inbred Lew; Reproducibility of Results; Rotenone; Substantia Nigra

2016
Double hit mouse model of Parkinson's disease.
    Oncotarget, 2016, 12-06, Volume: 7, Issue:49

    Topics: Animals; Mice; Mice, Knockout; Neuronal Plasticity; Parkinson Disease; Protein Kinases; Rotenone

2016
Morinda citrifolia mitigates rotenone-induced striatal neuronal loss in male Sprague-Dawley rats by preventing mitochondrial pathway of intrinsic apoptosis.
    Redox report : communications in free radical research, 2017, Volume: 22, Issue:6

    Topics: Animals; Apoptosis; Disease Models, Animal; Dopaminergic Neurons; Male; Mitochondria; Morinda; Parkinson Disease; Plant Extracts; Rats; Rats, Sprague-Dawley; Rotenone; Signal Transduction

2017
Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2017, Volume: 69, Issue:2

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Immunohistochemistry; Injections, Intraventricular; Insecticides; Male; Mice; Parkinson Disease; Rotenone; Substantia Nigra; Up-Regulation

2017
Neuronal hemoglobin affects dopaminergic cells' response to stress.
    Cell death & disease, 2017, 01-05, Volume: 8, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Autophagy; Brain; Dopaminergic Neurons; Epigenesis, Genetic; Gene Expression; Hemoglobins; Humans; Mice; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Substantia Nigra

2017
Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models.
    Disease models & mechanisms, 2017, 02-01, Volume: 10, Issue:2

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Feeding Behavior; Locomotion; Mass Spectrometry; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Deglycase DJ-1; Proteomics; Rats, Wistar; Rotenone; Serotonin; Snails; Substantia Nigra; Survival Analysis

2017
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
    Human molecular genetics, 2017, 02-01, Volume: 26, Issue:3

    Topics: Autopsy; Cells, Cultured; Clioquinol; Dopamine; Dopaminergic Neurons; Gene Expression Profiling; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mutation; Parkinson Disease; Rotenone; Transcriptome

2017
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
    Scientific reports, 2017, 01-18, Volume: 7

    Topics: Administration, Oral; Aging; Animals; Apoptosis; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Electron Transport Complex I; Gene Knock-In Techniques; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Neurons; Parkinson Disease; Rotenone; Synaptosomes; Vacuolar Proton-Translocating ATPases

2017
Autophagic modulation by rosuvastatin prevents rotenone-induced neurotoxicity in an in vitro model of Parkinson's disease.
    Neuroscience letters, 2017, 03-06, Volume: 642

    Topics: Adenylate Kinase; alpha-Synuclein; Autophagy; Beclin-1; Cell Line; Cell Survival; Humans; Neurons; Neuroprotective Agents; Parkinson Disease; Reactive Oxygen Species; Rosuvastatin Calcium; Rotenone

2017
Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway.
    Cellular and molecular biology (Noisy-le-Grand, France), 2016, Dec-30, Volume: 62, Issue:14

    Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Cyclohexenes; Dopaminergic Neurons; Female; Gene Expression; Heme Oxygenase-1; Insecticides; Kelch-Like ECH-Associated Protein 1; Models, Neurological; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Rotenone; Signal Transduction; Terpenes

2016
Sitagliptin and liraglutide reversed nigrostriatal degeneration of rodent brain in rotenone-induced Parkinson's disease.
    Inflammopharmacology, 2017, Volume: 25, Issue:3

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; Interleukin-1beta; Interleukin-6; Liraglutide; Male; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Rats; Rodentia; Rotenone; Sitagliptin Phosphate; Transforming Growth Factor beta1; Tyrosine 3-Monooxygenase

2017
Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet.
    Nutritional neuroscience, 2018, Volume: 21, Issue:6

    Topics: alpha-Synuclein; Animals; Brain; Diet; Docosahexaenoic Acids; Fish Oils; Gastrointestinal Tract; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Rotenone; Uridine

2018
Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model.
    Neurobiology of aging, 2010, Volume: 31, Issue:4

    Topics: alpha-Synuclein; Biomarkers; Cell Line, Tumor; Coenzymes; DNA Damage; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Electron Transport Complex I; Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; Models, Biological; Nerve Tissue Proteins; Oxidative Stress; Oxygen Consumption; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; Rotenone; Transcription Factors; Ubiquitin; Uncoupling Agents; Vitamin B Complex

2010
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Sep-30, Volume: 105, Issue:39

    Topics: Animals; Apoptosis; Dopamine; Gene Deletion; Mice; Mice, Mutant Strains; NADH Dehydrogenase; Neurons; Paraquat; Parkinson Disease; Rotenone

2008
Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity.
    Brain research, 2008, Dec-03, Volume: 1243

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Cytoprotection; Electron Transport Complex I; Energy Metabolism; Hazardous Substances; Herbicides; Light; Neurons; Neurotoxins; Parkinson Disease; Phototherapy; Rats; Rats, Sprague-Dawley; Rotenone; Telencephalon; Treatment Outcome; Uncoupling Agents

2008
Extranigral neurodegeneration in Parkinson's disease.
    Annals of the New York Academy of Sciences, 2008, Volume: 1139

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Calpain; Cell Line; Dipeptides; Humans; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Parkinsonian Disorders; Rotenone; Spinal Cord; Substantia Nigra; Uncoupling Agents

2008
Pesticide/environmental exposures and Parkinson's disease in East Texas.
    Journal of agromedicine, 2008, Volume: 13, Issue:1

    Topics: Aged; Aged, 80 and over; Case-Control Studies; Confidence Intervals; Environmental Exposure; Female; Humans; Male; Middle Aged; Occupational Exposure; Odds Ratio; Parkinson Disease; Pesticides; Risk; Risk Factors; Rotenone; Texas

2008
Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation.
    The Journal of biological chemistry, 2009, Feb-06, Volume: 284, Issue:6

