rotenone has been researched along with Neuroblastoma in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.02) | 18.7374 |
| 1990's | 1 (1.02) | 18.2507 |
| 2000's | 38 (38.78) | 29.6817 |
| 2010's | 31 (31.63) | 24.3611 |
| 2020's | 27 (27.55) | 2.80 |
| Authors | Studies |
|---|---|
| Cunha-Oliveira, T; Kovarova, J; Moreira-Soares, M; Neuzil, J; Oliveira, PJ; Pereira, FB; Pino, R; Simões, RF; Travasso, R | 1 |
| Alonso, A; Ballesteros, U; Etxaniz, A; Goñi, FM; Hervás, JH; Iriondo, MN; Montes, LR; Varela, YR | 1 |
| Arulkumar, K; Balakrishnan, R; Manimaran, D; Mohankumar, T; Namasivayam, E; Renuka, M; Sulthana, AS | 1 |
| Carrettiero, DC; Ferrari, MFR; Lima, RS | 1 |
| Agrawal, BK; Chakrabarti, S; Chakrabarti, SS; Chandan, G; Ganguly, U; Pal, S; Saini, RV; Singh, S; Thakur, R | 1 |
| Dieter, F; Eckert, GP; Esselun, C | 1 |
| Cao, X; Du, W; Gan, J; Han, B; Han, X; He, J; Li, G; Wang, T; Wang, Z; Zhao, Y; Zheng, W | 1 |
| Bang, Y; Choi, HJ; Jung, K; Kim, M; Kwon, Y; Moon, SH | 1 |
| Annunziato, L; Della Notte, S; Scorziello, A; Secondo, A; Sisalli, MJ; Ventra, C | 1 |
| Khatri, DK; Kumar, R; Preeti, K; Shirgadwar, SM; Singh, SB | 1 |
| Aleksandrova, Y; Ardashov, O; Chaprov, K; Neganova, M; Podturkina, A; Salakhutdinov, N; Volcho, K; Yandulova, E | 1 |
| Chen, RS; Chen, YC; Cheng, YC; Chiu, CC; Chiu, TJ; Hsu, CC; Hwang, TL; Liu, HF; Liu, YC; Lu, JC; Wang, HL; Wang, YT; Wei, KC; Weng, YH; Yeh, TH | 1 |
| Kim, BH; Koh, HC | 1 |
| Cediel-Ulloa, A; Forsby, A; Gabring, N; Gliga, A; Hinojosa, MG; Ivanova, E; Johansson, Y | 1 |
| Cao, X; Du, W; Gan, J; Han, B; Han, X; He, J; Li, G; Wang, T; Wang, Z; Xu, B; Zheng, W | 1 |
| Chakkittukandiyil, A; Kothandan, R; Rymbai, E; Selvaraj, D; Selvaraj, J; Sugumar, D | 1 |
| Garikapati, KK; Krishnamurthy, PT; Kumari, M; Sola, P | 1 |
| Dahlan, W; Mahamud, N; Muangnoi, C; Rodsiri, R; Songvut, P; Tansawat, R | 1 |
| Ding, Y; Huang, W; Kong, D; Li, L; Lim, K; Lu, X; Ma, B; Wang, Q; Wu, Q; Xin, C; Xu, J; Yang, ND; Zhang, C; Zhang, H; Zhou, T | 1 |
| Aladdin, A; Batista, F; Boto, P; Czinege, R; Douida, A; Robaszkiewicz, A; Szenykiv, M; Tar, K; Virág, L | 1 |
| Araujo, AK; de Barros, CM; de Sousa, GF; de Souza-Menezes, J; Guimarães, AG; Palmero, CY | 1 |
| Chamorro, B; Chioua, M; Diez-Iriepa, D; Fernández, I; García-Vieira, D; Gonzàlez-Nieto, D; Hadjipavlou-Litina, D; Iriepa, I; López-Muñoz, F; Marco-Contelles, J; Martínez-Murillo, R; Merás-Sáiz, B; Oset-Gasque, MJ | 1 |
| Chin, TY; Chueh, SH; Hu, MK; Kuo, CW; Ma, KH; Wang, CC | 1 |
| Evinová, A; Hajdúchová, D; Hatoková, Z; Kráľová-Trančíková, A; Menichová, V; Pokusa, M | 1 |
| Cheng, B; Dou, S; Shao, Z; Wang, C; Wang, H; Xu, X; Zhu, J | 1 |
| Xue, Y; Yan, F; Yu, S; Zheng, X | 1 |
| Delijewski, M; Kranner, B; Krewenka, C; Moldzio, R; Radad, K | 1 |
| Fernández-Moriano, C; Gómez-Serranillos, MP; González-Burgos, E; Iglesias, I; Lozano, R | 1 |
| Abdul Sattar Khan, M; Akbar, M; Balakrishnan, R; Elangovan, N; Essa, MM; Justin Thenmozhi, A; Manivasagam, T; Mohankumar, T; Nataraj, J | 1 |
| Chen, Y; Huang, K; Jing, X; Lei, M; Liang, Y; Lin, D; Liu, J; Peng, S; Tao, E; Wu, X; Xiao, S; Yang, L; Zeng, Z; Zheng, D; Zhou, T | 1 |
| de Bem, AF; de Oliveira, J; Engel, DF; Gabilan, NH; Lieberknecht, V; Rodrigues, ALS | 1 |
| Rajendran, M; Ramachandran, R | 1 |
| Andrieu, T; Baron, T; Bétemps, D; Chorfa, A; Hogeveen, K; Lazizzera, C; Morignat, E | 1 |
| Deng, YN; Liu, J; Qu, QM; Shi, J | 1 |
| Chang, HC; Hsu, WH; Jiang, G; Li, Q; Li, X; Wang, X; Yu, X | 1 |
| Milani, ZH; Parsons, RB; Ramsden, DB | 1 |
| Seoposengwe, K; Steenkamp, V; van Tonder, JJ | 1 |
| Essa, MM; Karthikeyan, S; Kavitha, M; Manivasagam, T; Selvakumar, GP; Subash, S; Tamilselvam, K; Thenmozhi, JA | 1 |
| Desrosiers, RR; Levros, LC; Ouazia, D; Rassart, E | 1 |
