rolipram and Disease Models, Animal

Topics: Acetates; Angiotensin I; Animals; Annexin A1; Anti-Inflammatory Agents; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Docosahexaenoic Acids; Humans; Hydrogen Peroxide; Inflammation; Inflammation Mediators; Mice; Orthomyxoviridae Infections; Oxidants; Peptide Fragments; Peptides; Phosphodiesterase 4 Inhibitors; Pneumonia, Viral; Rolipram; Vasodilator Agents

Topics: Animals; Cyclic AMP; Disease Models, Animal; Electric Stimulation Therapy; Growth Cones; Humans; Nerve Regeneration; Peripheral Nerves; Peripheral Nervous System Diseases; Phosphodiesterase Inhibitors; Rats; Recovery of Function; Rolipram; Treatment Outcome

Topics: Adrenal Cortex Hormones; Aged; Albuterol; Animals; Bacterial Infections; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Therapy, Combination; Humans; Inflammation; Mucociliary Clearance; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Randomized Controlled Trials as Topic; Rats; Rolipram; Salmeterol Xinafoate; Smoking; Theophylline; Time Factors

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibody Specificity; Antirheumatic Agents; Arthritis, Rheumatoid; CD4 Antigens; CD4-Positive T-Lymphocytes; Cyclosporine; Disease Models, Animal; Drug Therapy, Combination; Humans; Interleukin-10; Interleukin-12; Mice; Pyrrolidinones; Rolipram; Time Factors; Tumor Necrosis Factor-alpha

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Female; Humans; Leukopenia; Lipopolysaccharides; Mice; Mice, Inbred Strains; Molecular Structure; Monocytes; Neutrophils; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pteridines; Tumor Necrosis Factor-alpha; Xanthines

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Topical; Animals; Anti-Inflammatory Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dose-Response Relationship, Drug; Ear Diseases; Enzyme Inhibitors; Humans; Imidazoles; Inflammation; Inhibitory Concentration 50; Rats; Structure-Activity Relationship

Topics: Animals; Anti-Inflammatory Agents; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Male; Mice; Phosphodiesterase 4 Inhibitors; Pyridines; Structure-Activity Relationship

Topics: Animals; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Drug Design; Humans; Inhibitory Concentration 50; Molecular Conformation; Molecular Docking Simulation; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Rolipram; Sepsis; Structure-Activity Relationship; Tetrahydroisoquinolines

Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries

Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Receptors, Serotonin; Structure-Activity Relationship

Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Female; Humans; Imidazoles; Inflammation; Male; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyridines; Rats, Wistar

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Astrocytes; Biomarkers; Cerebral Hemorrhage; Cyclic AMP; Disease Models, Animal; Male; Mice; Neuroglia; Neurons; Phosphodiesterase 4 Inhibitors; Rolipram; Signal Transduction; Sirtuin 1

Topics: Animals; Disease Models, Animal; Hyperalgesia; Mice; Neuralgia; Peripheral Nerve Injuries; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Rolipram; Tumor Necrosis Factor-alpha

Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Disease Models, Animal; Polyethyleneimine; Rats; Recovery of Function; Rolipram

Topics: Animals; Calcineurin; Cyclic AMP-Dependent Protein Kinases; Dentate Gyrus; Disease Models, Animal; Dopamine; Hippocampus; Mice; Mice, Knockout; Rolipram

Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Fibrosis; Hypercholesterolemia; Kidney; Kidney Diseases; Matrix Metalloproteinase 9; Mice; Phosphodiesterase 4 Inhibitors; Rolipram

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Depression; Disease Models, Animal; Memory Disorders; Mice; Mice, Transgenic; Neuroinflammatory Diseases; Phosphodiesterase 4 Inhibitors; Presenilin-1; Rolipram

Topics: Animals; Anti-Inflammatory Agents; Cardiomyopathies; Cells, Cultured; Cytokines; Disease Models, Animal; Dual Specificity Phosphatase 1; Endotoxemia; Fibroblasts; Inflammation Mediators; Male; Mice, Inbred C57BL; Rolipram; Signal Transduction; Stroke Volume; Ventricular Function, Left

Topics: Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Female; Gastroparesis; Mice; Mice, Nude; Phosphodiesterase 4 Inhibitors; Pyridines; Pyrimidinones; Rolipram

Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteremia; Ciprofloxacin; Disease Models, Animal; Drug Carriers; Lipids; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Nanoparticles; Nanostructures; Rolipram; Sepsis; Staphylococcal Infections

