rome and Endometriosis

The results obtained by treating 137 patients suffering from advanced carcinoma of the endometrium with medroxyprogesterone acetate (MPA) at a hospital in Rome, Italy, are reported. 48 cases were treated wtih 250 mg of MPA twice weekly for 3 months, followed by a long-term treatment with 250 mg weekly; later 89 cases were treated with 500 mg twice weekly for 3 months, followed by a long-term treatment with 500 mg weekly. Positive results were obtained in 20.8% of the cases in the 1st group and in 41.5% of the cases in the 2nd, which shows the greater effectiveness of the larger doses. Side effects mainly included asthma, skin rashes, and jaundice symptoms, which could be treated; it was always possible to continue the MPA treatment. Results appeared to be better in the case of patients with a localized disease, while the age of the patient appeared to be unrelated to the effectiveness of treatment. The survival time of the patients who responded to MPA treatment was markedly longer, the average being 2 years.

Topics: Adenocarcinoma; Clinical Trials as Topic; Drug Evaluation; Endometriosis; Female; Hospital Departments; Humans; Medroxyprogesterone; Rome; Time Factors; Uterine Neoplasms

Association between p53 codon 72 and endometriosis has been observed in populations of East Asia but not in those of European descent. Genetic polymorphisms could interact with p53 codon 72 influencing its association with endometriosis, thus explaining these differences among populations.. 130 women hospitalized for endometriosis and a sample of 250 women without endometriosis have been studied. All women were from the White population of Rome. ACP1, PTPN22, ADA6 and p53 codon 72 genotypes were determined by DNA analysis. Statistical analysis was performed by SPSS package. Three-way contingency table analyses were performed by a log linear model according to Sokal and Rohlf.. There is an epistatic interaction among ADA6, p53 codon 72 and endometriosis resulting in a positive association between carriers of *Pro allele of p53 codon 72 and endometriosis in women carrying the ADA6 *1 allele. PTPN22 and ACP1 show an additive effect with p53 codon 72 concerning their effect on endometriosis. The strength of association between p53 codon 72 and endometriosis is positively correlated with the number of the three factors considered.. ADA6, PTPN22 and ACP1 are involved in immune reactions: since endometriosis has an autoimmune component, a cooperative interaction among these genetic systems appears biological plausible. The present result could contribute to explain the differences observed among populations concerning the association between p53 codon 72 and endometriosis.

Topics: Adenosine Deaminase; Adult; Alleles; Case-Control Studies; Codon; Endometriosis; Female; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Polymorphism, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Rome; Tumor Suppressor Protein p53; White People