rolipram has been researched along with Spinal Cord Injuries in 26 studies
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rolipram was administered subcutaneously for 4 weeks immediately after contusion at vertebral T8 (25." | 1.39 | Combining neurotrophin-transduced schwann cells and rolipram to promote functional recovery from subacute spinal cord injury. ( Barakat, DJ; Bleicher, D; Bunge, MB; Fenton, S; Flora, G; Garg, M; Joseph, G; Louro, J; Patel, S; Pearse, DD; Singh, A, 2013) |
| " With the ability to control the release of drug dosage locally within the spinal cord, drug-eluting microfibrous patches demonstrate the importance of appropriate local release-kinetics of rolipram, proving their usefulness as a therapeutic platform for the study and repair of SCI." | 1.38 | Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. ( Beattie, MS; Bresnahan, JC; Downing, TL; Farmer, DL; Lee, AL; Li, S; Nout, Y; Wang, A; Yan, ZQ, 2012) |
| " Chronic administration of rolipram, a specific phosphodiesterase-IV inhibitor, promotes synaptic plasticity and restores phrenic nerve function after a high cervical spinal cord lesion." | 1.35 | Systemic administration of rolipram increases medullary and spinal cAMP and activates a latent respiratory motor pathway after high cervical spinal cord injury. ( Goshgarian, HG; Kajana, S, 2009) |
| " Since theophylline has two modes of action, in the present study we tested whether chronic administration of pentoxifylline, a non-selective phosphodiesterase inhibitor, rolipram, a phosphodiesterase-4 specific inhibitor, and 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), an adenosine A1 receptor antagonist, would induce recovery similar to that induced by theophylline in male Sprague-Dawley rats following a left C2 spinal cord lesion." | 1.35 | Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. ( Goshgarian, HG; Kajana, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 13 (50.00) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, J | 1 |
| Khang, MK | 1 |
| Liao, Z | 1 |
| Webb, K | 1 |
| Detloff, MR | 1 |
| Lee, JS | 2 |
| Vismara, I | 1 |
| Papa, S | 1 |
| Veneruso, V | 1 |
| Mauri, E | 1 |
| Mariani, A | 1 |
| De Paola, M | 1 |
| Affatato, R | 1 |
| Rossetti, A | 1 |
| Sponchioni, M | 1 |
| Moscatelli, D | 1 |
| Sacchetti, A | 1 |
| Rossi, F | 1 |
| Forloni, G | 1 |
| Veglianese, P | 1 |
| Macks, C | 1 |
| Gwak, SJ | 1 |
| Lynn, M | 1 |
| Yin, Y | 1 |
| Sun, W | 1 |
| Li, Z | 1 |
| Zhang, B | 1 |
| Cui, H | 1 |
| Deng, L | 1 |
| Xie, P | 1 |
| Xiang, J | 1 |
| Zou, J | 1 |
| Heidemann, M | 1 |
| Streit, J | 1 |
| Tscherter, A | 1 |
| Boomkamp, SD | 1 |
| McGrath, MA | 1 |
| Houslay, MD | 1 |
| Barnett, SC | 1 |
| Grosso, MJ | 1 |
| Matheus, V | 1 |
| Clark, M | 2 |
| van Rooijen, N | 2 |
| Iannotti, CA | 2 |
| Steinmetz, MP | 2 |
| Bonnici, B | 1 |
| Kapfhammer, JP | 1 |
| Dai, H | 1 |
| MacArthur, L | 1 |
| McAtee, M | 1 |
| Hockenbury, N | 1 |
| Tidwell, JL | 2 |
| McHugh, B | 1 |
| Mansfield, K | 1 |
| Finn, T | 1 |
