Page last updated: 2024-08-17

rotenone and Aging

rotenone has been researched along with Aging in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.25)18.7374
1990's6 (12.50)18.2507
2000's14 (29.17)29.6817
2010's22 (45.83)24.3611
2020's3 (6.25)2.80

Authors

AuthorsStudies
Horibe, I; Ishikawa, Y; Miyazawa, M; Nakatani, S; Sakai, N; Tsukamoto, T; Yoshioka, Y1
Azzolin, VF; Barbisan, F; da Cruz, IBM; de Afonso Bonotto, NC; Piccoli, JDCE; Ribeiro, EAM; Teixeira, CF; Turra, BO1
Baker, BA; Booth, FW; Childs, TE; Gladden, LB; Kavazis, AN; Mumford, PW; Osburn, SC; Parry, HA; Roberson, PA; Roberts, MD; Romero, MA; Schwartz, TS; Toedebusch, RG1
Brunetti, G; Calabrese, EJ; Calabrese, V; Crea, R; Di Rosa, G; Saul, N; Schmitz-Linneweber, C; Scuto, M; Trovato Salinaro, A1
Ho, DH; Nam, D; Park, SW; Seo, MK; Seol, W; Son, I1
Jagota, A; Mattam, U1
Costa, AJ; Erustes, AG; Pereira, GJDS; Sinigaglia-Coimbra, R; Smaili, SS; Ureshino, RP1
Abdel-Hamid, AES; Abdel-Rahman, M; Galhom, RA; Mohammed Ali, MH; Nasr El-Din, WA1
Hayashi, Y; Meng, J; Nakanishi, H; Ni, J; Peters, C; Qing, H; Stoka, V; Turk, V; Wu, Z1
Bush, AI; Chrysostomou, V; Cimdins, K; Cook, MJ; Crowston, JG; Duce, JA; Hill, AF; Johannsen, VA; Lopez Sanchez, MIG; Trounce, IA; Waugh, HS1
Gai, WP; Meedeniya, A; Pountney, DL; Rcom-H'cheo-Gauthier, A; Sharry, S; Weetman, J; Wong, MB1
Hearon, CM; Henson, GD; LaRocca, TJ; Seals, DR1
Lee, D; Podolsky, E; Qi, C; Varga, SJ1
Tsukada, H1
Gattupalli, NK; Pandey, SK; Saha, G; Singh, AK1
Bai, J; Guan, Q; Liu, Z; Wang, M; Wang, X; Yan, Z; Yang, L; Zhang, Y1
Croco, E; Lorenzini, A; Maier, AB; Sedivy, JM; Slagboom, PE; Waaijer, ME; Westendorp, RG1
Andersen, PM; Birve, A; Forsgren, E; Gilthorpe, JD; Keskin, I; Lange, DJ; Marklund, SL; Synofzik, M; Weber, M1
Ho, PW; Ho, SL; Kung, MH; Lam, CS; Leung, GC; Li, L; Liu, HF; Pang, SY; Ramsden, DB1
Hayashi, Y; Ide, T; Kang, D; Kanki, T; Nakanishi, H; Ochi-Shindou, M; Sunagawa, K; Tsutsui, H; Wu, Z; Yamato, M; Yoshida, M1
Chan, D; Cookson, M; Ferree, A; Ghosh, J; Goldstein, L; Guillily, MD; Hisamoto, N; Hsu, CH; Iwatsubo, T; Kuwahara, T; Lanceta, J; Matsumoto, K; Moore, L; Raghavan, K; Saha, S; Segal, L; Wolozin, B1
Blom, J; de Koning-Treurniet, C; Dekker, P; Dirks, RW; Maier, AB; Tanke, HJ; van Heemst, D; Westendorp, RG1
Blom, J; de Koning-Treurniet, C; Dekker, P; Dirks, RW; Maier, AB; Noppe, G; Tanke, HJ; van Heemst, D; Westendorp, RG1
Brawek, B; Feuerstein, TJ; Huppertz, HJ; Jackisch, R; Löffler, M; Wagner, K; Wendling, AS; Weyerbrock, A1
Kristek, F; Kucharská, J; Sumbalová, Z1
Hsieh, CC; Papaconstantinou, J2
Ago, T; Fu, C; Kuroda, J; Li, H; Pain, J; Sadoshima, J1
Arnold, B; Berman, SB; Cassady, SJ; VanLaar, VS1
Lu, GQ; Wang, XJ; Wang, Y; Yan, ZQ; Zhang, JD; Zhang, S; Zhao, YX; Zhou, HY1
Dekker, P; Dirks, RW; Maier, AB; Slagboom, PE; Tanke, HJ; van Baalen, LM; van Heemst, D; Westendorp, RG1
Chaves, RS; D'unhao, AM; Farizatto, KL; Ferrari, MF; Martins, SA; Melo, TQ1
Brand, MD; Buckingham, JA; Roebuck, SJ; St-Pierre, J1
Andringa, G; Bol, JG; Drukarch, B; Phinney, AL; van Dam, AM; van Muiswinkel, FL; Wolters, ECh1
Chan, CS; Guzman, JN; Ilijic, E; Mercer, JN; Meredith, GE; Rick, C; Surmeier, DJ; Tkatch, T1
Dlasková, A; Hlavatá, L; Jezek, P1
Lemeshko, VV; Shekh, VE1
Chang, YF; Pan, X; Rao, VV; Tsai, MJ1
Bovina, C; Cometti, GG; Formiggini, G; Genova, ML; Ghelli, A; Lenaz, G; Marchetti, M; Merlo Pich, M; Parenti Castelli, G; Semeraro, S1
Biagini, G; Bovina, C; Genova, ML; Gorini, A; Lenaz, G; Marchetti, M; Pallotti, F; Pugnaloni, A; Tietz, C; Villa, RF; Viticchi, C1
Bizzozero, OA; Sanchez, P; Tetzloff, SU1
Ishii, S; Kobayashi, T; Nagai, H; Sasaki, T; Senda, M; Soga, S1
Botta, M; Crescenzo, R; Lionetti, L; Liverini, G; Lossa, S; Mollica, MP1
Rasmusson, AG; Svensson, AS1
Bovina, C; Formiggini, G; Genova, ML; Lenaz, G; Ventura, B1
Abe, H; Furuyama, F; Hagihara, B; Kamada, T; Sato, N; Suematsu, T1
McMillin Wood, J1
Catani, C; Margreth, A; Salviati, G1

