rosuvastatin and Hyperlipidemias

rosuvastatin has been researched along with Hyperlipidemias* in 1 studies

Other Studies

1 other study(ies) available for rosuvastatin and Hyperlipidemias

Article	Year
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Bioorganic & medicinal chemistry letters, 2007, Aug-15, Volume: 17, Issue:16 This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models. Topics: Animals; Cricetinae; Dose-Response Relationship, Drug; Drug Design; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Liver; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Structure-Activity Relationship; Sulfonamides	2007

Article

Year

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

Bioorganic & medicinal chemistry letters, 2007, Aug-15, Volume: 17, Issue:16

This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.

Topics: Animals; Cricetinae; Dose-Response Relationship, Drug; Drug Design; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Liver; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Structure-Activity Relationship; Sulfonamides

2007