rolipram has been researched along with Bronchial Hyperreactivity in 20 studies
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the present study was to evaluate the effects of selective PDE4 (rolipram, ROL) and PDE7 inhibitors (BRL50481, BRL) on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity in both healthy and ovalbumin sensitized guinea pigs." | 7.79 | Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs. ( Christensen, I; Joskova, M; Mokra, D; Mokry, J; Nosalova, G, 2013) |
| "PPE-SVC and viscolin attenuate airway inflammation and eosinophil infiltration in OVA-sensitized mice." | 7.77 | Partially purified extract and viscolin from Viscum coloratum attenuate airway inflammation and eosinophil infiltration in ovalbumin-sensitized mice. ( Chiang, MS; Huang, WC; Hwang, TL; Kuo, ML; Leu, YL; Liou, CJ; Shen, JJ, 2011) |
| "This study investigates the role of adrenal-derived catecholamines and corticosterone on the inhibition by rolipram, a phosphodiesterase (PDE)-4 inhibitor, of pulmonary eosinophilia and airway hyperresponsiveness (AHR) in allergic mice." | 7.70 | Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines. ( Chapman, RW; Crawley, Y; Kreutner, W; Kung, TT; Luo, B; Young, S, 2000) |
| " The aim of the present study was to evaluate the effects of selective PDE4 (rolipram, ROL) and PDE7 inhibitors (BRL50481, BRL) on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity in both healthy and ovalbumin sensitized guinea pigs." | 3.79 | Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs. ( Christensen, I; Joskova, M; Mokra, D; Mokry, J; Nosalova, G, 2013) |
| "PPE-SVC and viscolin attenuate airway inflammation and eosinophil infiltration in OVA-sensitized mice." | 3.77 | Partially purified extract and viscolin from Viscum coloratum attenuate airway inflammation and eosinophil infiltration in ovalbumin-sensitized mice. ( Chiang, MS; Huang, WC; Hwang, TL; Kuo, ML; Leu, YL; Liou, CJ; Shen, JJ, 2011) |
| " Therefore, we were interested in investigating its selectivity on PDE4 and binding ability on high-affinity rolipram-binding sites (HARBs) in vitro, and its effects on ovalbumin-induced airway hyperresponsiveness in vivo, and clarifying its potential for treating asthma and chronic obstructive pulmonary disease (COPD)." | 3.77 | Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. ( Chen, CM; Han, CY; Hsu, HT; Ko, WC; Wang, KH; Yang, YL, 2011) |
| "Chronic exposure of human isolated bronchi to beta2-adrenergic agonists, especially fenoterol, potentiates smooth muscle contraction in response to endothelin-1 (ET-1), a peptide implicated in chronic inflammatory airway diseases." | 3.73 | Phosphodiesterase 4 inhibitors modulate beta2-adrenoceptor agonist-induced human airway hyperresponsiveness. ( Advenier, C; Devillier, P; Fagon, JY; Faisy, C; Guerot, E; Naline, E; Risse, PA, 2006) |
| "The aim of this study was to establish a conscious guinea-pig model with these essential features of asthma and to correlate these with bronchoalveolar lavage fluid (BALF) histamine and nitric oxide (NO) levels." | 3.72 | Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram. ( Broadley, KJ; Toward, TJ, 2004) |
| " Effects of cilostazol and vesnarinone (selective PDE III inhibitors), rolipram (selective PDE IV inhibitor) and theophylline (nonselective PDE inhibitor) on LPS-induced bronchial hyperreactivity were investigated in guinea pigs." | 3.70 | Effects of isoenzyme selective phosphodiesterase inhibitors on bacterial lipopolysaccharide-induced bronchial hyperreactivity in guinea pigs. ( Nagai, H; Tanaka, H; Uno, T, 1998) |
| "This study investigates the role of adrenal-derived catecholamines and corticosterone on the inhibition by rolipram, a phosphodiesterase (PDE)-4 inhibitor, of pulmonary eosinophilia and airway hyperresponsiveness (AHR) in allergic mice." | 3.70 | Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines. ( Chapman, RW; Crawley, Y; Kreutner, W; Kung, TT; Luo, B; Young, S, 2000) |