| Andreazza, AC; Grinberg, LT; Kim, HK; Lafer, B; Mendonça, KM; Nascimento, C; Young, LT | 1 |
| Fenelon, K; Hwang, MS; Kabiraj, P; Marin, JE; Mendez, L; Narayan, M; Ramirez, DA; Skouta, R; Valenzuela, CA; Varela-Ramirez, A | 1 |
| Chan, HM; Mailloux, RJ; Yumvihoze, E | 1 |
| Auwärter, V; Buerkle, H; Goebel, U; Kaufmann, K; Kempf, J; Loop, T; Roesslein, M; Ulbrich, F; Wellner, F | 1 |
| Alberghina, L; Arosio, A; Brighina, L; Colangelo, AM; Ferrarese, C; Formenti, M; Marinig, D; Riva, C; Sala, G; Stefanoni, G | 1 |
| Chidambaram, R; Dhanalakshmi, C; Essa, MM; Justin Thenmozhi, A; Manivasagam, T; Rajasankar, S; Ramkumar, M; Venkatesh Gobi, V | 1 |
| Li, M; Liu, Q; Wood, K; Yang, L; Yang, X; Zhao, P; Zhu, X | 1 |
| Feng, D; Gong, J; He, X; Ji, J; Jin, T; Li, L; Liu, C; Sun, H; Sun, J; Xiang, L; Yue, S; Zhou, R | 1 |
| Dächsel, JC; Gasser, T; Kahle, PJ; Koch, A; Lehmann-Horn, K; Lücking, CB | 1 |
| Nakaki, T; Watabe, M | 2 |
| Chang, LS; Chen, KC; Lin, SR | 1 |
| Bian, JS; Hu, LF; Lu, M; Wong, PT; Wu, ZY | 1 |
| Chung, JH; Kim, HJ; Park, HJ; Park, HK | 2 |
| Chen, S; Fan, X; Gu, Q; Le, W; Li, L; Li, X; Ming, M; Yang, D | 1 |
| Centonze, D; Ciriolo, MR; De Zio, D; Dini, L; Filomeni, G; Graziani, I; Rotilio, G | 1 |
| Duan, C; Gu, L; Liang, Y; Lu, L; Sun, X; Yang, H | 1 |
| Bauereis, B; Haskins, WE; Lebaron, RG; Renthal, R | 1 |
| Alvarez, LD; Badorrey, MS; Barreto, G; Capani, F; de Oliveira, DM; Galeano, P; Holubiec, MI; Romero, JI | 1 |
| Caccamo, D; Calabrò, E; Condello, S; Currò, M; Ferlazzo, N; Ientile, R; Magazù, S; Satriano, J | 1 |
| Lozano, AM; Monnier, PP; Nash, JE; Warre, R; Yong-Kee, CJ | 1 |
| Boulton, SJ; Keane, PC; Manning, P; McNeil, CJ; Morris, CM | 1 |
| Chen, M; Markov, O; Nguyen, HT; Sawmiller, DR | 1 |
| Lundius, EG; Stroth, N; Svenningsson, P; Terenius, L; Vukojević, V | 1 |
| Caputi, M; Lorusso, FP; Panelli, D; Panelli, P; Papa, F; Papa, S; Sardanelli, AM; Stella, A | 1 |
| Kim, HJ; Park, HJ | 1 |
| Conn, KJ; Eisenhauer, PB; Fine, RE; Gao, WW; McKeon-O'Malley, C; Ullman, MD; Wells, JM | 1 |
| Baptista, M; Betarbet, R; Cookson, MR; Greenamyre, JT; Lund, S; Panov, AV; Sherer, TB; Stout, AK | 1 |
| Inden, M; Kakimura, J; Kitamura, Y; Miyamura, A; Shimohama, S; Taniguchi, T | 1 |
| Bennett, MC; Chase, TN; Jin, X; Leng, Y; Qin, ZH; Wang, X; Wang, Y | 1 |
| Benedi, J; Molina-Jimenez, MF; Sanchez-Reus, MI | 1 |
| Allsop, D; El-Agnaf, OM; Hewitt, R; Martin, FL; Paleologou, KE; Williamson, SJ | 1 |
| Isobe, K; Kato, Y; Maruyama, W; Naoi, M; Osawa, T; Shamoto-Nagai, M; Tanaka, M | 1 |
| Betarbet, R; Greenamyre, JT; Kim, JH; Matsuno-Yagi, A; Miller, GW; Richardson, JR; Seo, BB; Sherer, TB; Testa, CM; Yagi, T | 1 |
| Andler, W; Funk, RH; Gille, G; Janetzky, B; Menke, T; Reber, F; Reichmann, H | 1 |
| Asanuma, M; Diaz-Corrales, FJ; Miyazaki, I; Ogawa, N | 1 |
| Khoshaghideh, F; Lee, HJ; Lee, SJ; Patel, S | 1 |
| Andres, D; Benedi, J; Cascales, M; Molina-Jiménez, MF; Sánchez-Reus, MI | 2 |
| Cooper, JM; Gu, M; Iravani, MM; Irvani, M; Jenner, P; King, D; Schapira, AH | 1 |
| Wang, XJ; Xu, JX | 1 |
| Jope, RS; King, TD | 1 |
| Benedí, J; Molina-Jiménez, MF; Peinado, II; Sánchez-Reus, MI | 1 |
| Greenamyre, JT; Miller, GW; Quan, Y; Richardson, JR; Sherer, TB | 1 |
| Lev, N; Melamed, E; Offen, D | 1 |
| Lai, JS; Li, PP; Warsh, JJ; Zhao, C | 1 |
| Aquilano, K; Ciriolo, MR; Rotilio, G; Vigilanza, P | 1 |
| Hu, JH; Zhao, FL; Zhu, XZ | 1 |
| Fountaine, TM; Wade-Martins, R | 1 |
| Greenamyre, JT; Matsuno-Yagi, A; Miller, GW; Panov, AV; Richardson, JR; Seo, BB; Sherer, TB; Testa, CM; Yagi, T | 1 |
| Hu, JH; Zhu, XZ | 1 |
| Chung, WG; Maier, CS; Miranda, CL | 1 |
| Nicholson, LF; Shaikh, S | 1 |
| Griffiths, HR; Lunec, J; Willets, JM; Williams, AC | 1 |
| Burkhardt, K; Kaftan, A; Schwarz, J; Storch, A | 1 |
