rotenone has been researched along with Innate Inflammatory Response in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (7.02) | 29.6817 |
| 2010's | 31 (54.39) | 24.3611 |
| 2020's | 22 (38.60) | 2.80 |
| Authors | Studies |
|---|---|
| Bao, XQ; Li, G; Ma, J; Ning, J; Shang, M; Zhang, D; Zhao, Z | 1 |
| Akindahunsi, AA; Akinmoladun, AC; Famusiwa, CD; Josiah, SS; Lawal, AO; Olaleye, MT | 1 |
| Akindahunsi, AA; Akinmoladun, AC; Crown, OO; Famusiwa, CD; Josiah, SS; Lawal, AO; Olaleye, MT | 1 |
| Anantharam, V; Charli, A; Jin, H; Kanthasamy, A; Kanthasamy, AG; Malovic, E; Palanisamy, BN; Samidurai, M; Sarkar, S; Zenitsky, G | 1 |
| Assmann, CE; Barbisan, F; da Cruz, IBM; Jung, IEDC; Mastella, MH; Melazzo, C; Morais-Pinto, L; Roggia, I; Teixeira, CF; Turra, BO; Vidal, T | 1 |
| Si, Y; Sun, L; Yan, Z; Yang, F; Yao, L; Yu, J | 1 |
| Ahmed, MK; Budzyńska, B; El Sayed, NS; Kandil, EA; Sayed, AS; Skalicka-Woźniak, K | 1 |
| Adem, A; Azimullah, S; Beiram, R; Jalal, FY; Jayaraj, RL; Meeran, MFN; Ojha, S | 1 |
| Cai, Z; Chen, J; Fu, C; Li, M; Liu, X; Lu, R; Ming, Q; Peng, Y; Xie, A; Xie, Z; Zhang, H; Zheng, D; Zhong, J | 1 |
| Abdelrazik, E; Abdulhai, EA; Elnagdy, MH; Ezz Elregal, FM; Hamza, E; Hassan, HM | 1 |
| Arunachalam, S; Ayoob, K; Azimullah, S; Beiram, R; Meeran, MFN; Ojha, S | 1 |
| Cadet, P; Neuwirth, LS; Zhu, W | 1 |
| Cardoso, FDS; de Andrade, GM; de Barros Viana, GS; de Castro Brito, GA; Dos Santos, JCC; Lima, MPP; Nascimento, TS; Oliveira, AV; Oliveira, LF; Rebouças, CDSM | 1 |
| Aghsami, M; Ashabi, G; Fartoosi, A; Kheradmand, A; Montazeri, H; Salari, Z; Shariatpanahi, M | 1 |
| Cheng, J; Li, H; Liu, Q; Wang, F; Wang, Y; Yang, J | 1 |
| Chen, AD; Jing, YH; Wang, DX; Wang, QJ; Xin, YY; Yin, J | 1 |
| Al-Emam, A; Al-Shraim, M; Kranner, B; Moldzio, R; Radad, K; Rausch, WD; Wang, F | 1 |
| Geng, Y; Liu, Y; Xu, W; Zhang, L; Zhang, N | 1 |
| Cheng, Q; Ding, F; Shen, M; Xu, H; Yu, S; Zhang, Q; Zhou, J | 1 |
| Ateş, PS; Emekli-Alturfan, E; Ünal, İ; Üstündağ, ÜV; Yurtsever, İ | 1 |
| Bowles, KR; Goate, AM; Gupta, I; Herbinet, M; Machlovi, SI; Marcora, E; Pimenova, AA | 1 |
| Du, G; Kong, D; Liang, Y; Song, J; Wei, G; Zhao, X; Zhou, Q | 1 |
| Altinoz, MA; Alturfan, AA; Cansız, D; Elmacı, İ; Emekli-Alturfan, E; Ünal, İ; Üstündağ, ÜV | 1 |
| Cacabelos, R; Egea, J; Farré-Alins, V; González-Lafuente, L; Parada, E; Ramos, E; Romero, A | 1 |
| Anusha, C; Joseph, LD; Sumathi, T | 1 |
| Bao, Z; Lu, G; Tong, Z; Tu, L; Yan, B; Yang, G; Yao, Y; Zhang, P; Zhou, J | 1 |