| "A new guinea pig model of allergic asthma was used to investigate the effects of low doses of the phosphodiesterase inhibitors, rolipram (phosphodiesterase IV selective), ORG 20241 (N-hydroxy-4-(3,4-dimethoxyphenyl)-thiazole-2-carboximidamide; dual phosphodiesterase III/IV inhibitor with some selectivity for the phosphodiesterase IV isoenzyme), and of theophylline (non-selective) on allergen-induced early and late phase asthmatic reactions, bronchial hyperreactivity to histamine inhalation, and airway inflammation." | 3.69 | Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. ( Meurs, H; Olymulder, CG; Santing, RE; Van der Molen, K; Zaagsma, J, 1995) |
| " We have investigated the effects of RP 73401, a novel, potent and highly selective cyclic nucleotide phosphodiesterase (PDE) type IV inhibitor, in guinea-pig and rat models of bronchoconstriction and allergic inflammation." | 3.69 | Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. ( Battram, CH; Jordan, R; Lewis, SA; Raeburn, D; Sharma, S; Souness, JE; Tomkinson, A; Underwood, SL; Webber, SE; Woodman, VR, 1994) |
| "Airway hyperreactivity (AHR), lung inflammation, and atopy are clinical signs of allergic asthma." | 1.35 | Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammation and a ( Campen, M; Kurup, V; Mishra, NC; Razani-Boroujerdi, S; Rir-Sima-Ah, J; Singh, SP; Sopori, ML, 2009) |
| ") administered 30 min before and 6 h after antigen challenge (double dosing regimen), did not affect the development of the early or late phase responses." | 1.30 | Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration. ( Broadley, KJ; Danahay, H, 1997) |
| " Acute airway hyperreactivity was evidenced by significant leftward shifts in dose-response curves to i." | 1.29 | Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs. ( Howell, RE; Sickels, BD; Woeppel, SL, 1993) |
| ") did not bronchodilate but caused a parallel 7 fold rightward shift in the histamine dose-response curve." | 1.29 | Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor. ( Gozzard, N; Higgs, G; Holbrook, M; Hughes, B; James, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, SP | 1 |
| Mishra, NC | 1 |
| Rir-Sima-Ah, J | 1 |
| Campen, M | 1 |
| Kurup, V | 1 |
| Razani-Boroujerdi, S | 1 |
| Sopori, ML | 1 |
| Shen, JJ | 1 |
| Chiang, MS | 1 |
| Kuo, ML | 1 |
| Leu, YL | 1 |
| Hwang, TL | 1 |
| Liou, CJ | 1 |
| Huang, WC | 1 |
| Yougbare, I | 1 |
| Morin, C | 1 |
| Senouvo, FY | 1 |
| Sirois, C | 1 |
| Albadine, R | 1 |
| Lugnier, C | 1 |
| Rousseau, E | 1 |
| Yang, YL | 1 |
| Hsu, HT | 1 |
| Wang, KH | 1 |
| Han, CY | 1 |
| Chen, CM | 2 |
| Ko, WC | 1 |
| Chang, W | 1 |
| Chen, J | 1 |
| Schlueter, CF | 1 |
| Rando, RJ | 1 |
| Pathak, YV | 1 |
| Hoyle, GW | 1 |
| Mokry, J | 1 |
| Joskova, M | 1 |
| Mokra, D | 1 |
| Christensen, I | 1 |
| Nosalova, G | 1 |
| Toward, TJ | 2 |
| Broadley, KJ | 2 |
| Johnson, FJ | 1 |
| Boult, JE | 1 |
| Maillard, JY | 1 |
| Faisy, C | 1 |
| Risse, PA | 1 |
| Naline, E | 1 |
| Guerot, E | 1 |
| Fagon, JY | 1 |
| Devillier, P | 1 |
| Advenier, C | 1 |
| Nejman-Gryz, P | 1 |
| Grubek-Jaworska, H | 1 |
| Glapińiski, J | 1 |
| Chazan, R | 1 |
| Santing, RE | 1 |
| Olymulder, CG | 1 |
| Van der Molen, K | 1 |
| Meurs, H | 1 |
| Zaagsma, J | 1 |
| Raeburn, D | 1 |
| Underwood, SL | 1 |
| Lewis, SA | 1 |
| Woodman, VR | 1 |
| Battram, CH | 1 |
| Tomkinson, A | 1 |
| Sharma, S | 1 |
| Jordan, R | 1 |
| Souness, JE | 1 |
| Webber, SE | 1 |
| Howell, RE | 1 |
| Sickels, BD | 1 |
| Woeppel, SL | 1 |
| Holbrook, M | 1 |
| Gozzard, N | 1 |
| James, T | 1 |
| Higgs, G | 1 |
| Hughes, B | 1 |
| Danahay, H | 1 |
| Uno, T | 1 |
| Tanaka, H | 1 |
| Nagai, H | 1 |
| Manabe, H | 1 |
| Akuta, K | 1 |
| Kawasaki, H | 1 |
| Ohmori, K | 2 |