| Bennett, JP; Borland, K; Parks, JK; Sherer, TB; Trimmer, PA; Tuttle, JB | 1 |
| Bettendorff, L; Grisar, T; Lakaye, B; Margineanu, I; Wins, P | 1 |
| Baichwal, R; Nichols, T; Rogers, TB; Sandberg, K; Schnaar, RL; Staub, GC; Walton, KM | 1 |
98 other study(ies) available for rotenone and Neuroblastoma
| Article | Year |
|---|---|
Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine.
Topics: Adrenergic Agents; Cell Differentiation; Humans; Mitochondria; Mitochondrial Dynamics; Neuroblastoma; Neurons; Oxidopamine; Rotenone; Uncoupling Agents | 2021 |
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs.
Topics: Autophagy; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cardiolipins; gamma-Aminobutyric Acid; Humans; Microtubule-Associated Proteins; Mitophagy; Neuroblastoma; Rotenone; Unilamellar Liposomes | 2022 |
PIASA, A Novel Peptide, Prevents SH-SY5Y Neuroblastoma Cells against Rotenone-induced Toxicity.
Topics: bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Survival; Humans; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Rotenone | 2023 |
BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration.
Topics: Humans; Molecular Chaperones; Neuroblastoma; Protein Aggregates; Rotenone; Sequestosome-1 Protein; tau Proteins | 2022 |
Protective effects of cyclosporine A on neurodegeneration and motor impairment in rotenone-induced experimental models of Parkinson's disease.
Topics: Animals; Cyclosporine; Humans; Models, Theoretical; Motor Disorders; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Rotenone | 2022 |
Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer and Its Control Cells.
Topics: Adenosine Triphosphate; Alzheimer Disease; Cell Line, Tumor; Citrate (si)-Synthase; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Oxidation-Reduction; Rotenone; Thioctic Acid | 2022 |
Rosmarinic Acid Attenuates Rotenone-Induced Neurotoxicity in SH-SY5Y Parkinson's Disease Cell Model through Abl Inhibition.
Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Cell Survival; Cinnamates; Depsides; Humans; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Reactive Oxygen Species; Rosmarinic Acid; Rotenone | 2022 |
Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson's disease mice model.
Topics: Animals; Autophagy; Humans; Mice; Neuroblastoma; Parkinson Disease; Rotenone; Ubiquitins; Ursolic Acid | 2023 |
L-Ornithine L-Aspartate Restores Mitochondrial Function and Modulates Intracellular Calcium Homeostasis in Parkinson's Disease Models.
Topics: Aspartic Acid; Calcium; Dipeptides; Dopaminergic Neurons; Fluorescent Dyes; Homeostasis; Humans; Mitochondria; Neuroblastoma; Ornithine; Oxidopamine; Parkinson Disease; Reactive Oxygen Species; Rotenone | 2022 |
Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk.
Topics: Animals; Antioxidants; Autophagy; Humans; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Inbred C57BL; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Phloretin; Prospective Studies; Rotenone; TOR Serine-Threonine Kinases | 2023 |
Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson's Disease Model by Alleviating Mitochondrial Dysfunction.
Topics: Animals; Cell Line, Tumor; Humans; Mitochondria; Monoterpenes; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phenotype; Reactive Oxygen Species; Rotenone | 2023 |
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
Topics: Animals; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Humans; Inflammasomes; Interleukin-6; Mice; Microglia; Neuroblastoma; Neuroinflammatory Diseases; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Receptors, Formyl Peptide; Rotenone; Tumor Necrosis Factor-alpha; Zebrafish | 2023 |
The role of CK2 in the regulation of mitochondrial autophagy induced by rotenone.