| Abd El Fattah, MA; Ahmed, LA; El-Sayeh, BM; Kandil, EA; Sayed, RH | 1 |
| Berwin, BL; Havrda, MC; Martinez, EM; Patankar, YR; von Herrmann, KM; Wang, L; Weier, JM; Young, AL | 1 |
| Chen, WJ; Du, JK; Hu, X; Li, DX; Liu, YJ; Wang, CN; Yu, Q; Zhu, XY | 1 |
| Azmy, MS; El-Naga, RN; Menze, ET; Tadros, MG | 1 |
| Bicca, MA; Hara, DB; Morais, LH; Poli, A; Takahashi, RN | 1 |
| Stanford, KR; Taylor-Clark, TE | 1 |
| Han, W; Li, X; Liu, Q; Lu, X; Qian, Y; Yang, W; Zhang, T; Zhao, K | 1 |
| Chen, L; Ge, X; Hua, H; Huang, S; Jia, Z; Wu, M; Yang, G; Zhang, A; Zhang, Y; Zhu, C | 1 |
| Elmazoglu, Z; Karasu, C; Sonmez, C; Yar Saglam, AS | 1 |
| Hong, JS; Huang, C; Li, H; Liu, J; Song, S; Wang, Y; Zhang, F | 1 |
| Fang, Q; Homberg, JR; Li, W; Liao, P; Liu, C; Luan, Y; Meng, X; Shan, L; Shen, J; Swaab, DF; Wang, J; Zhou, P | 1 |
| Hayashi, Y; Meng, J; Nakanishi, H; Ni, J; Peters, C; Qing, H; Stoka, V; Turk, V; Wu, Z | 1 |
| Feng, B; Mu, J; Qi, W; Tang, JY; Wei, Y; Wu, Q; Yang, LL; Zeng, W; Zhang, Q | 1 |
| Chen, L; Fransisca, S; Gu, X; Hu, Z; Liu, Q; Lv, X; Qian, H; Xie, P; Zhang, Z | 1 |
| Adem, A; Azimullah, S; Beiram, R; Jalal, FY; Jayaraj, RL; Meeran, MFN; Ojha, SK | 1 |
| Cai, Z; Fan, LW; Kaizaki, A; Lin, RC; Lin, S; Ma, T; Pang, Y; Simpson, KL; Tien, LT | 1 |
| Beretta, O; Conforti-Andreoni, C; Derks, H; Lai, J; Laudisi, F; Liang Qian, H; Licandro, G; Ling Khor, H; Mortellaro, A; Ricciardi-Castagnoli, P; Teng, GG | 1 |
| Cannon, JR; Greenamyre, JT; Tapias, V | 1 |
| Nehru, B; Thakur, P | 2 |
| Ding, G; Huang, S; Jia, Z; Sun, Y; Zhang, A; Zhang, Y; Zhao, D | 1 |
| Ding, W; Wang, B; Xu, C; Zhang, M | 1 |
| Elbatsh, MM; Gaballah, HH; Tahoon, NM; Zakaria, SS | 1 |
| Brody, KM; Crack, PJ; Kirby, FJ; Main, BS; Taylor, JM; Zhang, M | 1 |
| Cheema, P; Fain, JN; Madan, AK; Tichansky, DS | 1 |
| Argüelles, S; Bández, MJ; Cano, J; de Pablos, RM; Delgado-Cortés, MJ; Espinosa-Oliva, AM; Hernández-Romero, MC; Herrera, AJ; Machado, A; Mauriño, R; Santiago, M; Sarmiento, M; Venero, JL; Villarán, RF | 1 |
| Billiar, TR; Kang, R; Livesey, KM; Lotze, MT; Loux, T; Schapiro, NE; Tang, D; Van Houten, B; Wang, H; Zeh, HJ | 1 |
| Connelly, L; Hobbs, AJ; Madhani, M | 1 |
| Staines, DR | 1 |
| James-Kracke, M; Miller, RL; Sun, AY; Sun, GY | 1 |
| Alencar, NM; Aragão, KS; Assreuy, AM; Cavada, BS; Cavalcante, CF; Leite, KB; Nogueira, NA; Vale, MR; Vasconcelos, MP | 1 |
2 review(s) available for rotenone and Innate Inflammatory Response
| Article | Year |
|---|---|
Rotenone: from modelling to implication in Parkinson's disease.