Topics: Animals; Behavior, Animal; Cerebral Cortex; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Female; Gene Expression; Humans; Induced Pluripotent Stem Cells; Male; Mice, Mutant Strains; Mutation; Nerve Tissue Proteins; Neurons; Phosphodiesterase 4 Inhibitors; Rolipram; Schizophrenia; Synapses

Topics: Analysis of Variance; Animals; Antidepressive Agents; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Gene Expression Regulation; GTP-Binding Proteins; Kindling, Neurologic; Male; Perforant Pathway; Rats; Rats, Wistar; Rolipram; Signal Transduction; Time Factors

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Extinction, Psychological; Fear; Hippocampus; Male; Memory; Mice; Mice, Inbred C57BL; MPTP Poisoning; Parkinson Disease; Rolipram

Topics: Alcohol-Related Disorders; Animals; Astrocytes; Brain; Cells, Cultured; Central Nervous System Depressants; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; Ethanol; Gene Expression; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Microglia; Phosphodiesterase 4 Inhibitors; RNA, Messenger; Rolipram

Topics: Acoustic Stimulation; Animals; Anxiety; Basolateral Nuclear Complex; Benzazepines; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dopamine Antagonists; Down-Regulation; Electric Stimulation; In Vitro Techniques; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Phosphodiesterase 4 Inhibitors; Psychoacoustics; Rats; Rats, Sprague-Dawley; Reflex, Acoustic; RNA, Messenger; Rolipram; Stress, Psychological

Topics: Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Female; gamma-Aminobutyric Acid; Inflammation; Male; Memory Disorders; Neurons; Nootropic Agents; Peptide Fragments; Random Allocation; Rats; Recognition, Psychology; Risperidone; Rolipram; Synapses

Topics: Adrenergic beta-3 Receptor Agonists; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Ethanolamines; Humans; Male; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Rolipram; Tadalafil; Treatment Outcome; Urinary Bladder; Urinary Bladder, Overactive

Topics: Animals; Bone Marrow Cells; Cardiopulmonary Bypass; Chemotaxis, Leukocyte; Disease Models, Animal; Glycine; Lung; Macaca fascicularis; Male; Neutrophils; Phosphodiesterase 4 Inhibitors; Rolipram; Serine Proteinase Inhibitors; Sulfonamides

Topics: Animals; Axons; Disease Models, Animal; Female; Methylprednisolone; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Rolipram; Spinal Cord Injuries

Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cytokines; Disease Models, Animal; Encephalitis; Endothelin-1; Hemodynamics; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Occludin; Phosphodiesterase 4 Inhibitors; Rolipram; Stroke; Thrombosis

Topics: Animals; Antitubercular Agents; Bacterial Load; Cilostazol; Disease Models, Animal; Drug Interactions; Humans; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Phosphodiesterase Inhibitors; Piperazines; Purines; Rifampin; Rolipram; Sildenafil Citrate; Sulfones; Survival Analysis; Tetrazoles; Treatment Outcome; Tuberculosis

Topics: Acute Kidney Injury; Animals; Blood Flow Velocity; Disease Models, Animal; Glomerular Filtration Rate; Kidney; Male; Mice; Mice, Inbred C57BL; Microcirculation; Phosphodiesterase 4 Inhibitors; Renal Circulation; Rolipram; Sepsis

Topics: Animals; Coinfection; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium; Hemodynamics; Male; Microcirculation; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Sepsis

Topics: Animals; Bone Density Conservation Agents; Chondroitin ABC Lyase; Clodronic Acid; Combined Modality Therapy; Disease Models, Animal; Female; Immunomodulation; Immunotherapy; Liposomes; Male; Motor Activity; Phosphodiesterase 4 Inhibitors; Rats; Recovery of Function; Rolipram; Spinal Cord Injuries

Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Femoral Artery; Focal Adhesion Kinase 2; Humans; Macrophage-1 Antigen; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; P-Selectin; Phosphodiesterase 4 Inhibitors; Phosphorylation; Platelet Adhesiveness; Rolipram; Signal Transduction; src-Family Kinases; Time Factors; Vascular System Injuries

Topics: Animals; Benzo(a)pyrene; Cadherins; Carcinogenesis; Chemoprevention; Disease Models, Animal; Female; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Inbred Strains; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphodiesterase 4 Inhibitors; Rolipram; Vimentin

Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldehyde; Purines; Rolipram; Theophylline