Topics: Autophagy; Cell Line, Tumor; HeLa Cells; Humans; Mitochondria; Neuroblastoma; Protein Kinases; Rotenone; Ubiquitin-Protein Ligases | 2023 |
Evaluation of mRNA markers in differentiating human SH-SY5Y cells for estimation of developmental neurotoxicity.
Topics: Animals; Cell Differentiation; Humans; Methylmercury Compounds; Neuroblastoma; Neurons; Neurotoxicity Syndromes; RNA, Messenger; Rotenone | 2023 |
LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson's Disease Cell Model.
Topics: Adenosine Triphosphate; Apoptosis; Astrocytes; Dopaminergic Neurons; Down-Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glycogen Synthase Kinase 3 beta; Humans; Neuroblastoma; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinson Disease; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rotenone | 2023 |
The identification of cianidanol as a selective estrogen receptor beta agonist and evaluation of its neuroprotective effects on Parkinson's disease models.
Topics: Animals; Catechin; Disease Models, Animal; Estrogen Receptor beta; Estrogens; Humans; Neuroblastoma; Neuroprotective Agents; Parkinson Disease; Rats; Rotenone | 2023 |
Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Drug Carriers; Gene Expression; Humans; Lipids; Mice; Nanoparticles; Neuroblastoma; Oxidative Stress; Parkinson Disease; Particle Size; Polysorbates; Rats; Rotenone | 2023 |
Untargeted metabolomics reveal pathways associated with neuroprotective effect of oxyresveratrol in SH-SY5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Humans; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Rotenone; Tandem Mass Spectrometry | 2023 |
α-Arbutin Protects Against Parkinson's Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo.
Topics: Adenosine Triphosphate; Adenylate Kinase; Animals; Antioxidants; Apoptosis; Arbutin; Autophagy; Cell Line, Tumor; Drosophila melanogaster; Drosophila Proteins; Drug Evaluation, Preclinical; Ericaceae; Female; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Rotenone; Ubiquitin-Protein Ligases | 2020 |
The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells.
Topics: Apoptosis; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Chromatin; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Neuroblastoma; Nuclear Proteins; Oligomycins; Reproducibility of Results; Rotenone | 2020 |
Dermatan sulfate obtained from the Phallusia nigra marine organism is responsible for antioxidant activity and neuroprotection in the neuroblastoma-2A cell lineage.
Topics: Animals; Antioxidants; Brain Neoplasms; Cell Line, Tumor; Cell Lineage; Cell Survival; Dermatan Sulfate; Glycosaminoglycans; Lipid Peroxidation; Mice; Microscopy, Electron, Scanning; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Regeneration; Rotenone; Signal Transduction; Urochordata | 2020 |
Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Drug Evaluation, Preclinical; Free Radical Scavengers; Glucose; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Neuroblastoma; Neurons; Neuroprotection; Neuroprotective Agents; Nitrogen Oxides; Oligomycins; Oxygen; Rotenone | 2020 |
Antioxidative effect of DJ-1 is enhanced in NG108-15 cells by DPMQ-induced copper influx.
Topics: Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Chelating Agents; Copper; Glioma; Humans; Hybridomas; Hydrogen Peroxide; Mitochondria; Neuroblastoma; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Protein Deglycase DJ-1; Rats; Rotenone; Superoxide Dismutase-1 | 2021 |
Vulnerability of subcellular structures to pathogenesis induced by rotenone in SH-SY5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Insecticides; Microtubules; Mitochondria; NADPH Oxidases; Neuroblastoma; Neurodegenerative Diseases; Rotenone | 2021 |
Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway.
Topics: alpha-Synuclein; AMP-Activated Protein Kinases; Apoptosis; Cell Line, Tumor; Drug Evaluation, Preclinical; Gene Expression Regulation; Ghrelin; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; Nerve Tissue Proteins; Neuroblastoma; Oxidative Stress; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Kinases; Protein Transport; Reactive Oxygen Species; Rotenone; Signal Transduction; Sirtuin 1; Ubiquitin-Protein Ligases | 2021 |
FBXO22, ubiquitination degradation of PHLPP1, ameliorates rotenone induced neurotoxicity by activating AKT pathway.
Topics: Animals; Apoptosis; Cells, Cultured; Down-Regulation; F-Box Proteins; Gene Expression Regulation; Humans; Male; Models, Animal; Neuroblastoma; Neurotoxins; Nuclear Proteins; Parkinson Disease; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rotenone; Signal Transduction; Ubiquitination | 2021 |
The Reassessed Impact of Nicotine against Neurotoxicity in Mesencephalic Dopaminergic Cell Cultures and Neuroblastoma N18TG2 Cells.
Topics: Cell Culture Techniques; Cells, Cultured; Dopamine; Dopaminergic Neurons; Neuroblastoma; Neuroprotective Agents; Nicotine; Rotenone | 2022 |
Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Cytochromes c; Ginsenosides; Glutathione; Humans; Mitochondria; Neuroblastoma; Oxidative Stress; Panax; Reactive Oxygen Species; Rotenone; Superoxide Dismutase | 2017 |
Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis.
Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Interactions; Glycogen Synthase Kinase 3; Humans; Lipid Peroxidation; Mitochondria; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rotenone; Sesquiterpenes | 2018 |
Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy.