| Hamers, FP | 1 |
| Bregman, BS | 2 |
| Koopmans, GC | 1 |
| Deumens, R | 1 |
| Buss, A | 1 |
| Geoghegan, L | 1 |
| Myint, AM | 1 |
| Honig, WH | 1 |
| Kern, N | 1 |
| Joosten, EA | 1 |
| Noth, J | 1 |
| Brook, GA | 1 |
| Kajana, S | 2 |
| Goshgarian, HG | 2 |
| Beaumont, E | 2 |
| Whitaker, CM | 2 |
| Burke, DA | 1 |
| Hetman, M | 2 |
| Onifer, SM | 2 |
| Horn, KP | 1 |
| Silver, J | 1 |
| Bretzner, F | 1 |
| Plemel, JR | 1 |
| Liu, J | 1 |
| Richter, M | 1 |
| Roskams, AJ | 1 |
| Tetzlaff, W | 1 |
| Sharp, KG | 1 |
| Flanagan, LA | 1 |
| Yee, KM | 1 |
| Steward, O | 1 |
| Bunge, MB | 3 |
| Pearse, DD | 4 |
| Downing, TL | 1 |
| Wang, A | 1 |
| Yan, ZQ | 1 |
| Nout, Y | 1 |
| Lee, AL | 1 |
| Beattie, MS | 1 |
| Bresnahan, JC | 1 |
| Farmer, DL | 1 |
| Li, S | 1 |
| Schaal, SM | 1 |
| Garg, MS | 1 |
| Ghosh, M | 1 |
| Lovera, L | 1 |
| Lopez, M | 1 |
| Patel, M | 1 |
| Louro, J | 2 |
| Patel, S | 2 |
| Tuesta, L | 1 |
| Chan, WM | 1 |
| Flora, G | 1 |
| Joseph, G | 1 |
| Singh, A | 1 |
| Bleicher, D | 1 |
| Barakat, DJ | 1 |
| Fenton, S | 1 |
| Garg, M | 1 |
| Costa, LM | 1 |
| Pereira, JE | 1 |
| Filipe, VM | 1 |
| Magalhães, LG | 1 |
| Couto, PA | 1 |
| Gonzalo-Orden, JM | 1 |
| Raimondo, S | 1 |
| Geuna, S | 1 |
| Maurício, AC | 1 |
| Nikulina, E | 2 |
| Filbin, MT | 4 |
| Varejão, AS | 1 |
| Pereira, FC | 1 |
| Marcillo, AE | 1 |
| Bates, ML | 1 |
| Berrocal, YA | 1 |
| Dai, HN | 1 |
| Wang, X | 1 |
| Baughman, KW | 1 |
| Basso, DM | 1 |
| Strittmatter, SM | 1 |
| Hannila, SS | 1 |
| Wells, MJ | 1 |
| Magnuson, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Regeneration in Cervical Degenerative Myelopathy - a Multi-centre, Double-blind, Randomised, Placebo Controlled Trial Assessing the Efficacy of Ibudilast as an Adjuvant Treatment to Decompressive Surgery for Degenerative Cervical Myelopathy[NCT04631471] | Phase 3 | 400 participants (Anticipated) | Interventional | 2021-12-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for rolipram and Spinal Cord Injuries
| Article | Year |
|---|---|
The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury.
Topics: Animals; Axons; Cyclic AMP; Humans; Models, Biological; Nerve Regeneration; Phosphodiesterase Inhibi | 2008 |
25 other studies available for rolipram and Spinal Cord Injuries
| Article | Year |
|---|---|
Rolipram-loaded PgP nanoparticle reduces secondary injury and enhances motor function recovery in a rat moderate contusion SCI model.
Topics: Animals; Contusions; Nanoparticles; Rats; Rats, Sprague-Dawley; Recovery of Function; Rolipram; Spin | 2023 |
Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cells, Cultured; Humans; Mice; Mice, I | 2020 |
Rolipram-Loaded Polymeric Micelle Nanoparticle Reduces Secondary Injury after Rat Compression Spinal Cord Injury.
Topics: Animals; Drug Carriers; Micelles; Nanoparticles; Neuroprotective Agents; Phosphodiesterase 4 Inhibit | 2018 |
Effects of combining methylprednisolone with rolipram on functional recovery in adult rats following spinal cord injury.