    Topics: Adult; B-Lymphocytes; Cell Line; Colchicine; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Humans; Insecticides; Male; Mesencephalon; Middle Aged; Mutation; Neurons; Nocodazole; Parkinson Disease; Protein Structure, Tertiary; Rotenone; Tubulin Modulators; Ubiquitin-Protein Ligases

2009
Rotenone damages striatal organotypic slice culture.
    Annals of the New York Academy of Sciences, 2008, Volume: 1148

    Topics: Animals; Corpus Striatum; Indicators and Reagents; Insecticides; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Neurons; Nitric Oxide; Parkinson Disease; Propidium; Reactive Oxygen Species; Rotenone; Tissue Culture Techniques; Uncoupling Agents

2008
[Cellular pathophysiology of Parkinson's disease].
    Rinsho shinkeigaku = Clinical neurology, 2008, Volume: 48, Issue:11

    Topics: Agglutination; alpha-Synuclein; Caspase 3; Endoplasmic Reticulum; Humans; Lewy Bodies; Mutation; Oxidative Stress; Parkinson Disease; Phosphorylation; Protein Structure, Secondary; Quinones; Rotenone

2008
Modulation of connexin 43 in rotenone-induced model of Parkinson's disease.
    Neuroscience, 2009, Apr-21, Volume: 160, Issue:1

    Topics: Animals; Astrocytes; Blotting, Western; Brain; Cell Communication; Cells, Cultured; Connexin 43; Disease Models, Animal; Fluorescent Antibody Technique; Gap Junctions; Parkinson Disease; Phosphorylation; Random Allocation; Rats; Rats, Inbred Lew; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotenone; Signal Transduction

2009
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
    Neurobiology of disease, 2009, Volume: 34, Issue:3

    Topics: Aged; Animals; Dopamine; Electron Transport Complex I; Humans; Iron; Macaca fascicularis; Macaca mulatta; Mitochondria; Neurons; Oxidation-Reduction; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Inbred Lew; Receptors, Transferrin; Rotenone; Signal Transduction; Substantia Nigra; Transferrin

2009
Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease.
    Neurochemistry international, 2009, Volume: 55, Issue:6

    Topics: Animals; Antiparkinson Agents; Cerebellum; Cerebral Cortex; Cytoprotection; Disease Models, Animal; Male; Meclofenoxate; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Uncoupling Agents

2009
A role for a novel protein, nucleolin, in Parkinson's disease.
    Neuroscience letters, 2009, Jul-31, Volume: 459, Issue:1

    Topics: Cell Line; Cell Nucleus; Cell Survival; Cytosol; Electron Transport Complex I; Female; Humans; Male; Mitochondria; Neurons; Neurotoxins; Nucleolin; Oxidative Stress; Parkinson Disease; Phosphoproteins; Proteasome Endopeptidase Complex; RNA-Binding Proteins; Rotenone; Signal Transduction; Substantia Nigra

2009
Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease.
    Neuroscience letters, 2009, Jul-17, Volume: 458, Issue:2

    Topics: Adrenergic Agents; Animals; Cell Death; Disease Models, Animal; Embryo, Mammalian; Eye Proteins; Female; Insecticides; Nerve Growth Factors; Neurites; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Rotenone; Serpins; Tissue Culture Techniques; Tyrosine 3-Monooxygenase

2009
Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.
    Journal of translational medicine, 2009, Jun-28, Volume: 7

    Topics: Adrenergic Agents; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Culture Media, Conditioned; Dopamine; Female; Glial Cell Line-Derived Neurotrophic Factor; Humans; Mesencephalon; Nerve Growth Factors; Neuroblastoma; Neurons; Neurotoxins; Oxidopamine; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Retinal Pigment Epithelium; Rotenone

2009
Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.
    Neurobiology of disease, 2009, Volume: 36, Issue:1

    Topics: alpha-Synuclein; Animals; Body Weight; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; ELAV Proteins; ELAV-Like Protein 3; Formates; Gastrointestinal Diseases; Gastrointestinal Motility; Insecticides; Male; Neurons; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Statistics, Nonparametric

2009
Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives: their cytoprotection effect from rotenone toxicity and preliminary DMPK properties.
    Bioorganic & medicinal chemistry letters, 2009, Nov-01, Volume: 19, Issue:21

    Topics: Animals; Cytoprotection; Insecticides; Male; Microsomes, Liver; Parkinson Disease; Rats; Rotenone; Structure-Activity Relationship; Triazines

2009
HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells.
    Neuroscience letters, 2009, Dec-31, Volume: 467, Issue:3

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Apoptosis; Cell Line; Cell Survival; Dopamine; Drug Evaluation, Preclinical; Genetic Predisposition to Disease; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mice; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Rotenone; Substantia Nigra

2009
Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.
    Free radical biology & medicine, 2010, Feb-01, Volume: 48, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic Agents; alpha-Synuclein; Alternative Splicing; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dopamine Agents; Humans; Immunoblotting; Immunoenzyme Techniques; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Oxidants; Oxidopamine; Parkinson Disease; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase; Uncoupling Agents

2010
Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease.
    PloS one, 2009, Nov-18, Volume: 4, Issue:11

    Topics: alpha-Synuclein; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Electron Transport Complex I; Female; Humans; Lewy Bodies; Neurons; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Serotonin

2009
The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:3

    Topics: Acetylcysteine; Animals; Blotting, Western; Canavanine; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Immunohistochemistry; Locus Coeruleus; Male; Nerve Degeneration; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Protein Folding; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Uncoupling Agents

2010
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.
    PloS one, 2010, Jan-19, Volume: 5, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Enteric Nervous System; Mice; Mice, Inbred BALB C; Parkinson Disease; Rotenone; Stomach

2010
Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease.
    Neurobiology of disease, 2010, Volume: 40, Issue:1

    Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Dopamine; Drosophila melanogaster; Humans; Models, Genetic; Nerve Degeneration; Parkinson Disease; Rotenone

2010
Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.
    Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:1-2