Other Studies

48 other study(ies) available for rotenone and Aging

ArticleYear
Comparison of larvicidal, adulticidal and acaricidal activity of two geometrical butylidenephthalide isomers.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:3

    Topics: Aging; Angelica; Animals; Chromatography, Gas; DEET; Drosophila; Gas Chromatography-Mass Spectrometry; Insecticides; Isomerism; Larva; Mites; Phthalic Anhydrides; Rotenone; Siphonaptera

2006
Rotenone-exposure as cytofunctional aging model of human dermal fibroblast prior replicative senescence.
    Toxicology in vitro : an international journal published in association with BIBRA, 2023, Volume: 91

    Topics: Aging; Cells, Cultured; Cellular Senescence; Collagen; Fibroblasts; Humans; Rotenone

2023
Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.
    American journal of physiology. Cell physiology, 2019, 12-01, Volume: 317, Issue:6

    Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Caffeine; Chromatin; Chromosomal Proteins, Non-Histone; Cyclophilin A; DNA Methylation; Female; Gene Expression Regulation; Hydroxamic Acids; Long Interspersed Nucleotide Elements; Muscle Fibers, Skeletal; Muscle, Skeletal; Physical Conditioning, Animal; Primary Cell Culture; Rats; Rats, Wistar; Resveratrol; Ribonucleotides; RNA, Messenger; Rotenone; Sedentary Behavior

2019
Healthspan Enhancement by Olive Polyphenols in
    International journal of molecular sciences, 2020, May-29, Volume: 21, Issue:11

    Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Biomarkers; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Diet, Mediterranean; Disease Models, Animal; Dopaminergic Neurons; Humans; Longevity; Microscopy, Fluorescence; Olea; Olive Oil; Parkinson Disease; Polyphenols; Rotenone

2020
LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Aging; Cellular Senescence; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lysosomes; Neurons; Oxidative Stress; Parkinson Disease; Rotenone

2021
Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.
    Biogerontology, 2017, Volume: 18, Issue:4

    Topics: Age Factors; Aging; Animals; Biomarkers; Brain; Circadian Rhythm; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Male; Melatonin; Nerve Tissue Proteins; Parkinsonian Disorders; Pineal Gland; Proteomics; Rats, Wistar; Rotenone; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substantia Nigra; Suprachiasmatic Nucleus; Time Factors

