romurtide and Hemorrhagic-Fever-with-Renal-Syndrome

romurtide has been researched along with Hemorrhagic-Fever-with-Renal-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for romurtide and Hemorrhagic-Fever-with-Renal-Syndrome

Article	Year
Effect of MDP-Lys(L18), a derivative of MDP, on enhancing host resistance against Hantaan virus infection in newborn mice. Vaccine, 1995, Volume: 13, Issue:14 We examined the effect of MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide, on the enhancement of host resistance against virus infection in newborn mice. Newborn mice were inoculated with 4 LD50/mouse of Hantaan virus strain 76-118 (HTN) one day after birth. Mice given 100 micrograms/mouse of MDP-Lys(L18) before infection exhibited significantly higher survival rates than those of non-treated mice. The effect of MDP-Lys(L18) was also restorative when given to the mice 4 or 7 days after infection. The titers of virus isolated from the lungs and spleens 12 days after infection, were about 30-times lower in MDP-Lys(L18)-treated (lung: 1.0 x 10(3) FFU; spleen: 6.8 x 10(1) FFU/mouse), than those of non-treated mice (lung: 3.4 x 10(4) FFU; spleen: 1.9 x 10(3) FFU/mouse). Furthermore, the virus was undetectable in the brains of MDP-Lys(L18)-treated mice, whereas viruses were isolated from 3 of 6 non-treated mice. MDP-Lys(L18) augmented the number of peripheral leukocytes and splenocytes, as well as mitogenic responses of the cells from bone marrow and spleen of newborn mice. These results suggest that MDP-Lys(L18) enhanced the resistance of newborn mice against HTN virus in a systemic infection model, and that this mechanism is involved in the enhancement of hematopoiesis and responsiveness of immune-related cells to mitogens. Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Aging; Animals; Animals, Newborn; Bone Marrow; Bone Marrow Cells; Brain; Cell Division; Concanavalin A; Disease Susceptibility; Female; Hantaan virus; Hematopoiesis; Hemorrhagic Fever with Renal Syndrome; Immunity, Innate; Lipopolysaccharides; Lung; Mice; Mice, Inbred BALB C; Pregnancy; Spleen	1995

Article

Year

Effect of MDP-Lys(L18), a derivative of MDP, on enhancing host resistance against Hantaan virus infection in newborn mice.

Vaccine, 1995, Volume: 13, Issue:14

We examined the effect of MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide, on the enhancement of host resistance against virus infection in newborn mice. Newborn mice were inoculated with 4 LD50/mouse of Hantaan virus strain 76-118 (HTN) one day after birth. Mice given 100 micrograms/mouse of MDP-Lys(L18) before infection exhibited significantly higher survival rates than those of non-treated mice. The effect of MDP-Lys(L18) was also restorative when given to the mice 4 or 7 days after infection. The titers of virus isolated from the lungs and spleens 12 days after infection, were about 30-times lower in MDP-Lys(L18)-treated (lung: 1.0 x 10(3) FFU; spleen: 6.8 x 10(1) FFU/mouse), than those of non-treated mice (lung: 3.4 x 10(4) FFU; spleen: 1.9 x 10(3) FFU/mouse). Furthermore, the virus was undetectable in the brains of MDP-Lys(L18)-treated mice, whereas viruses were isolated from 3 of 6 non-treated mice. MDP-Lys(L18) augmented the number of peripheral leukocytes and splenocytes, as well as mitogenic responses of the cells from bone marrow and spleen of newborn mice. These results suggest that MDP-Lys(L18) enhanced the resistance of newborn mice against HTN virus in a systemic infection model, and that this mechanism is involved in the enhancement of hematopoiesis and responsiveness of immune-related cells to mitogens.

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Aging; Animals; Animals, Newborn; Bone Marrow; Bone Marrow Cells; Brain; Cell Division; Concanavalin A; Disease Susceptibility; Female; Hantaan virus; Hematopoiesis; Hemorrhagic Fever with Renal Syndrome; Immunity, Innate; Lipopolysaccharides; Lung; Mice; Mice, Inbred BALB C; Pregnancy; Spleen

1995