rolipram has been researched along with Anasarca in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study the anti-inflammatory activity of the phosphodiesterase inhibitor rolipram (ZK 62,711, CAS 61413-54-5) was tested in a rat model where edema was induced in the ears of the animals by the epicutaneous application of croton oil in ethanol (5%, by volume)." | 7.69 | Anti-inflammatory activity of rolipram in a rat ear edema model. ( Krause, W; Kühne, G, 1994) |
| " We found that 6-Benzyl-3-methyl-4-phenylpyrazolo[3,4-d]pyridazin-7(6H)-one (CC4), ethyl 6,7-dihydro-6-ethyl-3-methyl-7-oxo-4-phenyl-thieno[2,3-d]pyridazine-2-carboxylate (CC6) and ethyl 6,7-dihydro-6-ethyl-3-methyl-4-phenyl-1H-pyrrolo[2,3-d]pyridazine-2-carboxylate (CC12) reduced the paw edema induced by zymosan in mice as rolipram (the PDE4 inhibitor prototype with anti-inflammatory activity) and indomethacin did." | 3.73 | Local anti-inflammatory effect and behavioral studies on new PDE4 inhibitors. ( Cesari, N; Dal Piaz, V; Di Giannuario, A; Dominici, L; Pieretti, S, 2006) |
| " Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively." | 3.70 | Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors. ( Jain, NK; Kulkarni, SK; Kumar, A, 2000) |
| "In the present study the anti-inflammatory activity of the phosphodiesterase inhibitor rolipram (ZK 62,711, CAS 61413-54-5) was tested in a rat model where edema was induced in the ears of the animals by the epicutaneous application of croton oil in ethanol (5%, by volume)." | 3.69 | Anti-inflammatory activity of rolipram in a rat ear edema model. ( Krause, W; Kühne, G, 1994) |
| "Paw edema was induced in male Swiss mice (20-30 g) by subplantar injection of carrageenan (0." | 1.42 | The effect of inhaled nitric oxide on the carrageenan-induced paw edema. ( Borbely, AU; Coelho, CF; Frigo, L; Gouvea, IM; Lopes-Martins, PS; Lopes-Martins, RÁ; Teixeira, SA; Vieira, RP, 2015) |
| "Rolipram was given orally to the animals daily from days 0-20." | 1.33 | Effect of rolipram, a phosphodiesterase IV inhibitor, on allergic footpad swelling using various adjuvants in mice. ( Alam, AH; Hossain, MA; Takano, H; Taneda, S; Yamaki, K; Yanagisawa, R; Yoshino, S, 2005) |
| "Pretreatment with rolipram abrogated oedema formation and significantly inhibited hyperalgesia." | 1.31 | Anti-inflammatory and analgesic effects of the phosphodiesterase 4 inhibitor rolipram in a rat model of arthritis. ( Cunha, FQ; Francischi, JN; Poole, S; Tafuri, WL; Teixeira, MM; Yokoro, CM, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van der Mey, M | 1 |
| Boss, H | 1 |
| Couwenberg, D | 1 |
| Hatzelmann, A | 1 |
| Sterk, GJ | 1 |
| Goubitz, K | 1 |
| Schenk, H | 1 |
| Timmerman, H | 1 |
| Akama, T | 2 |
| Baker, SJ | 2 |
| Zhang, YK | 2 |
| Hernandez, V | 1 |
| Zhou, H | 1 |
| Sanders, V | 2 |
| Freund, Y | 2 |
| Kimura, R | 2 |
| Maples, KR | 1 |
| Plattner, JJ | 2 |
| Hernandez, VS | 1 |
| Bu, W | 1 |
| Hold, KM | 1 |
| Lu, XS | 1 |
| Coelho, CF | 1 |
| Vieira, RP | 1 |
| Lopes-Martins, PS | 1 |
| Teixeira, SA | 1 |
| Borbely, AU | 1 |
| Gouvea, IM | 1 |
| Frigo, L | 1 |
| Lopes-Martins, RÁ | 1 |
| Zygmunt, M | 1 |
| Chłoń-Rzepa, G | 1 |
| Sapa, J | 1 |
| Yamaki, K | 1 |
| Alam, AH | 1 |
| Hossain, MA | 1 |
| Taneda, S | 1 |
| Yanagisawa, R | 1 |
| Takano, H | 1 |
| Yoshino, S | 1 |
| Pieretti, S | 1 |
| Dominici, L | 1 |
| Di Giannuario, A | 1 |
| Cesari, N | 1 |
| Dal Piaz, V | 1 |
| Warren, JB | 1 |
| Wilson, AJ | 1 |
| Loi, RK | 1 |
| Coughlan, ML | 1 |
| Teixeira, MM | 2 |
| Rossi, AG | 1 |
| Williams, TJ | 1 |
| Hellewell, PG | 1 |
| Krause, W | 1 |
| Kühne, G | 1 |
| Schermuly, RT | 1 |
| Roehl, A | 1 |
| Weissmann, N | 1 |
| Ghofrani, HA | 1 |
| Schudt, C | 1 |
| Tenor, H | 1 |
| Grimminger, F | 1 |
| Seeger, W | 1 |
| Walmrath, D | 1 |
| Francischi, JN | 1 |
| Yokoro, CM | 1 |
| Poole, S | 1 |
| Tafuri, WL | 1 |
| Cunha, FQ | 1 |
| Kumar, A | 1 |
| Jain, NK | 1 |
| Kulkarni, SK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Regeneration in Cervical Degenerative Myelopathy - a Multi-centre, Double-blind, Randomised, Placebo Controlled Trial Assessing the Efficacy of Ibudilast as an Adjuvant Treatment to Decompressive Surgery for Degenerative Cervical Myelopathy[NCT04631471] | Phase 3 | 400 participants (Anticipated) | Interventional | 2021-12-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for rolipram and Anasarca
| Article | Year |
|---|---|
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adamantane; Administration, Oral; Animals; Anti-Inflammatory Ag | 2002 |
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Boron Compounds; Bridged | 2009 |
Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.
Topics: Animals; Anti-Inflammatory Agents; Boron; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear; Edema; | 2010 |
The effect of inhaled nitric oxide on the carrageenan-induced paw edema.
Topics: Animals; Carrageenan; Edema; Inflammation; Male; Mice; Nitric Oxide; Piperazines; Purines; Rolipram; | 2015 |
Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldeh | 2014 |
Effect of rolipram, a phosphodiesterase IV inhibitor, on allergic footpad swelling using various adjuvants in mice.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adjuvants, Immunologic; Animals; Cells, Cultured; Cyclic Nucleo | 2005 |
Local anti-inflammatory effect and behavioral studies on new PDE4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents; Cyclic Nucleotide Phosphodie | 2006 |
Opposing roles of cyclic AMP in the vascular control of edema formation.
Topics: Albuterol; Alprostadil; Animals; Blood Vessels; Bradykinin; Cyclic AMP; Dinoprostone; Drug Synergism | 1993 |
Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.
Topics: Animals; Calmodulin; Cardiotonic Agents; Dermatitis; Edema; Eosinophils; Female; Guinea Pigs; In Vit | 1994 |
Anti-inflammatory activity of rolipram in a rat ear edema model.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Croton | 1994 |
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aerosols; Animals; Antihypertens | 2000 |
Anti-inflammatory and analgesic effects of the phosphodiesterase 4 inhibitor rolipram in a rat model of arthritis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Exper | 2000 |
Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageen | 2000 |