2017
Effects of Aging in the Striatum and Substantia Nigra of a Parkinson's Disease Animal Model.
    Toxicologic pathology, 2018, Volume: 46, Issue:3

    Topics: Aging; Animals; Corpus Striatum; Parkinsonian Disorders; Rats; Rats, Wistar; Rotenone; Substantia Nigra; Uncoupling Agents

2018
Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Aging; Animals; Cells, Cultured; Male; Mesencephalon; Motor Activity; Olfactory Bulb; Parkinsonian Disorders; Rats; Rotenone; Stem Cell Transplantation; Stem Cells; Treatment Outcome; Tyrosine 3-Monooxygenase

2018
Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
    Aging cell, 2019, Volume: 18, Issue:1

    Topics: Aging; Animals; Cathepsin B; Cell Line; Cells, Cultured; Cognitive Dysfunction; Cytosol; DNA-Binding Proteins; High Mobility Group Proteins; Hippocampus; Inflammation; Memory; Mice, Inbred C57BL; Microglia; Mitochondria; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Rotenone; Subcellular Fractions

2019
Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity.
    Molecular neurobiology, 2019, Volume: 56, Issue:8

    Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Child; Child, Preschool; Enzyme Activation; Female; Humans; Male; Mice; Middle Aged; Mitochondria; Neurons; Neuroprotection; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rotenone; Toxicity Tests; Young Adult

2019
Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease.
    Neuroscience letters, 2013, Jun-07, Volume: 544

    Topics: Aging; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Rotenone; SUMO-1 Protein; Up-Regulation

2013
Mitochondrial quality control and age-associated arterial stiffening.
    Experimental gerontology, 2014, Volume: 58

    Topics: Age Factors; Aging; Animals; Aorta, Thoracic; Aortic Diseases; Collagen Type I; Male; Mice, Inbred C57BL; Mitochondria; Mitophagy; Oxidation-Reduction; Oxidative Stress; Pulse Wave Analysis; Rotenone; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Superoxides; Tissue Culture Techniques; Trehalose; Vascular Stiffness

2014
A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease.
    Brain research, 2014, Oct-02, Volume: 1583

    Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Dopaminergic Neurons; Drosophila melanogaster; Gene-Environment Interaction; Humans; Image Processing, Computer-Assisted; Larva; Motor Activity; Mutation; Olfactory Perception; Parkinson Disease; Rotenone; Software; Video Recording

2014
The use of ¹⁸F-BCPP-EF as a PET probe for complex I activity in the brain.
    Methods in enzymology, 2014, Volume: 547

    Topics: Aging; Amyloid beta-Peptides; Animals; Drug Design; Electron Transport Complex I; Hypoxia-Ischemia, Brain; Macaca fascicularis; Male; Molecular Probes; Positron-Emission Tomography; Pyridazines; Pyridines; Rats, Sprague-Dawley; Rotenone; Stroke

2014
Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.
    Experimental gerontology, 2015, Volume: 66

    Topics: Aging; Animals; Antioxidants; Escherichia coli; Glutathione; Hyperlipidemias; Lipid Peroxidation; Male; Mitochondria; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PQQ Cofactor; Rats; Reactive Oxygen Species; Rotenone; Succinate Dehydrogenase; Superoxide Dismutase; Transcription Factors

2015
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Aging; Animals; Benzamides; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; Neuroprotective Agents; Oxidation-Reduction; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotenone; Sirtuin 2; Substantia Nigra; Sulfonamides

2015
DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.
    Aging, 2016, Volume: 8, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Cells, Cultured; Cellular Senescence; DNA Damage; Female; Fibroblasts; Humans; Male; Micronuclei, Chromosome-Defective; Middle Aged; Rotenone; Telomere; Time Factors; Tissue Banks; Tumor Suppressor p53-Binding Protein 1; Young Adult

2016
Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Adenine; Age of Onset; Aging; Amyotrophic Lateral Sclerosis; Autophagy; Bortezomib; C9orf72 Protein; Case-Control Studies; Cells, Cultured; DNA Repeat Expansion; Electron Transport Complex I; Endoplasmic Reticulum Stress; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Genotype; Humans; Mutation; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Aggregation, Pathological; Protein Folding; Proteins; Proteolysis; Rotenone; Solubility; Superoxide Dismutase; Superoxide Dismutase-1

