rolitetracycline and Myocardial-Infarction

The myocardial infarct induced by isoproterenol in spontaneously hypertensive rats accumulates higher activities of 99mTc-PM tetracycline compared with the cardiac infarct in normotensive rats caused by the same method. The isoproterenol model of the myocardial necrosis was induced in intact rats without opening the thorax and is a convenient method for experimental radioisotope studies.

Topics: Animals; Disease Models, Animal; Female; Hypertension; Isoproterenol; Male; Myocardial Infarction; Myocardium; Necrosis; Organotechnetium Compounds; Radionuclide Imaging; Rats; Rats, Inbred Strains; Rolitetracycline; Technetium

The single intramuscular injection of 275 mg Rolitetracyclin (Reverin) led to a rise in serum creatine phosphokinase in 11 out of 20 heart healthy patients, 7 cases with values over 100 mU/ml. In sane cases the initial values had still not been reached 72 hours after injection. With Rolitetracyclin given intravenously the creatine phosphokinase values do not alter, as with an isotonic Na-Cl solution given intramuscularly. A rise in the serum creatine phosphokinase was seen in 2 out of 6 cases after an intramuscular injection of Oxytetracyclin (Terramycin -Depot). One is not dealing with a reaction which is typical only to Rolitetracyclin. The cause is thought to be the setting free of enzymes through the musclelesions. The results underline the sensitivity of and problems involved with creatine phosphokinase in the diagnosis of heart-infarction.

Topics: Adult; Aspartate Aminotransferases; Creatine Kinase; Diagnostic Errors; False Positive Reactions; Female; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Myocardial Infarction; Oxytetracycline; Rolitetracycline; Sodium Chloride; Tetracycline; Time Factors