rolipram has been researched along with Pregnancy in 25 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor." | 5.91 | Rolipram suppresses migration and invasion of human choriocarcinoma cells by inhibiting phosphodiesterase 4-mediated epithelial-mesenchymal transition. ( Huang, Y; Qi, C; Wang, Q; Zheng, Y, 2023) |
| " We evaluated the ability of oxytocin receptor-targeted liposomes to localize to uterine tissue in vivo, and assessed if targeted liposomes loaded with indomethacin were capable of preventing lipopolysaccharide-induced preterm birth in mice." | 3.85 | Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor. ( Butler, T; Hua, S; Ilicic, M; Paul, JW; Robertson, S; Smith, R; Tolosa, JM, 2017) |
| " Human myometrial strips from cesarean sections at full-term pregnancy and at preterm labor were stimulated with oxytocin, and the inhibitory effects of theophylline, rolipram and terbutaline were studied." | 3.79 | Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on pregnant human myometrium in vitro. ( Ducza, E; Falkay, G; Gáspár, R; Hajagos-Tóth, J; Klukovits, A; Kormányos, Z; Seres, AB; Verli, J, 2013) |
| " Our aim was to study the effects of the non-selective phosphodiesterase (PDE) inhibitor theophylline and the selective PDE4 inhibitor rolipram on the uteri of intact late-pregnant female rats (on days 20 and 22 of pregnancy) and of pregnant rats treated with lipopolysaccharide (LPS) to evoke preterm labor (on day 20)." | 3.76 | Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: studies on pregnant rat uteri in vitro. ( Falkay, G; Gáspár, R; Klukovits, A; Verli, J, 2010) |
| "Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor." | 1.91 | Rolipram suppresses migration and invasion of human choriocarcinoma cells by inhibiting phosphodiesterase 4-mediated epithelial-mesenchymal transition. ( Huang, Y; Qi, C; Wang, Q; Zheng, Y, 2023) |
| "Chorioamnionitis is implicated in the pathophysiology of bronchopulmonary disease, and the associated inflammatory response is responsible for adverse effects on alveolar development." | 1.38 | Antenatal phosphodiesterase 4 inhibition restores postnatal growth and pulmonary development in a model of chorioamnionitis in rabbits. ( Branger, B; Caillon, J; Gras-Leguen, C; Homer, L; Jacqueline, C; Jarreau, PH; Joram, N; Launay, E; Méhats, C; Moyon, T; Potel, G; Roze, JC, 2012) |
| "Airway hyperreactivity (AHR), lung inflammation, and atopy are clinical signs of allergic asthma." | 1.35 | Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammation and a ( Campen, M; Kurup, V; Mishra, NC; Razani-Boroujerdi, S; Rir-Sima-Ah, J; Singh, SP; Sopori, ML, 2009) |
| " CRH with P4 pretreatment caused a 40 +/- 13% (n = 4) reduction in contractility, whereas in matched samples, CRH alone exerted a 26 +/- 6% (n = 4) reduction, with a shift of CRH dose-response curves (P < 0." | 1.35 | Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy. ( Read, M; Smith, R; Tyson, EK, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hossain, MR | 1 |
| Tolosa, JM | 2 |
| Young, RC | 1 |
| Smith, R | 4 |
| Paul, JW | 2 |
| Huang, Y | 1 |
| Zheng, Y | 1 |
| Wang, Q | 1 |
| Qi, C | 1 |
| Hua, S | 1 |
| Ilicic, M | 1 |
| Butler, T | 1 |
| Robertson, S | 1 |
| Fernández-Martínez, E | 1 |
| Ponce-Monter, H | 1 |
| Soria-Jasso, LE | 1 |
| Ortiz, MI | 1 |
| Arias-Montaño, JA | 1 |
| Barragán-Ramírez, G | 1 |
| Mayén-García, C | 1 |
| Bruss, MD | 1 |
| Richter, W | 1 |
| Horner, K | 1 |
| Jin, SL | 1 |
| Conti, M | 2 |
| Tyson, EK | 2 |
| Macintyre, DA | 1 |
| Chan, EC | 1 |
| Read, M | 2 |
| Franova, S | 1 |
| Janicek, F | 1 |
| Visnovsky, J | 1 |
| Dokus, K | 1 |
| Zubor, P | 1 |
| Sutovska, M | 1 |
| Nosalova, G | 1 |
| Singh, SP | 1 |
| Mishra, NC | 1 |
| Rir-Sima-Ah, J | 1 |
| Campen, M | 1 |
| Kurup, V | 1 |
| Razani-Boroujerdi, S | 1 |
| Sopori, ML | 1 |
| Krahe, TE | 1 |
| Paul, AP | 1 |
| Medina, AE | 1 |
| Klukovits, A | 2 |
| Verli, J | 2 |
| Falkay, G | 2 |
| Gáspár, R | 2 |
| Homer, L | 1 |
| Launay, E | 1 |
| Joram, N | 1 |
| Jacqueline, C | 1 |
| Jarreau, PH | 1 |
| Caillon, J | 1 |
| Moyon, T | 1 |
| Branger, B | 1 |
| Potel, G | 1 |
| Roze, JC | 1 |
| Méhats, C | 5 |
| Gras-Leguen, C | 1 |
| Kormányos, Z | 1 |
| Hajagos-Tóth, J | 1 |
| Ducza, E | 1 |
| Seres, AB | 1 |
| Oger, S | 2 |
| Barnette, MS | 1 |
| Ferré, F | 3 |
| Cabrol, D | 3 |
| Leroy, MJ | 5 |
| Dallot, E | 1 |
| Menon, KM | 1 |
| Nair, AK | 1 |
| Wang, L | 1 |
| Peegel, H | 1 |
| Schmitz, T | 1 |
| Souil, E | 1 |
| Hervé, R | 1 |
| Nicco, C | 1 |
| Batteux, F | 1 |
| Germain, G | 1 |
| Evain-Brion, D | 1 |
| Baecker, PA | 1 |
| Obernolte, R | 1 |
| Bach, C | 1 |
| Yee, C | 1 |
| Shelton, ER | 1 |
| Yamashita, N | 1 |
| Miyashiro, M | 1 |
| Baba, J | 1 |
| Sawa, A | 1 |
| Wiersma, A | 1 |
| Hirsch, B | 1 |
| Tsafriri, A | 1 |
| Hanssen, RG | 1 |
| Van de Kant, M | 1 |
| Kloosterboer, HJ | 1 |
| Hsueh, AJ | 1 |
| Okogbule-Wonodi, AC | 1 |
| Ibe, BO | 1 |
| Yue, BW | 1 |
| Hsu, S | 1 |
| Raj, JU | 1 |
| Tanguy, G | 1 |
| Paris, B | 1 |
| Robert, B | 1 |
| Pernin, N | 1 |
| Suvarna, NU | 1 |
| O'Donnell, JM | 1 |
| Schultz, JE | 1 |
| Rösch, H | 1 |
| Cedrin, I | 1 |
| Breuiller, M | 1 |
| Giovagrandi, Y | 1 |
25 other studies available for rolipram and Pregnancy
| Article | Year |
|---|---|
Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium.