Topics: Animals; Cell Death; Disease Models, Animal; Humans; Inflammation; Parkinson Disease; Reactive Oxygen Species; Rotenone | 2019 |
Oxidative and inflammatory pathways in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Herbicides; Humans; Inflammation; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neurotoxins; Nitric Oxide Synthase; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Kinase C; Rotenone | 2009 |
55 other study(ies) available for rotenone and Innate Inflammatory Response
| Article | Year |
|---|---|
Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis.
Topics: Animals; Brain-Gut Axis; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Parkinson Disease; Rotenone; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Dihydroquercetin improves rotenone-induced Parkinsonism by regulating NF-κB-mediated inflammation pathway in rats.
Topics: Animals; Disease Models, Animal; Inflammation; Male; Neuroprotective Agents; NF-kappa B; Parkinsonian Disorders; Quercetin; Rats; Rats, Wistar; Rotenone | 2022 |
Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats.
Topics: Animals; Catechin; Dopamine; Genes, p53; Inflammation; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Parkinsonian Disorders; Quercetin; Rats; Rats, Wistar; Rotenone; Tumor Necrosis Factor-alpha | 2022 |
Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Park
Topics: Animals; Brain-Gut Axis; Inflammation; Mitochondria; Neuroglia; Parkinson Disease; Pesticides; Rats; Rotenone | 2022 |
Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm.
Topics: Animals; Inflammation; Oligochaeta; Plastics; Receptors, Nicotinic; Rotenone; Soil; Soil Pollutants; Superoxides | 2022 |
Role of gut microbiota-derived branched-chain amino acids in the pathogenesis of Parkinson's disease: An animal study.
Topics: Amino Acids, Branched-Chain; Animals; Gastrointestinal Microbiome; Inflammation; Interleukin-6; Lipopolysaccharides; Mice; Parkinson Disease; RNA, Ribosomal, 16S; Rotenone; Tumor Necrosis Factor-alpha | 2022 |
Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model.
Topics: alpha-Synuclein; Animals; Antioxidants; Dopamine; Dopaminergic Neurons; Inflammation; Methoxsalen; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease, Secondary; Rats; Rats, Wistar; Rotenone; Signal Transduction | 2022 |
Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy.
Topics: alpha-Synuclein; Antioxidants; Apoptosis; Autophagy; Cytokines; Dopaminergic Neurons; Humans; Inflammation; Oxidative Stress; Parkinson Disease; Rotenone | 2023 |
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Topics: Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Humans; Inflammation; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Poly (ADP-Ribose) Polymerase-1; Rotenone | 2023 |
Beneficial role of rosemary extract on oxidative stress-mediated neuronal apoptosis in rotenone-induced attention deficit hyperactivity disease in juvenile rat model.
Topics: Animals; Apoptosis; Disease Models, Animal; Inflammation; Neurons; Olive Oil; Oxidative Stress; Rats; Rosmarinus; Rotenone | 2023 |
Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats.
Topics: Animals; Antioxidants; Apoptosis; Cytokines; Dopaminergic Neurons; Glutamic Acid; Humans; Inflammation; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rotenone | 2023 |
Regulation of the Endogenous Opiate Signaling Pathway against Oxidative Stress and Inflammation: A Considerable Approach for Exploring Preclinical Treatment of Parkinson's Disease.
Topics: Animals; Dopaminergic Neurons; Humans; Inflammation; Morphine; Naloxone; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxidative Stress; Oxidopamine; Parkinson Disease; Rotenone; Signal Transduction | 2023 |
The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease.
Topics: Animals; Brain; Brain-Gut Axis; Inflammation; Parkinson Disease; Rats; Rotenone | 2023 |
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson's disease model.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Catalase; Disease Models, Animal; Inflammation; Interleukin-6; Male; Neuroprotective Agents; Parkinson Disease; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Rotenone; Sericins; Signal Transduction; Tumor Necrosis Factor-alpha | 2023 |
Neuroprotective effects of increasing levels of HSP70 against neuroinflammation in Parkinson's disease model by inhibition of NF-κB and STAT3.
