rolipram has been researched along with Aging in 22 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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" Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits of resveratrol, including prevention of diet-induced obesity and an increase in mitochondrial function, physical stamina, and glucose tolerance in mice." | 7.78 | Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. ( Ahmad, F; Baar, K; Beaven, MA; Brown, AL; Burgin, AB; Chung, JH; Ke, H; Kim, MK; Luo, H; Manganiello, V; Park, SJ; Philp, A; Rehmann, H; Taussig, R; Williams, T, 2012) |
"To clarify the quantitative and qualitative changes in type IV phosphodiesterase (PDE IV) with aging, phosphodiesterase (PDE) activity and [3H]rolipram binding in the cytosolic fraction from the brains of young and aged rats were examined." | 7.69 | Influence of aging on rolipram-sensitive phosphodiesterase activity and [3H]rolipram binding in the rat brain. ( Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1996) |
" Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits of resveratrol, including prevention of diet-induced obesity and an increase in mitochondrial function, physical stamina, and glucose tolerance in mice." | 3.78 | Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. ( Ahmad, F; Baar, K; Beaven, MA; Brown, AL; Burgin, AB; Chung, JH; Ke, H; Kim, MK; Luo, H; Manganiello, V; Park, SJ; Philp, A; Rehmann, H; Taussig, R; Williams, T, 2012) |
"Since aging and inflammation affect cognition and are risk factors for AD, these aspects were also evaluated." | 1.48 | The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges. ( Graf, R; Hughes, ZA; Longo, JL, 2018) |
"Treatment with rolipram increased the AMPK phosphorylation and SIRT6 levels in the liver and kidney while reducing NF-κB acetylation." | 1.48 | Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder. ( Liang, Y; Liu, Q; Wang, Z; Zhang, L; Zhang, N, 2018) |
"Rolipram treatment significantly attenuated STZ induced and age related memory deficits, biochemical and histopathological alterations." | 1.46 | Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type. ( Kumar, A; Singh, N, 2017) |
"[3H]Muscimol binding was the highest in the cerebellum, and decreased in many brain regions in aged rats." | 1.30 | Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains. ( Araki, T; Chen, T; Hiranuma, T; Itoyama, Y; Kato, H; Kogure, K; Liu, XH; Murase, K, 1997) |
"Rolipram is a clinically effective antidepressant with cyclic AMP-selective phosphodiesterase (cyclic-AMP PDE) inhibiting action." | 1.30 | Effect of rolipram on age-related changes in cyclic AMP-selective phosphodiesterase in the rat brain: an autoradiographic study. ( Araki, T; Chen, T; Itoyama, Y; Kato, H; Kogure, K, 1998) |
"Rolipram was administered per os to young (15 weeks old) and old (80 weeks old) Wistar rats at dosage of 0." | 1.30 | Age-related effects of rolipram on [3H]quinuclidinyl benzilate and [3H]phorbol 12,13-dibutyrate binding in the rat brain. ( Araki, T; Chen, T; Itoyama, Y; Kato, H; Kogure, K, 1998) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 9 (40.91) | 18.2507 |
2000's | 5 (22.73) | 29.6817 |
2010's | 7 (31.82) | 24.3611 |
2020's | 1 (4.55) | 2.80 |
Authors | Studies |
---|---|
Wimmer, ME | 1 |
Blackwell, JM | 1 |
Abel, T | 1 |
Graf, R | 1 |
Longo, JL | 1 |
Hughes, ZA | 1 |
Wang, Z | 2 |
Liang, Y | 1 |
Zhang, L | 1 |
Zhang, N | 1 |
Liu, Q | 1 |
Tauffenberger, A | 1 |
Julien, C | 1 |
Parker, JA | 1 |
Peters, M | 1 |
Bletsch, M | 1 |
Stanley, J | 1 |
Wheeler, D | 1 |
Scott, R | 1 |
Tully, T | 1 |
Kumar, A | 1 |
Singh, N | 1 |
Bonnici, B | 1 |
Kapfhammer, JP | 1 |
de Lima, MN | 1 |
Presti-Torres, J | 1 |
Garcia, VA | 1 |
Guimarães, MR | 1 |
Scalco, FS | 1 |
Roesler, R | 1 |
Schröder, N | 1 |
Park, SJ | 1 |
Ahmad, F | 1 |
Philp, A | 1 |
Baar, K | 1 |
Williams, T | 1 |
Luo, H | 1 |
Ke, H | 1 |
Rehmann, H | 1 |
Taussig, R | 1 |
Brown, AL | 1 |
Kim, MK | 1 |
Beaven, MA | 1 |
Burgin, AB | 1 |
Manganiello, V | 1 |
Chung, JH | 1 |
Whitney, KN | 1 |
Wenger, GR | 1 |
Ramos, BP | 1 |
Birnbaum, SG | 1 |
Lindenmayer, I | 1 |
Newton, SS | 1 |
Duman, RS | 1 |
Arnsten, AF | 1 |
Comery, TA | 1 |
Martone, RL | 1 |
Aschmies, S | 1 |
Atchison, KP | 1 |
Diamantidis, G | 1 |