    Topics: Acetylcarnitine; alpha-Synuclein; Antioxidants; Drug Synergism; Humans; Mitochondria; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Rotenone; Thioctic Acid; Ubiquitin; Uncoupling Agents

2010
Integrating multiple aspects of mitochondrial dynamics in neurons: age-related differences and dynamic changes in a chronic rotenone model.
    Neurobiology of disease, 2011, Volume: 41, Issue:1

    Topics: Aging; Animals; Cells, Cultured; Chronic Disease; Mitochondria; Mitochondrial Diseases; Models, Biological; Neurons; Parkinson Disease; Rats; Rotenone; Substantia Nigra; Uncoupling Agents

2011
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.
    Human molecular genetics, 2011, Jan-01, Volume: 20, Issue:1

    Topics: Autophagy; Cell Line, Tumor; Humans; Intracellular Signaling Peptides and Proteins; Mitochondria; Mutation; Oncogene Proteins; Oxidative Stress; Parkinson Disease; Protein Deglycase DJ-1; Protein Kinases; Rotenone; Ubiquitin-Protein Ligases

2011
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.
    Cell death & disease, 2010, Volume: 1

    Topics: 1-Methyl-4-phenylpyridinium; 14-3-3 Proteins; alpha-Synuclein; Animals; Caenorhabditis elegans; Cell Line, Tumor; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Parkinson Disease; Protein Isoforms; Proteins; RNA Interference; RNA, Small Interfering; Rotenone

2010
Rotenone, paraquat, and Parkinson's disease.
    Environmental health perspectives, 2011, Volume: 119, Issue:6

    Topics: Aged; Case-Control Studies; Female; Herbicides; Humans; Insecticides; Iowa; Male; Middle Aged; Mitochondria; North Carolina; Occupational Exposure; Oxidative Stress; Paraquat; Parkinson Disease; Parkinsonian Disorders; Rotenone

2011
Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK.
    Free radical biology & medicine, 2011, May-01, Volume: 50, Issue:9

    Topics: Aging; Animals; Antibodies, Blocking; Antigens, CD; Cell Culture Techniques; Cells, Cultured; Dopamine; Gene Expression; Intercellular Adhesion Molecule-1; Iron; Mesencephalon; Microglia; NADPH Oxidases; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Immunologic; Rotenone; Superoxides

2011
Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.
    The Journal of cell biology, 2011, Mar-07, Volume: 192, Issue:5

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Cytoplasm; Disease Models, Animal; Dopamine; Electron Transport Complex I; Mice; Microtubules; NAD; Nerve Degeneration; Parkinson Disease; Reactive Oxygen Species; Rotenone; Substantia Nigra; Vesicular Monoamine Transport Proteins

2011
Neoechinulin a impedes the progression of rotenone-induced cytotoxicity in PC12 cells.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Alkaloids; Animals; Biological Products; Cell Death; Cytoprotection; Electron Transport Complex I; Fungi; Glucose; Insecticides; Mitochondria; Parkinson Disease; PC12 Cells; Piperazines; Rats; Rotenone

2011
Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.
    Neurotoxicology, 2011, Volume: 32, Issue:6

    Topics: alpha-Synuclein; Cell Death; Cell Line, Tumor; Cytoprotection; Dopamine; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Maneb; Membrane Potential, Mitochondrial; Mutagenesis, Site-Directed; Mutation; Neurons; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Transfection

2011
14-3-3theta protects against neurotoxicity in a cellular Parkinson's disease model through inhibition of the apoptotic factor Bax.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: 14-3-3 Proteins; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Gene Expression Regulation; Immunoprecipitation; Membrane Potential, Mitochondrial; Neurotoxins; Parkinson Disease; Rotenone; Signal Transduction

2011
Protective effects of agmatine in rotenone-induced damage of human SH-SY5Y neuroblastoma cells: fourier transform infrared spectroscopy analysis in a model of Parkinson's disease.
    Amino acids, 2012, Volume: 42, Issue:2-3

    Topics: Agmatine; Cell Line, Tumor; Humans; Models, Biological; Neuroblastoma; Parkinson Disease; Rotenone; Spectroscopy, Fourier Transform Infrared

2012
Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.
    Neuroscience research, 2011, Volume: 71, Issue:4

    Topics: Animals; Antiparkinson Agents; Apoptosis; Disease Models, Animal; Levodopa; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rotenone; Thioctic Acid; Uncoupling Agents

2011
Leaf extract of Rhus verniciflua Stokes protects dopaminergic neuronal cells in a rotenone model of Parkinson's disease.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:10

    Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Dopamine; Humans; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phytotherapy; Plant Extracts; Plant Leaves; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rhus; Rotenone; Tyrosine 3-Monooxygenase

2011
Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 100, Issue:3

    Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Antioxidants; Dietary Supplements; Dopamine; Dopaminergic Neurons; Hypokinesia; Lipid Peroxides; Male; Mitochondria; Neuroprotective Agents; Parkinson Disease; Protein Carbonylation; Psychomotor Disorders; Random Allocation; Rats; Rotenone; Substantia Nigra; Survival Analysis; Thioctic Acid; Vitamin B Complex

2012
Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7.
    Journal of pharmacological sciences, 2011, Volume: 117, Issue:3

    Topics: Animals; Behavior, Animal; Benzamides; Benzodioxoles; CD11b Antigen; Cell Line, Tumor; Disease Models, Animal; Dopaminergic Neurons; Gene Knockdown Techniques; Glial Fibrillary Acidic Protein; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Neurotoxins; Oncogene Proteins; Oxidation-Reduction; Oxidative Stress; Oxidopamine; Parkinson Disease; Protein Deglycase DJ-1; Rats; Rats, Wistar; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2011
Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y.
    Neuroscience, 2011, Dec-29, Volume: 199

    Topics: Apoptosis; Autophagy; Blotting, Western; Carbamazepine; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Humans; Immunohistochemistry; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Parkinson Disease; Reactive Oxygen Species; Rotenone; Uncoupling Agents; Valproic Acid

