rolipram has been researched along with Depression in 9 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rolipram attenuated cognitive decline as well as anxiety- and depression-like behaviors." | 8.31 | Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling. ( Cong, YF; Hou, XQ; Liu, D; Liu, FW; Shen, XR; Song, SS; Xu, L; Zhang, HT, 2023) |
| "Using three rodent models of ethanol abstinence, we examined the effects of rolipram, a prototypical, selective PDE4 inhibitor, on (1) anxiety-like behavior induced by repeated ethanol abstinence in the elevated plus maze test in fawn-hooded (FH/Wjd) rats, (2) anxiety-like behavior in the open-field test and light-dark transition test following acute ethanol abstinence in C57BL/6J mice, and (3) anxiety- and depressive-like behavior induced by protracted ethanol abstinence in the elevated plus maze, forced-swim, and tail-suspension tests in C57BL/6J mice." | 7.85 | Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. ( Fei, N; Gong, MF; Liang, JH; Pan, JC; Wen, RT; Xu, JP; Xu, Y; Zhang, HT; Zhou, YM, 2017) |
| "Rolipram attenuated cognitive decline as well as anxiety- and depression-like behaviors." | 4.31 | Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling. ( Cong, YF; Hou, XQ; Liu, D; Liu, FW; Shen, XR; Song, SS; Xu, L; Zhang, HT, 2023) |
| "Using three rodent models of ethanol abstinence, we examined the effects of rolipram, a prototypical, selective PDE4 inhibitor, on (1) anxiety-like behavior induced by repeated ethanol abstinence in the elevated plus maze test in fawn-hooded (FH/Wjd) rats, (2) anxiety-like behavior in the open-field test and light-dark transition test following acute ethanol abstinence in C57BL/6J mice, and (3) anxiety- and depressive-like behavior induced by protracted ethanol abstinence in the elevated plus maze, forced-swim, and tail-suspension tests in C57BL/6J mice." | 3.85 | Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. ( Fei, N; Gong, MF; Liang, JH; Pan, JC; Wen, RT; Xu, JP; Xu, Y; Zhang, HT; Zhou, YM, 2017) |
| " In the present study, animals exposed to the chronic unpredictable stress (CUS), a rodent model of depression, exhibited elevated corticosterone, depressive-like behavior, memory deficits, accompanied with decreased cAMP-PKA-CREB and cAMP-ERK1/2-CREB signaling and neuroplasticity." | 3.81 | Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. ( Li, YF; Liu, YQ; O'Donnell, JM; Wang, ZZ; Wilson, SP; Xu, Y; Yang, WX; Zhang, HT; Zhang, Y; Zhang, YZ; Zhao, N, 2015) |
| " In this study, chronic administration of rolipram (0." | 1.35 | Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. ( Amsdell, SL; Huang, Y; Li, YF; O'Donnell, JM; Xiao, L; Zhang, HT, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Czopek, A | 1 |
| Bucki, A | 1 |
| Kołaczkowski, M | 1 |
| Zagórska, A | 1 |
| Drop, M | 1 |
| Pawłowski, M | 1 |
| Siwek, A | 1 |
| Głuch-Lutwin, M | 1 |
| Pękala, E | 1 |
| Chrzanowska, A | 1 |
| Struga, M | 1 |
| Partyka, A | 1 |
| Wesołowska, A | 1 |
| Cong, YF | 1 |
| Liu, FW | 1 |
| Xu, L | 1 |
| Song, SS | 1 |
| Shen, XR | 1 |
| Liu, D | 1 |
| Hou, XQ | 1 |
| Zhang, HT | 4 |
| Gong, MF | 1 |
| Wen, RT | 1 |
| Xu, Y | 2 |
| Pan, JC | 1 |
| Fei, N | 1 |
| Zhou, YM | 1 |
| Xu, JP | 2 |
| Liang, JH | 1 |
| Callaghan, CK | 1 |
| O'Mara, SM | 1 |
| Wang, ZZ | 1 |
| Yang, WX | 1 |
| Zhang, Y | 1 |
| Zhao, N | 1 |
| Zhang, YZ | 1 |
| Liu, YQ | 1 |
| Wilson, SP | 1 |
| O'Donnell, JM | 2 |
| Li, YF | 2 |
| Zhou, ZZ | 1 |
| Cheng, YF | 1 |
| Zou, ZQ | 1 |
| Ge, BC | 1 |
| Yu, H | 1 |
| Huang, C | 1 |
| Wang, HT | 1 |
| Yang, XM | 1 |
| Fujita, M | 1 |
| Richards, EM | 1 |
| Niciu, MJ | 1 |
| Ionescu, DF | 1 |
| Zoghbi, SS | 1 |
| Hong, J | 1 |
| Telu, S | 1 |
| Hines, CS | 1 |
| Pike, VW | 1 |
| Zarate, CA | 1 |
| Innis, RB | 1 |
| Huang, Y | 1 |
| Amsdell, SL | 1 |
| Xiao, L | 1 |
| Itoh, T | 1 |
| Abe, K | 1 |
| Tokumura, M | 1 |
| Horiuchi, M | 1 |
| Inoue, O | 1 |
| Ibii, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE 4) in Depressed Patients[NCT00369798] | Phase 1 | 100 participants (Actual) | Interventional | 2006-08-02 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for rolipram and Depression
| Article | Year |
|---|---|
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Receptors, Serotonin; St | 2019 |
Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Depres | 2023 |
Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents.
Topics: Alcohol Abstinence; Alcohol Drinking; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; | 2017 |
Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipram.
Topics: Animals; Antineoplastic Agents; Behavior, Animal; Cyclic Nucleotide Phosphodiesterases, Type 4; Depr | 2015 |
Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.
Topics: Animals; Body Weight; Corticosterone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cycli | 2015 |
Discovery of N-Alkyl Catecholamides as Selective Phosphodiesterase-4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Cyclic Nucleotide Phosphodiesterases, Type | 2017 |
cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Antidepressive Agents; Brain; Carbon Radioisotopes; Case | 2017 |
Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; CREB-Binding Protein; Dentate Gyrus; D | 2009 |
Different regulation of adenylyl cyclase and rolipram-sensitive phosphodiesterase activity on the frontal cortex and hippocampus in learned helplessness rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Corticosterone; Cyclic AMP; Cyclic | 2003 |