ropinirole has been researched along with Amyotrophic Lateral Sclerosis in 5 studies
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed drug screening using motor neurons derived from disease-specific induced pluripotent stem cells (iPSCs) for amyotrophic lateral sclerosis (ALS) and found that ropinirole hydrochloride prevented motor neuron death." | 5.30 | [Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment]. ( Morimoto, S; Okano, H; Takahashi, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morimoto, S | 4 |
| Takahashi, S | 4 |
| Ito, D | 1 |
| Daté, Y | 1 |
| Okada, K | 1 |
| Kato, C | 1 |
| Nakamura, S | 1 |
| Ozawa, F | 1 |
| Chyi, CM | 1 |
| Nishiyama, A | 1 |
| Suzuki, N | 2 |
| Fujimori, K | 3 |
| Kondo, T | 1 |
| Takao, M | 1 |
| Hirai, M | 1 |
| Kabe, Y | 1 |
| Suematsu, M | 1 |
| Jinzaki, M | 1 |
| Aoki, M | 2 |
| Fujiki, Y | 1 |
| Sato, Y | 1 |
| Nakahara, J | 2 |
| Okano, H | 5 |
| Fukushima, K | 1 |
| Yasuda, D | 1 |
| Ishikawa, M | 1 |
| Otomo, A | 1 |
| Atsuta, N | 1 |
| Nakamura, R | 1 |
| Akiyama, T | 1 |
| Hadano, S | 1 |
| Saya, H | 1 |
| Sobue, G | 1 |
1 review available for ropinirole and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Ropinirole, a New ALS Drug Candidate Developed Using iPSCs.
Topics: Amyotrophic Lateral Sclerosis; Humans; Indoles; Induced Pluripotent Stem Cells; Pharmaceutical Prepa | 2020 |
3 trials available for ropinirole and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Topics: Amyotrophic Lateral Sclerosis; Humans; Indoles; Induced Pluripotent Stem Cells; Motor Neurons | 2023 |
[Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment].
Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Humans; Indoles; Motor Neurons | 2019 |
[Ropinirole Hydrochloride for ALS].
Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Humans; Indoles; Induced Pluripotent Stem Cells; | 2019 |
1 other study available for ropinirole and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.
Topics: Amyotrophic Lateral Sclerosis; Cell Differentiation; Humans; Indoles; Induced Pluripotent Stem Cells | 2018 |