Topics: Aminopyridines; Animals; Benzamides; Capillary Permeability; Chemokines; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Cytoskeleton; Disease Models, Animal; Enzyme Activation; Epithelial Cells; Gene Expression; Male; Mice; Neutrophil Infiltration; Neutrophils; Phosphodiesterase 4 Inhibitors; Pneumonia; Protein Transport; Rolipram; Time Factors

Topics: Animals; Antineoplastic Agents; Behavior, Animal; Cyclic Nucleotide Phosphodiesterases, Type 4; Depression; Disease Models, Animal; Docetaxel; Male; Memory Disorders; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram; Spatial Memory; Taxoids

Topics: Animals; Body Weight; Corticosterone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dendrites; Depression; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Prefrontal Cortex; RNA Interference; RNA, Small Interfering; Rolipram; Signal Transduction; Stress, Physiological

Topics: Adrenergic alpha-2 Receptor Agonists; Aminopyridines; Animals; Antihypertensive Agents; Benzamides; Brain-Derived Neurotrophic Factor; Clonidine; Cognition Disorders; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclopropanes; Desoxycorticosterone Acetate; Disease Models, Animal; Hippocampus; Hypertension; Male; Memory; Nootropic Agents; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram

Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Flavonoids; Lipopolysaccharides; Lung; Macrophages; Male; Mice; Mice, Inbred BALB C; NIH 3T3 Cells; Phosphodiesterase 4 Inhibitors; Plant Extracts; RAW 264.7 Cells; Rolipram; Rosaceae; Tumor Necrosis Factor-alpha

Topics: Animals; Baclofen; Behavior, Animal; Benzazepines; Benzodiazepines; Body Weight; Bulimia; Disease Models, Animal; Eating; Feeding Behavior; Female; Idazoxan; Lisdexamfetamine Dimesylate; Naltrexone; Olanzapine; Prazosin; Prodrugs; Raclopride; Rats; Rats, Wistar; Rolipram

Topics: Animals; Behavior, Animal; Brain; Cognition; Cognition Disorders; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Fluorescent Antibody Technique; HEK293 Cells; Humans; Immunoblotting; Immunoprecipitation; In Vitro Techniques; Mice; Mice, Transgenic; Native Polyacrylamide Gel Electrophoresis; Phosphodiesterase 4 Inhibitors; Proteasome Endopeptidase Complex; Protein Aggregation, Pathological; Rolipram; Signal Transduction; tau Proteins; Tauopathies; Ubiquitination

Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Brain; Brain Infarction; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Male; Neuroprotective Agents; Phosphoric Diester Hydrolases; Phosphorylation; Rats; Rats, Sprague-Dawley; Resveratrol; Rolipram; Signal Transduction; Sirtuin 1; Stilbenes; Stroke

Topics: Amyloid beta-Peptides; Animals; Antioxidants; Avoidance Learning; Cognition; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Maze Learning; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peptide Fragments; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Thioredoxins; Up-Regulation

Topics: Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Ethanol; Fatty Acids, Nonesterified; Fatty Liver, Alcoholic; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphodiesterase 4 Inhibitors; Rolipram

Topics: Animals; Brain Injuries, Traumatic; Caspase 3; Cell Movement; Cytokines; Disease Models, Animal; Encephalitis; Female; Gene Expression Regulation; Hydrocortisone; Leukocytes; Lymph Nodes; Lymphocytes; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphodiesterase 4 Inhibitors; Rolipram; Sphingosine

Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclooxygenase 2; Depression; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Encephalitis; Exploratory Behavior; Gene Expression Regulation; Hindlimb Suspension; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Nitric Oxide Synthase Type II; Phosphodiesterase 4 Inhibitors; Rolipram; Swimming; Tumor Necrosis Factor-alpha; Vomiting

Topics: Animals; Bleomycin; Cell Differentiation; Collagen; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; DNA Topoisomerases, Type I; Fibroblasts; Fibrosis; Gene Expression; Graft vs Host Disease; Humans; Interleukin-13; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphodiesterase 4 Inhibitors; RNA, Messenger; Rolipram; Scleroderma, Systemic; Skin; Thalidomide; Transforming Growth Factor beta1; Transforming Growth Factor beta2

Topics: Aminopyridines; Animals; Benzamides; Carboxylic Acids; Cyclohexanecarboxylic Acids; Cyclopropanes; Dermatitis; Dermatitis, Contact; Disease Models, Animal; Eosinophil Peroxidase; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Nitriles; Peroxidase; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Picryl Chloride; Rolipram

Topics: Acute Disease; Animals; Disease Models, Animal; Kidney; Male; Oxidation-Reduction; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyelonephritis; Rats; Rats, Wistar; Rolipram

Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Signaling; Disease Models, Animal; Excitatory Amino Acid Agonists; Glaucoma; Male; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quinoxalines; Rabbits; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Rolipram

Topics: Age Factors; Aging; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Iron; Male; Memory Disorders; Pattern Recognition, Visual; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Rolipram; Statistics, Nonparametric; Time Factors

Topics: Animals; Central Nervous System; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Lovastatin; Nerve Fibers, Myelinated; Nerve Regeneration; Neuroprotective Agents; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Rolipram; Treatment Outcome; Wallerian Degeneration

Topics: Acetylcysteine; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Brain; Cognition Disorders; Conditioning, Psychological; Cyclic AMP; Disease Models, Animal; Erythromycin; Exploratory Behavior; Fear; Female; Gene Expression Regulation, Developmental; GTP-Binding Protein alpha Subunits, Gs; Haloperidol; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphodiesterase Inhibitors; Psychophysics; Reflex, Startle; Rolipram; Time Factors

Topics: Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motor Activity; Phosphodiesterase Inhibitors; Psychomotor Performance; Rats; Rats, Wistar; Recovery of Function; Rolipram; Rotarod Performance Test; Time Factors

Topics: Acute Disease; Amylases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Interleukin-1beta; Male; Pancreas; Pancreatitis; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram; Severity of Illness Index; Taurocholic Acid

Topics: Analysis of Variance; Animals; Corpus Striatum; CREB-Binding Protein; Disease Models, Animal; Exploratory Behavior; Female; Huntington Disease; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Movement Disorders; Parvalbumins; Phosphodiesterase Inhibitors; Protein Transport; Psychomotor Performance; Rolipram; Trinucleotide Repeats; Ubiquitin

Topics: Animals; Biotin; Cervical Vertebrae; Dextrans; Disease Models, Animal; Environment, Controlled; Exercise Therapy; Exploratory Behavior; Female; Forelimb; Gait Disorders, Neurologic; Movement Disorders; Neuronal Plasticity; Neuronal Tract-Tracers; Paralysis; Phosphodiesterase Inhibitors; Physical Conditioning, Animal; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Recovery of Function; Rolipram; Spinal Cord Injuries; Treatment Outcome

Topics: Animals; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Immunosuppressive Agents; Interleukin-1beta; Locomotion; Male; Myelin Basic Protein; Nerve Regeneration; Neurofilament Proteins; Phosphodiesterase Inhibitors; Psychomotor Performance; Rats; Rats, Inbred Lew; Recovery of Function; Rolipram; Spinal Cord Injuries; Thalidomide; Time Factors; Tumor Necrosis Factor-alpha

Topics: Animals; Carboxylic Acids; Cell Line, Transformed; Cyclic AMP; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dogs; Female; Guinea Pigs; Humans; Inflammation; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Rolipram; Tumor Necrosis Factor-alpha; Vomiting

Topics: Animals; Cervical Vertebrae; Cyclic AMP; Disease Models, Animal; Functional Laterality; Injections, Intravenous; Male; Phosphodiesterase Inhibitors; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Respiration; Respiratory Center; Rolipram; Spinal Cord Injuries

Topics: Administration, Oral; Animals; Azepines; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Male; Niacinamide; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Rats; Rats, Inbred BN; Rolipram; Tumor Necrosis Factor-alpha

Topics: Administration, Oral; Animals; Chemokine CCL2; Collagen; Disease Models, Animal; Fibrosis; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Neutrophils; Peritoneum; Phosphodiesterase Inhibitors; Rolipram; Surgical Sponges; Tissue Adhesions; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A

Topics: Analysis of Variance; Animals; Chondroitin ABC Lyase; Cyclic AMP; Disease Models, Animal; Extracellular Matrix; Female; Ganglia, Spinal; Injections, Subcutaneous; Microscopy, Electron, Transmission; Motor Neurons; Nerve Regeneration; Peroneal Neuropathies; Phosphodiesterase Inhibitors; Proteoglycans; Rats; Rats, Sprague-Dawley; Rolipram; Sensory Receptor Cells; Time Factors

Topics: Animals; Bleomycin; Cyclic AMP; Cytokines; Disease Models, Animal; Humans; Idiopathic Pulmonary Fibrosis; Phosphodiesterase Inhibitors; Rats; Rolipram

Topics: Animals; Bleomycin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; Humans; Hydroxyproline; Idiopathic Pulmonary Fibrosis; Lung; Male; Malondialdehyde; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Rolipram; Tumor Necrosis Factor-alpha

