rolipram and Aging
rolipram has been researched along with Aging in 22 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits of resveratrol, including prevention of diet-induced obesity and an increase in mitochondrial function, physical stamina, and glucose tolerance in mice." | 7.78 | Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. ( Ahmad, F; Baar, K; Beaven, MA; Brown, AL; Burgin, AB; Chung, JH; Ke, H; Kim, MK; Luo, H; Manganiello, V; Park, SJ; Philp, A; Rehmann, H; Taussig, R; Williams, T, 2012) |
| "To clarify the quantitative and qualitative changes in type IV phosphodiesterase (PDE IV) with aging, phosphodiesterase (PDE) activity and [3H]rolipram binding in the cytosolic fraction from the brains of young and aged rats were examined." | 7.69 | Influence of aging on rolipram-sensitive phosphodiesterase activity and [3H]rolipram binding in the rat brain. ( Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1996) |
| " Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits of resveratrol, including prevention of diet-induced obesity and an increase in mitochondrial function, physical stamina, and glucose tolerance in mice." | 3.78 | Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. ( Ahmad, F; Baar, K; Beaven, MA; Brown, AL; Burgin, AB; Chung, JH; Ke, H; Kim, MK; Luo, H; Manganiello, V; Park, SJ; Philp, A; Rehmann, H; Taussig, R; Williams, T, 2012) |
| "Since aging and inflammation affect cognition and are risk factors for AD, these aspects were also evaluated." | 1.48 | The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges. ( Graf, R; Hughes, ZA; Longo, JL, 2018) |
| "Treatment with rolipram increased the AMPK phosphorylation and SIRT6 levels in the liver and kidney while reducing NF-κB acetylation." | 1.48 | Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder. ( Liang, Y; Liu, Q; Wang, Z; Zhang, L; Zhang, N, 2018) |
| "Rolipram treatment significantly attenuated STZ induced and age related memory deficits, biochemical and histopathological alterations." | 1.46 | Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type. ( Kumar, A; Singh, N, 2017) |
| "[3H]Muscimol binding was the highest in the cerebellum, and decreased in many brain regions in aged rats." | 1.30 | Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains. ( Araki, T; Chen, T; Hiranuma, T; Itoyama, Y; Kato, H; Kogure, K; Liu, XH; Murase, K, 1997) |
| "Rolipram is a clinically effective antidepressant with cyclic AMP-selective phosphodiesterase (cyclic-AMP PDE) inhibiting action." | 1.30 | Effect of rolipram on age-related changes in cyclic AMP-selective phosphodiesterase in the rat brain: an autoradiographic study. ( Araki, T; Chen, T; Itoyama, Y; Kato, H; Kogure, K, 1998) |
| "Rolipram was administered per os to young (15 weeks old) and old (80 weeks old) Wistar rats at dosage of 0." | 1.30 | Age-related effects of rolipram on [3H]quinuclidinyl benzilate and [3H]phorbol 12,13-dibutyrate binding in the rat brain. ( Araki, T; Chen, T; Itoyama, Y; Kato, H; Kogure, K, 1998) |
Research
Studies (22)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wimmer, ME | 1 |
| Blackwell, JM | 1 |
| Abel, T | 1 |
| Graf, R | 1 |
| Longo, JL | 1 |
| Hughes, ZA | 1 |
| Wang, Z | 2 |
| Liang, Y | 1 |
| Zhang, L | 1 |
| Zhang, N | 1 |
| Liu, Q | 1 |
| Tauffenberger, A | 1 |
| Julien, C | 1 |
| Parker, JA | 1 |
| Peters, M | 1 |
| Bletsch, M | 1 |
| Stanley, J | 1 |
| Wheeler, D | 1 |
| Scott, R | 1 |
| Tully, T | 1 |
| Kumar, A | 1 |
| Singh, N | 1 |
| Bonnici, B | 1 |
| Kapfhammer, JP | 1 |
| de Lima, MN | 1 |
| Presti-Torres, J | 1 |
| Garcia, VA | 1 |
| Guimarães, MR | 1 |
| Scalco, FS | 1 |
| Roesler, R | 1 |
| Schröder, N | 1 |
| Park, SJ | 1 |
| Ahmad, F | 1 |
| Philp, A | 1 |
| Baar, K | 1 |
| Williams, T | 1 |
| Luo, H | 1 |
| Ke, H | 1 |
| Rehmann, H | 1 |
| Taussig, R | 1 |
| Brown, AL | 1 |
| Kim, MK | 1 |
| Beaven, MA | 1 |
| Burgin, AB | 1 |
| Manganiello, V | 1 |
| Chung, JH | 1 |
| Whitney, KN | 1 |
| Wenger, GR | 1 |
| Ramos, BP | 1 |
| Birnbaum, SG | 1 |
| Lindenmayer, I | 1 |
| Newton, SS | 1 |
| Duman, RS | 1 |
| Arnsten, AF | 1 |
| Comery, TA | 1 |
| Martone, RL | 1 |
| Aschmies, S | 1 |
| Atchison, KP | 1 |
| Diamantidis, G | 1 |
| Gong, X | 1 |
| Zhou, H | 1 |
| Kreft, AF | 1 |
