rotenone has been researched along with Degenerative Diseases, Central Nervous System in 58 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (29.31) | 29.6817 |
| 2010's | 15 (25.86) | 24.3611 |
| 2020's | 26 (44.83) | 2.80 |
| Authors | Studies |
|---|---|
| Battaglini, M; Ciofani, G; Desii, A; Genchi, G; Lavarello, C; Marino, A; Petretto, A | 1 |
| Chen, Z; Gu, H; Hu, Y; Huang, Y; Li, H; Shen, L; Shen, Y; Sun, B; Xu, X; Yang, J; Zhang, J | 1 |
| Adebayo, OG; Adebayo, OR; Aduema, W; Ajayi, AM; Akpakpan, E; Ben-Azu, B; Emmanuel, MU; Onuoha, OG; Orji, BO | 1 |
| Bian, L; Guo, J; Li, J; Li, Q; Shi, J; Wan, G; Wang, X; Wang, Y; Wei, X; Yang, X; Yao, Z | 1 |
| Barbiero, JK; Bassani, T; Boschen, S; Da Cunha, C; Ramos, DC; Vital, MABF | 1 |
| Asanuma, M; Imafuku, F; Isooka, N; Kamimai, S; Kikuoka, R; Kitamura, Y; Miyazaki, I; Okamoto, Y; Shimizu, T; Sun, J; Toyota, T | 1 |
| Dolrahman, N; Mukkhaphrom, W; Sutirek, J; Thong-Asa, W | 1 |
| Jiang, Z; Li, H; Li, Y; Ma, J; Qian, Z; Zhou, S; Zhou, X | 1 |
| Khatri, DK; Kumar, R; Preeti, K; Shirgadwar, SM; Singh, SB | 1 |
| da Silva Martins, C; de Barros Viana, GS; de Castro Brito, GA; de Menezes, RRPPB; de Siqueira, EA; Lima, DB; Magalhães, EP; Martins, AMC; Neves, KRT; Sampaio, TL | 1 |
| Adeyemi, OO; Awogbindin, IO; Ishola, IO; Olajiga, AE; Olubodun-Obadun, TG | 1 |
| Aleksandrova, Y; Ardashov, O; Chaprov, K; Neganova, M; Podturkina, A; Salakhutdinov, N; Volcho, K; Yandulova, E | 1 |
| Azevedo, EM; Chuproski, AP; Ilkiw, J; Lima, MMS; Miloch, J | 1 |
| Bai, HW; Chung, BY; Jeong, GH; Kim, TH; Lee, H; Lee, SS | 1 |
| Chang, MY; Cheng, SH; Lee, YZ; Lin, YF; Tsai, YC; Wu, CC | 1 |
| Aboellail, TA; Chatterjee, D; Kirkley, KS; Rocha, SM; Smeyne, RJ; Tjalkens, RB | 1 |
| Arunachalam, S; Ayoob, K; Azimullah, S; Beiram, R; Meeran, MFN; Ojha, S | 1 |
| Darbinyan, L; Hambardzumyan, L; Manukyan, L; Simonyan, K | 1 |
| Dahlan, W; Mahamud, N; Muangnoi, C; Rodsiri, R; Songvut, P; Tansawat, R | 1 |
| El-Esawy, RO; El-Sakaa, MH; Ibrahim, RR | 1 |
| Agar, A; Aslan, M; Nemutlu-Samur, D; Ozbey, G; Parlak, H; Tanriover, G; Yildirim, S | 1 |
| Ateş, PS; Emekli-Alturfan, E; Ünal, İ; Üstündağ, ÜV; Yurtsever, İ | 1 |
| Evinová, A; Hajdúchová, D; Hatoková, Z; Kráľová-Trančíková, A; Menichová, V; Pokusa, M | 1 |
| Jang, S; Jeong, HS; Ramalingam, M | 1 |
| Anantharam, V; Kalyanaraman, B; Kanthasamy, AG; Mallapragada, SK; Narasimhan, B; Panthani, MG; Schlichtmann, BW; Schlichtmann, RL | 1 |
| Jedsadavitayakol, S; Jutarattananon, S; Thong-Asa, W | 1 |
| Chung, CG; Jeon, YM; Kim, HJ; Kim, K; Kim, S; Kwon, Y; Lee, S; Lee, SB | 1 |
| Hu, S; Mao, Y; Wang, J; Wang, R; Xie, J; Zhao, X | 1 |
| Almeida, MF; Almeida, RS; Cardoso, SM; Chaves, RS; Demasi, M; Fernandes, T; Ferrari, MFR; Lima, NCR; Melo, KP; Netto, LES; Oliveira, EM; Silva, CM | 1 |
