rolipram has been researched along with Asthma in 46 studies
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Excerpt | Relevance | Reference |
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"The aim of this study was to evaluate the influence of pretreatment with the phosphodiesterase-4 inhibitor rolipram on pulmonary resistance, influx of inflammatory cells, and histamine concentration in bronchoalveolar lavage fluid (BALF) during an experimental asthmatic reaction induced in ovalbumin (OA)-sensitized guinea pigs, challenged with OA inhalation." | 7.73 | Effects of the phosphodiestrase-4 inhibitor rolipram on lung resistance and inflammatory reaction in experimental asthma. ( Chazan, R; Glapiński, J; Grubek-Jaworska, H; Hoser, G; Nejman-Gryz, P, 2006) |
" Theophylline possesses anti-inflammatory activities in asthma." | 7.72 | Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma. ( Chung, KF; Huang, KH; Kuo, HP; Lin, CH; Lin, HC; Liu, SL; Wang, CH; Yu, CT, 2003) |
" Therefore, we were interested in investigating its selectivity on PDE4 and binding ability on high-affinity rolipram-binding sites (HARBs) in vitro, and its effects on ovalbumin-induced airway hyperresponsiveness in vivo, and clarifying its potential for treating asthma and chronic obstructive pulmonary disease (COPD)." | 3.77 | Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. ( Chen, CM; Han, CY; Hsu, HT; Ko, WC; Wang, KH; Yang, YL, 2011) |
"The aim of this study was to evaluate the influence of pretreatment with the phosphodiesterase-4 inhibitor rolipram on pulmonary resistance, influx of inflammatory cells, and histamine concentration in bronchoalveolar lavage fluid (BALF) during an experimental asthmatic reaction induced in ovalbumin (OA)-sensitized guinea pigs, challenged with OA inhalation." | 3.73 | Effects of the phosphodiestrase-4 inhibitor rolipram on lung resistance and inflammatory reaction in experimental asthma. ( Chazan, R; Glapiński, J; Grubek-Jaworska, H; Hoser, G; Nejman-Gryz, P, 2006) |
" Theophylline possesses anti-inflammatory activities in asthma." | 3.72 | Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma. ( Chung, KF; Huang, KH; Kuo, HP; Lin, CH; Lin, HC; Liu, SL; Wang, CH; Yu, CT, 2003) |
"The aim of this study was to establish a conscious guinea-pig model with these essential features of asthma and to correlate these with bronchoalveolar lavage fluid (BALF) histamine and nitric oxide (NO) levels." | 3.72 | Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram. ( Broadley, KJ; Toward, TJ, 2004) |
"PBMCs from control subjects and allergic asthmatic patients were stimulated with PHA in the presence of low doses of fluticasone propionate (FP) with or without salmeterol for 72 hours." | 3.72 | Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists. ( Dunlap, A; Goleva, E; Leung, DY, 2004) |
" Selected compounds have also been examined for their activities in inhibiting histamine-induced bronchospasm in anaesthetized guinea pigs." | 3.69 | Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues. ( Ashton, MJ; Cook, DC; Fenton, G; Karlsson, JA; Palfreyman, MN; Raeburn, D; Ratcliffe, AJ; Souness, JE; Thurairatnam, S; Vicker, N, 1994) |
