rolipram has been researched along with Brain Injuries in 8 studies
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rolipram treatment remarkably promoted the expression of Sirtuin 1 (SIRT1) while inhibited NF-κB activation." | 5.48 | Rolipram Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats: Possibly via Regulating the SIRT1/NF-κB Pathway. ( Chen, G; Chen, T; Fan, L; He, P; Jin, J; Li, J; Peng, Y; Ruan, W; Xu, H, 2018) |
| "Rolipram is a multifaceted antiinflammatory and antithrombotic compound that protects from ischemic neurodegeneration in clinically meaningful settings." | 5.39 | The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis. ( Brede, M; Göb, E; Heydenreich, N; Kleinschnitz, C; Kraft, P; Meuth, SG; Schwarz, T, 2013) |
| "Rolipram treatment remarkably promoted the expression of Sirtuin 1 (SIRT1) while inhibited NF-κB activation." | 1.48 | Rolipram Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats: Possibly via Regulating the SIRT1/NF-κB Pathway. ( Chen, G; Chen, T; Fan, L; He, P; Jin, J; Li, J; Peng, Y; Ruan, W; Xu, H, 2018) |
| "Rolipram is a multifaceted antiinflammatory and antithrombotic compound that protects from ischemic neurodegeneration in clinically meaningful settings." | 1.39 | The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis. ( Brede, M; Göb, E; Heydenreich, N; Kleinschnitz, C; Kraft, P; Meuth, SG; Schwarz, T, 2013) |
| "Rolipram treatment restored cAMP to sham levels and significantly reduced cortical contusion volume and improved neuronal cell survival in the parietal cortex and CA3 region of the hippocampus." | 1.34 | Modulation of the cAMP signaling pathway after traumatic brain injury. ( Alonso, OF; Atkins, CM; Bramlett, HM; Dietrich, WD; Oliva, AA; Pearse, DD, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, Y | 2 |
| Jin, J | 1 |
| Fan, L | 2 |
| Xu, H | 2 |
| He, P | 2 |
| Li, J | 2 |
| Chen, T | 2 |
| Ruan, W | 2 |
| Chen, G | 2 |
| Li, Q | 1 |
| Cao, S | 1 |
| Titus, DJ | 1 |
| Sakurai, A | 1 |
| Kang, Y | 3 |
| Furones, C | 2 |
| Jergova, S | 1 |
| Santos, R | 1 |
| Sick, TJ | 1 |
| Atkins, CM | 4 |
| Kraft, P | 1 |
| Schwarz, T | 1 |
| Göb, E | 1 |
| Heydenreich, N | 1 |
| Brede, M | 1 |
| Meuth, SG | 1 |
| Kleinschnitz, C | 1 |
| Truettner, JS | 1 |
| Alonso, OF | 2 |
| Dietrich, WD | 3 |
| Cepero, ML | 1 |
| Liebl, DJ | 1 |
| Oliva, AA | 1 |
| Pearse, DD | 1 |
| Bramlett, HM | 1 |
| Arvin, B | 1 |
| Neville, LF | 1 |
| Barone, FC | 1 |
| Feuerstein, GZ | 1 |
1 review available for rolipram and Brain Injuries
| Article | Year |
|---|---|
Brain injury and inflammation. A putative role of TNF alpha.
Topics: Animals; Brain Injuries; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cell Death; Central Nervou | 1995 |
7 other studies available for rolipram and Brain Injuries
| Article | Year |
|---|---|
Rolipram Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats: Possibly via Regulating the SIRT1/NF-κB Pathway.
Topics: Animals; Brain Injuries; Injections, Intraperitoneal; Male; Neuroprotective Agents; NF-kappa B; Phos | 2018 |
Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway.
Topics: Animals; Apoptosis; Benzamides; Brain Edema; Brain Injuries; Cyclic Nucleotide Phosphodiesterases, T | 2018 |
Phosphodiesterase inhibition rescues chronic cognitive deficits induced by traumatic brain injury.
Topics: Animals; Brain Injuries; Chronic Disease; Cognition Disorders; Conditioning, Psychological; Cyclic A | 2013 |
The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cytokines; Disease Models, Animal; Enceph | 2013 |
Postinjury treatment with rolipram increases hemorrhage after traumatic brain injury.
Topics: Animals; Brain Injuries; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; E | 2012 |
Effects of early rolipram treatment on histopathological outcome after controlled cortical impact injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Injuries; Cell Death; Male; Mice; Mic | 2013 |
Modulation of the cAMP signaling pathway after traumatic brain injury.
Topics: Amyloid beta-Protein Precursor; Animals; Blotting, Western; Brain Injuries; Cyclic AMP; Cyclic AMP-D | 2007 |