| Che, DN; Jang, SI; Jeon, SH; Jin, HY; Kim, YS; Youn, Y | 1 |
| Lenaers, G; Reynier, P; Thany, SH | 1 |
| Monroe, TO; Pal, R; Palmieri, M; Rodney, GG; Sardiello, M | 1 |
| Chaves, RS; D'Unhao, AM; Farizatto, KLG; Ferrari, MFR; Melo, TQ | 1 |
| Bétourné, A; Ferré, CA; Foret, C; Gonzalez-Dunia, D; Hunot, S; Monnet, Y; Peyrin, JM; Szelechowski, M; Thouard, A | 1 |
| Assaf, N; ElShebiney, SA; Khalil, WK; Salem, NA | 1 |
| Beart, PM; Cater, MA; Cheung, NS; La Fontaine, S; Llanos, RM; Yap, YW | 1 |
| Fragola, G; McCoy, ES; Pearson, BL; Salazar, G; Simon, JM; Zylka, MJ | 1 |
| Das, D; Fox, PL; Mukhopadhyay, C; Mukhopadhyay, CK; Tapryal, N | 1 |
| Shimohama, S | 1 |
| Au, Q; Barber, JR; Brady, TP; Chen, J; Murali Mohan Redddy, PS; Ng, SC; Nguyen, T; Wei, L; Yip, G; Yoon, IS; Zhang, B; Zhou, Y | 1 |
| Daniels, WM; Hattingh, S; Pienaar, IS; Schallert, T | 1 |
| Johnson, F; Kaplitt, MG | 1 |
| Davey, GP; Kilbride, SM; Telford, JE | 1 |
| Barreto, GE; Cabezas, R; El-Bachá, RS; González, J | 1 |
| Cabeza-Arvelaiz, Y; Schiestl, RH | 1 |
| Chaves, RS; D'unhao, AM; Farizatto, KL; Ferrari, MF; Martins, SA; Melo, TQ | 1 |
| Betarbet, R; Greenamyre, JT; Kim, JH; Sherer, TB | 1 |
| Trojanowski, JQ | 1 |
| Champy, P; Féger, J; Hirsch, EC; Höglinger, GU; Michel, PP; Oertel, WH; Parain, K; Prigent, A; Ruberg, M | 1 |
| Kotake, Y; Ohta, S | 1 |
| Blanchet, J; Cicchetti, F; Gould, P; Lapointe, N; Martinoli, MG; Rouillard, C; St-Hilaire, M | 1 |
| Khoshaghideh, F; Lee, HJ; Lee, SJ; Patel, S | 1 |
| Clark, JB; Clayton, R; Sharpe, M | 1 |
| Boyle, JP; Brown, ST; Fearon, IM; Hudasek, K; Peers, C; Scragg, JL | 1 |
| Hirsch, EC; Höglinger, GU; Oertel, WH | 1 |
| Ayala, A; Cano, J; Machado, A; Venero, JL | 1 |
| Ariga, H; Inden, M; Kaneko, M; Kitamura, Y; Kobayashi, Y; Okuma, Y; Shimohama, S; Taira, T; Takata, K; Takeuchi, H; Taniguchi, T; Yanagida, T; Yoshimoto, K | 1 |
| Greenamyre, JT; Greene, JG; Higgins, DS; Talpade, DJ | 1 |
6 review(s) available for rotenone and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy-Lysosomal Pathway.
Topics: Acetylcysteine; Animals; Autophagy; Calcium Signaling; Humans; Lysosomes; Microarray Analysis; Neurodegenerative Diseases; Neurons; Oxidative Stress; Pesticides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, N-Methyl-D-Aspartate; Rotenone; Ubiquitin | 2016 |
Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Drug Synergism; Galantamine; Glutamic Acid; Motor Neurons; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Oxidopamine; Parkinson Disease, Secondary; Phosphatidylinositol 3-Kinases; Rats; Receptors, Nicotinic; Rotenone; Signal Transduction; Spinal Cord | 2009 |
Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone.