"A new guinea pig model of allergic asthma was used to investigate the effects of low doses of the phosphodiesterase inhibitors, rolipram (phosphodiesterase IV selective), ORG 20241 (N-hydroxy-4-(3,4-dimethoxyphenyl)-thiazole-2-carboximidamide; dual phosphodiesterase III/IV inhibitor with some selectivity for the phosphodiesterase IV isoenzyme), and of theophylline (non-selective) on allergen-induced early and late phase asthmatic reactions, bronchial hyperreactivity to histamine inhalation, and airway inflammation." | 3.69 | Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. ( Meurs, H; Olymulder, CG; Santing, RE; Van der Molen, K; Zaagsma, J, 1995) |
"The effect of rolipram, an isozyme IV-selective inhibitor of cAMP-specific phosphodiesterase, was evaluated in a guinea pig eye model of tissue eosinophilia." | 3.68 | cAMP-specific phosphodiesterase inhibitor, rolipram, reduces eosinophil infiltration evoked by leukotrienes or by histamine in guinea pig conjunctiva. ( Newsholme, SJ; Schwartz, L, 1993) |
"Theophylline has been widely used in the treatment of bronchial asthma mainly due to its bronchodilating effect." | 1.32 | Theophylline attenuates the adhesion of eosinophils to endothelial cells. ( Choo, JH; Kikuchi, I; Nagata, M; Sakamoto, Y; Sutani, A, 2003) |
" Multiple day dosing also improved activity." | 1.31 | Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil peroxidase (EPO) levels following either systemic or intratracheal administration in sephadex- or ovalbumin-induced inflammatory models. ( Egging, EA; Gullikson, GW; Hammerbeck, DM; Hupperts, AM; Johnson, DD; McGurran, SM; Radziszewski, PL, 2000) |
"Rolipram was characterized for its emetic, behavioral, cardiovascular and pulmonary activities in dogs, to assess its systemic pharmacology and potential bronchodilatory selectivity." | 1.29 | Emetic, central nervous system, and pulmonary activities of rolipram in the dog. ( Evans, DY; Heaslip, RJ, 1995) |
"Pretreatment with rolipram (10 mg kg-1, i." | 1.29 | Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs. ( Cortijo, J; Martí-Cabrera, M; Morcillo, EJ; Ortiz, JL; Vallés, JM, 1996) |
"Treatment with rolipram, but not theophylline, prevented the increase in responsiveness to inhaled histamine 24 h after antigen challenge." | 1.29 | Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits. ( Blake, SM; Gozzard, N; Herd, CM; Higgs, GA; Holbrook, M; Hughes, B; Page, CP, 1996) |
"4." | 1.29 | The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. ( Alexander, R; Allen, R; Blease, K; Bloxham, D; Boyd, E; Catterall, C; Eaton, M; Gozzard, N; Head, J; Higgs, G; Holbrook, M; Howat, D; Hughes, B; Hughes, P; James, T; Kingaby, R; Lisle, H; Lumb, S; Merriman, M; Owens, R; Perry, M; Russell, A; Smith, B; Wales, M; Warrellow, G, 1996) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 14 (30.43) | 18.2507 |
2000's | 23 (50.00) | 29.6817 |
2010's | 9 (19.57) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Ashton, MJ | 1 |