Topics: Analysis of Variance; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Chloroquine; Coculture Techniques; Humans; Insecticides; Interleukin-1beta; Interleukin-6; Membrane Potential, Mitochondrial; Microglia; Microscopy, Electron, Transmission; Mitochondria; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Rifampin; Rotenone | 2017 |
Duloxetine Protects Human Neuroblastoma Cells from Oxidative Stress-Induced Cell Death Through Akt/Nrf-2/HO-1 Pathway.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; Duloxetine Hydrochloride; Heme Oxygenase-1; Humans; Neuroblastoma; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rotenone | 2018 |
Fisetin protects against rotenone-induced neurotoxicity through signaling pathway.
Topics: Antioxidants; Apoptosis; Blotting, Western; Cell Line, Tumor; Down-Regulation; Flavonoids; Flavonols; Humans; Lipid Peroxidation; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone; Signal Transduction | 2019 |
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
Topics: alpha-Synuclein; Cell Death; Cell Line, Tumor; Cell Survival; Glycine; Glyphosate; Humans; Insecticides; Maneb; Melanoma; Neuroblastoma; Paraquat; Parkinson Disease; Rotenone; Transduction, Genetic | 2013 |
Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Neuroblastoma; Pentacyclic Triterpenes; Rotenone; Triterpenes | 2013 |
Isradipine prevents rotenone-induced intracellular calcium rise that accelerates senescence in human neuroblastoma SH-SY5Y cells.
Topics: Calcium; Cell Line, Tumor; Cellular Senescence; Humans; Intracellular Fluid; Isradipine; Neuroblastoma; Rotenone; Time Factors | 2013 |
Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide.
Topics: 2,4-Dinitrophenol; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Neuroblastoma; Neuroprotective Agents; Niacinamide; Nicotinamide N-Methyltransferase; Oxidopamine; Potassium Cyanide; Rotenone | 2013 |
In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Intracellular Space; Magnoliopsida; Membrane Potential, Mitochondrial; Neuroblastoma; Neuroprotective Agents; Oxidation-Reduction; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Rotenone | 2013 |
Mangiferin antagonizes rotenone: induced apoptosis through attenuating mitochondrial dysfunction and oxidative stress in SK-N-SH neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Rotenone; Xanthones | 2014 |
Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells.
Topics: Antioxidants; Catalase; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Humans; Hydrogen Peroxide; Insecticides; Mutation; Neuroblastoma; Promoter Regions, Genetic; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; RNA, Messenger; Rotenone; Transfection | 2014 |
Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction.
Topics: Cell Line, Tumor; Cell Survival; Electron Transport Complex I; Glutathione; Humans; Immunohistochemistry; Lithium Compounds; Neuroblastoma; Protein Carbonylation; Rotenone; Tyrosine; Uncoupling Agents | 2015 |
The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Cyclohexylamines; Dopamine; Endoplasmic Reticulum Stress; Humans; Neuroblastoma; Neurons; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Phenylenediamines; Reactive Oxygen Species; Rotenone | 2015 |
Superoxide produced in the matrix of mitochondria enhances methylmercury toxicity in human neuroblastoma cells.
Topics: Antimycin A; Cell Line, Tumor; Cysteine; Humans; Mercury; Methylmercury Compounds; Mitochondria; Neuroblastoma; Paraquat; Rotenone; Sulfhydryl Compounds; Superoxides | 2015 |
Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like Receptor 2 and 4.
Topics: Apoptosis; Argon; Caspase 3; Cell Line, Tumor; Humans; MAP Kinase Signaling System; Neuroblastoma; Neuroprotection; Neuroprotective Agents; Phosphorylation; Rotenone; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2015 |
Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.
Topics: alpha-Synuclein; Animals; Animals, Newborn; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Gene Expression Regulation; HSC70 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Insecticides; Mice; Mice, Inbred C57BL; Neuroblastoma; Neurons; Reactive Oxygen Species; RNA, Small Interfering; Rotenone; Time Factors; Transfection | 2016 |
Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells.
Topics: Agaricales; Agaricus; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2018 |
Neuroprotective effects of fingolimod in mouse models of Parkinson's disease.
Topics: Animals; Cell Line, Tumor; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Male; Mice; Neuroblastoma; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Receptors, Lysosphingolipid; Rotenone; Sphingosine-1-Phosphate Receptors | 2017 |
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
Topics: Alkaloids; Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Brain; Cell Line, Tumor; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Insecticides; L-Lactate Dehydrogenase; Male; MAP Kinase Signaling System; Mice; Monoamine Oxidase; Neuroblastoma; Neuroprotective Agents; Parkinson Disease, Secondary; Phenols; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rotenone; Statistics, Nonparametric; Tyrosine 3-Monooxygenase | 2017 |
Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells.
Topics: Animals; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leupeptins; Neuroblastoma; Nuclear Proteins; Oligopeptides; PC12 Cells; Proteasome Inhibitors; Rats; RNA, Messenger; Rotenone; Time Factors; Tunicamycin; Ubiquitin-Protein Ligases | 2009 |
Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Cytosol; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Fluorescent Antibody Technique, Direct; Humans; Mitochondria; Neuroblastoma; NG-Nitroarginine Methyl Ester; Nitrogen; Piperazines; Rotenone; Time Factors; Tyrosine; Uncoupling Agents; Vesicular Monoamine Transport Proteins | 2008 |
Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells.
Topics: Acetylcysteine; Apoptosis; Caspases; Cell Line, Tumor; Cobra Cardiotoxin Proteins; Cyclosporine; Cytochromes c; Elapid Venoms; Enzyme Activation; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Uncoupling Agents | 2008 |
Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function.
