rokitamycin and Sinusitis

rokitamycin has been researched along with Sinusitis* in 2 studies

Trials

1 trial(s) available for rokitamycin and Sinusitis

ArticleYear
[Clinical evaluation of TMS-19-Q, a new macrolide antibiotic, in otorhinolaryngological infections].
    The Japanese journal of antibiotics, 1985, Volume: 38, Issue:3

    The clinical study for TMS-19-Q.O tablet was performed with multicenter trial. The results obtained were as follows; Final global improvement rating in 332 cases of otorhinolaryngological infections were excellent in 99, good in 142, fair in 40 and poor in 51 and the effective rate was 72.6%. Those of 266 cases with acute infection were excellent in 93 and good in 121 and the effective rate was 80.5%. Optimum daily doses would be 600 mg based on the analysis of 144 cases of the acute infection with sensitive bacteria (MIC: less than or equal to 3.13 micrograms/ml). In acute infection, major causative bacteria were Gram-positive cocci (GPC) indicating the frequency of 72.0% in total isolates and 87.5% in singly isolated cases. In chronic infection, although GPC were also dominant, Gram-negative bacilli were observed in 31.9%. Clinical and bacteriological effective rates of 160 cases of acute infection with single species were 80.6% and 90.3%, and those of 43 cases in chronic infection were 44.2% and 72.7%, respectively. The resistant rates of isolates in acute infection to TMS-19-Q were 13.3% in S. aureus, 7.7% in S. epidermidis, 6.0% in S. pyogenes and 0% in S. pneumoniae. Those in chronic infection were 20.0% in S. aureus and 25.0% in S. epidermidis. Slight adverse reactions, such as skin eruption or gastrointestinal disorders were observed in 14 cases and no severe one was observed. Slight elevation of GOT, GPT, Al-P, BUN, S-Cr. or eosinophil were observed in 12 cases. These results suggest that TMS-19-Q would be useful antibiotic for otorhinolaryngological infections.

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Clinical Trials as Topic; Female; Humans; Laryngitis; Leucomycins; Male; Microbial Sensitivity Tests; Middle Aged; Miocamycin; Otitis Media, Suppurative; Otorhinolaryngologic Diseases; Sinusitis; Staphylococcus aureus; Staphylococcus epidermidis; Tonsillitis

1985

Other Studies

1 other study(ies) available for rokitamycin and Sinusitis

ArticleYear
The effect of a macrolide antibiotic against experimental sinusitis.
    Rhinology, 1986, Volume: 24, Issue:2

    The effect of a macrolide antibiotic on experimentally induced sinusitis in rabbits was evaluated. Compared with the control group, the effect on sinus mucosal pathology was significantly superior in the drug-treated groups. Inflammation models as used in the present study will contribute to the establishment of a suitable pharmacotherapy for sinusitis.

    Topics: Animals; Leucomycins; Maxillary Sinus; Microscopy, Electron, Scanning; Miocamycin; Nasal Mucosa; Rabbits; Sinusitis

1986