Topics: Agricultural Workers' Diseases; Animals; Apoptosis; Astrocytes; Brain; Chaperonins; Electron Transport; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; Lipid Peroxidation; Mitochondria; Mitochondrial Membranes; Nerve Tissue Proteins; Neurodegenerative Diseases; NF-kappa B; Oxidative Stress; Parkinsonian Disorders; Pesticides; Rotenone; Superoxide Dismutase; Transcription Factors | 2012 |
MPP+ analogs acting on mitochondria and inducing neuro-degeneration.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Electron Transport; Humans; Isoquinolines; Mitochondria; Neurodegenerative Diseases; Neurons; Parkinson Disease, Secondary; Rotenone; Ubiquinone; Uncoupling Agents | 2003 |
The rotenone model of parkinsonism--the five years inspection.
Topics: Animals; Disease Models, Animal; Dopamine; Humans; Movement; Neurodegenerative Diseases; Neurons; Parkinson Disease, Secondary; Rotenone; Substantia Nigra; tau Proteins; Uncoupling Agents | 2006 |
Mitochondrial toxins and neurodegenerative diseases.
Topics: Animals; Disease Models, Animal; Humans; Huntington Disease; Mitochondria; MPTP Poisoning; Neurodegenerative Diseases; Nitro Compounds; Parkinson Disease, Secondary; Propionates; Rotenone; Succinate Dehydrogenase; Tetrahydroisoquinolines | 2007 |
52 other study(ies) available for rotenone and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Liposomes loaded with polyphenol-rich grape pomace extracts protect from neurodegeneration in a rotenone-based
Topics: Antioxidants; Humans; Liposomes; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Plant Extracts; Polyphenols; Rotenone; Vitis | 2021 |
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.
Topics: Adenosine Triphosphate; alpha-Synuclein; Animals; Dependovirus; Disease Models, Animal; Electron Transport Complex I; Genetic Therapy; Mammals; Mice; Neurodegenerative Diseases; Parkinson Disease; Reactive Oxygen Species; Rotenone; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2022 |
The Anti-Parkinson Potential of Gingko biloba-Supplement Mitigates Cortico-Cerebellar Degeneration and Neuropathobiological Alterations via Inflammatory and Apoptotic Mediators in Mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Dopamine; Ginkgo biloba; Mice; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinson Disease; Plant Preparations; Rotenone | 2022 |
Nootkatone alleviates rotenone-induced Parkinson's disease symptoms through activation of the PI3K/Akt signaling pathway.
Topics: Animals; Dopaminergic Neurons; Molecular Docking Simulation; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rotenone; Signal Transduction | 2022 |
Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Fenofibrate; Male; Neurodegenerative Diseases; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Peroxisome Proliferator-Activated Receptors; Rats; Rotenone; Substantia Nigra | 2022 |
Central and Enteric Neuroprotective Effects by Eucommia ulmoides Extracts on Neurodegeneration in Rotenone-induced Parkinsonian Mouse.
Topics: alpha-Synuclein; Animals; Antioxidants; Chlorogenic Acid; Dopamine; Dopaminergic Neurons; Eucommiaceae; Metallothionein; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Plant Extracts; Rotenone | 2022 |
Benefits of p-coumaric acid in mice with rotenone-induced neurodegeneration.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Male; Malondialdehyde; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotenone; Tumor Necrosis Factor-alpha | 2023 |
The Mechanism of SNHG8/Microrna-421-3p/Sorting Nexin 8 Axis on Dopaminergic Neurons in Substantia Nigra in a Mouse Model of Parkinson's Disease.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; MicroRNAs; Neurodegenerative Diseases; Parkinson Disease; Rotenone; Sorting Nexins; Substantia Nigra | 2023 |
Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk.
Topics: Animals; Antioxidants; Autophagy; Humans; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Inbred C57BL; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Parkinson Disease; Phloretin; Prospective Studies; Rotenone; TOR Serine-Threonine Kinases | 2023 |
Vitamin D3 actions on astrocyte cells: A target for therapeutic strategy in Parkinson's disease?
Topics: Astrocytes; Cholecalciferol; Dopaminergic Neurons; Humans; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Rotenone | 2023 |
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Male; Neurodegenerative Diseases; Neuroinflammatory Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone | 2023 |
Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson's Disease Model by Alleviating Mitochondrial Dysfunction.
