rolipram has been researched along with Brain Ischemia in 10 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of treatment with rolipram, a specific phosphodiesterase IV inhibitor, on learning and memory function and on the cyclic AMP/PKA/CREB signal transduction system were examined in rats with microsphere embolism (ME)-induced cerebral ischaemia." | 7.71 | Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. ( Nagakura, A; Niimura, M; Takeo, S, 2002) |
| "Rolipram was administered at a dose of 0." | 5.35 | Improved sensorimotor function by rolipram following focal cerebral ischemia in rats. ( Hätinen, S; Jolkkonen, J; Sairanen, M; Sirviö, J, 2008) |
| "The effects of treatment with rolipram, a specific phosphodiesterase IV inhibitor, on learning and memory function and on the cyclic AMP/PKA/CREB signal transduction system were examined in rats with microsphere embolism (ME)-induced cerebral ischaemia." | 3.71 | Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. ( Nagakura, A; Niimura, M; Takeo, S, 2002) |
| "In the water-maze test, cerebral ischemia significantly increased the escape latency to reach the platform during acquisition training and decreased the exploration time in the target quadrant in the probe trial test; these were blocked by rolipram in a dose-dependent manner." | 1.37 | Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. ( Cheng, YF; Li, LX; Lin, HB; Wang, C; Xu, JP; Zhang, HT, 2011) |
| "Rolipram was administered at a dose of 0." | 1.35 | Improved sensorimotor function by rolipram following focal cerebral ischemia in rats. ( Hätinen, S; Jolkkonen, J; Sairanen, M; Sirviö, J, 2008) |
| "Scopolamine, cerebral ischemia induced by four-vessel occlusion and electric convulsive shock impaired working memory in the 3-panel runway task." | 1.30 | Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents. ( Ichimaru, Y; Imanishi, T; Kato, S; Miyashiro, M; Sawa, A; Ueki, S; Yamamoto, T, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soares, LM | 1 |
| De Vry, J | 1 |
| Steinbusch, HWM | 1 |
| Milani, H | 1 |
| Prickaerts, J | 1 |
| Weffort de Oliveira, RM | 1 |
| Hätinen, S | 1 |
| Sairanen, M | 1 |
| Sirviö, J | 1 |
| Jolkkonen, J | 1 |
| Li, LX | 1 |
| Cheng, YF | 1 |
| Lin, HB | 1 |
| Wang, C | 1 |
| Xu, JP | 1 |
| Zhang, HT | 1 |
| Sasaki, T | 1 |
| Kitagawa, K | 1 |
| Omura-Matsuoka, E | 1 |
| Todo, K | 1 |
| Terasaki, Y | 1 |
| Sugiura, S | 1 |
| Hatazawa, J | 1 |
| Yagita, Y | 1 |
| Hori, M | 1 |
| Kato, H | 3 |
| Araki, T | 3 |
| Murase, K | 2 |
| Kogure, K | 3 |
| Imanishi, T | 1 |
| Sawa, A | 1 |
| Ichimaru, Y | 1 |
| Miyashiro, M | 1 |
| Kato, S | 1 |
| Yamamoto, T | 1 |
| Ueki, S | 1 |
| Belayev, L | 1 |
| Busto, R | 1 |
| Ikeda, M | 1 |
| Rubin, LL | 1 |
| Kajiwara, A | 1 |
| Morgan, L | 1 |
| Ginsberg, MD | 1 |
| Nagakura, A | 1 |
| Niimura, M | 1 |
| Takeo, S | 1 |
10 other studies available for rolipram and Brain Ischemia
| Article | Year |
|---|---|
Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia.
Topics: Animals; Anxiety; Behavior, Animal; Brain Ischemia; Cognitive Dysfunction; Doublecortin Domain Prote | 2016 |
Improved sensorimotor function by rolipram following focal cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motor Activ | 2008 |
Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cyclic Nucleotide Phosphodiesterases, Type 4; Male | 2011 |
The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain Ischemia; Cell Proliferation; Cyclic AMP Respons | 2007 |
Alterations in [3H]MK-801, [3H]muscimol, [3H]cyclic AMP, and [3H]rolipram binding in the gerbil hippocampus following repeated ischemic insults.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Autoradiography; Brain Ischemia; Cyclic AMP; Dizocilpi | 1993 |
Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents.
Topics: Animals; Avoidance Learning; Brain Ischemia; Bucladesine; Cyclic AMP; Electroshock; Learning; Male; | 1997 |
Protection against blood-brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB022: a quantitative study.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Coloring A | 1998 |
Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding Sites; Brain Ischemia; Cell Nucleus; Cyclic AM | 2002 |
Mapping of second messenger and rolipram receptors in mammalian brain.
Topics: Animals; Autoradiography; Brain Ischemia; Brain Mapping; Colforsin; Cyclic AMP; Gerbillinae; Hippoca | 1992 |
Induction of tolerance to ischemia: alterations in second-messenger systems in the gerbil hippocampus.
Topics: Animals; Autoradiography; Brain Ischemia; Colforsin; Cyclic AMP; Gerbillinae; Hippocampus; Inosine T | 1992 |