rokitamycin and Laryngitis

rokitamycin has been researched along with Laryngitis* in 2 studies

Trials

1 trial(s) available for rokitamycin and Laryngitis

ArticleYear
[Clinical evaluation of TMS-19-Q, a new macrolide antibiotic, in otorhinolaryngological infections].
    The Japanese journal of antibiotics, 1985, Volume: 38, Issue:3

    The clinical study for TMS-19-Q.O tablet was performed with multicenter trial. The results obtained were as follows; Final global improvement rating in 332 cases of otorhinolaryngological infections were excellent in 99, good in 142, fair in 40 and poor in 51 and the effective rate was 72.6%. Those of 266 cases with acute infection were excellent in 93 and good in 121 and the effective rate was 80.5%. Optimum daily doses would be 600 mg based on the analysis of 144 cases of the acute infection with sensitive bacteria (MIC: less than or equal to 3.13 micrograms/ml). In acute infection, major causative bacteria were Gram-positive cocci (GPC) indicating the frequency of 72.0% in total isolates and 87.5% in singly isolated cases. In chronic infection, although GPC were also dominant, Gram-negative bacilli were observed in 31.9%. Clinical and bacteriological effective rates of 160 cases of acute infection with single species were 80.6% and 90.3%, and those of 43 cases in chronic infection were 44.2% and 72.7%, respectively. The resistant rates of isolates in acute infection to TMS-19-Q were 13.3% in S. aureus, 7.7% in S. epidermidis, 6.0% in S. pyogenes and 0% in S. pneumoniae. Those in chronic infection were 20.0% in S. aureus and 25.0% in S. epidermidis. Slight adverse reactions, such as skin eruption or gastrointestinal disorders were observed in 14 cases and no severe one was observed. Slight elevation of GOT, GPT, Al-P, BUN, S-Cr. or eosinophil were observed in 12 cases. These results suggest that TMS-19-Q would be useful antibiotic for otorhinolaryngological infections.

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Clinical Trials as Topic; Female; Humans; Laryngitis; Leucomycins; Male; Microbial Sensitivity Tests; Middle Aged; Miocamycin; Otitis Media, Suppurative; Otorhinolaryngologic Diseases; Sinusitis; Staphylococcus aureus; Staphylococcus epidermidis; Tonsillitis

1985

Other Studies

1 other study(ies) available for rokitamycin and Laryngitis

ArticleYear
[Clinical application of rokitamycin in pediatrics].
    The Japanese journal of antibiotics, 1988, Volume: 41, Issue:7

    Rokitamycin (RKM, TMS-19-Q) was used for the treatment of infections in patients with underlying diseases. Many antibiotics are tended to be used on these patients with underlying diseases mainly for prophylactic purposes and, as a consequence, microbes resistant to antibiotics frequently become pathogens in these cases. Responses of our patients to RKM, however, were generally excellent but one who had EB virus infection.

    Topics: Administration, Oral; Child; Drug Evaluation; Female; Humans; Infectious Mononucleosis; Laryngitis; Leucomycins; Male; Miocamycin; Streptococcal Infections

1988