| Pangalos, MN | 1 |
| Sonnenberg-Reines, J | 1 |
| Jacobsen, JS | 1 |
| Marquis, KL | 1 |
| Levallet, G | 1 |
| Levallet, J | 1 |
| Bouraïma-Lelong, H | 1 |
| Bonnamy, PJ | 1 |
| Akita, T | 1 |
| Joyner, RW | 1 |
| Lu, C | 1 |
| Kumar, R | 1 |
| Hartzell, HC | 1 |
| Araki, T | 5 |
| Kato, H | 5 |
| Kanai, Y | 1 |
| Kogure, K | 4 |
| Tohda, M | 1 |
| Murayama, T | 1 |
| Nogiri, S | 1 |
| Nomura, Y | 1 |
| Asanuma, M | 1 |
| Nishibayashi, S | 1 |
| Iwata, E | 1 |
| Kondo, Y | 1 |
| Nakanishi, T | 1 |
| Vargas, MG | 1 |
| Ogawa, N | 1 |
| Chen, T | 3 |
| Liu, XH | 1 |
| Hiranuma, T | 1 |
| Murase, K | 1 |
| Itoyama, Y | 4 |
| Shuto, K | 1 |
| Zhang, K | 1 |
| Farooqui, SM | 1 |
| O'Donnell, JM | 1 |
Other Studies
22 other studies available for rolipram and Aging
| Article | Year |
|---|---|
Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice.
Topics: Aging; Animals; Male; Memory Consolidation; Memory, Long-Term; Mice, Inbred C57BL; Phosphodiesterase | 2020 |
The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.
Topics: Aging; Animals; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Donepezil | 2018 |
Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder.
Topics: 3T3-L1 Cells; Adipose Tissue; Aging; AMP-Activated Protein Kinases; Animals; Calcium-Calmodulin-Depe | 2018 |
Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.
Topics: Aging; Animals; Caenorhabditis elegans; Chromans; DNA-Binding Proteins; Ethosuximide; Longevity; Mot | 2013 |
The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice.
Topics: Age Factors; Aging; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Conditioning, Psych | 2014 |
Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Cholinesterase Inhibit | 2017 |
Spontaneous regeneration of intrinsic spinal cord axons in a novel spinal cord slice culture model.
Topics: Aging; Animals; Animals, Newborn; Axons; Calbindin 2; Cell Differentiation; Dissection; Growth Cones | 2008 |
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, D | 2008 |
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue, White; Aging; AMP-Activated Protein Kinase Kina | 2012 |
Working memory in the aged Ts65Dn mouse, a model for Down syndrome.
Topics: Aging; Animals; Antidepressive Agents; Central Nervous System Stimulants; Cognition; Conditioning, O | 2012 |
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Cognition Disorders; Cyclic AMP; Cyclic AMP Res | 2003 |
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-P | 2005 |
Expression of the cAMP-phosphodiesterase PDE4D isoforms and age-related changes in follicle-stimulating hormone-stimulated PDE4 activities in immature rat sertoli cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Blotting, Western; Cyclic Nucleotide Phosphodie | 2007 |
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, | 1994 |
Age-dependent changes in second messenger and rolipram receptor systems in the gerbil brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Autoradiography; Brain; Brai | 1994 |
Influence of aging on rolipram-sensitive phosphodiesterase activity and [3H]rolipram binding in the rat brain.
Topics: Aging; Animals; Brain; Cyclic AMP; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases | 1996 |
Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor.
Topics: Afferent Pathways; Aging; Animals; Choline O-Acetyltransferase; Cyclic AMP; Cyclic AMP Response Elem | 1996 |
Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Dizocilpine Maleate; Excitat | 1997 |
Age-related changes in [3H]nimodipine and [3H]rolipram binding in the rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Binding Sites; Brain; Calcium | 1997 |
Effect of rolipram on age-related changes in cyclic AMP-selective phosphodiesterase in the rat brain: an autoradiographic study.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Brain; Male; Phosphodiesterase | 1998 |
Age-related effects of rolipram on [3H]quinuclidinyl benzilate and [3H]phorbol 12,13-dibutyrate binding in the rat brain.
Topics: Aging; Animals; Autoradiography; Brain; Male; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors | 1998 |
Ontogeny of rolipram-sensitive, low-K(m), cyclic AMP-specific phosphodiesterase in rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic Nuc | 1999 |