Page last updated: 2024-11-04

rolipram and Anesthesia

rolipram has been researched along with Anesthesia in 11 studies

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"The aim of the present study was to investigate the mode of action of luteolin on phisphodiesterase (PDE) 1-5, and the possible adverse effects, such as nausea, vomiting, and gastric hypersecretion, determined by replacing [(3)H]-rolipram binding and reversing xylazine/ketamine-induced anesthesia."7.76Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. ( Chen, JH; Han, CY; Ko, WC; Lai, CY; Yu, MC, 2010)
"The affinities of genistein on phosphodiesterase (PDE)1-4 and cause of gastrointestinal adverse effects of genistein remain unclear."1.36Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects. ( Chen, CM; Han, CY; Ko, WC; Lai, CY; Lai, YH; Lin, LH; Shih, CH, 2010)
"Pretreatment with rolipram decreased the duration of ventricular tachycardia without any change in the incidences of dysrhythmias or the mortality rate."1.32Effects of rolipram, pimobendan and zaprinast on ischaemia-induced dysrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Aleixandre, F; Carceles, MD; Fuente, T; Laorden, ML; López-Vidal, J, 2003)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (36.36)18.2507
2000's4 (36.36)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
García, AM1
Brea, J1
Morales-García, JA1
Perez, DI1
González, A1
Alonso-Gil, S1
Gracia-Rubio, I1
Ros-Simó, C1
Conde, S1
Cadavid, MI1
Loza, MI1
Perez-Castillo, A1
Valverde, O1
Martinez, A1
Gil, C1
Yu, MC1
Chen, JH1
Lai, CY2
Han, CY2
Ko, WC2
Shih, CH1
Lin, LH1
Lai, YH1
Chen, CM1
Carceles, MD1
Aleixandre, F1
Fuente, T1
López-Vidal, J1
Laorden, ML1
Büyüknacar, HS1
Kumcu, EK1
Göçmen, C1
Onder, S1
Turner, NC1
Dolan, JS1
Grimsditch, D1
Lamb, J1
Worby, A1
Murray, KJ1
Coates, WJ1
Warrington, BH1
Underwood, DC1
Osborn, RR1
Novak, LB1
Matthews, JK1
Newsholme, SJ1
Undem, BJ1
Hand, JM1
Torphy, TJ1
McVey, M1
Perrone, MH1
Clark, KL1
Tanahashi, M1
Hara, S1
Yoshida, M1
Suzuki-Kusaba, M1
Yokoyama, H1
Hosono, M1
Hisa, H1
Satoh, S1
Robichaud, A1
Savoie, C1
Stamatiou, PB1
Tattersall, FD1
Chan, CC1
Shah, MK1
Kadowitz, PJ1

Other Studies

11 other studies available for rolipram and Anesthesia

ArticleYear
Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.
    Journal of medicinal chemistry, 2014, Oct-23, Volume: 57, Issue:20

    Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Cell Survival; Ch

2014
Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia.
    European journal of pharmacology, 2010, Feb-10, Volume: 627, Issue:1-3

    Topics: Anesthesia; Animals; Binding, Competitive; Female; Guinea Pigs; Ketamine; Luteolin; Male; Mice; Phos

2010
Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects.
    European journal of pharmacology, 2010, Sep-15, Volume: 643, Issue:1

    Topics: Anesthesia; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cyclic Nucleotide Ph

2010
Effects of rolipram, pimobendan and zaprinast on ischaemia-induced dysrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
    European journal of anaesthesiology, 2003, Volume: 20, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Anesthesia; Animals; Arrhy

2003
Effect of phosphodiesterase type 4 inhibitor rolipram on cyclophosphamide-induced cystitis in rats.
    European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3

    Topics: Anesthesia; Animals; Antineoplastic Agents, Alkylating; Calcium Channel Blockers; Cyclophosphamide;

2008
Pulmonary effects of type V cyclic GMP specific phosphodiesterase inhibition in the anaesthetized guinea-pig.
    British journal of pharmacology, 1994, Volume: 111, Issue:4

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Anesthesia; Animals; Bronchoconstriction; Cyclic GMP; Guanidine

1994
Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: Anesthesia; Animals; Antigens; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Consciousness; Cyc

1993
Does tumor necrosis factor-alpha (TNF-alpha) contribute to myocardial reperfusion injury in anesthetized rats?
    General pharmacology, 1999, Volume: 32, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Enzyme-Linked Immunosorbent Assay; Heart Rate; Male; Myocardial

1999
Effects of NKH477 on renal functions and cyclic AMP production in anesthetized dogs.
    European journal of pharmacology, 1999, May-21, Volume: 372, Issue:3

    Topics: Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Colforsin; Cyclic AMP; Dogs; Female; Kidney

1999
PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway.
    Neuropharmacology, 2001, Volume: 40, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesth

2001
Cyclic adenosine monophosphate-dependent vascular responses to purinergic agonists adenosine triphosphate and uridine triphosphate in the anesthetized mouse.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:1

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine Triphosphate; Anesthesia; Animals; Blood Pressure; Cy

2002