Topics: Apoptosis; Benzimidazoles; Carbocyanines; Cell Line, Tumor; Cell Survival; Fluorescent Dyes; Formazans; Humans; Hydrogen Sulfide; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Rotenone; Tetrazolium Salts; Uncoupling Agents | 2009 |
Tranexamic acid protects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Topics: Antifibrinolytic Agents; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cell Survival; Chemoprevention; Enzyme Induction; Humans; Insecticides; JNK Mitogen-Activated Protein Kinases; Neuroblastoma; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease, Secondary; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Receptors, Dopamine; Rotenone; Tranexamic Acid | 2009 |
Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.
Topics: Adrenergic Agents; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Culture Media, Conditioned; Dopamine; Female; Glial Cell Line-Derived Neurotrophic Factor; Humans; Mesencephalon; Nerve Growth Factors; Neuroblastoma; Neurons; Neurotoxins; Oxidopamine; Parkinson Disease; Pregnancy; Rats; Rats, Sprague-Dawley; Retinal Pigment Epithelium; Rotenone | 2009 |
Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis.
Topics: Analysis of Variance; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Humans; In Situ Nick-End Labeling; Indoles; Insecticides; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Ranitidine; Rotenone; Up-Regulation | 2009 |
Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Cell Survival; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Humans; In Vitro Techniques; Insecticides; Kaempferols; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neuroblastoma; Neuroprotective Agents; Oxygen Consumption; Protein Carbonylation; Rats; Rats, Wistar; Reactive Oxygen Species; Rotenone; Time Factors; Transfection | 2012 |
Dual effects of alpha-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells.
Topics: alpha-Synuclein; Cell Line, Tumor; Cell Survival; Dopamine; Humans; Insecticides; Mitochondrial Swelling; Neuroblastoma; Neurons; Oxidative Stress; Oxygen; Rotenone; Time Factors; Transfection | 2010 |
Proteomic insights into the protective mechanisms of an in vitro oxidative stress model of early stage Parkinson's disease.
Topics: Analysis of Variance; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme-Linked Immunosorbent Assay; Heat-Shock Proteins; Humans; Insecticides; Neuroblastoma; Oxidative Stress; Proteome; Proteomics; Rotenone; Signal Transduction; Up-Regulation | 2011 |
Paullinia cupana Mart. var. Sorbilis protects human dopaminergic neuroblastoma SH-SY5Y cell line against rotenone-induced cytotoxicity.
Topics: Antioxidants; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Humans; Insecticides; Neuroblastoma; Neurons; Oxidative Stress; Paullinia; Plant Extracts; Rotenone; Seeds | 2011 |
Protective effects of agmatine in rotenone-induced damage of human SH-SY5Y neuroblastoma cells: fourier transform infrared spectroscopy analysis in a model of Parkinson's disease.
Topics: Agmatine; Cell Line, Tumor; Humans; Models, Biological; Neuroblastoma; Parkinson Disease; Rotenone; Spectroscopy, Fourier Transform Infrared | 2012 |
Evidence for synergism between cell death mechanisms in a cellular model of neurodegeneration in Parkinson's disease.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lysosomes; Mitochondria; Naphthoquinones; Neuroblastoma; Neurotoxins; Proteasome Endopeptidase Complex; Rotenone | 2012 |
Real-time monitoring of superoxide generation and cytotoxicity in neuroblastoma mitochondria induced by 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline.
Topics: Antimycin A; Antineoplastic Agents; Carbolines; Cell Line, Tumor; Cell Respiration; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Electron Transport Complex I; Humans; Mitochondria; Neuroblastoma; Oxazines; Rotenone; Superoxides; Time Factors; Xanthenes | 2012 |
High-energy compounds promote physiological processing of Alzheimer's amyloid-β precursor protein and boost cell survival in culture.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Age Factors; Amyloid beta-Protein Precursor; Analysis of Variance; Cell Count; Cell Survival; Cells, Cultured; Cyanates; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Humans; Hydrogen Peroxide; Neuroblastoma; Phosphocreatine; Purine Nucleotides; Rotenone; Skin | 2012 |
Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Catecholamines; Cell Line, Tumor; Green Fluorescent Proteins; Herbicides; Humans; Mice; Neuroblastoma; Oxidopamine; Protein Transport; Receptors, G-Protein-Coupled; Rotenone; Sympatholytics; Uncoupling Agents | 2013 |
The mechanism of alternative splicing of the X-linked NDUFB11 gene of the respiratory chain complex I, impact of rotenone treatment in neuroblastoma cells.
Topics: Alternative Splicing; Apoptosis; Cell Line, Tumor; Electron Transport Complex I; Exons; Gene Expression Regulation; Genes, X-Linked; HEK293 Cells; HeLa Cells; Humans; Neuroblastoma; Protein Isoforms; Rotenone | 2013 |
Inhibitory effect of nicardipine on rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells.