Cook, DC | 1 |
Fenton, G | 1 |
Karlsson, JA | 1 |
Palfreyman, MN | 1 |
Raeburn, D | 1 |
Ratcliffe, AJ | 1 |
Souness, JE | 2 |
Thurairatnam, S | 1 |
Vicker, N | 1 |
Hersperger, R | 1 |
Bray-French, K | 1 |
Mazzoni, L | 1 |
Müller, T | 1 |
Buckley, G | 1 |
Cooper, N | 2 |
Dyke, HJ | 2 |
Galleway, F | 1 |
Gowers, L | 2 |
Gregory, JC | 1 |
Hannah, DR | 1 |
Haughan, AF | 2 |
Hellewell, PG | 1 |
Kendall, HJ | 2 |
Lowe, C | 2 |
Maxey, R | 2 |
Montana, JG | 2 |
Naylor, R | 2 |
Picken, CL | 2 |
Runcie, KA | 2 |
Sabin, V | 2 |
Tuladhar, BR | 1 |
Warneck, JB | 2 |
Buckley, GM | 1 |
Galleway, FP | 1 |
Oxford, J | 1 |
Peake, JC | 1 |
Sharpe, A | 1 |
Kodimuthali, A | 1 |
Jabaris, SS | 1 |
Pal, M | 1 |
Kato, Y | 1 |
Kawasaki, M | 2 |
Nigo, T | 2 |
Nakamura, S | 2 |
Fusano, A | 2 |
Teranishi, Y | 2 |
Ito, MN | 2 |
Sumiyoshi, T | 2 |
Matsumoto, S | 1 |
Toda, H | 1 |
Nomura, N | 1 |
Song, G | 1 |
Zhu, X | 1 |
Li, J | 1 |
Hu, D | 1 |
Zhao, D | 1 |
Liao, Y | 1 |
Lin, J | 1 |
Zhang, LH | 2 |
Cui, ZN | 2 |
Hu, DK | 1 |
Zhao, DS | 1 |
He, M | 1 |
Jin, HW | 1 |
Tang, YM | 1 |
Song, GP | 1 |
Schymeinsky, J | 1 |
Mayer, H | 1 |
Tomsic, C | 1 |
Tilp, C | 1 |
Schuetz, JD | 1 |
Cui, Y | 1 |
Wollin, L | 1 |
Gantner, F | 1 |
Erb, KJ | 1 |
Park, K | 1 |
Lee, JS | 1 |
Choi, JS | 1 |
Nam, YJ | 1 |
Han, JH | 1 |
Byun, HD | 1 |
Song, MJ | 1 |
Oh, JS | 1 |
Kim, SG | 1 |
Choi, Y | 1 |
Yougbare, I | 1 |
Morin, C | 1 |
Senouvo, FY | 1 |
Sirois, C | 1 |
Albadine, R | 1 |
Lugnier, C | 1 |
Rousseau, E | 1 |
Yang, YL | 1 |
Hsu, HT | 1 |
Wang, KH | 1 |
Han, CY | 1 |
Chen, CM | 2 |
Ko, WC | 1 |
Kenk, M | 1 |
Thomas, A | 1 |
Lortie, M | 1 |
Dekemp, R | 1 |
Beanlands, RS | 1 |
Dasilva, JN | 1 |
Wang, CH | 1 |
Lin, HC | 1 |
Lin, CH | 1 |
Yu, CT | 1 |
Liu, SL | 1 |
Huang, KH | 1 |
Chung, KF | 1 |
Kuo, HP | 1 |
Choo, JH | 1 |
Nagata, M | 1 |
Sutani, A | 1 |
Kikuchi, I | 1 |
Sakamoto, Y | 1 |
Toward, TJ | 1 |
Broadley, KJ | 1 |
Goleva, E | 1 |
Dunlap, A | 1 |
Leung, DY | 1 |
Tang, HF | 1 |
Song, YH | 1 |
Chen, JC | 1 |
Chen, JQ | 1 |
Wang, P | 1 |
Jones, NA | 2 |
Leport, M | 1 |
Holand, T | 1 |
Vos, T | 1 |
Morgan, M | 1 |
Fink, M | 1 |
Pruniaux, MP | 1 |
Berthelier, C | 1 |
O'Connor, BJ | 3 |
Bertrand, C | 1 |
Page, CP | 4 |
Nejman-Gryz, P | 2 |
Grubek-Jaworska, H | 2 |
Glapiński, J | 1 |
Hoser, G | 1 |
Chazan, R | 2 |
Glapińiski, J | 1 |
Edwards, MR | 1 |
Haas, J | 1 |
Panettieri, RA | 1 |
Johnson, M | 1 |
Johnston, SL | 1 |
Hu, A | 1 |
Nino, G | 1 |
Grunstein, JS | 1 |
Fatma, S | 1 |
Grunstein, MM | 1 |
Nicholson, CD | 1 |
Shahid, M | 1 |
Bruin, J | 1 |
Barron, E | 1 |
Spiers, I | 1 |
de Boer, J | 1 |
van Amsterdam, RG | 1 |
Zaagsma, J | 2 |
Kelly, JJ | 1 |
Dent, G | 2 |
Torphy, TJ | 2 |
Barnette, MS | 1 |
Hay, DW | 1 |
Underwood, DC | 1 |
Lagente, V | 1 |
Hichami, A | 1 |
Boichot, E | 1 |
Martins, MA | 1 |
Silva, PM | 1 |
Santing, RE | 1 |
Olymulder, CG | 1 |
Van der Molen, K | 1 |
Meurs, H | 1 |
Newsholme, SJ | 1 |
Schwartz, L | 1 |
Cortijo, J | 2 |
Bou, J | 1 |
Beleta, J | 1 |
Cardelús, I | 1 |
Llenas, J | 1 |
Morcillo, E | 1 |
