romurtide and Paramyxoviridae-Infections

romurtide has been researched along with Paramyxoviridae-Infections* in 3 studies

Reviews

1 review(s) available for romurtide and Paramyxoviridae-Infections

Article	Year
Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice. Advances in experimental medicine and biology, 1992, Volume: 319 The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes simplex type 1 virus (HSV). The synthetic MDP derivative, MDP-Lys(L18), and recombinant cytokines, IL-1 beta, IFN-gamma, G-CSF and GM-CSF were shown to be effective for the stimulation of nonspecific protection against Sendai virus infection in mice. Both MDP-Lys(L18) and GM-CSF were effective for the protection against HSV infection in cyclophosphamide (CY)-treated mice. B30-MDP was suggested to be useful as an immunoadjuvant for the potentiation of antigenicity of recombinant or component vaccines. Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Amino Acid Sequence; Animals; Cytokines; Herpes Simplex; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Orthohantavirus; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Viral Envelope Proteins; Virus Diseases	1992

Article

Year

Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice.

Advances in experimental medicine and biology, 1992, Volume: 319

The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes simplex type 1 virus (HSV). The synthetic MDP derivative, MDP-Lys(L18), and recombinant cytokines, IL-1 beta, IFN-gamma, G-CSF and GM-CSF were shown to be effective for the stimulation of nonspecific protection against Sendai virus infection in mice. Both MDP-Lys(L18) and GM-CSF were effective for the protection against HSV infection in cyclophosphamide (CY)-treated mice. B30-MDP was suggested to be useful as an immunoadjuvant for the potentiation of antigenicity of recombinant or component vaccines.

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Amino Acid Sequence; Animals; Cytokines; Herpes Simplex; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Orthohantavirus; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Viral Envelope Proteins; Virus Diseases

1992

Other Studies

2 other study(ies) available for romurtide and Paramyxoviridae-Infections

Article	Year
Suppression of Sendai virus growth by treatment with N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine in mice. Vaccine, 1987, Volume: 5, Issue:4 Mice that received N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine [MDP-Lys (L18)] were resistant to Sendai virus infection. In these protected mice, a significant growth inhibition of the virus was confirmed repeatedly at 10(0.2) to 10(0.4) of haemadsorbing units at an early non-specific phase but not at a late virus-eliminating phase of the infection. Virus growth was enhanced by treatment with silica but not by treatment with anti-asialo GM1 serum in MDP-Lys (L18)-treated mice. Peritoneal adherent cells activated by MDP-Lys(L18) showed an enhanced uptake and ability to inactivate Sendai virus in vitro. Excess interferon production in MDP-Lys (L18)-treated mice was seen on day 1 but not on days 2 to 7 of the infection. The possible role of macrophages and interferon in providing non-specific protection against Sendai virus in the MDP-Lys (L18)-treated mice is discussed. Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; G(M1) Ganglioside; Glycosphingolipids; Immune Sera; Interferons; Lung; Male; Mice; Mice, Inbred BALB C; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Silicon Dioxide	1987
Experimental and clinical studies on the effects of synthetic muramyldipeptide derivatives on viral and opportunistic infections. Methods and findings in experimental and clinical pharmacology, 1986, Volume: 8, Issue:1 The efficacy of strearoyl-MDP derivatives, L18-MDP and MDP-Lys-18 against bacterial and viral infections in mice was examined. Both L18-MDP and MDP-Lys-L18 stimulated nonspecifically host-resistance against opportunistic infection with C. kutscheri in hydrocrotisone-treated mice against Sendai virus infection in mice. Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Corynebacterium Infections; Hydrocortisone; Immunity, Innate; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Time Factors	1986

Article

Year

Suppression of Sendai virus growth by treatment with N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine in mice.

Vaccine, 1987, Volume: 5, Issue:4

Mice that received N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine [MDP-Lys (L18)] were resistant to Sendai virus infection. In these protected mice, a significant growth inhibition of the virus was confirmed repeatedly at 10(0.2) to 10(0.4) of haemadsorbing units at an early non-specific phase but not at a late virus-eliminating phase of the infection. Virus growth was enhanced by treatment with silica but not by treatment with anti-asialo GM1 serum in MDP-Lys (L18)-treated mice. Peritoneal adherent cells activated by MDP-Lys(L18) showed an enhanced uptake and ability to inactivate Sendai virus in vitro. Excess interferon production in MDP-Lys (L18)-treated mice was seen on day 1 but not on days 2 to 7 of the infection. The possible role of macrophages and interferon in providing non-specific protection against Sendai virus in the MDP-Lys (L18)-treated mice is discussed.

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; G(M1) Ganglioside; Glycosphingolipids; Immune Sera; Interferons; Lung; Male; Mice; Mice, Inbred BALB C; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Silicon Dioxide

1987

Experimental and clinical studies on the effects of synthetic muramyldipeptide derivatives on viral and opportunistic infections.

Methods and findings in experimental and clinical pharmacology, 1986, Volume: 8, Issue:1

The efficacy of strearoyl-MDP derivatives, L18-MDP and MDP-Lys-18 against bacterial and viral infections in mice was examined. Both L18-MDP and MDP-Lys-L18 stimulated nonspecifically host-resistance against opportunistic infection with C. kutscheri in hydrocrotisone-treated mice against Sendai virus infection in mice.

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Corynebacterium Infections; Hydrocortisone; Immunity, Innate; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Time Factors

1986