Topics: Aniline Compounds; Apoptosis; bcl-2-Associated X Protein; Calcium; Calcium Channel Blockers; Caspase 3; Caspase 9; Cell Line, Tumor; Down-Regulation; Humans; Insecticides; JNK Mitogen-Activated Protein Kinases; Neuroblastoma; Nicardipine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Rotenone; Up-Regulation; Xanthenes | 2013 |
Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Adrenergic Agents; Blotting, Western; Caspase 3; Caspases; CCAAT-Enhancer-Binding Proteins; Enzyme Activation; Herbicides; Humans; Hydrogen Peroxide; Insecticides; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Oxidants; Oxidopamine; Polymerase Chain Reaction; RNA, Messenger; Rotenone; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured; Up-Regulation | 2002 |
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Respiration; Cytochrome c Group; DNA Damage; Drug Synergism; Electron Transport Complex I; Enzyme Inhibitors; Glutathione; Humans; Hydrogen Peroxide; Mitochondria; NADH, NADPH Oxidoreductases; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidants; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Synucleins; Time; Tumor Cells, Cultured; Ubiquitin; Uncoupling Agents | 2002 |
Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Caspase Inhibitors; Caspases; Endoplasmic Reticulum; Humans; Mitochondria; Neuroblastoma; Rotenone; Tumor Cells, Cultured | 2002 |
Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells.
Topics: Active Transport, Cell Nucleus; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Molecular Chaperones; Neoplasm Proteins; Neuroblastoma; Neurons; Neuroprotective Agents; NF-kappa B; Prostaglandins A; Rotenone; Uncoupling Agents | 2002 |
Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Coumarins; Flavonoids; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Rotenone | 2003 |
Fe(II)-induced DNA damage in alpha-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.
Topics: alpha-Synuclein; Amino Acid Substitution; Cell Line, Tumor; Comet Assay; Cytarabine; DNA; DNA Damage; DNA Repair; Dopamine; Electron Transport; Ferrous Compounds; Humans; Hydroxyurea; Nerve Tissue Proteins; Neuroblastoma; Rotenone; Synucleins; Transfection; Uncoupling Agents | 2003 |
An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells.
Topics: Acrolein; Apoptosis; Cysteine Endopeptidases; Humans; Inclusion Bodies; Mitochondria; Multienzyme Complexes; Neuroblastoma; Neurons; Oxidation-Reduction; Proteasome Endopeptidase Complex; Rotenone; Tumor Cells, Cultured; Uncoupling Agents | 2003 |
Mechanism of toxicity in rotenone models of Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Cell Death; Cell Line; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Enzyme Inhibitors; Humans; In Vitro Techniques; Mesencephalon; Neuroblastoma; Neurons; Neuroprotective Agents; Olfactory Bulb; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Inbred Lew; Rotenone; Time | 2003 |
Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential.
Topics: Antioxidants; Apoptosis; Benzimidazoles; Carbocyanines; Coenzymes; Cytoprotection; Electron Transport; Electron Transport Complex I; Energy Metabolism; Enzyme Inhibitors; Fluorescent Dyes; Humans; Membrane Potentials; Mitochondria; Neuroblastoma; Neurons; Rotenone; Tumor Cells, Cultured; Ubiquinone | 2003 |
Rotenone induces disassembly of the Golgi apparatus in the rat dopaminergic neuroblastoma B65 cell line.
Topics: Animals; Apoptosis; Cell Line, Tumor; Dopamine; Endoplasmic Reticulum; Golgi Apparatus; Nerve Degeneration; Neuroblastoma; Neurons; Rats; Rotenone; Uncoupling Agents | 2004 |
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.
Topics: alpha-Synuclein; Animals; Cell Compartmentation; Cell Death; Cell Survival; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dimethyl Sulfoxide; Enzyme Inhibitors; Gene Expression; Humans; Inclusion Bodies; Lysosomes; Macromolecular Substances; Nerve Tissue Proteins; Neuroblastoma; Neurodegenerative Diseases; Neurons; Rats; Rats, Sprague-Dawley; Rotenone; Synucleins; Time Factors; Transfection; Uncoupling Agents | 2004 |
Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.
Topics: Acetylcysteine; Analysis of Variance; Apoptosis; Blotting, Southern; Cell Line, Tumor; Cell Survival; Coumarins; DNA; Dose-Response Relationship, Drug; Ethidium; Flavonoids; Fluoresceins; Glutathione; Humans; Lipid Peroxidation; Microscopy, Confocal; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Rotenone; Time Factors | 2004 |
Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms.
Topics: 1-Methyl-4-phenylpyridinium; Aconitate Hydratase; Antioxidants; Benzothiazoles; Carbocyanines; Caspase 3; Caspases; Cell Count; Cell Death; Cell Line, Tumor; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Flow Cytometry; Humans; Jurkat Cells; L-Lactate Dehydrogenase; Mitochondria; Necrosis; Neuroblastoma; Pramipexole; Rotenone; Thiazoles | 2004 |
Possible involvement of Ca2+ signaling in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Calcium; Calcium Channel Blockers; Caspases; Cell Cycle; Cell Line, Tumor; Chelating Agents; Egtazic Acid; Flow Cytometry; Humans; Intracellular Fluid; Neuroblastoma; Nifedipine; Parkinson Disease; Reactive Oxygen Species; Rotenone; Signal Transduction; Uncoupling Agents | 2005 |
Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress.
Topics: bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Hydrogen Peroxide; Lithium; Neuroblastoma; Neurons; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rotenone; Uncoupling Agents | 2005 |
Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.
