rosmarinic-acid and Prostatic-Neoplasms

rosmarinic-acid has been researched along with Prostatic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for rosmarinic-acid and Prostatic-Neoplasms

Article	Year
Optimization of Ultrasound-Assisted Extraction Conditions Followed by Solid Phase Extraction Fractionation from Molecules (Basel, Switzerland), 2019, Nov-18, Volume: 24, Issue:22 Primarily, optimization of ultrasonic-assisted extraction (UAE) conditions of Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cinnamates; Depsides; Humans; Male; Models, Chemical; Orthosiphon; Plant Extracts; Plant Leaves; Prostatic Neoplasms; Rosmarinic Acid; Solid Phase Extraction; Solvents; Ultrasonics	2019
Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines. Nutrients, 2018, Nov-16, Volume: 10, Issue:11 Rosmarinic acid (RA), a main phenolic compound contained in rosemary which is used as tea, oil, medicine and so on, has been known to present anti-inflammatory, anti-oxidant and anti-cancer effects. Histone deacetylases (HDACs) are enzymes that play important roles in gene expression by removing the acetyl group from histone. The aberrant expression of HDAC in human tumors is related with the onset of human cancer. Especially, HDAC2, which belongs to HDAC class I composed of HDAC 1, 2, 3 and 8, has been reported to be highly expressed in prostate cancer (PCa) where it downregulates the expression of p53, resulting in an inhibition of apoptosis. The purpose of this study is to investigate the effect of RA in comparison with suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor used as an anti-cancer agent, on survival and apoptosis of PCa cell lines, PC-3 and DU145, and the expression of HDAC. RA decreased the cell proliferation in cell viability assay, and inhibited the colony formation and tumor spheroid formation. Additionally, RA induced early- and late-stage apoptosis of PC-3 and DU145 cells in Annexin V assay and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, respectively. In western blot analysis, RA inhibited the expression of HDAC2, as SAHA did. Proliferating cell nuclear antigen (PCNA), cyclin D1 and cyclin E1 were downregulated by RA, whereas p21 was upregulated. In addition, RA modulated the protein expression of intrinsic mitochondrial apoptotic pathway-related genes, such as Bax, Bcl-2, caspase-3 and poly (ADP-ribose) polymerase 1 ( Topics: Annexin A5; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cinnamates; Cyclin D1; Cyclin E; Depsides; DNA Fragmentation; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; In Situ Nick-End Labeling; Male; Oncogene Proteins; Poly (ADP-Ribose) Polymerase-1; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Rosmarinic Acid; Rosmarinus; Signal Transduction; Teas, Herbal; Teas, Medicinal; Vorinostat	2018

Article

Year

Optimization of Ultrasound-Assisted Extraction Conditions Followed by Solid Phase Extraction Fractionation from

Molecules (Basel, Switzerland), 2019, Nov-18, Volume: 24, Issue:22

Primarily, optimization of ultrasonic-assisted extraction (UAE) conditions of

Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cinnamates; Depsides; Humans; Male; Models, Chemical; Orthosiphon; Plant Extracts; Plant Leaves; Prostatic Neoplasms; Rosmarinic Acid; Solid Phase Extraction; Solvents; Ultrasonics

2019

Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines.

Nutrients, 2018, Nov-16, Volume: 10, Issue:11

Rosmarinic acid (RA), a main phenolic compound contained in rosemary which is used as tea, oil, medicine and so on, has been known to present anti-inflammatory, anti-oxidant and anti-cancer effects. Histone deacetylases (HDACs) are enzymes that play important roles in gene expression by removing the acetyl group from histone. The aberrant expression of HDAC in human tumors is related with the onset of human cancer. Especially, HDAC2, which belongs to HDAC class I composed of HDAC 1, 2, 3 and 8, has been reported to be highly expressed in prostate cancer (PCa) where it downregulates the expression of p53, resulting in an inhibition of apoptosis. The purpose of this study is to investigate the effect of RA in comparison with suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor used as an anti-cancer agent, on survival and apoptosis of PCa cell lines, PC-3 and DU145, and the expression of HDAC. RA decreased the cell proliferation in cell viability assay, and inhibited the colony formation and tumor spheroid formation. Additionally, RA induced early- and late-stage apoptosis of PC-3 and DU145 cells in Annexin V assay and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, respectively. In western blot analysis, RA inhibited the expression of HDAC2, as SAHA did. Proliferating cell nuclear antigen (PCNA), cyclin D1 and cyclin E1 were downregulated by RA, whereas p21 was upregulated. In addition, RA modulated the protein expression of intrinsic mitochondrial apoptotic pathway-related genes, such as Bax, Bcl-2, caspase-3 and poly (ADP-ribose) polymerase 1 (

Topics: Annexin A5; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cinnamates; Cyclin D1; Cyclin E; Depsides; DNA Fragmentation; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; In Situ Nick-End Labeling; Male; Oncogene Proteins; Poly (ADP-Ribose) Polymerase-1; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Rosmarinic Acid; Rosmarinus; Signal Transduction; Teas, Herbal; Teas, Medicinal; Vorinostat

2018