2011
Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinson's disease.
    Neurochemistry international, 2012, Volume: 60, Issue:3

    Topics: Blotting, Western; Cell Death; Cytosol; Dopaminergic Neurons; Enzyme Activation; Humans; Immunohistochemistry; L-Lactate Dehydrogenase; Matrix Metalloproteinase 3; Mitochondria; Nerve Tissue Proteins; Parkinson Disease; Real-Time Polymerase Chain Reaction; RNA; RNA-Binding Proteins; RNA, Small Interfering; Rotenone; Serine-Arginine Splicing Factors; Silver Staining; Subcellular Fractions; Transfection; Uncoupling Agents; X-Linked Inhibitor of Apoptosis Protein

2012
The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.
    PLoS genetics, 2012, Volume: 8, Issue:2

    Topics: Adenosine Triphosphate; alpha-Synuclein; Animals; Cell Survival; Dopamine; Dopaminergic Neurons; Drosophila melanogaster; Gene Expression Regulation; Gene Silencing; HEK293 Cells; HSP90 Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Chaperones; Mutation; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; RNA, Small Interfering; Rotenone

2012
Regenerative effects of umbilical cord matrix cells (UCMCs) in a rodent model of rotenone neurotoxicity.
    Environmental toxicology and pharmacology, 2012, Volume: 34, Issue:2

    Topics: Animals; Behavior, Animal; Catalepsy; Cell Transplantation; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Neurons; Neurotoxicity Syndromes; Parkinson Disease; Pesticides; Rotenone; Substantia Nigra; Tremor; Tyrosine 3-Monooxygenase; Umbilical Cord

2012
Selective protection of nigral dopaminergic neurons by echinacoside in a rat model of Parkinson disease induced by rotenone.
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2012, Volume: 10, Issue:7

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Glycosides; Male; Neuroprotective Agents; Parkinson Disease; Random Allocation; Rats; Rats, Sprague-Dawley; Rotenone

2012
DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.
    Journal of molecular biology, 2012, Oct-19, Volume: 423, Issue:2

    Topics: Animals; Apoptosis; Cells, Cultured; Dopaminergic Neurons; Electron Transport Complex I; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Microscopy, Electron, Transmission; Mitophagy; Oncogene Proteins; Parkinson Disease; Protein Deglycase DJ-1; Rats; Rotenone; Substantia Nigra

2012
Nitrosative stress mediated misfolded protein aggregation mitigated by Na-D-β-hydroxybutyrate intervention.
    Biochemical and biophysical research communications, 2012, Sep-28, Volume: 426, Issue:3

    Topics: 3-Hydroxybutyric Acid; Apoptosis; Carrier Proteins; Caspases; Cell Line, Tumor; Dopaminergic Neurons; Green Fluorescent Proteins; Humans; Mitochondrial Diseases; Necrosis; Nerve Tissue Proteins; Neuroprotective Agents; Nitrates; Nitrosation; Oxidative Stress; Parkinson Disease; Protein Folding; Rotenone

2012
Controlled release of rasagiline mesylate promotes neuroprotection in a rotenone-induced advanced model of Parkinson's disease.
    International journal of pharmaceutics, 2012, Nov-15, Volume: 438, Issue:1-2

    Topics: Animals; Apoptosis; Behavior, Animal; Cell Line, Tumor; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Humans; Indans; Lactic Acid; Male; Microspheres; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Rotenone

2012
Amelioration of rotenone-induced dopaminergic cell death in the striatum by oxytocin treatment.
    Peptides, 2012, Volume: 38, Issue:2

    Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Cell Death; Dopaminergic Neurons; Male; Neostriatum; Oxytocin; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone

2012
Colchicine protects dopaminergic neurons in a rat model of Parkinson's disease.
    CNS & neurological disorders drug targets, 2012, Nov-01, Volume: 11, Issue:7

    Topics: Animals; Antiparkinson Agents; Behavior, Animal; Catalepsy; Colchicine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Dyskinesias; Injections, Intraperitoneal; Locomotion; Nerve Tissue Proteins; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tremor; Tubulin Modulators; Tyrosine 3-Monooxygenase

2012
Establishment of a survival and toxic cellular model for Parkinson's disease from chicken mesencephalon.
    Neurotoxicity research, 2013, Volume: 24, Issue:2

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Chick Embryo; Chickens; Drug Evaluation, Preclinical; Mesencephalon; Neuroprotective Agents; Parkinson Disease; Rotenone

2013
The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats.
    Behavioural brain research, 2013, Apr-15, Volume: 243

    Topics: alpha-Synuclein; Animals; Behavior, Animal; Disease Models, Animal; Gene-Environment Interaction; Genetic Vectors; Infusion Pumps, Implantable; Insecticides; Male; Neuropsychological Tests; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Weight Loss

2013
The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
    Neurotoxicity research, 2013, Volume: 24, Issue:1

    Topics: Acetylcysteine; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Humans; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Rotenone; Time Factors; Tretinoin; Triterpenes

2013
Role of L-thyroxin in counteracting rotenone induced neurotoxicity in rats.
    Environmental toxicology and pharmacology, 2013, Volume: 35, Issue:2

    Topics: Animals; Catalepsy; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Thyroxine; Tremor; Tyrosine 3-Monooxygenase

2013
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Aug-15, Volume: 22, Issue:16

    Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Respiration; Cytochrome c Group; DNA Damage; Drug Synergism; Electron Transport Complex I; Enzyme Inhibitors; Glutathione; Humans; Hydrogen Peroxide; Mitochondria; NADH, NADPH Oxidoreductases; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidants; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Synucleins; Time; Tumor Cells, Cultured; Ubiquitin; Uncoupling Agents

2002
Activation of adenosine triphosphate-sensitive potassium channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson's disease.
    Journal of neuroscience research, 2002, Aug-15, Volume: 69, Issue:4

