rolitetracycline and Gonorrhea

Topics: Adult; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Rolitetracycline; Time Factors

Topics: Acute Disease; Adult; Arthritis, Reactive; Gonorrhea; Humans; Injections, Intramuscular; Male; Rolitetracycline; Tetracycline

Rising failure rates with single injections of penicillin in gonorrhea are causing alarm. In the Far East, the failure rate is about 30% after single injections of 2.4 mega units of aqueous procaine penicillin. In London, although there is rising gonoccoccus resistance to penicillin, single injections of 1.2 mega units of aqueous procaine penicillin nets a cure rate of 85.8% to 91.5% in male patients. Other recent experiences in the treatment of gonorrhea in London men are outlined in this article. The failure rate was reduced to 5.8% when a single injection of 2.4 mega units of procaine penicillin was given. When 1 gm probenecid was given orally along with 1.2 mega units of procaine penicillin, the failure rate was 6.6%. Streptomycin is so ineffective now against gonorrhea that it is no longer acceptable even as a first treatment in patients who are allergic to penicillin. In London, the failure rate with streptomycin is 31.7%. Experts think the rate will jump to 85.8% in the next year. Many other antibiotics can be used against gonorrhea, but, as in the case of streptomycin, they may lose their effectiveness. Some recent experiences show that a combination of rolitetracycline by injection and tetracycline by mouth does not give as good results as a single injection of aqueous procaine penicillin but that comparable results can be obtained with single oral doses of rifampicin and superior results (95.7% success) were obtained with 2 oral doses of dementhylchlortetracycline.

Topics: Demeclocycline; Drug Synergism; Gonorrhea; Humans; Male; Penicillin G Procaine; Penicillin Resistance; Probenecid; Rifampin; Rolitetracycline

Topics: Adolescent; Adult; Female; Gonorrhea; Humans; Male; Middle Aged; Penicillin Resistance; Penicillins; Rolitetracycline