Topics: Amphetamine; Animals; Bupropion; Clozapine; Conditioning, Psychological; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Drug Interactions; Haloperidol; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Phosphodiesterase 4 Inhibitors; Piperazines; Rolipram; Schizophrenic Psychology

Topics: Animals; Anthracenes; Ceruletide; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutropenia; Pancreatitis; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Rats, Wistar; Rolipram; Vinblastine

Topics: Analysis of Variance; Animals; Axons; Brain Stem; Clodronic Acid; Contusions; Disease Models, Animal; Drug Therapy, Combination; Ectodysplasins; Exploratory Behavior; Female; Glial Fibrillary Acidic Protein; Hindlimb; Immunologic Factors; Liposomes; Locomotion; Macrophages; Motor Cortex; Myelin Basic Protein; Myelin Sheath; Neural Pathways; Neurofilament Proteins; Neuroprotective Agents; Phosphodiesterase 4 Inhibitors; Psychomotor Performance; Rats; Recovery of Function; Rolipram; Spinal Cord Injuries; Stilbamidines; Vimentin

Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rolipram; Severity of Illness Index; Synovial Membrane; Thalidomide; Tumor Necrosis Factor-alpha

Topics: Animals; Axons; Cell Transplantation; Cyclic AMP; Disease Models, Animal; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Hyperalgesia; Mice; Mice, Transgenic; Movement; Nerve Regeneration; Olfactory Bulb; Phosphodiesterase Inhibitors; Physical Stimulation; Psychomotor Performance; Rolipram; Schwann Cells; Sensory Thresholds; Spinal Cord Injuries; Statistics as Topic

Topics: Anesthesia; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Tract; Genistein; Guinea Pigs; Male; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Protein Binding; Radioligand Assay; Respiratory Hypersensitivity; Rolipram

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory Disorders; Peptide Fragments; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Swimming

Topics: Animals; Base Sequence; Cyclic AMP; Disease Models, Animal; DNA Primers; Lipopolysaccharides; Low-Level Light Therapy; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Respiratory Distress Syndrome; RNA, Messenger; Rolipram; Tumor Necrosis Factor-alpha

Topics: Animals; Biological Clocks; Brefeldin A; Cyclic AMP; Disease Models, Animal; Female; Guanine Nucleotide Exchange Factors; In Vitro Techniques; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Mutant Strains; Neurites; Neurons; Patch-Clamp Techniques; Phosphodiesterase 4 Inhibitors; Rett Syndrome; Rolipram

Topics: Amyloid beta-Peptides; Animals; Apoptosis; Avoidance Learning; bcl-2-Associated X Protein; Cognition Disorders; CREB-Binding Protein; Dark Adaptation; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Gene Expression Regulation; Male; Maze Learning; Neuropsychological Tests; NF-kappa B; Peptide Fragments; Phosphodiesterase 4 Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Rolipram

Topics: Animals; Asthma; Binding Sites; Blood Cell Count; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; Female; Guinea Pigs; Hesperidin; Immunoglobulins; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Rolipram

Topics: Animals; Chorioamnionitis; Disease Models, Animal; Elastic Tissue; Female; Lung; Lung Volume Measurements; Phosphodiesterase 4 Inhibitors; Pregnancy; Rabbits; Rolipram; Weight Gain

Topics: Animals; Disease Models, Animal; Huntington Disease; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphodiesterase 4 Inhibitors; Rolipram

Topics: Animals; Brain Injuries; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Tumor Necrosis Factor-alpha

Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motor Activity; Phosphodiesterase 4 Inhibitors; Rats; Rats, Inbred Strains; Rolipram

Topics: Animals; Antipsychotic Agents; Cyclic AMP; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Injections, Subcutaneous; Long-Term Potentiation; Male; Mental Recall; Neuronal Plasticity; Neuroprotective Agents; Pattern Recognition, Visual; Phosphodiesterase 4 Inhibitors; Psychotic Disorders; Rats; Rats, Wistar; Rolipram; Synapses; Synaptic Transmission

Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Female; Infusion Pumps, Implantable; Motor Activity; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Recovery of Function; Rolipram; Spinal Cord Injuries; Thoracic Vertebrae; Treatment Outcome

Topics: Animals; Capillary Permeability; Cyclic AMP; Disease Models, Animal; Drug Synergism; Epoprostenol; Female; Lung Transplantation; Male; Microcirculation; Nebulizers and Vaporizers; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Pulmonary Circulation; Pulmonary Wedge Pressure; Rabbits; Reperfusion Injury; Rolipram; Weight Gain