Topics: Aminophylline; Female; Humans; Indomethacin; Infant, Newborn; Myometrium; Nifedipine; Pregnancy; Pre | 2023 |
Rolipram suppresses migration and invasion of human choriocarcinoma cells by inhibiting phosphodiesterase 4-mediated epithelial-mesenchymal transition.
Topics: Cell Line, Tumor; Choriocarcinoma; Cyclic Nucleotide Phosphodiesterases, Type 4; Epithelial-Mesenchy | 2023 |
Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor.
Topics: Albuterol; Animals; Drug Delivery Systems; Female; Indomethacin; Liposomes; Mice; Myometrium; Nifedi | 2017 |
Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade.
Topics: Adolescent; Adult; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP; Dose-Response Rel | 2016 |
Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.
Topics: Animals; Cell Division; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic | 2008 |
Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy.
Topics: Actins; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide | 2008 |
Utero-relaxant effect of PDE4-selective inhibitor alone and in simultaneous administration with beta2-mimetic on oxytocin-induced contractions in pregnant myometrium.
Topics: Adrenergic beta-Agonists; Albuterol; Drug Synergism; Female; Humans; In Vitro Techniques; Myometrium | 2009 |
Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammation and a
Topics: Airway Resistance; Allergens; Animals; Bronchial Hyperreactivity; Cyclic Nucleotide Phosphodiesteras | 2009 |
Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy.
Topics: Adult; Albuterol; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Synergism; | 2009 |
Phosphodiesterase type 4 inhibition does not restore ocular dominance plasticity in a ferret model of fetal alcohol spectrum disorders.
Topics: Animals; Dominance, Ocular; Female; Ferrets; Fetal Alcohol Spectrum Disorders; Neuronal Plasticity; | 2010 |
Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: studies on pregnant rat uteri in vitro.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Cyclic AMP; Drug Synergism; Female; Lipopolysaccharide | 2010 |
Antenatal phosphodiesterase 4 inhibition restores postnatal growth and pulmonary development in a model of chorioamnionitis in rabbits.
Topics: Animals; Chorioamnionitis; Disease Models, Animal; Elastic Tissue; Female; Lung; Lung Volume Measure | 2012 |
Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on pregnant human myometrium in vitro.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type | 2013 |
Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Anti-Inflammatory Agents; Bronchodilator Agents; Carboxylic Aci | 2004 |
Evidence for a role of phosphodiesterase 4 in lipopolysaccharide-stimulated prostaglandin E2 production and matrix metalloproteinase-9 activity in human amniochorionic membranes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adjuvants, Immunologic; Amnion; Chorion; Cyclic AMP; Cyclic Nuc | 2005 |
Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary.
Topics: Animals; Base Sequence; Binding Sites; Cholesterol; Chorionic Gonadotropin; Down-Regulation; Female; | 2007 |
PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amniotic Fluid; Animals; Cell Movement; Cervical Ripening; Cycl | 2007 |
Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular | 1994 |
Rolipram, a selective inhibitor of phosphodiesterase type 4, pronouncedly enhanced the forskolin-induced promotion of dopamine biosynthesis in primary cultured rat mesencephalic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2- | 1997 |
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Fem | 1998 |
Phosphodiesterase activity in intrapulmonary arteries and veins of perinatal lambs.
Topics: Animals; Animals, Newborn; Cyclic AMP; Cyclic GMP; Cytosol; Female; Hydrolysis; Phosphodiesterase In | 1998 |
Pregnancy induces a modulation of the cAMP phosphodiesterase 4-conformers ratio in human myometrium: consequences for the utero-relaxant effect of PDE4-selective inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Benzamides; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, T | 2000 |
Hydrolysis of N-methyl-D-aspartate receptor-stimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine; Animals; Cells, Cultured; Cerebral Cortex; | 2002 |
Differential effects of ovarian steroid hormones on beta-adrenoceptor downregulation caused by the antidepressants imipramine and rolipram.
Topics: Animals; Antidepressive Agents; Body Weight; Cerebral Cortex; Down-Regulation; Estrone; Female; Gona | 1991 |
Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Dose-Response Relationship, Drug; Female; Humans; Pregna | 1989 |