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rolipram and Aging

rolipram has been researched along with Aging in 22 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits of resveratrol, including prevention of diet-induced obesity and an increase in mitochondrial function, physical stamina, and glucose tolerance in mice."7.78Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. ( Ahmad, F; Baar, K; Beaven, MA; Brown, AL; Burgin, AB; Chung, JH; Ke, H; Kim, MK; Luo, H; Manganiello, V; Park, SJ; Philp, A; Rehmann, H; Taussig, R; Williams, T, 2012)
"To clarify the quantitative and qualitative changes in type IV phosphodiesterase (PDE IV) with aging, phosphodiesterase (PDE) activity and [3H]rolipram binding in the cytosolic fraction from the brains of young and aged rats were examined."7.69Influence of aging on rolipram-sensitive phosphodiesterase activity and [3H]rolipram binding in the rat brain. ( Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1996)
" Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits of resveratrol, including prevention of diet-induced obesity and an increase in mitochondrial function, physical stamina, and glucose tolerance in mice."3.78Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. ( Ahmad, F; Baar, K; Beaven, MA; Brown, AL; Burgin, AB; Chung, JH; Ke, H; Kim, MK; Luo, H; Manganiello, V; Park, SJ; Philp, A; Rehmann, H; Taussig, R; Williams, T, 2012)
"Since aging and inflammation affect cognition and are risk factors for AD, these aspects were also evaluated."1.48The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges. ( Graf, R; Hughes, ZA; Longo, JL, 2018)
"Treatment with rolipram increased the AMPK phosphorylation and SIRT6 levels in the liver and kidney while reducing NF-κB acetylation."1.48Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder. ( Liang, Y; Liu, Q; Wang, Z; Zhang, L; Zhang, N, 2018)
"Rolipram treatment significantly attenuated STZ induced and age related memory deficits, biochemical and histopathological alterations."1.46Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type. ( Kumar, A; Singh, N, 2017)
"[3H]Muscimol binding was the highest in the cerebellum, and decreased in many brain regions in aged rats."1.30Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains. ( Araki, T; Chen, T; Hiranuma, T; Itoyama, Y; Kato, H; Kogure, K; Liu, XH; Murase, K, 1997)
"Rolipram is a clinically effective antidepressant with cyclic AMP-selective phosphodiesterase (cyclic-AMP PDE) inhibiting action."1.30Effect of rolipram on age-related changes in cyclic AMP-selective phosphodiesterase in the rat brain: an autoradiographic study. ( Araki, T; Chen, T; Itoyama, Y; Kato, H; Kogure, K, 1998)
"Rolipram was administered per os to young (15 weeks old) and old (80 weeks old) Wistar rats at dosage of 0."1.30Age-related effects of rolipram on [3H]quinuclidinyl benzilate and [3H]phorbol 12,13-dibutyrate binding in the rat brain. ( Araki, T; Chen, T; Itoyama, Y; Kato, H; Kogure, K, 1998)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (40.91)18.2507
2000's5 (22.73)29.6817
2010's7 (31.82)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Wimmer, ME1
Blackwell, JM1
Abel, T1
Graf, R1
Longo, JL1
Hughes, ZA1
Wang, Z2
Liang, Y1
Zhang, L1
Zhang, N1
Liu, Q1
Tauffenberger, A1
Julien, C1
Parker, JA1
Peters, M1
Bletsch, M1
Stanley, J1
Wheeler, D1
Scott, R1
Tully, T1
Kumar, A1
Singh, N1
Bonnici, B1
Kapfhammer, JP1
de Lima, MN1
Presti-Torres, J1
Garcia, VA1
Guimarães, MR1
Scalco, FS1
Roesler, R1
Schröder, N1
Park, SJ1
Ahmad, F1
Philp, A1
Baar, K1
Williams, T1
Luo, H1
Ke, H1
Rehmann, H1
Taussig, R1
Brown, AL1
Kim, MK1
Beaven, MA1
Burgin, AB1
Manganiello, V1
Chung, JH1
Whitney, KN1
Wenger, GR1
Ramos, BP1
Birnbaum, SG1
Lindenmayer, I1
Newton, SS1
Duman, RS1
Arnsten, AF1
Comery, TA1
Martone, RL1
Aschmies, S1
Atchison, KP1
Diamantidis, G1
Gong, X1
Zhou, H1
Kreft, AF1
Pangalos, MN1
Sonnenberg-Reines, J1
Jacobsen, JS1
Marquis, KL1
Levallet, G1
Levallet, J1
Bouraïma-Lelong, H1
Bonnamy, PJ1
Akita, T1
Joyner, RW1
Lu, C1
Kumar, R1
Hartzell, HC1
Araki, T5
Kato, H5
Kanai, Y1
Kogure, K4
Tohda, M1
Murayama, T1
Nogiri, S1
Nomura, Y1
Asanuma, M1
Nishibayashi, S1
Iwata, E1
Kondo, Y1
Nakanishi, T1
Vargas, MG1
Ogawa, N1
Chen, T3
Liu, XH1
Hiranuma, T1
Murase, K1
Itoyama, Y4
Shuto, K1
Zhang, K1
Farooqui, SM1
O'Donnell, JM1