Topics: Animals; Cell Line, Tumor; Humans; Mitochondria; Monoterpenes; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phenotype; Reactive Oxygen Species; Rotenone | 2023 |
Metabolic dysfunctions in the intranigral rotenone model of Parkinson's disease.
Topics: Animals; Cholesterol; Disease Models, Animal; Dopaminergic Neurons; Male; Neurodegenerative Diseases; Parkinson Disease; Rats; Rats, Wistar; Rotenone | 2023 |
Inhibitory Effects of Thermolysis Transformation Products of Rotenone on Nitric Oxide Production.
Topics: Anti-Inflammatory Agents; Biological Control Agents; Derris; Fabaceae; Neurodegenerative Diseases; Nitric Oxide; Rotenone | 2023 |
Neuroprotective Effects of
Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Lactobacillus plantarum; Mice; Mice, Inbred C57BL; MicroRNAs; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Rotenone | 2023 |
Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Autophagy; Dopaminergic Neurons; Female; Male; Mice; Microglia; Neurodegenerative Diseases; Neuroinflammatory Diseases; NF-kappa B; Parkinson Disease; Rotenone | 2023 |
Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats.
Topics: Animals; Antioxidants; Apoptosis; Cytokines; Dopaminergic Neurons; Glutamic Acid; Humans; Inflammation; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rotenone | 2023 |
EFFECTS OF DIMETHYL SULFOXIDE ON HIPPOCAMPAL ACTIVITY IN A ROTENONE-INDUCED RAT MODEL OF PARKINSON'S DISEASE.
Topics: Dimethyl Sulfoxide; Hippocampus; Humans; Neurodegenerative Diseases; Parkinson Disease; Rotenone | 2023 |
Untargeted metabolomics reveal pathways associated with neuroprotective effect of oxyresveratrol in SH-SY5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Humans; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Rotenone; Tandem Mass Spectrometry | 2023 |
Troxerutin downregulates C/EBP-β gene expression via modulating the IFNγ-ERK1/2 signaling pathway to ameliorate rotenone-induced retinal neurodegeneration.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Disease Models, Animal; Down-Regulation; Gene Expression; Hydroxyethylrutoside; Interferon-gamma; Male; MAP Kinase Signaling System; Neurodegenerative Diseases; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Retinal Diseases; RNA, Messenger; Rotenone; Tumor Necrosis Factor-alpha | 2020 |
Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation.
Topics: alpha-Synuclein; Animals; Dopamine; Dopaminergic Neurons; Lipid Peroxidation; Male; Metformin; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroprotective Agents; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase | 2020 |
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish.
Topics: Animals; Calcium; Homeostasis; Inflammation; Mitochondria; Neurodegenerative Diseases; Neuroinflammatory Diseases; Oxidative Stress; Rifampin; Rotenone; Zebrafish | 2022 |
Vulnerability of subcellular structures to pathogenesis induced by rotenone in SH-SY5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Insecticides; Microtubules; Mitochondria; NADPH Oxidases; Neuroblastoma; Neurodegenerative Diseases; Rotenone | 2021 |
Neural-Induced Human Adipose Tissue-Derived Stem Cells Conditioned Medium Ameliorates Rotenone-Induced Toxicity in SH-SY5Y Cells.
Topics: Adipose Tissue; alpha-Synuclein; bcl-2-Associated X Protein; Culture Media, Conditioned; Humans; Neurodegenerative Diseases; Neurons; Poly (ADP-Ribose) Polymerase-1; Proto-Oncogene Proteins c-bcl-2; Rotenone; Signal Transduction; Stem Cells | 2021 |
Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction.
Topics: Aged; Humans; Mitochondria; Nanoparticles; Neurodegenerative Diseases; Polyanhydrides; Rotenone | 2022 |
Benefits of betanin in rotenone-induced Parkinson mice.
Topics: Animals; Betacyanins; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase | 2021 |
Neuroprotective Effects of Protein Tyrosine Phosphatase 1B Inhibition against ER Stress-Induced Toxicity.
