rokitamycin has been researched along with Drug-Related-Side-Effects-and-Adverse-Reactions* in 1 studies
1 other study(ies) available for rokitamycin and Drug-Related-Side-Effects-and-Adverse-Reactions
Article | Year |
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[Rokitamycin tolerance in patients with adverse reactions to chemotherapeutic agents].
The main task in the drug intolerance reactions is the choice of "alternative" drug by oral challenge. The tolerance of rokitamycine (RKM), a new macrolide with a wide activity spectrum in 133 antibiotic-intolerant patients has been studied by open oral challenge with incremental dosage until a cumulative dose of 406 mg. The RKM in 96.2% of cases has been well tolerated. Only 5 patients (3.8%) have had reactions, mainly "atypical" and of minor clinical importance, at cumulative doses ranging from 31.25 to 250 mg. The RKM has been well tolerated also by 6 patients who have had reactions to macrolides belonging to the same group (16 membered). Finally, the use of RKM as alternative drug in chemotherapeutics-intolerant patients has been proposed. Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Miocamycin | 1996 |