Gristwood, RW | 1 |
Heaslip, RJ | 1 |
Evans, DY | 1 |
Ortiz, JL | 1 |
Vallés, JM | 1 |
Martí-Cabrera, M | 1 |
Morcillo, EJ | 1 |
Gozzard, N | 3 |
Herd, CM | 1 |
Blake, SM | 1 |
Holbrook, M | 2 |
Hughes, B | 3 |
Higgs, GA | 1 |
Howat, D | 1 |
Lisle, H | 1 |
James, T | 1 |
Blease, K | 1 |
Hughes, P | 1 |
Kingaby, R | 1 |
Warrellow, G | 1 |
Alexander, R | 1 |
Head, J | 1 |
Boyd, E | 1 |
Eaton, M | 1 |
Perry, M | 2 |
Wales, M | 2 |
Smith, B | 1 |
Owens, R | 1 |
Catterall, C | 1 |
Lumb, S | 1 |
Russell, A | 1 |
Allen, R | 1 |
Merriman, M | 1 |
Bloxham, D | 1 |
Higgs, G | 2 |
Foissier, L | 1 |
Lonchampt, M | 1 |
Cogé, F | 1 |
Canet, E | 1 |
Manabe, H | 2 |
Akuta, K | 2 |
Okamura, K | 1 |
Ohmori, K | 2 |
Hidi, R | 1 |
Timmermans, S | 1 |
Liu, E | 1 |
Schudt, C | 1 |
Holgate, ST | 1 |
Djukanović, R | 1 |
Kawasaki, H | 1 |
Hammerbeck, DM | 1 |
McGurran, SM | 1 |
Radziszewski, PL | 1 |
Egging, EA | 1 |
Johnson, DD | 1 |
Hupperts, AM | 1 |
Gullikson, GW | 1 |
Pang, L | 1 |
Knox, AJ | 1 |
Dal Piaz, V | 1 |
Giovannoni, MP | 1 |
Landells, LJ | 2 |
Spina, D | 2 |
Szilagy, CM | 1 |
Banner, KH | 1 |
Allen, JM | 1 |
Doherty, A | 1 |
Yoshida, N | 1 |
Shimizu, Y | 1 |
Kitaichi, K | 1 |
Hiramatsu, K | 1 |
Takeuchi, M | 1 |
Ito, Y | 1 |
Kume, H | 1 |
Yamaki, K | 1 |
Suzuki, R | 1 |
Shibata, E | 1 |
Hasegawa, T | 1 |
Takagi, K | 1 |
Alexander, RP | 1 |
Warrellow, GJ | 1 |
Eaton, MA | 1 |
Boyd, EC | 1 |
Head, JC | 1 |
Porter, JR | 1 |
Brown, JA | 1 |
Reuberson, JT | 1 |
Hutchinson, B | 1 |
Turner, P | 1 |
Boyce, B | 1 |
Barnes, D | 1 |
Mason, B | 1 |
Cannell, A | 1 |
Taylor, RJ | 1 |
Zomaya, A | 1 |
Millican, A | 1 |
Leonard, J | 1 |
Morphy, R | 1 |
Allen, RA | 1 |
Livi, GP | 1 |
Balcarek, JM | 1 |
White, JR | 1 |
Chilton, FH | 1 |
Undem, BJ | 1 |
4 reviews available for rolipram and Asthma
Article | Year |
---|---|
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chr | 2008 |
PET measurements of cAMP-mediated phosphodiesterase-4 with (R)-[11C]rolipram.
Topics: Animals; Asthma; Brain; Carbon Radioisotopes; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type | 2011 |
Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Arthritis, Rheumatoid; Asthma; Cyclic Nucleotide Phosphodiester | 2000 |
Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Asthma; Colforsin; | 1992 |
42 other studies available for rolipram and Asthma
Article | Year |
---|---|
Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Asthma; Benzamides; Bronchial Spasm; Eosinophil | 1994 |
Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; B | 2000 |
7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Asthma; Benzamides; Benzofurans; | 2000 |
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amides; Anti-Asthmatic Agents; Asthma; Cyclic Nucleotide Phosph | 2002 |
Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Mod | 2013 |
Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors.
Topics: Administration, Oral; Asthma; Emetics; Enzyme Activation; Molecular Structure; Phosphodiesterase 4 I | 2014 |
Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors.