Topics: Apoptosis; Cell Line; Down-Regulation; HSP70 Heat-Shock Proteins; Humans; Inflammation; Neuroprotective Agents; NF-kappa B; Parkinson Disease, Secondary; RNA, Messenger; Rotenone; STAT3 Transcription Factor | 2019 |
Protective effect of metformin against rotenone-induced parkinsonism in mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Inflammation; Interleukin-1beta; Male; Metformin; Mice; Mice, Inbred C57BL; Microglia; Parkinson Disease, Secondary; Protective Agents; Rotenone; Tumor Necrosis Factor-alpha | 2020 |
Long noncoding RNA GAS5 promotes microglial inflammatory response in Parkinson's disease by regulating NLRP3 pathway through sponging miR-223-3p.
Topics: Animals; Behavior, Animal; Binding Sites; Cell Line; Computational Biology; Disease Models, Animal; Down-Regulation; Gene Knockdown Techniques; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; MicroRNAs; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; RNA, Long Noncoding; Rotenone; Substantia Nigra; Tumor Necrosis Factor-alpha; Up-Regulation | 2020 |
Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy.
Topics: Anti-Inflammatory Agents; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Inflammation; Microglia; Neuroprotective Agents; PQQ Cofactor; Rotenone | 2020 |
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish.
Topics: Animals; Calcium; Homeostasis; Inflammation; Mitochondria; Neurodegenerative Diseases; Neuroinflammatory Diseases; Oxidative Stress; Rifampin; Rotenone; Zebrafish | 2022 |
Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Line; Cytokines; Gene Expression Profiling; Gene Knockdown Techniques; Inflammation; Lipopolysaccharides; Mice; Microglia; Nitric Oxide; Peptide Fragments; Proto-Oncogene Proteins; Rotenone; Staurosporine; Trans-Activators; Uncoupling Agents | 2021 |
Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Flavanones; Flavonoids; Homeostasis; Inflammation; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neuroprotective Agents; Neurotransmitter Agents; Parkinson Disease; Protein-Tyrosine Kinases; Rotenone; Signal Transduction | 2021 |
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish.
Topics: Animals; Brain; Brain-Gut Axis; Caprylates; Disease Models, Animal; Gastrointestinal Tract; Glutathione; Inflammation; Lipid Peroxidation; Oxidative Stress; Parkinson Disease; Rotenone; Superoxide Dismutase; Zebrafish; Zebrafish Proteins | 2021 |
Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hippocampus; Humans; Inflammation; Lipopolysaccharides; Mice; Microglia; Neuroprotective Agents; Oligomycins; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Plant Preparations; Rats; Rotenone; Tissue Culture Techniques | 2017 |
Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.
Topics: Animals; Apigenin; Apoptosis; Behavior, Animal; Calcium-Transporting ATPases; Catalase; Corpus Striatum; Disease Models, Animal; Immunohistochemistry; Inflammation; Male; Nerve Growth Factors; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase | 2017 |
Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice.
Topics: Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Line; Cell Survival; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunoglobulin E; Immunoglobulin G; Inflammation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Real-Time Polymerase Chain Reaction; Rotenone | 2017 |
Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats.
Topics: alpha-Synuclein; Animals; Dabigatran; Dopamine; Dopaminergic Neurons; Inflammation; Male; Neostriatum; Neuroprotective Agents; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Rats, Wistar; Rotenone; Substantia Nigra; Thrombin | 2018 |
Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.
Topics: Animals; Behavior, Animal; Cells, Cultured; Female; Inflammation; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Parkinson Disease; Rotenone; Stomach; Substantia Nigra; Toxicity Tests, Chronic | 2017 |
Protective effects of resveratrol on mitochondrial function in the hippocampus improves inflammation-induced depressive-like behavior.
Topics: Animals; Antidepressive Agents; Antioxidants; Apoptosis; Cyclic N-Oxides; Depression; Disease Models, Animal; Food Preferences; Hippocampus; Inflammation; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred ICR; Mitochondria; Resveratrol; Rotenone; Stilbenes; Swimming; Uncoupling Agents | 2017 |
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.