Topics: Animals; Cell Death; Cerebral Cortex; Down-Regulation; Drosophila; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Humans; Leupeptins; Mice; Neurodegenerative Diseases; Neurons; Neuroprotection; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Reactive Oxygen Species; Rotenone; Tumor Cells, Cultured; Uncoupling Agents | 2017 |
Neuroprotective effect of resveratrol on rotenone-treated C57BL/6 mice.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Insecticides; Iron; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroprotective Agents; Psychomotor Disorders; Random Allocation; Resveratrol; Rotarod Performance Test; Rotenone; Stilbenes; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
Effects of mild running on substantia nigra during early neurodegeneration.
Topics: alpha-Synuclein; Animals; Autophagy; Disease Models, Animal; Hydrogen Peroxide; Male; Mitophagy; Neurodegenerative Diseases; Physical Conditioning, Animal; Proteasome Endopeptidase Complex; Rats, Inbred Lew; Rotenone; Running; Substantia Nigra; Tyrosine 3-Monooxygenase | 2018 |
Chlorogenic acid-rich Solanum melongena extract has protective potential against rotenone-induced neurotoxicity in PC-12 cells.
Topics: Animals; Apoptosis; Chlorogenic Acid; Functional Food; Neurodegenerative Diseases; PC12 Cells; Plant Extracts; Rats; Rotenone; Solanum melongena | 2019 |
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Topics: alpha-Synuclein; Alzheimer Disease; Animals; Genetic Predisposition to Disease; Humans; Insecticides; Mitochondria; Neurodegenerative Diseases; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rotenone | 2013 |
Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Cytosol; Endoplasmic Reticulum Stress; Humans; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neurodegenerative Diseases; rac1 GTP-Binding Protein; Reactive Oxygen Species; Rotenone; Signal Transduction | 2014 |
Dynein c1h1, dynactin and syntaphilin expression in brain areas related to neurodegenerative diseases following exposure to rotenone.
Topics: Animals; Animals, Newborn; Brain; Carrier Proteins; Cells, Cultured; Dynactin Complex; Dyneins; Microtubule-Associated Proteins; Mitochondria; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Rats; Rats, Inbred Lew; Rotenone | 2013 |
A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson's disease.
Topics: Animals; Axons; Disease Models, Animal; Female; HEK293 Cells; Humans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microfluidics; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptides; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Viral Nonstructural Proteins | 2014 |
Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.
Topics: Acupuncture Therapy; Animals; Apoptosis; Bee Venoms; Male; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Rotenone | 2015 |
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.
Topics: Animals; Antioxidants; Autistic Disorder; Brain; Cells, Cultured; Environmental Exposure; Fungicides, Industrial; Gene Expression Regulation; Mice; Microtubules; Neurodegenerative Diseases; Pesticides; Risk Assessment; Risk Factors; Rotenone; Transcription, Genetic | 2016 |
Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.
Topics: 3' Untranslated Regions; Acetylcysteine; Animals; Antifungal Agents; Antimycin A; Cell Line, Tumor; Ceruloplasmin; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iron Overload; Mice; Mice, Knockout; Neurodegenerative Diseases; Organ Specificity; Oxidants; Oxidation-Reduction; Oxidative Stress; RNA Stability; RNA-Binding Proteins; Rotenone; Uncoupling Agents | 2009 |
Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers.
Topics: Animals; Cell Line, Tumor; Chemistry, Pharmaceutical; DNA-Binding Proteins; Drug Design; Glucose; Heat Shock Transcription Factors; Humans; Models, Chemical; Molecular Chaperones; Neurodegenerative Diseases; Oxygen; Protein Conformation; Protein Folding; Pyrimidinones; Rats; Rotenone; Structure-Activity Relationship; Transcription Factors; Triazines; Uracil | 2009 |
Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration.
Topics: Animals; Disease Models, Animal; Electron Transport Chain Complex Proteins; Free Radicals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mass Spectrometry; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Recovery of Function; Rotenone; Simvastatin; Substantia Nigra; Uncoupling Agents | 2009 |
Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.
Topics: Catalase; Cell Line; Gene Expression Regulation, Enzymologic; High-Temperature Requirement A Serine Peptidase 2; Humans; Isocitrate Dehydrogenase; Mitochondria; Mitochondrial Proteins; Molecular Chaperones; Neurodegenerative Diseases; Neurons; Oxygen; Point Mutation; Pyruvate Dehydrogenase Complex; Rotenone; Serine Endopeptidases; Time Factors | 2009 |
Decylubiquinone increases mitochondrial function in synaptosomes.