    Topics: Adenosine Triphosphate; Animals; Cell Death; Dose-Response Relationship, Drug; Electron Transport Complex I; Ferrous Compounds; Glyburide; Ischemic Preconditioning; Mitochondria; NADH, NADPH Oxidoreductases; Neurons; Parkinson Disease; Parkinson Disease, Secondary; PC12 Cells; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Synthesis Inhibitors; Rats; Rotenone; Uncoupling Agents; Vasodilator Agents; Xanthine; Xanthine Oxidase

2002
Pesticide-Parkinson link explored.
    Nature medicine, 2002, Volume: 8, Issue:10

    Topics: Animals; Environmental Exposure; Humans; Insecticides; Lewy Bodies; Neurons; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rats; Rotenone

2002
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Dec-15, Volume: 22, Issue:24

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; eIF-2 Kinase; Endoplasmic Reticulum; Ganglia, Sympathetic; Gene Expression Profiling; Gene Expression Regulation; Mice; Mice, Knockout; Neurons; Oxidopamine; Parkinson Disease; PC12 Cells; Protein Folding; Rats; RNA, Messenger; Rotenone; Sympatholytics; Transcription, Genetic

2002
Rotenone neurotoxicity: a new window on environmental causes of Parkinson's disease and related brain amyloidoses.
    Experimental neurology, 2003, Volume: 179, Issue:1

    Topics: Amyloidosis; Animals; Brain; Disease Models, Animal; Environmental Exposure; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurotoxins; Parkinson Disease; Rats; Rotenone; Synucleins

2003
Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-15, Volume: 23, Issue:4

    Topics: Animals; Cells, Cultured; Dopamine; Drug Synergism; Inflammation Mediators; Insecticides; Lipopolysaccharides; Membrane Glycoproteins; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; NADPH Oxidase 2; NADPH Oxidases; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Rats, Inbred F344; Rotenone; Superoxides

2003
Selective microglial activation in the rat rotenone model of Parkinson's disease.
    Neuroscience letters, 2003, May-01, Volume: 341, Issue:2

    Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Astrocytes; Avian Proteins; Basigin; Blood Proteins; Corpus Striatum; Disease Models, Animal; Environmental Exposure; Glial Fibrillary Acidic Protein; Immunohistochemistry; Insecticides; Male; Membrane Glycoproteins; Microglia; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2003
The rotenone model of Parkinson's disease.
    Trends in neurosciences, 2003, Volume: 26, Issue:7

    Topics: Animals; Disease Models, Animal; Insecticides; Mitochondria; Parkinson Disease; Rats; Rotenone; Uncoupling Agents

2003
Molecular mechanisms of dopaminergic neurodegeneration: genetic and environmental basis.
    Annals of the New York Academy of Sciences, 2003, Volume: 993

    Topics: Animals; DNA-Binding Proteins; Dopamine; Humans; Mice; Middle Aged; Neurons; Nitric Oxide; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Rats; Rotenone; Transcription Factors; Uncoupling Agents

2003
Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jul-16, Volume: 23, Issue:15

    Topics: Acetophenones; Animals; Cells, Cultured; Coculture Techniques; Dopamine; Drug Resistance; Enzyme Inhibitors; Insecticides; Membrane Glycoproteins; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; NADPH Oxidase 2; NADPH Oxidases; Neurons; Neuroprotective Agents; Parkinson Disease; Rotenone; Superoxides

2003
Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.
    Human molecular genetics, 2004, Aug-15, Volume: 13, Issue:16

    Topics: Apoptosis; Blotting, Western; Caspase 3; Caspases; Dopamine; Enzyme Activation; Gene Expression; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Mutation; Neurons; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Tumor Cells, Cultured; Ubiquitin-Protein Ligases

2004
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Jul-20, Volume: 101, Issue:29

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Sequence; Animals; Humans; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Mutation; Nitrosation; Oxidative Stress; Parkinson Disease; Peptide Mapping; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Rotenone; S-Nitrosothiols; Ubiquitin; Ubiquitin-Protein Ligases; Uncoupling Agents

2004
Pesticides and organic agriculture.
    Environmental health perspectives, 2004, Volume: 112, Issue:15

    Topics: Agriculture; Environmental Health; Food, Organic; Humans; Insecticides; Parkinson Disease; Rotenone

2004
Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease.
    Chemical research in toxicology, 2004, Volume: 17, Issue:11

    Topics: Animals; Brain Chemistry; Cells, Cultured; Chromatography, High Pressure Liquid; Corpus Striatum; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Infusion Pumps, Implantable; Injections, Subcutaneous; Insecticides; Liver; Male; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Substantia Nigra; Uncoupling Agents

2004
Mitochondrial complex I inhibition depletes plasma testosterone in the rotenone model of Parkinson's disease.
    Physiology & behavior, 2004, Dec-15, Volume: 83, Issue:3

    Topics: Adenosine Triphosphate; Adrenal Glands; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Insecticides; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Testis; Testosterone; Time Factors

2004
Parkinson disease studies yield insights.
    JAMA, 2005, Jan-26, Volume: 293, Issue:4

    Topics: Animals; Cyclooxygenase Inhibitors; Exercise; Humans; Oxidative Stress; Parkinson Disease; Pesticides; Rotenone

2005
Possible involvement of Ca2+ signaling in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.
    Neuroscience letters, 2005, Mar-11, Volume: 376, Issue:2

    Topics: Apoptosis; Calcium; Calcium Channel Blockers; Caspases; Cell Cycle; Cell Line, Tumor; Chelating Agents; Egtazic Acid; Flow Cytometry; Humans; Intracellular Fluid; Neuroblastoma; Nifedipine; Parkinson Disease; Reactive Oxygen Species; Rotenone; Signal Transduction; Uncoupling Agents

2005
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
    International journal of molecular medicine, 2005, Volume: 15, Issue:6

    Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans; Male; Nitroglycerin; Papaverine; Parkinson Disease; Phenobarbital; Rats; Rats, Inbred Lew; Rotenone

