rostafuroxin has been researched along with Hypertension in 18 studies
*Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 11 (61.11) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bianchi, G; Cerri, A; Fedrizzi, G; Ferrari, P; Gobbini, M; Melloni, P; Quadri, L; Sputore, S; Torri, M | 1 |
| Rossoni, LV; Wenceslau, CF | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Manunta, P; Molinari, I; Rastaldi, MP | 1 |
| Ferrari, P | 1 |
| Argiolas, G; Bianchi, G; Carpini, SD; Citterio, L; Cusi, D; Ferrandi, M; Ferrari, P; Glorioso, N; Lanzani, C; Macciardi, F; Manunta, P; Messaggio, E; Salvi, E; Staessen, JA; Tripodi, G; Valentini, G | 1 |
| Bacchieri, A; Barton, J; Bianchi, G; Citterio, L; de Leeuw, PW; Dłużniewski, M; Espositi, ED; Ferrari, P; Glorioso, N; Januszewicz, A; Kawecka-Jaszcz, K; Lanzani, C; Manunta, P; Milyagin, V; Nikitin, Y; Souček, M; Staessen, JA; Stolarz-Skrzypek, K; Thijs, L; Timio, M; Tykarski, A; Valentini, G | 1 |
| Barassi, P; Bianchi, G; Duzzi, L; Ferrandi, M; Ferrari, P; Minotti, E; Molinari, I | 1 |
| Caulfield, MJ; Garcia, EA; Munroe, PB; Newhouse, S | 1 |
| Acceto, R; Bacchieri, A; Bianchi, G; Brand, E; Burnier, M; Celis, H; Citterio, L; de Leeuw, PW; Ferrari, P; Filipovský, J; Fournier, A; Kawecka-Jaszcz, K; Kuznetsova, T; Manunta, P; Nikitin, Y; O'Brien, ET; Redón, J; Staessen, JA; Thijs, L; Valentini, G | 1 |
| Barassi, P; Bianchi, G; Ferrandi, M; Ferrari, P; Minotti, E; Molinari, I; Torielli, L; Tripodi, G | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Valentini, G | 1 |
| Ferrandi, M; Ferrari, P; Manunta, P; Messaggio, E | 1 |
| Iwamoto, T; Kita, S | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Manunta, P; Valentini, G | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Molinari, I | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Melloni, P; Minotti, E; Padoani, G; Torielli, L; Tripodi, G | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Torielli, L; Tripodi, G | 1 |
| Schoner, W | 1 |
9 review(s) available for rostafuroxin and Hypertension
| Article | Year |
|---|---|
Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Clinical Trials, Phase II as Topic; Disease Models, Animal; ErbB Receptors; Humans; Hypertension; Kidney; Mutation; Ouabain; Polymorphism, Genetic; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase; src-Family Kinases | 2010 |
Genes and hypertension.
Topics: Androstanols; Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Carboxypeptidases; Genomics; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Minor Histocompatibility Antigens; Oligonucleotide Array Sequence Analysis; Peptidyl-Dipeptidase A; Pharmacogenetics; Protein Serine-Threonine Kinases; Renin-Angiotensin System; WNK Lysine-Deficient Protein Kinase 1 | 2003 |
Ouabain antagonists as antihypertensive agents.
Topics: Androstanols; Animals; Antihypertensive Agents; Humans; Hypertension; Ouabain; Rats; Rats, Inbred SHR; Sodium-Potassium-Exchanging ATPase | 2005 |
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Vessels; Calmodulin-Binding Proteins; Humans; Hypertension; Kidney; Ouabain; Sodium-Potassium-Exchanging ATPase; Treatment Outcome | 2006 |
A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin.
Topics: Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Humans; Hypertension; Ouabain; Risk Factors; Sodium Chloride; Sodium-Potassium-Exchanging ATPase | 2006 |
Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.
Topics: Androstanols; Aniline Compounds; Animals; Blood Pressure; Calcium; Cardiac Glycosides; Cardiovascular System; Cell Membrane; Humans; Hypertension; Kidney; Muscle, Smooth, Vascular; Ouabain; Phenyl Ethers; Protein Binding; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Vasoconstriction | 2006 |
Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Calmodulin-Binding Proteins; Caveolae; Humans; Hypertension; Ouabain; Rats; Signal Transduction | 2006 |
PST 2238: a new antihypertensive compound that modulates the Na-K pump 'in vivo' and 'in vitro'.
Topics: Androstanols; Animals; Antihypertensive Agents; Biological Transport; Humans; Hypertension; In Vitro Techniques; Sodium-Potassium-Exchanging ATPase | 2000 |
Endogenous cardiotonic steroids.
Topics: Androstanols; Animals; Antihypertensive Agents; Bufanolides; Cardenolides; Cardiac Glycosides; Cardiotonic Agents; Enzyme Inhibitors; Heart; Humans; Hypertension; Molecular Structure; Ouabain; Sodium-Potassium-Exchanging ATPase | 2001 |
3 trial(s) available for rostafuroxin and Hypertension
| Article | Year |
|---|---|
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.
Topics: Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Female; Genetic Loci; Humans; Hydrochlorothiazide; Hypertension; Intramolecular Transferases; Kidney; Losartan; Male; Middle Aged; Mutant Proteins; Ouabain; Placebos; Polymorphism, Single Nucleotide; Systole; Time Factors; Transfection | 2010 |
Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.
Topics: Adult; Aldosterone; Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Cross-Over Studies; Double-Blind Method; Europe; Female; Humans; Hypertension; Male; Middle Aged; Mutation; Ouabain; Renin; Sodium; Sodium-Potassium-Exchanging ATPase; Time Factors; Treatment Outcome | 2011 |
OASIS-HT: design of a pharmacogenomic dose-finding study.
Topics: Administration, Oral; Adult; Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Male; Middle Aged; Molecular Conformation; Ouabain; Risk Factors; Time Factors; Treatment Outcome | 2005 |
6 other study(ies) available for rostafuroxin and Hypertension
| Article | Year |
|---|---|
17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Kinetics; Molecular Structure; Ouabain; Rats; Rats, Mutant Strains; Sodium-Potassium-Exchanging ATPase | 1997 |
Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase/ cSRC pathway.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase 2; Desoxycorticosterone Acetate; Endothelium, Vascular; Humans; Hypertension; Male; Mesenteric Arteries; NADPH Oxidases; Ouabain; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Sodium Chloride, Dietary; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Vascular Resistance; Vasodilation | 2014 |
Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.
Topics: Androstanols; Animals; Antihypertensive Agents; Calmodulin-Binding Proteins; Disease Models, Animal; Female; Genetic Variation; Hypertension; Kidney; Male; Mice; Mice, Knockout; Ouabain; Podocytes; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2014 |
PST 2238: a new antihypertensive compound that modulates renal Na-K pump function without diuretic activity in Milan hypertensive rats.
Topics: Androstanols; Animals; Blood Pressure; Diuresis; Hydrochlorothiazide; Hypertension; Kidney; Rats; Sodium-Potassium-Exchanging ATPase | 2002 |
Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.
Topics: Androstanols; Animals; Antihypertensive Agents; Calmodulin-Binding Proteins; Cardiovascular System; Humans; Hypertension; Models, Cardiovascular; Ouabain; Sodium-Potassium-Exchanging ATPase | 2007 |
PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Heart Rate; Hypertension; Kidney Medulla; Male; Mutation; Ouabain; Rats; Rats, Inbred SHR; Rats, Inbred Strains; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Transfection | 1999 |