rolipram has been researched along with Age-Related Memory Disorders in 17 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rolipram attenuated cognitive decline as well as anxiety- and depression-like behaviors." | 8.31 | Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling. ( Cong, YF; Hou, XQ; Liu, D; Liu, FW; Shen, XR; Song, SS; Xu, L; Zhang, HT, 2023) |
| "Rolipram attenuated cognitive decline as well as anxiety- and depression-like behaviors." | 4.31 | Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling. ( Cong, YF; Hou, XQ; Liu, D; Liu, FW; Shen, XR; Song, SS; Xu, L; Zhang, HT, 2023) |
| " In the present study, animals exposed to the chronic unpredictable stress (CUS), a rodent model of depression, exhibited elevated corticosterone, depressive-like behavior, memory deficits, accompanied with decreased cAMP-PKA-CREB and cAMP-ERK1/2-CREB signaling and neuroplasticity." | 3.81 | Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. ( Li, YF; Liu, YQ; O'Donnell, JM; Wang, ZZ; Wilson, SP; Xu, Y; Yang, WX; Zhang, HT; Zhang, Y; Zhang, YZ; Zhao, N, 2015) |
| "We assessed memory deficits caused by Sleep Deprivation (SD) to determine the therapeutic effect of phosphodiesterase 4 (PDE4) inhibitors on SD-induced memory deficits and to investigate whether the modulation of memory deficits by PDE4 inhibitors is mediated by a protein kinase A (PKA)-independent pathway in conjunction with a PKA-dependent pathway." | 1.72 | Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways. ( El Sayed, N; Gad, M; Maher, A; Nafea, H, 2022) |
| "Rolipram treatment significantly attenuated STZ induced and age related memory deficits, biochemical and histopathological alterations." | 1.46 | Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type. ( Kumar, A; Singh, N, 2017) |
| "In the water-maze test, cerebral ischemia significantly increased the escape latency to reach the platform during acquisition training and decreased the exploration time in the target quadrant in the probe trial test; these were blocked by rolipram in a dose-dependent manner." | 1.37 | Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. ( Cheng, YF; Li, LX; Lin, HB; Wang, C; Xu, JP; Zhang, HT, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Cong, YF | 1 |
| Liu, FW | 1 |
| Xu, L | 1 |
| Song, SS | 1 |
| Shen, XR | 1 |
| Liu, D | 1 |
| Hou, XQ | 1 |
| Zhang, HT | 6 |
| Maher, A | 1 |
| El Sayed, N | 1 |
| Nafea, H | 1 |
| Gad, M | 1 |
| Watremez, W | 1 |
| Jackson, J | 1 |
| Almari, B | 1 |
| McLean, SL | 1 |
| Grayson, B | 1 |
| Neill, JC | 1 |
| Fischer, N | 1 |
| Allouche, A | 1 |
| Koziel, V | 1 |
| Pillot, T | 1 |
| Harte, MK | 1 |
| Titus, DJ | 1 |
| Sakurai, A | 1 |
| Kang, Y | 1 |
| Furones, C | 1 |
| Jergova, S | 1 |
| Santos, R | 1 |
| Sick, TJ | 1 |
| Atkins, CM | 1 |
| Zhang, H | 1 |
| Zhang, SB | 1 |
| Zhang, QQ | 1 |
| Liu, M | 1 |
| He, XY | 1 |
| Zou, Z | 1 |
| Sun, HJ | 1 |
| You, ZD | 1 |
| Shi, XY | 1 |
| Callaghan, CK | 1 |
| O'Mara, SM | 1 |
| Wang, ZZ | 1 |
| Yang, WX | 1 |
| Zhang, Y | 1 |
| Zhao, N | 1 |
| Zhang, YZ | 1 |
| Liu, YQ | 1 |
| Xu, Y | 1 |
| Wilson, SP | 1 |
| O'Donnell, JM | 3 |
| Li, YF | 2 |
| Kumar, A | 1 |
| Singh, N | 1 |
| de Lima, MN | 1 |
| Presti-Torres, J | 1 |
| Garcia, VA | 1 |
| Guimarães, MR | 1 |
| Scalco, FS | 1 |
| Roesler, R | 1 |
| Schröder, N | 1 |
| Wang, Y | 1 |
| Zhang, M | 1 |
| Moon, C | 1 |
| Hu, Q | 1 |
| Wang, B | 1 |
| Martin, G | 1 |
| Sun, Z | 1 |
| Wang, H | 1 |
| Cheng, YF | 2 |
| Wang, C | 2 |
| Lin, HB | 2 |
| Huang, Y | 2 |
| Xu, JP | 2 |
| Li, LX | 1 |
| Kanellopoulos, AK | 1 |
| Semelidou, O | 1 |
| Kotini, AG | 1 |
| Anezaki, M | 1 |
| Skoulakis, EM | 1 |
| Ramos, BP | 1 |
| Birnbaum, SG | 1 |
| Lindenmayer, I | 1 |
| Newton, SS | 1 |
| Duman, RS | 1 |
| Arnsten, AF | 1 |
| Zhao, Y | 1 |
| Dorairaj, NR | 2 |
| Chandler, LJ | 2 |
| Rutten, K | 1 |
| Lieben, C | 1 |
| Smits, L | 1 |
| Blokland, A | 1 |
| Crissman, AM | 1 |
17 other studies available for rolipram and Age-Related Memory Disorders
| Article | Year |
|---|---|
Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Depres | 2023 |
Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways.
Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guanine Nucleotide Exchange Factors; Huma | 2022 |
Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat.
Topics: Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Female; gamma-A | 2018 |
Phosphodiesterase inhibition rescues chronic cognitive deficits induced by traumatic brain injury.
Topics: Animals; Brain Injuries; Chronic Disease; Cognition Disorders; Conditioning, Psychological; Cyclic A | 2013 |
Rescue of cAMP response element-binding protein signaling reversed spatial memory retention impairments induced by subanesthetic dose of propofol.
Topics: Anesthetics, Intravenous; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cues; Cyclic | 2013 |
Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipram.
Topics: Animals; Antineoplastic Agents; Behavior, Animal; Cyclic Nucleotide Phosphodiesterases, Type 4; Depr | 2015 |
Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.
Topics: Animals; Body Weight; Corticosterone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cycli | 2015 |
Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Cholinesterase Inhibit | 2017 |
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, D | 2008 |
The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Biop | 2009 |
Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Cyclic AMP; Cyclic AMP Respon | 2010 |
Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cyclic Nucleotide Phosphodiesterases, Type 4; Male | 2011 |
Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Avoidance Learning; Behavior, Animal; | 2012 |
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Cognition Disorders; Cyclic AMP; Cyclic AMP Res | 2003 |
Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Avoidance Learning; Blotting, Western; Butadienes; Cel | 2004 |
The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.
Topics: Amino Acids; Animals; Behavior, Animal; Complex Mixtures; Cyclic AMP; Dose-Response Relationship, Dr | 2007 |
Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Avoidance Learning; Cells, Cultured; Cyclic AMP; Cycli | 2000 |