rosin and Diabetes-Mellitus--Type-1

Topics: Acrylates; Blood Glucose Self-Monitoring; Camphanes; Dermatitis, Allergic Contact; Diabetes Mellitus, Type 1; Glucose; Humans; Patch Tests

The number of patients with contact dermatitis from glucose sensors and insulin infusion sets is increasing. Patch testing is challenging because of a lack of information concerning the constituent materials of medical devices.. To report on products and causes of allergic reactions to glucose sensors or insulin infusion sets over a 5-year period and suggest a short screening series.. Analysis of patch test data from consecutive patients suspected of allergic contact dermatitis (ACD) to glucose sensors and/or insulin infusion sets from 2015-2019.. Patient numbers increased from 4 to 15 per year; 30/38 (78.9%) were children. In 29 (76.3%), a diagnosis of allergic/probable ACD was established, mostly due to the tapes of the device or allergens in these tapes (n = 23) followed by allergens in the device housing (n = 10). Isobornyl acrylate, abitol, and colophonium were the most common allergens. Information from manufacturers was often difficult to obtain and, if accessible, inadequate. For this reason, the diagnosis was delayed for more than 1.5 years in 12 (31%) patients.. The increasing number of patients, mostly children, with ACD from devices used in treatment of type 1 diabetes demonstrates the importance of this problem. Allergies can easily be overlooked, due to the lack of mandatory labeling of the constituent materials of the devices.

Topics: Abietanes; Acrylates; Adolescent; Adult; Allergens; Blood Glucose Self-Monitoring; Camphanes; Child; Child, Preschool; Dermatitis, Allergic Contact; Diabetes Mellitus, Type 1; Female; Humans; Insulin Infusion Systems; Male; Middle Aged; Patch Tests; Resins, Plant; Retrospective Studies; Surgical Tape; Young Adult

Topics: Adhesives; Blood Glucose Self-Monitoring; Child; Dermatitis, Allergic Contact; Diabetes Mellitus, Type 1; Female; Humans; Menarche; Menstrual Hygiene Products; Resins, Plant; Vulvar Diseases

In the past few years, the increasing use of devices for diabetes treatment, such as continuous subcutaneous insulin infusion pumps, flash glucose monitoring, continuous glucose monitoring systems, sensor-augmented pumps, and automated insulin delivery devices, has resulted in important improvements in disease management. Meanwhile, the longer a patient uses a device, the greater the likelihood of developing a skin reaction. Allergic contact dermatitis is the most frequently described skin side effect caused by adhesive tapes contained in the insulin infusion sets or glucose sensor sets and used to connect these devices to the body. We describe 18 patients, followed up at our Pediatric Diabetes Centre, who experienced dermatological complications due to diabetes device use from January 2018 to December 2018. All the patients were patch tested with allergens from a "standard" series and from a "plastics and glues" series. Patch tests resulted positive in 66.7% of patients. Colophonium was the most frequently isolated sensitizing allergen (41.1% of cases). It is a complex mixture of

Topics: Adhesives; Adolescent; Child; Dermatitis, Allergic Contact; Diabetes Mellitus, Type 1; Female; Humans; Italy; Male; Prevalence; Resins, Plant; Retrospective Studies; Wearable Electronic Devices

Allergic contact dermatitis caused by glucose sensors has become an increasing problem. Contact allergies to isobornyl acrylate, colophonium, ethyl cyanoacrylate and N,N-dimethylacrylamide have been reported. However, there is a paucity of information regarding the prevalence of sensor-related dermatitis and detailed patient histories.. To evaluate diabetes patients who have developed allergic contact dermatitis caused by glucose sensors.. Seventy patients with suspected contact allergy to glucose sensors referred to university hospital dermatology clinics in southern Finland were patch tested with the baseline series, an isobornyl acrylate dilution series, and a number of other acrylates. Atopic constitution, contact allergies, the severity of the dermatitis and the ability to continue with the same or another type of sensor were recorded.. Positive patch test reactions to isobornyl acrylate were seen in 51 of 63 (81%) Freestyle Libre users. Colophonium or its derivatives gave positive reactions in five of seven Medtronic Enlite users. The median duration of sensor use before dermatitis was 6 months. The estimated prevalences of contact allergy to sensor adhesives were 0.7% for Freestyle Libre and 0.8% for Enlite.. We suggest that patients who have difficulties in finding a tolerable glucose sensor or an insulin pump should be patch tested.

Topics: Acrylates; Adolescent; Adult; Aged; Blood Glucose Self-Monitoring; Camphanes; Child; Child, Preschool; Dermatitis, Allergic Contact; Diabetes Mellitus, Type 1; Disposable Equipment; Female; Humans; Male; Middle Aged; Patch Tests; Resins, Plant; Young Adult

Topics: Adhesives; Child; Dermatitis, Allergic Contact; Diabetes Mellitus, Type 1; Female; Humans; Insulin Infusion Systems; Male; Patch Tests; Resins, Plant