2016
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
    Scientific reports, 2017, 01-18, Volume: 7

    Topics: Administration, Oral; Aging; Animals; Apoptosis; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Electron Transport Complex I; Gene Knock-In Techniques; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Neurons; Parkinson Disease; Rotenone; Synaptosomes; Vacuolar Proton-Translocating ATPases

2017
Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Aug-20, Volume: 28, Issue:34

    Topics: Aging; Animals; Biological Transport; Brain; DNA Damage; DNA-Binding Proteins; DNA, Mitochondrial; HeLa Cells; Hippocampus; Humans; Intracellular Membranes; Learning; Long-Term Potentiation; Memory; Memory Disorders; Mice; Mice, Transgenic; Microglia; Mitochondrial Diseases; Mitochondrial Proteins; Motor Activity; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Recovery of Function; Rotenone; Transcription Factors; Up-Regulation

2008
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-22, Volume: 29, Issue:29

    Topics: Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Dopamine; Gene Knockdown Techniques; Herbicides; Insecticides; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mitochondria; Mortality; Mutation; Neurons; Paraquat; Protein Serine-Threonine Kinases; RNA, Messenger; Rotenone

2009
Stress-induced responses of human skin fibroblasts in vitro reflect human longevity.
    Aging cell, 2009, Volume: 8, Issue:5

    Topics: Adult; Aged, 80 and over; Aging; Annexin A5; Apoptosis; beta-Galactosidase; Cellular Senescence; Female; Fibroblasts; Health Status; Humans; Longevity; Male; Oxidative Stress; Rotenone; Siblings; Skin Aging; Skin Physiological Phenomena; Smoking; Stress, Physiological

2009
Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2009, Volume: 75, Issue:11

    Topics: Adult; Age Factors; Aged, 80 and over; Aging; beta-Galactosidase; Cellular Senescence; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Lysosomes; Macrolides; Models, Biological; Rotenone; Skin

2009
Reactive oxygen species (ROS) in the human neocortex: role of aging and cognition.
    Brain research bulletin, 2010, Mar-16, Volume: 81, Issue:4-5

    Topics: Adolescent; Adult; Aged; Aging; Animals; Child; Child, Preschool; Cognition; Electron Transport Complex I; Female; Humans; Infant; Male; Middle Aged; Mitochondria; Neocortex; Rats; Rats, Wistar; Reactive Oxygen Species; Reproducibility of Results; Rotenone; Young Adult

2010
Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats.
    Cellular and molecular neurobiology, 2010, Volume: 30, Issue:5

    Topics: Aging; alpha-Tocopherol; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Brain; Cell Respiration; Electron Transport; Electron Transport Complex IV; Glutamates; Losartan; Mitochondria; Rats; Rats, Inbred SHR; Rats, Wistar; Rotenone; Succinic Acid; Ubiquinone

2010
Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS).
    Aging, 2009, Jul-31, Volume: 1, Issue:9

    Topics: Acetylcysteine; Activating Transcription Factor 2; Aging; Animals; Antimycin A; Cell Proliferation; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Fibroblasts; Hydrogen Peroxide; Longevity; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mitochondria; Nitro Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Propionates; Protein Binding; Reactive Oxygen Species; Rotenone; Skin; Thioredoxins

2009
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.
    Circulation research, 2010, Apr-16, Volume: 106, Issue:7

    Topics: Aconitate Hydratase; Aging; Animals; Apoptosis; Cardiomegaly; Cell Proliferation; Cells, Cultured; Cysteine; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Genotype; Humans; Mice; Mice, Transgenic; Mitochondria, Heart; Myocytes, Cardiac; NADH Dehydrogenase; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; Oxidation-Reduction; Oxidative Stress; Phenotype; Rats; Rats, Wistar; Rotenone; Superoxides; Transfection; Uncoupling Agents; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Function, Left

2010
Integrating multiple aspects of mitochondrial dynamics in neurons: age-related differences and dynamic changes in a chronic rotenone model.
    Neurobiology of disease, 2011, Volume: 41, Issue:1

    Topics: Aging; Animals; Cells, Cultured; Chronic Disease; Mitochondria; Mitochondrial Diseases; Models, Biological; Neurons; Parkinson Disease; Rats; Rotenone; Substantia Nigra; Uncoupling Agents

2011
Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK.
    Free radical biology & medicine, 2011, May-01, Volume: 50, Issue:9

