rolipram has been researched along with Nerve Degeneration in 4 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the water-maze test, cerebral ischemia significantly increased the escape latency to reach the platform during acquisition training and decreased the exploration time in the target quadrant in the probe trial test; these were blocked by rolipram in a dose-dependent manner." | 1.37 | Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. ( Cheng, YF; Li, LX; Lin, HB; Wang, C; Xu, JP; Zhang, HT, 2011) |
| "Treatment with rolipram when started at 6 h after QA injection resulted in neuronal damage amounting to 60%; the result after starting at 24 h was not different from solvent (91%)." | 1.31 | Rolipram reduces excitotoxic neuronal damage. ( Block, F; Nolden-Koch, M; Schmidt, W; Schwarz, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paintlia, AS | 1 |
| Paintlia, MK | 1 |
| Singh, I | 1 |
| Singh, AK | 1 |
| Li, LX | 1 |
| Cheng, YF | 1 |
| Lin, HB | 1 |
| Wang, C | 1 |
| Xu, JP | 1 |
| Zhang, HT | 1 |
| DeMarch, Z | 1 |
| Giampà, C | 1 |
| Patassini, S | 1 |
| Martorana, A | 1 |
| Bernardi, G | 1 |
| Fusco, FR | 1 |
| Block, F | 1 |
| Schmidt, W | 1 |
| Nolden-Koch, M | 1 |
| Schwarz, M | 1 |
4 other studies available for rolipram and Nerve Degeneration
| Article | Year |
|---|---|
Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.
Topics: Animals; Demyelinating Diseases; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoi | 2008 |
Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cyclic Nucleotide Phosphodiesterases, Type 4; Male | 2011 |
Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity.
Topics: Animals; Cell Survival; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Disease Models | 2007 |
Rolipram reduces excitotoxic neuronal damage.
Topics: Animals; Antidepressive Agents; Cell Count; Dizocilpine Maleate; Drug Interactions; Excitatory Amino | 2001 |