Topics: alpha-Synuclein; Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Body Weight; Corpus Striatum; Filgrastim; Humans; Inflammation; Male; Mesencephalon; Microglia; Motor Activity; Nerve Growth Factors; Neuroprotective Agents; Parkinson Disease; Rats, Wistar; Rotenone; Tyrosine 3-Monooxygenase | 2018 |
Early signs of colonic inflammation, intestinal dysfunction, and olfactory impairments in the rotenone-induced mouse model of Parkinson's disease.
Topics: Animals; Brain; Colon; Disease Models, Animal; Gastrointestinal Tract; Inflammation; Mice; Neurons; Olfactory Bulb; Parkinson Disease; Peroxidase; Rotenone | 2018 |
Mitochondrial modulation-induced activation of vagal sensory neuronal subsets by antimycin A, but not CCCP or rotenone, correlates with mitochondrial superoxide production.
Topics: Action Potentials; Antimycin A; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Humans; Inflammation; Mitochondria; Nociceptors; Reactive Oxygen Species; Rotenone; Sensory Receptor Cells; Signal Transduction; Superoxides; TRPA1 Cation Channel; TRPV Cation Channels; Vagus Nerve | 2018 |
Deguelin inhibits RANKL-induced osteoclastogenesis in vitro and prevents inflammation-mediated bone loss in vivo.
Topics: Animals; Bone Diseases, Metabolic; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Gene Expression Regulation; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophages; Male; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Rotenone; Signal Transduction | 2019 |
Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Electron Transport Complex I; Inflammation; Mice; Oxidative Stress; Protective Agents; Rotenone; Uncoupling Agents | 2018 |
Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson's disease and inflammatory pathways.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Hormesis; Inflammation; L-Lactate Dehydrogenase; Luteolin; Mice; Microglia; Oxidation-Reduction; Oxidative Stress; Parkinsonian Disorders; Rotenone | 2020 |
Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats.
Topics: Animals; Circadian Clocks; Dopaminergic Neurons; Gene Expression; Inflammation; Inflammation Mediators; Insecticides; Lipopolysaccharides; Male; Nerve Degeneration; Period Circadian Proteins; Rats; Rats, Sprague-Dawley; Rotenone | 2019 |
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopaminergic Neurons; Histamine; Indoles; Inflammation; Male; Microglia; Nerve Degeneration; Parkinson Disease; Parkinsonian Disorders; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H4; Rotenone | 2019 |
Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
Topics: Aging; Animals; Cathepsin B; Cell Line; Cells, Cultured; Cognitive Dysfunction; Cytosol; DNA-Binding Proteins; High Mobility Group Proteins; Hippocampus; Inflammation; Memory; Mice, Inbred C57BL; Microglia; Mitochondria; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Rotenone; Subcellular Fractions | 2019 |
MG132 protects against renal dysfunction by regulating Akt-mediated inflammation in diabetic nephropathy.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glomerular Mesangium; Glucose; Humans; Inflammation; Inflammation Mediators; Kidney; Leupeptins; Male; Mesangial Cells; Proteasome Inhibitors; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rotenone; Signal Transduction | 2019 |
Protective effects of microRNA-22-3p against retinal pigment epithelial inflammatory damage by targeting NLRP3 inflammasome.
Topics: Animals; Base Sequence; Cell Line; Cytokines; Down-Regulation; Female; Humans; Inflammasomes; Inflammation; Light; Lipopolysaccharides; Male; Mice, Inbred BALB C; MicroRNAs; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Retinal Pigment Epithelium; RNA, Messenger; Rotenone; Up-Regulation | 2019 |
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Antioxidants; Brain; Catalase; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Glutathione; Inflammation; Inflammation Mediators; Lipid Peroxidation; Lycopodium; Male; Malondialdehyde; Matrix Metalloproteinases; Microglia; Nerve Degeneration; Neuroprotection; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Parkinson Disease; Plant Extracts; Rats, Wistar; Rotenone; Superoxide Dismutase | 2019 |
Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life.
Topics: Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Brain; Cell Count; Dopaminergic Neurons; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Inflammation; Lipopolysaccharides; Male; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Rotenone; Uncoupling Agents | 2013 |
The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.