    Topics: Aging; Animals; Antibodies, Blocking; Antigens, CD; Cell Culture Techniques; Cells, Cultured; Dopamine; Gene Expression; Intercellular Adhesion Molecule-1; Iron; Mesencephalon; Microglia; NADPH Oxidases; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Immunologic; Rotenone; Superoxides

2011
Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2012, Volume: 67, Issue:5

    Topics: Age Factors; Aged, 80 and over; Aging; beta-Galactosidase; Biopsy; Cells, Cultured; Electron Transport; Female; Fibroblasts; Flow Cytometry; Humans; Linear Models; Male; Netherlands; Reactive Oxygen Species; Rotenone; Telomere Shortening

2012
Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases.
    Cellular and molecular neurobiology, 2013, Volume: 33, Issue:3

    Topics: Aging; Animals; Body Weight; Brain; Gene Expression Regulation; Kinesins; Mitochondria; Molecular Motor Proteins; Motor Activity; Neurodegenerative Diseases; Organ Specificity; Protein Transport; Rats; Rats, Inbred Lew; RNA, Messenger; Rotenone

2013
Topology of superoxide production from different sites in the mitochondrial electron transport chain.
    The Journal of biological chemistry, 2002, Nov-22, Volume: 277, Issue:47

    Topics: Aging; Animals; Antimycin A; Columbidae; Electron Transport; Enzyme Inhibitors; Female; Hydrogen Peroxide; Liver; Malates; Methacrylates; Mitochondria, Liver; Mitochondria, Muscle; Muscle, Skeletal; Myocardium; Oligomycins; Oxidants; Palmitoylcarnitine; Pyruvic Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Reference Standards; Rotenone; Succinic Acid; Superoxide Dismutase; Superoxides; Thiazoles; Uncoupling Agents

2002
Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:2

    Topics: Aging; Animals; Catalytic Domain; Cell Line; Enzyme Activation; Gene Expression Regulation, Enzymologic; Heterozygote; Liver; Longevity; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Mice; Mice, Inbred Strains; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Rotenone; Thioredoxins

2006
Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging.
    Parkinsonism & related disorders, 2006, Volume: 12, Issue:4

    Topics: Aging; alpha-Synuclein; Animals; Astrocytes; Cell Count; Dopamine; Immunohistochemistry; Insecticides; Male; Microglia; Neostriatum; Neurons; Neurotransmitter Agents; Presynaptic Terminals; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase

2006
'Rejuvenation' protects neurons in mouse models of Parkinson's disease.
    Nature, 2007, Jun-28, Volume: 447, Issue:7148

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Antiparkinson Agents; Calcium; Calcium Channels, L-Type; Dendrites; Disease Models, Animal; Disease Progression; Dopamine; Electric Conductivity; Gene Deletion; Male; Mice; Mice, Inbred C57BL; Mitochondria; Models, Neurological; Neurons; Parkinson Disease; Rotenone; Substantia Nigra

2007
Oxidative stress caused by blocking of mitochondrial complex I H(+) pumping as a link in aging/disease vicious cycle.
    The international journal of biochemistry & cell biology, 2008, Volume: 40, Issue:9

    Topics: Aging; Cell Line, Tumor; Disease; DNA, Mitochondrial; Electron Transport; Electron Transport Complex I; Fluorescent Dyes; Glucose; Humans; Intracellular Space; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria; Mutation; Oxidative Stress; Phosphorylation; Rotenone; Superoxides; Uncoupling Agents

2008
Hypotonic fragility of outer membrane and activation of external pathway of NADH oxidation in rat liver mitochondria are increased with age.
    Mechanisms of ageing and development, 1993, Volume: 68, Issue:1-3

    Topics: Aging; Animals; Female; Hypotonic Solutions; Intracellular Membranes; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Rats, Wistar; Rotenone; Sex Characteristics

1993
L-pipecolic acid oxidation in rat: subcellular localization and developmental study.
    Biochimica et biophysica acta, 1993, Jun-24, Volume: 1164, Issue:1

    Topics: Aging; Animals; Antimycin A; Brain; Diethylhexyl Phthalate; Enzyme Induction; Glucagon; Liver; Male; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley; Rotenone; Subcellular Fractions