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Corticosterone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic Nucleotide Phosphodiesterases, Type 4; Depression; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Electroshock; Frontal Lobe; Helplessness, Learned; Hippocampus; Male; Rats; Rolipram; Signal Transduction; Stress, Psychological; Time Factors

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiopulmonary Bypass; CD11b Antigen; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; L-Selectin; Male; Neutrophil Activation; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Rolipram; Tumor Necrosis Factor-alpha

Topics: Acetylation; Analysis of Variance; Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cell Line; Chromatin; Conditioning, Psychological; CREB-Binding Protein; Disease Models, Animal; Dynorphins; Electrophysiology; Embryo, Mammalian; Excitatory Postsynaptic Potentials; Fear; Female; Gene Expression; Heterozygote; Hippocampus; Humans; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Kidney; Long-Term Potentiation; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neural Inhibition; Neurons; Nuclear Proteins; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Reaction Time; Recognition, Psychology; Rolipram; Rubinstein-Taybi Syndrome; Synaptophysin; Time Factors; Trans-Activators; Transfection

Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Blotting, Western; Brain-Derived Neurotrophic Factor; Carotid Stenosis; Cerebrovascular Circulation; Colforsin; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Fetal Hypoxia; Functional Laterality; Hypoxia-Ischemia, Brain; Immunohistochemistry; Ischemic Preconditioning; Ligation; Male; Maze Learning; Oligodeoxyribonucleotides, Antisense; Organ Size; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Serine; Time Factors

Topics: Amphetamine; Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine; Dopamine Agents; Evoked Potentials, Auditory; Mice; Phosphodiesterase Inhibitors; Rolipram; Schizophrenia; Signal Transduction

Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hippocampus; Humans; In Vitro Techniques; Learning; Long-Term Potentiation; Male; Membrane Proteins; Mice; Mice, Transgenic; Phosphodiesterase Inhibitors; Presenilin-1; Rolipram; Synaptic Transmission

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Adhesion; Chemokines; Chemotaxis, Leukocyte; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Enzyme Inhibitors; Inflammation; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Pulmonary Disease, Chronic Obstructive; Rolipram; Tumor Necrosis Factor-alpha

Topics: Analysis of Variance; Animals; Ascites; Cyclic AMP; Disease Models, Animal; Glomerular Filtration Rate; Infusions, Intravenous; Kidney Function Tests; Liver Cirrhosis, Experimental; Male; Phosphodiesterase Inhibitors; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Rolipram; Sensitivity and Specificity

Topics: Animals; Cyclic AMP; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase Inhibitors; Reaction Time; Receptors, N-Methyl-D-Aspartate; Rolipram; Schizophrenia; Signal Transduction

Topics: Animals; Cell Movement; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electrophoretic Mobility Shift Assay; Encephalomyelitis, Autoimmune, Experimental; Gene Expression; Luciferases; Lymph Nodes; Lymphocytes; Matrix Metalloproteinase 9; Myelin Basic Protein; NF-kappa B; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Spinal Cord; Transfection

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cognition; Cognition Disorders; Conditioning, Psychological; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Endopeptidases; Enzyme Inhibitors; Fear; gamma-Aminobutyric Acid; Mice; Mice, Transgenic; Mutation; Phosphodiesterase Inhibitors; Rolipram; Triglycerides

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arachidonic Acids; Basal Ganglia; Brain; Cannabinoid Receptor Modulators; Capsaicin; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Endocannabinoids; Gene Expression; Glycerides; Male; Multiple Sclerosis; Phosphodiesterase Inhibitors; Polyunsaturated Alkamides; Rats; Rats, Inbred Lew; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rolipram; TRPV Cation Channels

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chronic Disease; Colitis; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Fibrosis; Male; Methylprednisolone; Peroxidase; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Aminopyridines; Animals; Benzamides; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Immunization; Male; Neutrophils; Nitriles; Ovalbumin; Phosphodiesterase Inhibitors; Pneumonia; Pyridines; Rats; Respiratory Hypersensitivity; Rolipram; Serotonin; Treatment Outcome; Tumor Necrosis Factor-alpha

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Count; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclosporine; Cytokines; Dermatitis; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, Inner; Immunoglobulin E; Immunosuppressive Agents; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Peroxidase; Phosphodiesterase Inhibitors; Picryl Chloride; Prednisolone; Rolipram; T-Lymphocytes; Time Factors; Weight Gain