2005
Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures.
    Neurobiology of disease, 2005, Volume: 20, Issue:3

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Brain; Cell Death; Cell Nucleus; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Glutamic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2005
PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone.
    FEBS letters, 2005, Jul-18, Volume: 579, Issue:18

    Topics: Animals; Bucladesine; Caspase 3; Caspases; Cell Differentiation; Cell Survival; Colforsin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Intracellular Membranes; Isoquinolines; MAP Kinase Signaling System; Membrane Potentials; Mitochondria; Nerve Growth Factors; Neurons; Neuropeptides; Neurosecretory Systems; Neurotransmitter Agents; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase Inhibitors; Rats; Rotenone; Signal Transduction; Sulfonamides

2005
Selective vulnerability of dopaminergic neurons to microtubule depolymerization.
    The Journal of biological chemistry, 2005, Oct-07, Volume: 280, Issue:40

    Topics: Cell Death; Colchicine; Cytosol; Dopamine; Humans; Microtubules; Nerve Degeneration; Nocodazole; Oxidative Stress; Paclitaxel; Parkinson Disease; Polymers; Receptors, Dopamine; Rotenone; Substantia Nigra; Uncoupling Agents

2005
A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease.
    Biomaterials, 2006, Volume: 27, Issue:6

    Topics: Animals; Body Weight; Calorimetry, Differential Scanning; Catalepsy; Chemical Phenomena; Chemistry, Physical; Disease Models, Animal; Drug Delivery Systems; Immunohistochemistry; Microscopy, Electron, Scanning; Microspheres; Parkinson Disease; Particle Size; Rats; Rats, Sprague-Dawley; Rotenone; Tyrosine 3-Monooxygenase; X-Ray Diffraction

2006
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
    Current biology : CB, 2005, Sep-06, Volume: 15, Issue:17

    Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Blotting, Western; Cluster Analysis; Computational Biology; Crosses, Genetic; Drosophila; Drosophila Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Phylogeny; Protein Deglycase DJ-1; Rotenone; Sequence Alignment; Survival Analysis

2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases

2005
Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication.
    The Journal of biological chemistry, 2005, Dec-23, Volume: 280, Issue:51

    Topics: Animals; Brain; Disease Models, Animal; Male; Mitochondria; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone

2005
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
    Human molecular genetics, 2005, Dec-15, Volume: 14, Issue:24

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Cells, Cultured; Dopamine; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mutation; Nitric Oxide Donors; Nitroso Compounds; Paraquat; Parkinson Disease; Proteasome Endopeptidase Complex; Reference Values; Rotenone; Solubility; Stress, Physiological; Ubiquitin-Protein Ligases

2005
Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease.
    Neurochemistry international, 2006, Volume: 48, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Biopterins; Cell Line; Cytochromes c; Dopamine; Humans; Membrane Potentials; Mitochondria; Oxidative Stress; Parkinson Disease; Rotenone

2006
In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease.
    The Journal of biological chemistry, 2006, May-19, Volume: 281, Issue:20

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dependovirus; Disease Models, Animal; Electron Transport Complex I; Glial Fibrillary Acidic Protein; Mice; NADH Dehydrogenase; Parkinson Disease; Rotenone; Saccharomyces cerevisiae Proteins; Substantia Nigra; Tyrosine 3-Monooxygenase; Uncoupling Agents

2006
Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.
    Molecular & cellular proteomics : MCP, 2006, Volume: 5, Issue:7

    Topics: Age Factors; Blotting, Western; Case-Control Studies; Cell Fractionation; Cells, Cultured; Gene Expression Profiling; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Mitochondrial Proteins; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Proteomics; Reproducibility of Results; Rotenone; Sequence Analysis, Protein; Transfection

2006
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.
    Journal of neurochemistry, 2006, Volume: 97, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genetic Predisposition to Disease; Immunity, Innate; Male; Mice; Mice, Knockout; Mice, Transgenic; Microglia; Minocycline; NADPH Oxidases; Neurons; Neuroprotective Agents; Parkinson Disease; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases; Uncoupling Agents

2006
Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry.
    Analytical chemistry, 2006, Apr-01, Volume: 78, Issue:7

    Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Mitochondria; Molecular Sequence Data; Nerve Degeneration; Nervous System Diseases; Neurons; Oxidative Stress; Parkinson Disease; PC12 Cells; Protein Processing, Post-Translational; Rats; Rotenone; Tandem Mass Spectrometry

2006
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
    Neuroscience letters, 2006, May-15, Volume: 399, Issue:1-2

    Topics: alpha-Synuclein; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cytoplasm; Ferrous Compounds; Humans; Immunohistochemistry; Molsidomine; Mutation; Neuroblastoma; Oxidative Stress; Parkinson Disease; Proteasome Inhibitors; Reactive Oxygen Species; Rotenone; Thiazoles; Ubiquitin

2006
Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.
    Neurobiology of disease, 2006, Volume: 23, Issue:1

    Topics: Animals; Cell Hypoxia; Disease Models, Animal; Dopamine; Energy Metabolism; Enzyme Inhibitors; Glucose; Membrane Potentials; Mice; Mice, Knockout; Neurons; Oncogene Proteins; Organ Culture Techniques; Ouabain; Parkinson Disease; Patch-Clamp Techniques; Peroxiredoxins; Protein Deglycase DJ-1; Rotenone; Sodium-Potassium-Exchanging ATPase; Substantia Nigra; Uncoupling Agents

2006
Identification of novel proteins associated with both alpha-synuclein and DJ-1.
    Molecular & cellular proteomics : MCP, 2007, Volume: 6, Issue:5

    Topics: alpha-Synuclein; Animals; Cell Line; Intracellular Signaling Peptides and Proteins; Isotope Labeling; Parkinson Disease; Proteins; Proteomics; Rats; Rotenone

2007
Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease.
    Experimental neurology, 2007, Volume: 203, Issue:2