Topics: Acetylcysteine; Antioxidants; Blotting, Northern; Blotting, Western; Catalase; Coumarins; Cytosol; Dose-Response Relationship, Drug; Flavonoids; Flow Cytometry; Fluorescence; Glutathione Peroxidase; Glutathione Reductase; HSP70 Heat-Shock Proteins; Humans; Immunoblotting; Luminescent Measurements; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Tumor Cells, Cultured | 2005 |
Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Count; Cell Line, Tumor; Cell Survival; Coumarins; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glutathione; Humans; Insecticides; Mitochondria; Neuroblastoma; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rotenone | 2005 |
Paraquat neurotoxicity is distinct from that of MPTP and rotenone.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Brain; Cell Line, Tumor; Dopamine Agents; Dose-Response Relationship, Drug; Herbicides; Humans; Insecticides; Mitochondria; Neuroblastoma; Neurons; Paraquat; Rotenone; Substrate Specificity | 2005 |
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
Topics: alpha-Synuclein; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cytoplasm; Ferrous Compounds; Humans; Immunohistochemistry; Molsidomine; Mutation; Neuroblastoma; Oxidative Stress; Parkinson Disease; Proteasome Inhibitors; Reactive Oxygen Species; Rotenone; Thiazoles; Ubiquitin | 2006 |
Cytoprotection by lithium and valproate varies between cell types and cellular stresses.
Topics: Antimanic Agents; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cytochromes c; Cytoprotection; Electron Transport Complex I; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; Glioma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hydrogen Peroxide; Lithium Compounds; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rotenone; Thapsigargin; Up-Regulation; Valproic Acid | 2006 |
Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1.
Topics: Cell Line, Tumor; Homeostasis; Humans; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Rotenone; Superoxide Dismutase; Superoxide Dismutase-1 | 2006 |
Monocyte-mediated rotenone neurotoxicity towards human neuroblastoma SH-SY5Y: role of mitogen-activated protein kinases.
Topics: Apoptosis; Cell Communication; Cell Line; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Mitogen-Activated Protein Kinases; Monocytes; Neuroblastoma; Rotenone | 2006 |
ATP depletion does not account for apoptosis induced by inhibition of mitochondrial electron transport chain in human dopaminergic cells.
Topics: Adenosine Triphosphate; Annexin A5; Apoptosis; Cell Line, Tumor; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Neuroblastoma; Oxidants; Protein Carbonylation; Reactive Oxygen Species; Rotenone; Uncoupling Agents | 2007 |
RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Blotting, Western; Cell Line, Tumor; Cell Survival; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluorescent Antibody Technique; Humans; Neuroblastoma; Neurons; Neurotoxins; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Rotenone; Transfection | 2007 |
Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease.
Topics: Adenosine Triphosphate; alpha-Tocopherol; Animals; Animals, Newborn; Antioxidants; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Electron Transport Complex I; Humans; In Vitro Techniques; Male; Mesencephalon; Mitochondria; NADH Dehydrogenase; Neuroblastoma; Pesticides; Protein Carbonylation; Rats; Rats, Inbred Lew; Rotenone; Saccharomyces cerevisiae Proteins; Tyrosine 3-Monooxygenase | 2007 |
Rotenone-induced neurotoxicity of THP-1 cells requires production of reactive oxygen species and activation of phosphatidylinositol 3-kinase.
Topics: Analysis of Variance; Cell Line; Culture Media, Conditioned; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Insecticides; Monocytes; Neuroblastoma; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Rotenone; Tetrazolium Salts; Thiazoles; Up-Regulation | 2007 |
Epigallocatechin gallate (EGCG) potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Brain; Catechin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Humans; Insecticides; Neuroblastoma; Neurons; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone; Superoxides | 2007 |
Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation.
Topics: alpha-Synuclein; Cell Line, Tumor; Cross-Linking Reagents; Glycation End Products, Advanced; Humans; Inclusion Bodies; Neuroblastoma; Reactive Oxygen Species; Recombinant Proteins; Rotenone | 2008 |
Neurotoxicity of nicotinamide derivatives: their role in the aetiology of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Humans; Isomerism; Kinetics; L-Lactate Dehydrogenase; Neuroblastoma; Neurotoxins; Niacinamide; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Tumor Cells, Cultured | 1993 |
1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Electron Transport Complex II; Energy Metabolism; Glucose; Herbicides; Humans; Isoquinolines; Mitochondria; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Neuroblastoma; Oxidoreductases; Parkinson Disease, Secondary; Rotenone; Succinate Dehydrogenase; Tumor Cells, Cultured; Uncoupling Agents | 2000 |
Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells.
Topics: Animals; Calcium Signaling; Cell Death; Electron Transport Complex I; Humans; Mitochondria; Models, Biological; NADH, NADPH Oxidoreductases; Nerve Degeneration; Neuroblastoma; Parkinson Disease; Reactive Oxygen Species; Rotenone; Tumor Cells, Cultured; Uncoupling Agents | 2001 |
ATP-driven, Na(+)-independent inward Cl- pumping in neuroblastoma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Cell Membrane Permeability; Chlorides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Intracellular Fluid; Ion Transport; Ionophores; Mice; Neuroblastoma; RNA, Messenger; Rotenone; Sodium; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Tumor Cells, Cultured; Uncoupling Agents | 2002 |
Characterization of the binding and internalization of tetanus toxin in a neuroblastoma hybrid cell line.
Topics: Animals; Binding, Competitive; Cell Line; Chromatography, Thin Layer; Drug Resistance; Gangliosides; Hybrid Cells; Membrane Proteins; Mice; Neuroblastoma; Oligomycins; Pronase; Rats; Receptors, Cholinergic; Rotenone; Temperature; Tetanus Toxin | 1986 |