rome and Diabetes-Mellitus--Type-1

Topics: Adult; Diabetes Complications; Diabetes Mellitus, Type 1; Female; Humans; Hypoglycemic Agents; Infusions, Subcutaneous; Insulin; Insulin Infusion Systems; Male; Middle Aged; Protective Factors; Risk Factors; Rome; Time Factors; Treatment Outcome; Young Adult

Topics: Adolescent; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Humans; Incidence; Infant; Infant, Newborn; Italy; Male; Prospective Studies; Rome

To analyze the age at menarche of girls with type 1 diabetes (T1D) who were diagnosed with the disease before puberty and compare it with that of an age-matched group of normal girls. Previous studies on the appearance of menarche showed that the mean age of onset of menarche is delayed in girls affected by T1D compared with normal girls.. Case-control study.. Patients and controls in an academic research environment.. We studied, retrospectively, the charts of 162 consecutive girls with T1D born in a geographically defined region between 1984 and 1994 with a mean disease duration of 3-5 years, all of whom were on intensive insulin therapy since diagnosis of T1D. The control group consisted of 214 normal girls born between 1984 and 1994, who agreed to fill in an anonymous questionnaire regarding age at menarche and other clinical information.. There was no intervention per se in the study. Age at menarche appears as a dependent variable of body mass index (BMI), HbA1c, and so on.. BMI, HbA1c, and duration of T1D at menarche were considered among the potential factors affecting the age of menarche.. Age at menarche in girls with T1D was significantly delayed compared with control girls (12.6 +/- 1.5 years vs. 12.25 +/- 1.4 years, respectively). HbA1c levels and BMI did not influence the age at menarche.. Despite intensive insulin therapy and good metabolic control since diagnosis of T1D, the age at menarche is still delayed in girls who develop T1D before puberty.

Topics: Age Factors; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Menarche; Puberty, Delayed; Retrospective Studies; Rome

This study investigated whether nondipping (defined as a day-night change in blood pressure (BP)

Topics: Adult; Analysis of Variance; Autonomic Nervous System Diseases; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Case-Control Studies; Circadian Rhythm; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Predictive Value of Tests; ROC Curve; Rome

To provide data on the incidence of IDDM in Rome and the Lazio region evaluated prospectively from 1989 to 1993 for a total of > 5 million subjects younger than 15 years.. All patients with newly discovered IDDM diagnosed between 1 January 1989 and 31 December 1993 among residents in Rome and its region were recorded. Primary ascertainment was based in diabetes clinics and specialized hospitals in the region, whereas the secondary independent source was taken from the archives of the region where patients are registered to obtain exemption from paying for medications.. We identified 330 new patients with a degree of ascertainment of 85%. Overall the incidence rate of the disease was 7.9 per 100,000 per year (95% CI 7.1-8.8). The incidence was higher in the 5- to 9-year-old age-group (10.4 per 100,000) and in winter (36.2%). The cumulative risk for the disease is on the order of 1.18 per 1,000 subjects < 15 years of age. No significant differences in incidence were observed between boys and girls. There were 14 instances of coma at diagnosis (4.3%), but hyperglycemia without ketonuria was diagnosed in 35% of patients, suggesting an early diagnosis.. Compared with the other continental Italian regions for which data are available for a single year, the IDDM incidence rate in Rome is similar. We conclude that the IDDM incidence rate in Rome and its region is comparable to that in other Southern European countries and remained stable over the 5-year observation period.

Topics: Adolescent; Age Factors; Blood Glucose; Child; Child, Preschool; Demography; Diabetes Mellitus, Type 1; Female; Humans; Incidence; Infant; Italy; Male; Prospective Studies; Rome; Sex Characteristics; Sex Factors; Time Factors

The blood glucose levels of pregnant women with insulin-dependent diabetes mellitus and the blood glucose levels of newborns during the first few hours of life show an association with maternal Rh genotype. Distortions of joint maternal-fetal Rh phenotype distribution have also been observed. Because a cluster of genes involved in glycide metabolism is located on the short arm of chromosome 1, the present observations may reflect the action of these genes.

Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Genotype; Haplotypes; Humans; Hypoglycemia; Infant, Newborn; Phenotype; Pregnancy; Pregnancy in Diabetics; Rh-Hr Blood-Group System; Rome; Selection, Genetic