    Topics: Animals; Cell Size; Dendrites; Dopamine; Dopamine Plasma Membrane Transport Proteins; Herbicides; Immunohistochemistry; Male; Mesencephalon; Mice; Microscopy, Confocal; Microscopy, Immunoelectron; Mitochondria; Neurons; Paraquat; Parkinson Disease; Pyridinium Compounds; Rotenone; Substantia Nigra; Uncoupling Agents

2007
Differential effect of nerve growth factor on dopaminergic neurotoxin-induced apoptosis.
    Journal of neurochemistry, 2006, Volume: 99, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Caspases; Dopamine; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Manganese; MAP Kinase Signaling System; Nerve Growth Factor; Neurons; Neurotoxins; Parkinson Disease; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Reactive Oxygen Species; Receptor Protein-Tyrosine Kinases; Rotenone; Signal Transduction; Substantia Nigra

2006
Behavioural and neural deficits induced by rotenone in the pond snail Lymnaea stagnalis. A possible model for Parkinson's disease in an invertebrate.
    The European journal of neuroscience, 2007, Volume: 25, Issue:7

    Topics: Animals; Behavior, Animal; Central Nervous System; Disease Models, Animal; Dopamine; Electrophysiology; Humans; Insecticides; Lymnaea; Neurons; Parkinson Disease; Rotenone; Synaptic Transmission; Tyrosine 3-Monooxygenase

2007
'Rejuvenation' protects neurons in mouse models of Parkinson's disease.
    Nature, 2007, Jun-28, Volume: 447, Issue:7148

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Antiparkinson Agents; Calcium; Calcium Channels, L-Type; Dendrites; Disease Models, Animal; Disease Progression; Dopamine; Electric Conductivity; Gene Deletion; Male; Mice; Mice, Inbred C57BL; Mitochondria; Models, Neurological; Neurons; Parkinson Disease; Rotenone; Substantia Nigra

2007
Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides?
    Medical hypotheses, 2007, Volume: 69, Issue:6

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Autoimmune Diseases; Autoimmunity; Cyclic AMP; Humans; Inflammation; Mice; Models, Theoretical; Neuropeptides; Neurotoxins; Parkinson Disease; Rotenone; Treatment Outcome

2007
Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism.
    Journal of neurochemistry, 2007, Volume: 103, Issue:1

    Topics: Amobarbital; Animals; Cell Death; Cells, Cultured; Colchicine; Electron Transport Complex I; Mesencephalon; Microtubules; Neurons; Parkinson Disease; Rats; Rotenone; Serotonin; Ubiquitin-Protein Ligases

2007
Epigallocatechin gallate (EGCG) potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y cells.
    Brain research, 2007, Oct-24, Volume: 1176

    Topics: Antioxidants; Brain; Catechin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Humans; Insecticides; Neuroblastoma; Neurons; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Superoxides

2007
Dopaminergic neurons are preferentially sensitive to long-term rotenone toxicity in primary cell culture.
    Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:1

    Topics: Animals; Astrocytes; Cell Count; Cells, Cultured; Dopamine; Environmental Pollutants; Insecticides; Mesencephalon; Mice; Neurons; Parkinson Disease; Rotenone; Time Factors

2008
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells.
    Brain research, 2008, Mar-10, Volume: 1198

    Topics: Apoptosis; Cell Line, Tumor; Cell Shape; Cell Survival; Cytoprotection; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Microscopy, Electron, Transmission; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Plant Extracts; Rotenone; Tetrazolium Salts; Thiazoles

2008
Investigating convergent actions of genes linked to familial Parkinson's disease.
    Neuro-degenerative diseases, 2008, Volume: 5, Issue:3-4

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Genetic Linkage; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Parkinson Disease; Protein Serine-Threonine Kinases; Rotenone; Signal Transduction

2008
Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.
    Journal of neurochemistry, 2008, Jun-01, Volume: 105, Issue:6

    Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Female; Humans; Intracellular Signaling Peptides and Proteins; Neurons; Neuroprotective Agents; Oncogene Proteins; Oxidative Stress; Parkinson Disease; Pregnancy; Protein Deglycase DJ-1; Rats; Rats, Sprague-Dawley; Rotenone

2008
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults.
    Free radical biology & medicine, 2008, Aug-01, Volume: 45, Issue:3

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Antioxidants; Blotting, Western; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Humans; Leupeptins; Mesencephalon; Methionine Sulfoxide Reductases; Mice; Neurons; Oxidation-Reduction; Oxidoreductases; Parkinson Disease; Rats; Rotenone; Uncoupling Agents; Vitamin E

2008
Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease.
    Journal of neurochemistry, 1994, Volume: 63, Issue:5

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Dose-Response Relationship, Drug; Electron Transport Complex I; NADH, NADPH Oxidoreductases; Necrosis; Parkinson Disease; PC12 Cells; Rats; Rotenone; Substantia Nigra

1994
Neurotoxicity of nicotinamide derivatives: their role in the aetiology of Parkinson's disease.
    Biochemical Society transactions, 1993, Volume: 21 ( Pt 3), Issue:3

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Humans; Isomerism; Kinetics; L-Lactate Dehydrogenase; Neuroblastoma; Neurotoxins; Niacinamide; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Tumor Cells, Cultured

1993
Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors.
    Brain research, 1997, Nov-28, Volume: 777, Issue:1-2

    Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Cell Survival; Dopamine; Dopamine Agents; Free Radical Scavengers; Isoquinolines; Ketoglutarate Dehydrogenase Complex; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Neurons; Parkinson Disease; PC12 Cells; Rats; Rotenone; Uncoupling Agents

1997
Metabolic inhibition enhances selective toxicity of L-DOPA toward mesencephalic dopamine neurons in vitro.
    Brain research, 1997, Nov-28, Volume: 777, Issue:1-2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antioxidants; Cells, Cultured; Dizocilpine Maleate; Dopamine; Dopamine Agents; Drug Synergism; Excitatory Amino Acid Antagonists; Levodopa; Mesencephalon; NAD(P)H Dehydrogenase (Quinone); Neurons; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Uncoupling Agents

