rolipram has been researched along with Arthritis, Rheumatoid in 8 studies
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We assessed the anti-inflammatory effects of a novel PDE4 inhibitor, apremilast, in human synovial cells from rheumatoid arthritis (RA) patients, as well as two murine models of arthritis." | 3.76 | Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. ( Andrews, M; Brennan, FM; Feldmann, M; Inglis, JJ; McCann, FE; Palfreeman, AC; Perocheau, DP; Schafer, P; Williams, RO, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCann, FE | 1 |
| Palfreeman, AC | 1 |
| Andrews, M | 1 |
| Perocheau, DP | 1 |
| Inglis, JJ | 1 |
| Schafer, P | 1 |
| Feldmann, M | 2 |
| Williams, RO | 3 |
| Brennan, FM | 2 |
| Ozegbe, P | 1 |
| Foey, AD | 2 |
| Ahmed, S | 2 |
| Field, S | 1 |
| Jain, A | 1 |
| Williams, R | 1 |
| Singh, HN | 1 |
| Blancuzzi, V | 1 |
| Greenwood, S | 1 |
| Skiles, JW | 1 |
| O'Byrne, EM | 1 |
| Kitagawa, M | 1 |
| Mitsui, H | 1 |
| Nakamura, H | 1 |
| Yoshino, S | 1 |
| Miyakawa, S | 1 |
| Ochiai, N | 1 |
| Onobori, M | 1 |
| Suzuki, H | 1 |
| Sumida, T | 1 |
| Dal Piaz, V | 1 |
| Giovannoni, MP | 1 |
| Eigler, A | 1 |
| Loher, F | 1 |
| Endres, S | 1 |
3 reviews available for rolipram and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Combination therapy in mice: what can we learn that may be useful for understanding rheumatoid arthritis?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibody Specificity; Anti | 1998 |
Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Arthritis, Rheumatoid; Asthma; Cyclic Nucleotide Phosphodiester | 2000 |
[Suppression of synthesis of tumor necrosis factor].
Topics: Animals; Arthritis, Rheumatoid; Crohn Disease; Humans; Inflammation; Interleukin-10; Phosphodiestera | 2001 |
5 other studies available for rolipram and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Disease Models, Animal; Do | 2010 |
Impact of cAMP on the T-cell response to type II collagen.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antigen-Presenting Cells; Arthritis, Experimental; | 2004 |
Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Arthritis, Rheumatoid; Bucladesine; Cells, Cultured; Colforsin; | 2003 |
Synovial fluid levels of tumor necrosis factor-alpha in the inflamed rat knee: modulation by dexamethasone and inhibitors of matrix metalloproteinase and phosphodiesterase.
Topics: Animals; Arthritis, Rheumatoid; Dexamethasone; Female; Kinetics; Lipopolysaccharides; Metalloendopep | 1997 |
Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor alpha and CD40 signals.
Topics: Adjuvants, Immunologic; Antibodies; Antigens, Differentiation, T-Lymphocyte; Arthritis, Rheumatoid; | 1999 |