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain; Cognition Disorders; Disease Models, Animal; Environment; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Phosphodiesterase Inhibitors; Presenilin-1; Rolipram; Silver Staining

Topics: Animals; Bone Density Conservation Agents; Bone Resorption; Disease Models, Animal; Early Diagnosis; Estradiol; Female; Femur; Imaging, Three-Dimensional; Mice; Osteogenesis; Osteoporosis; Ovariectomy; Parathyroid Hormone; Peptide Fragments; Raloxifene Hydrochloride; Rolipram; Tomography, X-Ray Computed

Topics: Animals; Axons; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Female; Injections, Intraventricular; Locomotion; Myelin Sheath; Phosphodiesterase Inhibitors; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Recovery of Function; Rolipram; Spinal Cord Injuries; Time Factors; Treatment Outcome

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aquaporin 2; Cyclic Nucleotide Phosphodiesterases, Type 4; Diabetes Insipidus, Nephrogenic; Disease Models, Animal; DNA Mutational Analysis; Female; Frameshift Mutation; Genes, Dominant; Humans; Kidney Concentrating Ability; Kidney Tubules, Collecting; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osmolar Concentration; Phosphodiesterase Inhibitors; Protein Transport; Rolipram; Urine

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiopulmonary Bypass; CD11b Antigen; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; Male; Neutrophils; Phosphodiesterase Inhibitors; Rats; Rolipram; Systemic Inflammatory Response Syndrome; Treatment Outcome

Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Dexamethasone; Disease Models, Animal; Guinea Pigs; Histamine Release; Ovalbumin; Phosphodiesterase Inhibitors; Rolipram

Topics: Animals; Cell Survival; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Huntington Disease; Immunohistochemistry; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphodiesterase Inhibitors; Phosphorylation; Quinolinic Acid; Rats; Rats, Wistar; Rolipram; Treatment Outcome; Up-Regulation

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Conditioning, Operant; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperkinesis; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Motor Activity; Polymorphism, Genetic; Psychotic Disorders; Rats; Rolipram; Schizophrenia; Signal Transduction

Topics: Animals; Animals, Newborn; Benzamides; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression Profiling; Humans; Infant, Newborn; Inflammation; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Alveoli; Pulmonary Fibrosis; Pyridines; Rats; Rats, Wistar; Respiration, Artificial; Respiratory Distress Syndrome; Rolipram

Topics: Anemia, Sickle Cell; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Mice; Mice, Transgenic; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rolipram; Up-Regulation

Topics: Action Potentials; Animals; Cervical Vertebrae; Diaphragm; Disease Models, Animal; Electromyography; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Recovery of Function; Respiration; Rolipram; Spinal Cord Injuries; Time Factors; Xanthines

Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Phosphodiesterase Inhibitors; Rolipram

Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Female; Huntington Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Rolipram

Topics: Animals; Animals, Newborn; Astrocytes; Brain; Cell Proliferation; Cerebral Ventricles; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Hypoxia-Ischemia, Brain; Male; Oligodendroglia; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction

Topics: Animals; Apoptosis; CD11b Antigen; Cell Survival; Cervical Vertebrae; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Efferent Pathways; Female; Isoenzymes; Microglia; Nerve Fibers, Myelinated; Neuroprotective Agents; Oligodendroglia; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Spinal Cord; Spinal Cord Injuries; Time Factors; Wallerian Degeneration

Topics: Aerosols; Aminophylline; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Guinea Pigs; Lipopolysaccharides; Male; Phosphodiesterase Inhibitors; Pulmonary Edema; Pyridazines; Pyrrolidinones; Respiratory Distress Syndrome; Rolipram

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Shock, Septic; Tumor Necrosis Factor-alpha; Xanthines

Topics: Administration, Inhalation; Aerosols; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Eosinophils; Female; Injections, Intraperitoneal; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Pyrrolidinones; Rats; Rats, Inbred BN; Rolipram; Thiazoles

Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Hippocampus; Injections, Intraperitoneal; Ischemic Attack, Transient; Male; Neurons; Phosphodiesterase Inhibitors; Prosencephalon; Pyrrolidinones; Rolipram

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Hypersensitivity; Inflammation; Injections, Intraperitoneal; Isoenzymes; Macrophages; Male; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Specific Pathogen-Free Organisms; Theophylline; Thiazoles

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Female; Guinea Pigs; Humans; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Middle Aged; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Theophylline; Xanthines

Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Interleukin-1; Leukocyte Elastase; Leukocytes; Male; Mice; Pancreatic Elastase; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Time Factors; Tumor Necrosis Factor-alpha; Zymosan