1997
Quantitative study of mitochondrial complex I in platelets of parkinsonian patients.
    Movement disorders : official journal of the Movement Disorder Society, 1998, Volume: 13, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Aged; Aged, 80 and over; Blood Platelets; Case-Control Studies; Dopamine Agents; Dose-Response Relationship, Drug; Electron Transport Complex I; Female; Humans; Insecticides; Male; Middle Aged; Mitochondria; NADH, NADPH Oxidoreductases; Neurotoxins; Parkinson Disease; Radioligand Assay; Rotenone

1998
Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins.
    Brain research, 1998, Oct-26, Volume: 809, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Coloring Agents; Cyclosporine; Dopamine Agents; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Dyes; In Situ Nick-End Labeling; Intracellular Membranes; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Parkinson Disease; PC12 Cells; Propidium; Rats; Rotenone; Uncoupling Agents

1998
Pesticide study aids Parkinson research.
    JAMA, 1999, Dec-15, Volume: 282, Issue:23

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Humans; Insecticides; Parkinson Disease; Rats; Rotenone

1999
3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells.
    Brain research, 2000, Jun-23, Volume: 868, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Dopamine; Energy Metabolism; Enzyme Inhibitors; Estrogens, Non-Steroidal; Fluorenes; Hydantoins; Isoflavones; Mitochondria; Neurons; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; PC12 Cells; Phenylethyl Alcohol; Rats; Rotenone

2000
A new link between pesticides and Parkinson's disease.
    Nature neuroscience, 2000, Volume: 3, Issue:12

    Topics: Animals; Environmental Exposure; Humans; Lewy Bodies; Nerve Tissue Proteins; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rotenone; Synucleins

2000
Chronic systemic pesticide exposure reproduces features of Parkinson's disease.
    Nature neuroscience, 2000, Volume: 3, Issue:12

    Topics: Animals; Dopamine; Dyskinesias; Electron Transport Complex I; Environmental Exposure; Lewy Bodies; Male; NADH, NADPH Oxidoreductases; Neostriatum; Nerve Degeneration; Neural Pathways; Neurons; Parkinson Disease; Parkinson Disease, Secondary; Presynaptic Terminals; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rotenone; Substantia Nigra

2000
Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease.
    Journal of neurochemistry, 2001, Volume: 76, Issue:1

    Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electron Transport Complex I; Energy Metabolism; Guinea Pigs; Hydrogen Peroxide; Mitochondria; NADH, NADPH Oxidoreductases; Oxidative Stress; Parkinson Disease; Presynaptic Terminals; Rotenone; Synaptosomes

2001
Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells.
    Brain research, 2001, Feb-09, Volume: 891, Issue:1-2

    Topics: Animals; Calcium Signaling; Cell Death; Electron Transport Complex I; Humans; Mitochondria; Models, Biological; NADH, NADPH Oxidoreductases; Nerve Degeneration; Neuroblastoma; Parkinson Disease; Reactive Oxygen Species; Rotenone; Tumor Cells, Cultured; Uncoupling Agents

2001
Neuroscience. Pesticide causes Parkinson's in rats.
    Science (New York, N.Y.), 2000, Nov-10, Volume: 290, Issue:5494

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Disease Models, Animal; Dopamine; Electron Transport Complex I; Free Radicals; Humans; Insecticides; Lewy Bodies; Mitochondria; NADH, NADPH Oxidoreductases; Neurons; Parkinson Disease; Parkinsonian Disorders; Rats; Risk Factors; Rotenone; Uncoupling Agents

2000
Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria.
    Free radical biology & medicine, 2001, Apr-15, Volume: 30, Issue:8

    Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Aminobenzoic Acid; Aminobenzoates; Animals; Aristolochic Acids; Cell Death; Cell Differentiation; Cyclosporine; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; Ion Channels; Male; Membrane Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nerve Growth Factor; para-Aminobenzoates; Parkinson Disease; PC12 Cells; Phenanthrenes; Rats; Rats, Inbred F344; Respiration; Rotenone; Trifluoperazine; Uncoupling Agents

2001
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.
    FEBS letters, 2001, Jul-06, Volume: 500, Issue:3

    Topics: alpha-Synuclein; Circular Dichroism; Dieldrin; Ditiocarb; Nerve Tissue Proteins; Paraquat; Parkinson Disease; Pesticides; Protein Binding; Protein Conformation; Protein Folding; Rotenone; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins

2001
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease.
    Journal of neurochemistry, 2002, Volume: 80, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biomarkers; Brain; Cell Survival; Corpus Striatum; Diet; Dopamine; Drug Synergism; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Male; Mice; Mice, Inbred C57BL; Mitochondria; Motor Activity; Neurons; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Tumor Cells, Cultured

2002
Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Feb-01, Volume: 22, Issue:3

    Topics: Animals; Coculture Techniques; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Male; Mesencephalon; Microglia; Monocytes; NADPH Oxidases; Neurons; Neutrophils; Parkinson Disease; Rats; Rats, Inbred F344; Rotenone; Superoxides; Time Factors; Uncoupling Agents

2002
Selected presentations and general discussion: session IX summary and research needs.
    Neurotoxicology, 2001, Volume: 22, Issue:6

    Topics: Animals; Dopamine; Humans; Neurotoxicity Syndromes; Parkinson Disease; Parkinson Disease, Secondary; Polychlorinated Biphenyls; Rotenone; Saimiri; Thiocarbamates; Uncoupling Agents

2001
Therapy of Morbus Parkinson and radical-induced neurotoxicity in the rat--in vivo voltammetric studies.
    Journal of neural transmission. Supplementum, 1992, Volume: 38

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Dopamine; Electrochemistry; Free Radicals; Haloperidol; Hydroxyindoleacetic Acid; Male; Memantine; Neurotoxins; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Serotonin; Substantia Nigra

1992