Page last updated: 2024-11-04

rolipram and Brain Ischemia

rolipram has been researched along with Brain Ischemia in 10 studies

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"The effects of treatment with rolipram, a specific phosphodiesterase IV inhibitor, on learning and memory function and on the cyclic AMP/PKA/CREB signal transduction system were examined in rats with microsphere embolism (ME)-induced cerebral ischaemia."7.71Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. ( Nagakura, A; Niimura, M; Takeo, S, 2002)
"Rolipram was administered at a dose of 0."5.35Improved sensorimotor function by rolipram following focal cerebral ischemia in rats. ( Hätinen, S; Jolkkonen, J; Sairanen, M; Sirviö, J, 2008)
"The effects of treatment with rolipram, a specific phosphodiesterase IV inhibitor, on learning and memory function and on the cyclic AMP/PKA/CREB signal transduction system were examined in rats with microsphere embolism (ME)-induced cerebral ischaemia."3.71Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. ( Nagakura, A; Niimura, M; Takeo, S, 2002)
"In the water-maze test, cerebral ischemia significantly increased the escape latency to reach the platform during acquisition training and decreased the exploration time in the target quadrant in the probe trial test; these were blocked by rolipram in a dose-dependent manner."1.37Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. ( Cheng, YF; Li, LX; Lin, HB; Wang, C; Xu, JP; Zhang, HT, 2011)
"Rolipram was administered at a dose of 0."1.35Improved sensorimotor function by rolipram following focal cerebral ischemia in rats. ( Hätinen, S; Jolkkonen, J; Sairanen, M; Sirviö, J, 2008)
"Scopolamine, cerebral ischemia induced by four-vessel occlusion and electric convulsive shock impaired working memory in the 3-panel runway task."1.30Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents. ( Ichimaru, Y; Imanishi, T; Kato, S; Miyashiro, M; Sawa, A; Ueki, S; Yamamoto, T, 1997)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (50.00)18.2507
2000's3 (30.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Soares, LM1
De Vry, J1
Steinbusch, HWM1
Milani, H1
Prickaerts, J1
Weffort de Oliveira, RM1
Hätinen, S1
Sairanen, M1
Sirviö, J1
Jolkkonen, J1
Li, LX1
Cheng, YF1
Lin, HB1
Wang, C1
Xu, JP1
Zhang, HT1
Sasaki, T1
Kitagawa, K1
Omura-Matsuoka, E1
Todo, K1
Terasaki, Y1
Sugiura, S1
Hatazawa, J1
Yagita, Y1
Hori, M1
Kato, H3
Araki, T3
Murase, K2
Kogure, K3
Imanishi, T1
Sawa, A1
Ichimaru, Y1
Miyashiro, M1
Kato, S1
Yamamoto, T1
Ueki, S1
Belayev, L1
Busto, R1
Ikeda, M1
Rubin, LL1
Kajiwara, A1
Morgan, L1
Ginsberg, MD1
Nagakura, A1
Niimura, M1
Takeo, S1

Other Studies

10 other studies available for rolipram and Brain Ischemia

ArticleYear
Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia.
    Neuroscience, 2016, 06-21, Volume: 326

    Topics: Animals; Anxiety; Behavior, Animal; Brain Ischemia; Cognitive Dysfunction; Doublecortin Domain Prote

2016
Improved sensorimotor function by rolipram following focal cerebral ischemia in rats.
    Restorative neurology and neuroscience, 2008, Volume: 26, Issue:6

    Topics: Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motor Activ

2008
Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats.
    Metabolic brain disease, 2011, Volume: 26, Issue:1

    Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cyclic Nucleotide Phosphodiesterases, Type 4; Male

2011
The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia.
    Stroke, 2007, Volume: 38, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain Ischemia; Cell Proliferation; Cyclic AMP Respons

2007
Alterations in [3H]MK-801, [3H]muscimol, [3H]cyclic AMP, and [3H]rolipram binding in the gerbil hippocampus following repeated ischemic insults.
    Neuroscience, 1993, Volume: 52, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Autoradiography; Brain Ischemia; Cyclic AMP; Dizocilpi

1993
Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents.
    European journal of pharmacology, 1997, Mar-05, Volume: 321, Issue:3

    Topics: Animals; Avoidance Learning; Brain Ischemia; Bucladesine; Cyclic AMP; Electroshock; Learning; Male;

1997
Protection against blood-brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB022: a quantitative study.
    Brain research, 1998, Mar-23, Volume: 787, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Coloring A

1998
Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats.
    British journal of pharmacology, 2002, Volume: 135, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding Sites; Brain Ischemia; Cell Nucleus; Cyclic AM

2002
Mapping of second messenger and rolipram receptors in mammalian brain.
    Brain research bulletin, 1992, Volume: 28, Issue:6

    Topics: Animals; Autoradiography; Brain Ischemia; Brain Mapping; Colforsin; Cyclic AMP; Gerbillinae; Hippoca

1992
Induction of tolerance to ischemia: alterations in second-messenger systems in the gerbil hippocampus.
    Brain research bulletin, 1992, Volume: 29, Issue:5

    Topics: Animals; Autoradiography; Brain Ischemia; Colforsin; Cyclic AMP; Gerbillinae; Hippocampus; Inosine T

1992