rosin has been researched along with Glioma* in 1 studies
1 other study(ies) available for rosin and Glioma
| Article | Year |
|---|---|
Design, Synthesis, and Bioactivity Evaluation of Novel Rosin Diterpenoid Derivatives as Potential Anti-glioma Agents.
Glioma is the most common brain tumor and its treatment options are limited. Abietic acid and dehydroabietic acid are tricyclic diterpenoid oxygen compounds with strong lip solubility and anti-glioma activity. In this study, novel rosin diterpenoid derivatives were designed and synthesized using abietic acid and dehydrogenated abietic acid as lead compounds and their activities against T98G, U87MG, and U251 cells were evaluated by CCK-8 methods. The in vivo activity of compounds with stronger activity in vitro was preliminarily studied through the Zebrafish model. The results showed that the IC Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diterpenes; Glioma; Molecular Docking Simulation; Structure-Activity Relationship; Zebrafish | 2023 |