rome and Hyperplasia

rome has been researched along with Hyperplasia* in 2 studies

Trials

1 trial(s) available for rome and Hyperplasia

ArticleYear
Impact of drug-eluting balloon (pre- or post-) dilation on neointima formation in de novo lesions treated by bare-metal stent: the IN-PACT CORO trial.
    Heart and vessels, 2016, Volume: 31, Issue:5

    The efficacy of DEB in modifying the high restenosis risk associated with BMS implantation is doubtful. Optical coherence tomography (OCT) may allow precise assessment of neointimal formation after stent implantation. We performed a single-center, prospective, 1:2 randomized trial comparing BMS implantation alone (BMS group) vs. additional DEB (DEB group). DEB patients were further randomized 1:1 to DEB before stenting (pre-DEB group), or after stenting (post-DEB group). Primary endpoint was OCT-assessed neointimal hyperplasia (expressed both as mean in-stent neointimal area and as percentage obstruction of the mean stent area) at 6 months. Secondary endpoints were the percentage of uncovered and malapposed stent struts. Thirty patients were enrolled and randomized to BMS (n = 10), pre-DEB (n = 10), post-DEB (n = 10). At 6-month OCT follow-up, DEB significantly reduced neointimal area compared with BMS: mean neointimal area 2.01 ± 0.89 vs. 3.03 ± 1.07 mm(2) (p = 0.02), percentage area obstruction 24.56 ± 12.50 vs. 37.51 ± 12.26 % (p = 0.02). The percentage of uncovered and malapposed stent struts did not differ significantly between BMS and DEB. In the comparison between pre-DEB and post-DEB, no significant difference was observed for both primary and secondary endpoints. In de novo coronary lesions treated with BMS, DEB use could be associated with a mild reduction in neointimal hyperplasia at 6 months; this effect could be unrelated to the timing of DEB dilation (pre- or post-stenting).. http://www.clinicaltrials.gov . Identifier: NCT01057563.

    Topics: Aged; Angioplasty, Balloon, Coronary; Cardiac Catheters; Cardiovascular Agents; Coated Materials, Biocompatible; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Female; Humans; Hyperplasia; Male; Metals; Middle Aged; Neointima; Percutaneous Coronary Intervention; Prospective Studies; Risk Factors; Rome; Stents; Time Factors; Tomography, Optical Coherence; Treatment Outcome

2016

Other Studies

1 other study(ies) available for rome and Hyperplasia

ArticleYear
Detection of human papillomavirus and adenovirus in benign and malignant lesions of the larynx.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2009, Volume: 141, Issue:2

    To investigate the role of human papillomavirus (HPV) and adenovirus (AdV) infections in the oncogenesis of squamous cell carcinomas of the larynx and of laryngeal dysplasia.. Cross-sectional study with planned data collection.. Department of Otorhinolaryngology G. Ferreri and Department of Experimental Medicine and Pathology-Section of Virology, Sapienza University of Rome.. Biopsy samples were taken from 68 patients with benign and malignant lesions of the larynx. All tissue samples were analyzed by means of polymerase chain reaction with two groups of primers for HPV and with a pair of primers for AdV.. All cases of carcinomas and dysplasia as well as all control cases were negative for both viruses. Four of the five cases of laryngeal papillomas were positive for only HPV, confirming the role of these viral types in the origin of papillomas.. The absence of viral genomes in laryngeal carcinomas as in the other cases studied suggests the existence of other factors that play a more important role than viral infection in the carcinogenesis of these lesions.

    Topics: Academic Medical Centers; Adenoviridae; Adult; Aged; Aged, 80 and over; Biopsy; Carcinoma, Squamous Cell; Female; Humans; Hyperplasia; Laryngeal Diseases; Laryngeal Neoplasms; Male; Middle Aged; Papillomaviridae; Papillomavirus Infections; Polymerase Chain Reaction; Predictive Value of Tests; Prospective Studies; Risk Factors; Rome; Tumor Virus Infections

2009