Other Studies

22 other studies available for rolipram and Aging

ArticleYear
Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice.
    Neurobiology of learning and memory, 2020, Volume: 169

    Topics: Aging; Animals; Male; Memory Consolidation; Memory, Long-Term; Mice, Inbred C57BL; Phosphodiesterase

2020
The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:9

    Topics: Aging; Animals; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Donepezil

2018
Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder.
    Aging, 2018, 09-18, Volume: 10, Issue:9

    Topics: 3T3-L1 Cells; Adipose Tissue; Aging; AMP-Activated Protein Kinases; Animals; Calcium-Calmodulin-Depe

2018
Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.
    Neurobiology of aging, 2013, Volume: 34, Issue:9

    Topics: Aging; Animals; Caenorhabditis elegans; Chromans; DNA-Binding Proteins; Ethosuximide; Longevity; Mot

2013
The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:13

    Topics: Age Factors; Aging; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Conditioning, Psych

2014
Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88

    Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Cholinesterase Inhibit

2017
Spontaneous regeneration of intrinsic spinal cord axons in a novel spinal cord slice culture model.
    The European journal of neuroscience, 2008, Volume: 27, Issue:10

    Topics: Aging; Animals; Animals, Newborn; Axons; Calbindin 2; Cell Differentiation; Dissection; Growth Cones

2008
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.
    Neuropharmacology, 2008, Volume: 55, Issue:5

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, D

2008
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
    Cell, 2012, Feb-03, Volume: 148, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue, White; Aging; AMP-Activated Protein Kinase Kina

2012
Working memory in the aged Ts65Dn mouse, a model for Down syndrome.
    Behavioural brain research, 2012, Jun-15, Volume: 232, Issue:1

    Topics: Aging; Animals; Antidepressive Agents; Central Nervous System Stimulants; Cognition; Conditioning, O

2012
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.
    Neuron, 2003, Nov-13, Volume: 40, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Cognition Disorders; Cyclic AMP; Cyclic AMP Res

2003
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Sep-28, Volume: 25, Issue:39

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-P

2005
Expression of the cAMP-phosphodiesterase PDE4D isoforms and age-related changes in follicle-stimulating hormone-stimulated PDE4 activities in immature rat sertoli cells.
    Biology of reproduction, 2007, Volume: 76, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Blotting, Western; Cyclic Nucleotide Phosphodie

2007
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
    Circulation, 1994, Volume: 90, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship,

1994
Age-dependent changes in second messenger and rolipram receptor systems in the gerbil brain.
    Journal of neural transmission. General section, 1994, Volume: 97, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Autoradiography; Brain; Brai

1994
Influence of aging on rolipram-sensitive phosphodiesterase activity and [3H]rolipram binding in the rat brain.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:2

    Topics: Aging; Animals; Brain; Cyclic AMP; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases

1996
Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor.
    Brain research. Molecular brain research, 1996, Sep-05, Volume: 41, Issue:1-2

    Topics: Afferent Pathways; Aging; Animals; Choline O-Acetyltransferase; Cyclic AMP; Cyclic AMP Response Elem

1996
Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:2-3

    Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Dizocilpine Maleate; Excitat

1997
Age-related changes in [3H]nimodipine and [3H]rolipram binding in the rat brain.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Binding Sites; Brain; Calcium

1997
Effect of rolipram on age-related changes in cyclic AMP-selective phosphodiesterase in the rat brain: an autoradiographic study.
    Methods and findings in experimental and clinical pharmacology, 1998, Volume: 20, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Brain; Male; Phosphodiesterase

1998
Age-related effects of rolipram on [3H]quinuclidinyl benzilate and [3H]phorbol 12,13-dibutyrate binding in the rat brain.
    The Tohoku journal of experimental medicine, 1998, Volume: 185, Issue:2

    Topics: Aging; Animals; Autoradiography; Brain; Male; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors

1998
Ontogeny of rolipram-sensitive, low-K(m), cyclic AMP-specific phosphodiesterase in rat brain.
    Brain research. Developmental brain research, 1999, Jan-11, Volume: 112, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic Nuc

1999