Topics: Animals; Antimycin A; Electron Transport; Female; Methacrylates; Mitochondria; Models, Biological; Neurodegenerative Diseases; Oxygen Consumption; Rats; Rats, Wistar; Rotenone; Synaptosomes; Thiazoles; Ubiquinone; Uncoupling Agents | 2010 |
Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.
Topics: Action Potentials; Cell Line; Humans; Models, Biological; Neurodegenerative Diseases; Oligonucleotide Array Sequence Analysis; Parkinsonian Disorders; Rotenone; Transcriptome | 2012 |
Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases.
Topics: Aging; Animals; Body Weight; Brain; Gene Expression Regulation; Kinesins; Mitochondria; Molecular Motor Proteins; Motor Activity; Neurodegenerative Diseases; Organ Specificity; Protein Transport; Rats; Rats, Inbred Lew; RNA, Messenger; Rotenone | 2013 |
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.
Topics: alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Infusion Pumps, Implantable; Injections, Subcutaneous; Insecticides; Male; Nerve Tissue Proteins; Neural Pathways; Neurodegenerative Diseases; Neurons; Parkinsonian Disorders; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Synucleins; Time; Tyrosine 3-Monooxygenase | 2003 |
Rotenone neurotoxicity: a new window on environmental causes of Parkinson's disease and related brain amyloidoses.
Topics: Amyloidosis; Animals; Brain; Disease Models, Animal; Environmental Exposure; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurotoxins; Parkinson Disease; Rats; Rotenone; Synucleins | 2003 |
Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats.
Topics: Animals; Behavior, Animal; Cell Count; Choline O-Acetyltransferase; Chronic Disease; Corpus Striatum; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Administration Schedule; Electron Transport Complex I; Enzyme Inhibitors; Inclusion Bodies; Infusions, Intravenous; Locus Coeruleus; Male; Mesencephalon; Motor Activity; Movement Disorders; NADH, NADPH Oxidoreductases; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglia; Neurons; Pesticides; Phosphoproteins; Rats; Rats, Inbred Lew; Rotenone; Serotonin; Substantia Nigra; Time; Tyrosine 3-Monooxygenase | 2003 |
Rotenone induces non-specific central nervous system and systemic toxicity.
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Motor Activity; Neurodegenerative Diseases; Neurons; Parkinson Disease, Secondary; Rats; Rotenone | 2004 |
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.
Topics: alpha-Synuclein; Animals; Cell Compartmentation; Cell Death; Cell Survival; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dimethyl Sulfoxide; Enzyme Inhibitors; Gene Expression; Humans; Inclusion Bodies; Lysosomes; Macromolecular Substances; Nerve Tissue Proteins; Neuroblastoma; Neurodegenerative Diseases; Neurons; Rats; Rats, Sprague-Dawley; Rotenone; Synucleins; Time Factors; Transfection; Uncoupling Agents | 2004 |
Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease.
Topics: Animals; Apoptosis; Brain; Cells, Cultured; Cytochromes c; Dose-Response Relationship, Drug; Male; Membrane Potentials; Mitochondria; Neurodegenerative Diseases; Rats; Rats, Wistar; Rotenone | 2005 |
Hypoxic augmentation of Ca2+ channel currents requires a functional electron transport chain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Ascorbic Acid; Biological Transport; Brain Ischemia; Calcium; Calcium Channels; Cell Line; Chromans; Electron Transport; Electrons; Electrophysiology; Ethidium; Humans; Hypoxia; Immunohistochemistry; Mitochondria; Neurodegenerative Diseases; Oxidants; Oxygen; Peptides; Reactive Oxygen Species; Rotenone; Superoxides; Transfection; Up-Regulation; Xanthine Oxidase | 2005 |
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.
Topics: alpha-Synuclein; Animals; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Endoplasmic Reticulum; Humans; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Oxidative Stress; Parkinsonian Disorders; Phenylbutyrates; Rotenone; Substantia Nigra; Tauopathies | 2007 |
In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Electron Transport Complex I; Electron Transport Complex II; Kidney; Liver; Male; Malonates; Microinjections; Mitochondria; Multienzyme Complexes; Myocardium; NADH, NADPH Oxidoreductases; Neurodegenerative Diseases; Organ Specificity; Oxidoreductases; Rats; Rats, Sprague-Dawley; Rotenone; Sodium Azide; Succinate Dehydrogenase; Tissue Distribution; Tritium | 2000 |