Topics: Analysis of Variance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Carbachol; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle Relaxation; Parasympathomimetics; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rolipram; Trachea; Vagus Nerve

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Analysis of Variance; Animals; Asthma; Benzamides; Bronchoconstriction; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Guinea Pigs; Humans; Interleukin-5; Isoenzymes; Lung; Male; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Pyrrolidinones; Rabbits; Rats; Rolipram

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Capillary Permeability; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Female; Humans; Infant, Newborn; Lipopolysaccharides; Lung; Mice; Mice, Inbred BALB C; Neutrophils; Phosphodiesterase Inhibitors; Pulmonary Circulation; Pyrrolidinones; Respiratory Distress Syndrome; Rolipram; Time Factors; Tumor Necrosis Factor-alpha; Zymosan

Topics: Adenine Nucleotides; Animals; Capillary Permeability; Chromatography, High Pressure Liquid; Cyclic AMP; Disease Models, Animal; Heart Arrest, Induced; In Vitro Techniques; Lung; Lung Transplantation; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rolipram

Topics: Adenosine; Animals; Blood-Brain Barrier; Cell Adhesion; Cyclic AMP; Disease Models, Animal; Drug Synergism; Humans; Leukocytosis; Meningitis, Bacterial; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Rolipram; Superoxides; Triazines; Triazoles; Tumor Necrosis Factor-alpha

Topics: Animals; Antibodies; Basement Membrane; Disease Models, Animal; Glomerulonephritis; Kidney; Kidney Glomerulus; Leukocytes; Male; Phosphodiesterase Inhibitors; Rats; Rats, Inbred WKY; Rolipram; Tumor Necrosis Factor-alpha

Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Aminophylline; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Male; Naphthyridines; Phosphodiesterase Inhibitors; Platelet Activating Factor; Pneumonia; Rolipram; Specific Pathogen-Free Organisms; Vasodilator Agents

Topics: Acute Disease; Animals; Antibodies, Monoclonal; Autoimmune Diseases; Callithrix; CD40 Antigens; Cebidae; Cercopithecidae; Chimera; Demyelinating Diseases; Desensitization, Immunologic; Disease Models, Animal; Disease Susceptibility; Encephalomyelitis, Autoimmune, Experimental; Genes, MHC Class II; Histocompatibility Antigens; Immunosuppressive Agents; Immunotherapy; Interferon-beta; Multiple Sclerosis; Rats; Rats, Inbred Lew; Receptors, Antigen, T-Cell; Rodentia; Rolipram; Species Specificity; Twins

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Asthma; Beclomethasone; Benzamides; Budesonide; Cyclic Nucleotide Phosphodiesterases, Type 4; Dexamethasone; Dextrans; Disease Models, Animal; Enzyme Inhibitors; Eosinophil Peroxidase; Eosinophils; Fluticasone; Glucocorticoids; Guinea Pigs; Inflammation; Lung; Male; Ovalbumin; Peroxidases; Pyridines; Rats; Rats, Sprague-Dawley; Rolipram

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Edema; Female; Hindlimb; Inflammation; Interleukin-1; Phosphodiesterase Inhibitors; Rats; Rolipram; Time Factors; Tumor Necrosis Factor-alpha

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Autoimmune Diseases; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Diabetes Mellitus, Type 1; Dibutyryl Cyclic GMP; Disease Models, Animal; Drug Evaluation, Preclinical; Enterotoxins; Enzyme Induction; Female; Interferon-gamma; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred NOD; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pentoxifylline; Phosphodiesterase Inhibitors; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Tumor Necrosis Factor-alpha

Topics: Adrenalectomy; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Humans; Inflammation; Interleukin-1; Lung Diseases; Lung Diseases, Obstructive; Male; Neutrophils; Nitriles; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Rolipram; Tumor Necrosis Factor-alpha

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Capillary Permeability; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Immune Sera; Male; Neutrophils; Nitriles; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Rolipram; Survival Rate; Tumor Necrosis Factor-alpha

Topics: Albuterol; Animals; Antidepressive Agents; Avoidance Learning; Body Temperature; Brain; Depressive Disorder; Disease Models, Animal; Drinking Behavior; Female; Motor Activity; Oxotremorine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Rolipram; Weight Gain

Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Behavior, Animal; Benzhydryl Compounds; Biological Assay; Catalytic Domain; Cell Line; Cognition; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Drug Design; Humans; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Phenylurea Compounds; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship; Vomiting