Gong, X | 1 |
Zhou, H | 1 |
Kreft, AF | 1 |
Pangalos, MN | 1 |
Sonnenberg-Reines, J | 1 |
Jacobsen, JS | 1 |
Marquis, KL | 1 |
Levallet, G | 1 |
Levallet, J | 1 |
Bouraïma-Lelong, H | 1 |
Bonnamy, PJ | 1 |
Akita, T | 1 |
Joyner, RW | 1 |
Lu, C | 1 |
Kumar, R | 1 |
Hartzell, HC | 1 |
Araki, T | 5 |
Kato, H | 5 |
Kanai, Y | 1 |
Kogure, K | 4 |
Tohda, M | 1 |
Murayama, T | 1 |
Nogiri, S | 1 |
Nomura, Y | 1 |
Asanuma, M | 1 |
Nishibayashi, S | 1 |
Iwata, E | 1 |
Kondo, Y | 1 |
Nakanishi, T | 1 |
Vargas, MG | 1 |
Ogawa, N | 1 |
Chen, T | 3 |
Liu, XH | 1 |
Hiranuma, T | 1 |
Murase, K | 1 |
Itoyama, Y | 4 |
Shuto, K | 1 |
Zhang, K | 1 |
Farooqui, SM | 1 |
O'Donnell, JM | 1 |
22 other studies available for rolipram and Aging
Article | Year |
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Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice.
Topics: Aging; Animals; Male; Memory Consolidation; Memory, Long-Term; Mice, Inbred C57BL; Phosphodiesterase | 2020 |
The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.
Topics: Aging; Animals; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Donepezil | 2018 |
Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder.
Topics: 3T3-L1 Cells; Adipose Tissue; Aging; AMP-Activated Protein Kinases; Animals; Calcium-Calmodulin-Depe | 2018 |
Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.
Topics: Aging; Animals; Caenorhabditis elegans; Chromans; DNA-Binding Proteins; Ethosuximide; Longevity; Mot | 2013 |
The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice.
Topics: Age Factors; Aging; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Conditioning, Psych | 2014 |
Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Cholinesterase Inhibit | 2017 |
Spontaneous regeneration of intrinsic spinal cord axons in a novel spinal cord slice culture model.
Topics: Aging; Animals; Animals, Newborn; Axons; Calbindin 2; Cell Differentiation; Dissection; Growth Cones | 2008 |
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, D | 2008 |
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue, White; Aging; AMP-Activated Protein Kinase Kina | 2012 |
Working memory in the aged Ts65Dn mouse, a model for Down syndrome.
Topics: Aging; Animals; Antidepressive Agents; Central Nervous System Stimulants; Cognition; Conditioning, O | 2012 |
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Cognition Disorders; Cyclic AMP; Cyclic AMP Res | 2003 |
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-P | 2005 |
Expression of the cAMP-phosphodiesterase PDE4D isoforms and age-related changes in follicle-stimulating hormone-stimulated PDE4 activities in immature rat sertoli cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Blotting, Western; Cyclic Nucleotide Phosphodie | 2007 |
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, | 1994 |
Age-dependent changes in second messenger and rolipram receptor systems in the gerbil brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Autoradiography; Brain; Brai | 1994 |
Influence of aging on rolipram-sensitive phosphodiesterase activity and [3H]rolipram binding in the rat brain.
Topics: Aging; Animals; Brain; Cyclic AMP; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases | 1996 |
Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor.
Topics: Afferent Pathways; Aging; Animals; Choline O-Acetyltransferase; Cyclic AMP; Cyclic AMP Response Elem | 1996 |
Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Dizocilpine Maleate; Excitat | 1997 |
Age-related changes in [3H]nimodipine and [3H]rolipram binding in the rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Binding Sites; Brain; Calcium | 1997 |
Effect of rolipram on age-related changes in cyclic AMP-selective phosphodiesterase in the rat brain: an autoradiographic study.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Brain; Male; Phosphodiesterase | 1998 |
Age-related effects of rolipram on [3H]quinuclidinyl benzilate and [3H]phorbol 12,13-dibutyrate binding in the rat brain.
Topics: Aging; Animals; Autoradiography; Brain; Male; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors | 1998 |
Ontogeny of rolipram-sensitive, low-K(m), cyclic AMP-specific phosphodiesterase in rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic Nuc | 1999 |