| Kung, TT | 1 |
| Crawley, Y | 1 |
| Luo, B | 1 |
| Young, S | 2 |
| Kreutner, W | 2 |
| Chapman, RW | 2 |
| Ikemura, T | 1 |
| Schwarze, J | 1 |
| Makela, M | 1 |
| Kanehiro, A | 1 |
| Joetham, A | 1 |
| Gelfand, EW | 1 |
| Billah, MM | 1 |
| Cooper, N | 1 |
| Minnicozzi, M | 1 |
| Warneck, J | 1 |
| Wang, P | 1 |
| Hey, JA | 1 |
| Rizzo, CA | 1 |
| Smith, SR | 1 |
| Dyke, H | 1 |
| Shih, NY | 1 |
| Piwinski, JJ | 1 |
| Cuss, FM | 1 |
| Montana, J | 1 |
| Ganguly, AK | 1 |
| Egan, RW | 1 |
1 trial available for rolipram and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adolescent; Adult; Aged; Animals; Anti-Asthmatic Agents; Bindin | 2002 |
19 other studies available for rolipram and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammation and a
Topics: Airway Resistance; Allergens; Animals; Bronchial Hyperreactivity; Cyclic Nucleotide Phosphodiesteras | 2009 |
Partially purified extract and viscolin from Viscum coloratum attenuate airway inflammation and eosinophil infiltration in ovalbumin-sensitized mice.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Biphenyl Compounds; Bronchial Hyperreactiv | 2011 |
NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anti-Inflammatory Agents; Asthma | 2011 |
Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.
Topics: Animals; Asthma; Binding Sites; Blood Cell Count; Bronchial Hyperreactivity; Bronchoalveolar Lavage | 2011 |
Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram.
Topics: Acute Lung Injury; Administration, Intranasal; Animals; Bronchial Hyperreactivity; Chlorine; Cyclic | 2012 |
Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs.
Topics: Acetylcholine; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Citric Ac | 2013 |
Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram.
Topics: Administration, Inhalation; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar La | 2004 |
Airway function and reactivity, leukocyte influx and nitric oxide after inoculation with parainfluenza-3 virus: effects of dexamethasone or rolipram.
Topics: Animals; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Cell Movement; Dexamethasone; Guinea P | 2005 |
Phosphodiesterase 4 inhibitors modulate beta2-adrenoceptor agonist-induced human airway hyperresponsiveness.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; | 2006 |
[Effect of phosphodiestrase 4 inhibitor (rolipram) on experimental allergic asthma-guinea pig model].
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L | 2006 |
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asth | 1995 |
Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor.
Topics: Albuterol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bronchial Hyperreactivity; | 1994 |
Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs.
Topics: Aminophylline; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Bronchodilator Agents; Guine | 1993 |
Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor.
Topics: Analysis of Variance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Carbachol | 1996 |
Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-(3-Butoxy-4-methoxybenzyl)-2-i | 1997 |
Effects of isoenzyme selective phosphodiesterase inhibitors on bacterial lipopolysaccharide-induced bronchial hyperreactivity in guinea pigs.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cilostazol; Guinea | 1998 |
The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Aminophylline; Animals; Asthma; Bronch | 2000 |
Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines.
Topics: Animals; Antihypertensive Agents; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Catecholamines; | 2000 |
Type 4 phosphodiesterase inhibitors attenuate respiratory syncytial virus-induced airway hyper-responsiveness and lung eosinophilia.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bronch | 2000 |