Topics: Animals; Axons; Disease Models, Animal; Female; Methylprednisolone; Neurons; Neuroprotective Agents; | 2013 |
Functional regeneration of intraspinal connections in a new in vitro model.
Topics: Action Potentials; Age Factors; Animals; Axons; Electrodes; Fluorescent Antibody Technique; In Vitro | 2014 |
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
Topics: Acetylcysteine; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Erythr | 2014 |
Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury.
Topics: Animals; Bone Density Conservation Agents; Chondroitin ABC Lyase; Clodronic Acid; Combined Modality | 2014 |
Spontaneous regeneration of intrinsic spinal cord axons in a novel spinal cord slice culture model.
Topics: Aging; Animals; Animals, Newborn; Axons; Calbindin 2; Cell Differentiation; Dissection; Growth Cones | 2008 |
Activity-based therapies to promote forelimb use after a cervical spinal cord injury.
Topics: Animals; Biotin; Cervical Vertebrae; Dextrans; Disease Models, Animal; Environment, Controlled; Exer | 2009 |
Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury.
Topics: Animals; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Enzyme-Linked Immun | 2009 |
Systemic administration of rolipram increases medullary and spinal cAMP and activates a latent respiratory motor pathway after high cervical spinal cord injury.
Topics: Animals; Cervical Vertebrae; Cyclic AMP; Disease Models, Animal; Functional Laterality; Injections, | 2009 |
Effects of rolipram on adult rat oligodendrocytes and functional recovery after contusive cervical spinal cord injury.
Topics: Animals; Axons; Cell Count; Cervical Vertebrae; Female; Nerve Fibers, Myelinated; Neural Pathways; N | 2009 |
A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI.
Topics: Analysis of Variance; Animals; Axons; Brain Stem; Clodronic Acid; Contusions; Disease Models, Animal | 2011 |
Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury.
Topics: Animals; Axons; Cell Transplantation; Cyclic AMP; Disease Models, Animal; Glial Fibrillary Acidic Pr | 2010 |
A re-assessment of a combinatorial treatment involving Schwann cell transplants and elevation of cyclic AMP on recovery of motor function following thoracic spinal cord injury in rats.
Topics: Animals; Bucladesine; Cell Transplantation; Combined Modality Therapy; Cyclic AMP; Injections, Spina | 2012 |
Response to the report, "A re-assessment of a combinatorial treatment involving Schwann cell transplants and elevation of cyclic AMP on recovery of motor function following thoracic spinal cord injury in rats" by Sharp et al. (this volume).
Topics: Animals; Cyclic AMP; Motor Activity; Recovery of Function; Rolipram; Schwann Cells; Spinal Cord Inju | 2012 |
Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Drug Delivery Systems; Excipients; Female; Glucuronic | 2012 |
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury.
Topics: Animals; Axons; Cell Survival; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Female; Moto | 2012 |
Combining neurotrophin-transduced schwann cells and rolipram to promote functional recovery from subacute spinal cord injury.
Topics: Animals; Antidepressive Agents; Axons; Brain-Derived Neurotrophic Factor; Cells, Cultured; Female; G | 2013 |
Rolipram promotes functional recovery after contusive thoracic spinal cord injury in rats.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Female; Infusion Pumps, Implantable; | 2013 |
cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury.
Topics: Animals; Axons; Brain Stem; Bucladesine; Cell Transplantation; Cyclic AMP; Female; Interleukin-1; Mo | 2004 |
The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery.
Topics: Animals; Axons; Central Nervous System Agents; Cyclic AMP; Fetal Tissue Transplantation; Nerve Regen | 2004 |
Delayed Nogo receptor therapy improves recovery from spinal cord contusion.
Topics: Animals; Axons; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Fem | 2006 |
Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats.
Topics: Action Potentials; Animals; Cervical Vertebrae; Diaphragm; Disease Models, Animal; Electromyography; | 2008 |
Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury.
Topics: Animals; Apoptosis; CD11b Antigen; Cell Survival; Cervical Vertebrae; Cyclic AMP; Cyclic Nucleotide | 2008 |