Current computer-aided drug design, 2022, Volume: 18, Issue:3
Annona muricata is a member of the Annonaceae family. This plant has a high concentration of acetogenin, which gives it excellent therapeutic property. Researchers have tested this miraculous herb in breast cancer cells treatment and observed that it could be a source of anti-cancer agents. The proposed study focused on screening the anticancer biological activity of Annona muricata plant by using the in vitro, in vivo, and in silico methods.. In in vitro analysis, the IC. In vitro and in vivo results revealed the IC50 value of 2D MDA-MB-231 cells as 330 μg.mℓ-1, of 2D MCF-7 cells as290 μg.mℓ-1, and of 3D MCF-7 and MDA-MB-231 cells about 0.005 g.mℓ-1; the LC50 value of Drosophila melanogaster was determined as 0.1 g.mℓ-1. In silico results revealed that the docked complex formed by Isoquercetin showed better binding affinity towards target proteins.. As a result of the analysis, the Annona muricata plant has been observed to be effective against cancer and likely to be a potential drug. Topics: Acetogenins; Animals; Annona; Aporphines; Breast Neoplasms; Dioxoles; Drosophila melanogaster; Female; Glucosides; Humans; Molecular Docking Simulation; Norisoprenoids; Plant Extracts; Plastics; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quercetin | 2022 |