Topics: Animals; Antioxidants; Apoptosis; Carrier Proteins; Caspase 1; Cell Survival; Cells, Cultured; Dendritic Cells; DNA Damage; DNA Repair; Enzyme Activation; Inflammasomes; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Peritonitis; Reactive Oxygen Species; Rotenone; Signal Transduction; Tumor Suppressor Protein p53; Uncoupling Agents; Uric Acid | 2013 |
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
Topics: Animals; Caspase 3; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Lythraceae; Male; Mitochondrial Diseases; Nitric Oxide Synthase Type II; Oxidative Stress; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Tyrosine | 2014 |
Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone in the rotenone model of Parkinson's disease.
Topics: Animals; Antioxidants; Astrocytes; Carbenoxolone; Citrulline; Cytokines; Disease Models, Animal; Electron Transport; Enzyme Activation; Glial Fibrillary Acidic Protein; Glutathione; Inflammation; Inflammation Mediators; Male; Mesencephalon; Mitochondria; Nervous System; Nitric Oxide; Nitric Oxide Synthase Type II; Parkinson Disease; Rats, Sprague-Dawley; Rotenone | 2015 |
Rotenone remarkably attenuates oxidative stress, inflammation, and fibrosis in chronic obstructive uropathy.
Topics: Animals; Fibrosis; Immunohistochemistry; Inflammation; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Rotenone; Ureteral Obstruction | 2014 |
Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation.
Topics: Adenosine Triphosphate; Aldosterone; Animals; Carrier Proteins; DNA, Mitochondrial; Glomerulosclerosis, Focal Segmental; Immunohistochemistry; Inflammasomes; Inflammation; Kidney; Male; Malondialdehyde; Microscopy, Electron; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Rotenone; Thiobarbituric Acid Reactive Substances; Transcription Factor RelA | 2015 |
Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Chemically-Induced Disorders; Disease Models, Animal; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Inflammation; Male; Membrane Proteins; Parkinson Disease; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Resveratrol; Rotenone; Stilbenes; Transcription Factor CHOP | 2016 |
Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone.
Topics: Animals; Antibodies, Monoclonal; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Female; Immunity, Innate; Inflammation; Inflammation Mediators; Interferon Type I; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotoxicity Syndromes; Pregnancy; Rotenone | 2017 |
Dexamethasone and the inflammatory response in explants of human omental adipose tissue.
Topics: Adipose Tissue; Adult; Anti-Inflammatory Agents; Dexamethasone; Female; Gene Expression Profiling; Humans; Inflammation; Interleukin-8; Omentum; RNA, Messenger; Rotenone; Tissue Culture Techniques; Uncoupling Agents; Up-Regulation | 2010 |
Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system.
Topics: Animals; Astrocytes; Basal Ganglia; Blood-Brain Barrier; C-Reactive Protein; Carrageenan; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Encephalitis; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Rotenone; Striatonigral Degeneration; Substantia Nigra; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Catalase; Cytokines; Dopamine; Homovanillic Acid; Inflammation; Male; Monoamine Oxidase; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Sodium Salicylate | 2013 |
The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics.
Topics: Adenosine Triphosphate; Animals; Butadienes; CD24 Antigen; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cycloheximide; Electron Transport Complex I; Energy Metabolism; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; HMGB1 Protein; Humans; Inflammation; MAP Kinase Kinase 2; Mice; Mitochondria; NF-kappa B; Nitriles; Pancreatic Neoplasms; Phosphorylation; Protein Binding; Protein Synthesis Inhibitors; Receptor for Advanced Glycation End Products; RNA Interference; RNA, Small Interfering; Rotenone; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Microenvironment; Uncoupling Agents | 2014 |
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo.
Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Chromones; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rotenone; Sepsis; Shock, Septic; Time Factors; Tissue Distribution | 2005 |
Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides?
Topics: Adenosine Triphosphate; Animals; Apoptosis; Autoimmune Diseases; Autoimmunity; Cyclic AMP; Humans; Inflammation; Mice; Models, Theoretical; Neuropeptides; Neurotoxins; Parkinson Disease; Rotenone; Treatment Outcome | 2007 |
Anti-inflammatory and antimicrobial effect of lectin from Lonchocarpus sericeus seeds in an experimental rat model of infectious peritonitis.
Topics: Animals; Bacteria; Cell Movement; Derris; Inflammation; Lectins; Male; Neutrophils; Peritonitis; Plant Extracts; Rats; Rats, Wistar; Seeds | 2005 |