Topics: Animals; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Drug Design; | 2017 |
Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Inhibitory Concentration 50; Mice; Phosphodiesterase | 2018 |
The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.
Topics: Adenosine; Allergens; Animals; Asthma; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP- | 2013 |
Identification and Characterization of Baicalin as a Phosphodiesterase 4 Inhibitor.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Fla | 2016 |
NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anti-Inflammatory Agents; Asthma | 2011 |
Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.
Topics: Animals; Asthma; Binding Sites; Blood Cell Count; Bronchial Hyperreactivity; Bronchoalveolar Lavage | 2011 |
Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma.
Topics: Albuterol; Animals; Antigens, CD34; Apoptosis; Asthma; Cell Division; Female; Humans; Male; Methacho | 2003 |
Theophylline attenuates the adhesion of eosinophils to endothelial cells.
Topics: Adult; Asthma; Bronchodilator Agents; Cell Adhesion; Cyclic AMP; Endothelium, Vascular; Eosinophils; | 2003 |
Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram.
Topics: Administration, Inhalation; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar La | 2004 |
Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Androstadienes; Anti-Inflammatory Agents; Asthma; Cell C | 2004 |
Upregulation of phosphodiesterase-4 in the lung of allergic rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Animals; Asthma; Cyclic Nucleotide Phosphodi | 2005 |
Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Asthma; Benzamides; CD4-Positive T-Lymphocytes; CD | 2007 |
Effects of the phosphodiestrase-4 inhibitor rolipram on lung resistance and inflammatory reaction in experimental asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Guinea Pigs; | 2006 |
[Effect of phosphodiestrase 4 inhibitor (rolipram) on experimental allergic asthma-guinea pig model].
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L | 2006 |
Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Androstadienes; Anti-Inflammatory Agen | 2007 |
Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Asthma; Butadienes; Cells, Cultured; Colforsin; Cyclic | 2008 |
Characterization of ORG 20241, a combined phosphodiesterase IV/III cyclic nucleotide phosphodiesterase inhibitor for asthma.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Asthma; Cattle; Guinea Pigs; Humans; In Vitro T | 1995 |
Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antigens; Asthma; Bronchoconstriction; Cell Adhesion; | 1994 |
Asthma and airway inflammation: potential anti-inflammatory activities of phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Airway Resistan | 1995 |
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asth | 1995 |
cAMP-specific phosphodiesterase inhibitor, rolipram, reduces eosinophil infiltration evoked by leukotrienes or by histamine in guinea pig conjunctiva.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Asthma; Conjunctiva; Conjunctivitis; Eosinophilia; Eos | 1993 |
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nuc | 1993 |
Emetic, central nervous system, and pulmonary activities of rolipram in the dog.
Topics: Animals; Anxiety; Asthma; Brain; Bronchi; Dogs; Female; Heart Rate; Male; Nadolol; Pentobarbital; Ph | 1995 |
Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs.
Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine; Male; Phosph | 1996 |
Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits.
Topics: Airway Resistance; Alternaria; Animals; Anti-Inflammatory Agents; Antigens, Fungal; Asthma; Bronchia | 1996 |
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Analysis of Variance; Animals; Asthma; Benza | 1996 |
In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antigens; Asthma; Cyclic AMP; Cyclic Nucleotide Phosph | 1996 |
KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Animals; As | 1997 |
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
Topics: Albuterol; Asthma; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Humans; Interleukin-8; | 2000 |
The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Aminophylline; Animals; Asthma; Bronch | 2000 |
Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil peroxidase (EPO) levels following either systemic or intratracheal administration in sephadex- or ovalbumin-induced inflammatory models.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Asthma; Beclomethasone; Benzamides; Bu | 2000 |
Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Antagoni | 2000 |
A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Asthma; Case-Control Studies; Guanidines; Humans; | 2000 |
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adolescent; Adult; Allergens; Asthma; CD4-Positive T-Lymphocyte | 2001 |
Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells.
Topics: Adult; Asthma; Cilostazol; Colforsin; Cyclic AMP; Dexamethasone; Humans; In Vitro Techniques; Interl | 2001 |
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-St | 2002 |