1993
Inhibitor sensitivity of respiratory complex I in human platelets: a possible biomarker of ageing.
    FEBS letters, 1996, Feb-12, Volume: 380, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Blood Platelets; Electron Transport Complex I; Enzyme Inhibitors; Female; Humans; Mitochondria; NADH, NADPH Oxidoreductases; Rotenone

1996
Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain non-synaptic mitochondria of aged rats.
    FEBS letters, 1997, Jun-30, Volume: 410, Issue:2-3

    Topics: Aging; Animals; Cerebral Cortex; DNA, Mitochondrial; Enzyme Inhibitors; Male; Mitochondria; Multienzyme Complexes; NAD; NAD(P)H Dehydrogenase (Quinone); NADH, NADPH Oxidoreductases; Neuroglia; Neurons; Rats; Rats, Wistar; Rotenone; Synapses

1997
Effect of ATP depletion on the palmitoylation of myelin proteolipid protein in young and adult rats.
    Journal of neurochemistry, 1999, Volume: 72, Issue:6

    Topics: Acylation; Adenosine Triphosphate; Aging; Animals; Brain; Cycloheximide; Female; Kinetics; Male; Mitochondria; Myelin Proteolipid Protein; Oligomycins; Palmitic Acid; Peptide Mapping; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Rotenone

1999
Visualization of mitochondrial oxygen fixation in brain slices by gas-tissue autoradiography.
    Brain research, 1999, Jun-12, Volume: 831, Issue:1-2

    Topics: Aging; Animals; Autoradiography; Brain; Electron Transport; Energy Metabolism; In Vitro Techniques; Male; Mitochondria; Oxygen; Oxygen Consumption; Oxygen Radioisotopes; Rats; Rats, Wistar; Reactive Oxygen Species; Rotenone; Tomography, Emission-Computed

1999
Mitochondrial respiration and triiodothyronine concentration in liver from postpubertal and adult rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:6

    Topics: Adenosine Triphosphate; Aging; Animals; Cell Respiration; Cytochrome c Group; Electron Transport Complex III; Electron Transport Complex IV; Hydroquinones; Liver; Male; Mitochondria; Rats; Rats, Wistar; Rotenone; Succinate Dehydrogenase; Succinic Acid; Triiodothyronine; Uncoupling Agents

2001
Light-dependent gene expression for proteins in the respiratory chain of potato leaves.
    The Plant journal : for cell and molecular biology, 2001, Volume: 28, Issue:1

    Topics: Aging; Blotting, Western; Circadian Rhythm; Darkness; Electron Transport; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant; Light; Mitochondria; NAD; NADH Dehydrogenase; NADP; Oxidation-Reduction; Plant Leaves; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Plant; Rotenone; Solanum tuberosum

2001
Control of oxidative phosphorylation by Complex I in rat liver mitochondria: implications for aging.
    Biochimica et biophysica acta, 2002, Feb-15, Volume: 1553, Issue:3

    Topics: Age Factors; Aging; Animals; Electron Transport Complex I; Electron Transport Complex III; Energy Metabolism; Enzyme Inhibitors; Male; Mitochondria, Liver; NAD; NADH, NADPH Oxidoreductases; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Rats; Rats, Wistar; Rotenone

2002
Cadmium toxicity and liver mitochondria. II. Protective effect of hepatic soluble fraction against cadmium-induced mitochondrial dysfunction.
    Journal of biochemistry, 1978, Volume: 84, Issue:1

    Topics: Adenosine Diphosphate; Aging; Animals; Cadmium; Cytochromes; Cytosol; Liver; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rotenone; Spironolactone; Succinates

1978
Carnitine palymityltransferase in neonatal and adult heart and liver mitochondria. Effect of phospholipase C treatment.
    The Journal of biological chemistry, 1975, Apr-25, Volume: 250, Issue:8

    Topics: Acyltransferases; Aging; Animals; Animals, Newborn; Carnitine; Cytochrome Reductases; Kinetics; Liver; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxygen Consumption; Palmitic Acids; Phospholipases; Rats; Rotenone

1975
Electron transport in sarcoplasmic reticulum of fast and slow muscles.
    Archives of biochemistry and biophysics, 1971, Volume: 144, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Chickens; Chlorine; Cytochromes; Electron Transport; Endoplasmic Reticulum; Ferricyanides; Indophenol; Microsomes; Muscles; NAD; NADP; Oxidoreductases; Polarography; Rabbits; Rats; Rotenone; Spectrophotometry

1971